Iron Oxide Nanoparticles for Magnetically-Guided and Magnetically-Responsive Drug Delivery
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In this review, we discuss the recent advances in and problems with the use of magnetically-guided and magnetically-responsive nanoparticles in drug delivery and magnetofection. In magnetically-guided nanoparticles, a constant external magnetic field is used to transport magnetic nanoparticles loaded with drugs to a specific site within the body or to increase the transfection capacity. Magnetofection is the delivery of nucleic acids under the influence of a magnetic field acting on nucleic acid vectors that are associated with magnetic nanoparticles. In magnetically-responsive nanoparticles, magnetic nanoparticles are encapsulated or embedded in a larger colloidal structure that carries a drug. In this last case, an alternating magnetic field can modify the structure of the colloid, thereby providing spatial and temporal control over drug release.
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Superparamagnetic iron oxide nanoparticles (SPIONs) have been widely used with magnetite (Fe3O4) or maghemite (Fe2O3) as a magnetic core and core-shell structure conjugated with polymer or silica on the outer surface.
“In particular, superparamagnetic iron oxide nanoparticles (SPIONs) have been widely used with magnetite (Fe3O4) or maghemite (Fe2O3) as a magnetic core and core-shell structure conjugated with polymer or silica on the outer surface.191”
From Smart nanoparticles for cancer therapy (2023) · cites this paper as [191]
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Synthesis, characterization, applications, and challenges of iron oxide nanoparticles
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Smart nanoparticles for cancer therapy
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Recent Advances in the Development of Magnetic Nanoparticles for Biomedical Applications
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- Authors
- Estelrich, J., Escribano, E., Queralt, J., & Busquets, M.
- Affiliations
- Institut de Nanociència i Nanotecnologia de la Universitat de Barcelona (ES)
- Corresponding author
- Estelrich, Joan
- Venue
- International Journal of Molecular Sciences
- Publisher
- MDPI AG
- Published
- 2015-04-10
- Volume
- 16
- Issue
- 4
- Pages
- 8070-8101
- ISSN
- 1422-0067 (ISSN-L)
- PMC
- PMC4425068
- OpenAlex
- W2002279353
- Cited by
- 532
- References
- 145
- Citations by year
- 2026: 57 · 2025: 50 · 2024: 44 · 2023: 44 · 2022: 63 · 2021: 50 · 2020: 39 · 2019: 52 · 2018: 60 · 2017: 37 · 2016: 27 · 2015: 9
- FWCI
- 2.67
- Type
- journal article
- Language
- en
- Open access
- gold
- dx.doi.org
- Licence
- Locations
- International Journal of Molecular Sciences (publishedVersion, cc-by)
- PubMed Central (publishedVersion, cc-by)
- PubMed (publishedVersion)
- Dipòsit Digital de la Universitat de Barcelona (Universitat de Barcelona) (submittedVersion, cc-by)
- DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion, cc-by-sa)
- RECERCAT (Consorci de Serveis Universitaris de Catalunya) (submittedVersion, cc-by)
- Funders
- Ministerio de Economía y Competitividad (MAT2012-36270-C04-03, MAT2012)
- Topics
- Physical Sciences › Materials Science › Biomaterials › Nanoparticle-Based Drug Delivery
- Physical Sciences › Engineering › Biomedical Engineering › Characterization and Applications of Magnetic Nanoparticles
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › RNA Interference and Gene Delivery
- Keywords
- iron oxide nanoparticles, magnetic drug delivery, magnetofection, magnetic nanoparticles, nucleic acid delivery, alternating magnetic field, controlled drug release, magnetic targeting, colloidal structure
- MeSH terms
- Animals, Ferric Compounds, Genetic Vectors, Humans, Magnetics, Nucleic Acids, Transfection, Drug Delivery Systems, Magnetite Nanoparticles
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
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