The DOI matches its Crossref record; 1 of the 1 references it cites were found in a registry or an index.
Mode of antiviral action of silver nanoparticles against HIV-1
Open accessAbstract
BACKGROUND: Silver nanoparticles have proven to exert antiviral activity against HIV-1 at non-cytotoxic concentrations, but the mechanism underlying their HIV-inhibitory activity has not been not fully elucidated. In this study, silver nanoparticles are evaluated to elucidate their mode of antiviral action against HIV-1 using a panel of different in vitro assays. RESULTS: Our data suggest that silver nanoparticles exert anti-HIV activity at an early stage of viral replication, most likely as a virucidal agent or as an inhibitor of viral entry. Silver nanoparticles bind to gp120 in a manner that prevents CD4-dependent virion binding, fusion, and infectivity, acting as an effective virucidal agent against cell-free virus (laboratory strains, clinical isolates, T and M tropic strains, and resistant strains) and cell-associated virus. Besides, silver nanoparticles inhibit post-entry stages of the HIV-1 life cycle. CONCLUSIONS: These properties make them a broad-spectrum agent not prone to inducing resistance that could be used preventively against a wide variety of circulating HIV-1 strains.
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Cites
Formation of silver nanoparticles by laser ablation of a silver target in NaCl solution
Bae, C. H., Nam, S. H., & Park, S. M. (2002) · Applied Surface Science · doi:10.1016/s0169-4332(02)00430-0 · Cited by 272
Cited by
Metal-Based Nanoparticles as Antimicrobial Agents: An Overview
Sánchez-López, E., Gomes, D., Esteruelas, G., Bonilla, L., Lopez-Machado, A. L., Galindo, R., Cano, A., Espina, M., Ettcheto, M., Camins, A., et al. (2020) · Nanomaterials · doi:10.3390/nano10020292 · Cited by 1,474
Nanosilver as a new generation of nanoproduct in biomedical applications
Chaloupka, K., Malam, Y., & Seifalian, A. M. (2010) · Trends in Biotechnology · doi:10.1016/j.tibtech.2010.07.006 · Cited by 1,451
Ferdous, Z., & Nemmar, A. (2020) · International Journal of Molecular Sciences · doi:10.3390/ijms21072375 · Cited by 1,019
Silver nanoparticles: synthesis, properties, toxicology, applications and perspectives
Tran, Q. H., Nguyen, V. Q., & Le, A.-T. (2013) · Advances in Natural Sciences: Nanoscience and Nanotechnology · doi:10.1088/2043-6262/4/3/033001 · Cited by 988
Silver Nanoparticles as Potential Antiviral Agents
Galdiero, S., Falanga, A., Vitiello, M., Cantisani, M., Marra, V., & Galdiero, M. (2011) · Molecules · doi:10.3390/molecules16108894 · Cited by 963
Metadata
- Authors
- Lara, H. H., Ayala-Nuñez, N. V., Ixtepan-Turrent, L., & Rodriguez-Padilla, C.
- Venue
- Journal of Nanobiotechnology
- Published
- 2010
- Volume
- 8
- Issue
- 1
- Pages
- 1
- ISSN
- 1477-3155 (ISSN-L)
- OpenAlex
- W2145617208
- Cited by
- 1,061
- References
- 1
- FWCI
- 21.93
- Type
- journal article
- Language
- en
- Open access
- gold
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- Lara, H. H., Ayala-Nuñez, N. V., Ixtepan-Turrent, L., & Rodriguez-Padilla, C. (2010). Mode of antiviral action of silver nanoparticles against HIV-1. Journal of Nanobiotechnology. https://doi.org/10.1186/1477-3155-8-1
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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