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Application of magnetic techniques in the field of drug discovery and biomedicine
Open accessAbstract
Magnetic separation technology, using magnetic particles, is quick and easy method for sensitive and reliable capture of specific proteins, genetic material and other biomolecules. The technique offers an advantage in terms of subjecting the analyte to very little mechanical stress compared to other methods. Secondly, these methods are non-laborious, cheap and often highly scalable. Moreover, techniques employing magnetism are more amenable to automation and miniaturization. Now that the human genome is sequenced and about 30,000 genes are annotated, the next step is to identify the function of these individual genes, carrying out genotyping studies for allelic variation and SNP analysis, ultimately leading to identification of novel drug targets. In this post-genomic era, technologies based on magnetic separation are becoming an integral part of todays biology laboratory. This article briefly reviews the selected applications of magnetic separation techniques in the field of biotechnology, biomedicine and drug discovery.
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Cited by
Multifunctional Magnetic Nanoparticles: Design, Synthesis, and Biomedical Applications
Gao, J., Gu, H., & Xu, B. (2009) · Accounts of Chemical Research · doi:10.1021/ar9000026 · Cited by 1,907
Potential applications of enzymes immobilized on/in nano materials: A review
Ansari, S. A., & Husain, Q. (2012) · Biotechnology Advances · doi:10.1016/j.biotechadv.2011.09.005 · Cited by 1,118
Nanodiamond Particles: Properties and Perspectives for Bioapplications
Schrand, A. M., Hens, S. A. C., & Shenderova, O. A. (2009) · Critical Reviews in Solid State and Materials Sciences · doi:10.1080/10408430902831987 · Cited by 802
Iron Oxide Nanoparticles for Magnetically-Guided and Magnetically-Responsive Drug Delivery
Estelrich, J., Escribano, E., Queralt, J., & Busquets, M. (2015) · International Journal of Molecular Sciences · doi:10.3390/ijms16048070 · Cited by 532
Magnetic techniques for the isolation and purification of proteins and peptides
Safarik, I., & Safarikova, M. (2004) · BioMagnetic Research and Technology · doi:10.1186/1477-044x-2-7 · Cited by 503
Metadata
- Authors
- Saiyed, Z., Telang, S., & Ramchand, C.
- Venue
- BioMagnetic Research and Technology
- Published
- 2003-09-18
- Volume
- 1
- Issue
- 1
- Pages
- 2-2
- ISSN
- 1477-044X (ISSN-L)
- OpenAlex
- W2138922360
- Cited by
- 198
- References
- 0
- FWCI
- 5.64
- Type
- journal article
- Language
- en
- Open access
- bronze
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