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Cited by 333Cancer Cells and MetastasisCellular Mechanics and InteractionsTGF-β signaling in diseases

Interaction of tumor cells with the microenvironment

Open access
Ungefroren, Hendrik, Sebens, Susanne, Seidl, Daniel, Lehnert, Hendrik, Hass, Ralf·2011·Cell Communication and Signaling
DOI 10.1186/1478-811x-9-18PMC PMC3180438
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Abstract

Recent advances in tumor biology have revealed that a detailed analysis of the complex interactions of tumor cells with their adjacent microenvironment (tumor stroma) is mandatory in order to understand the various mechanisms involved in tumor growth and the development of metastasis. The mutual interactions between tumor cells and cellular and non-cellular components (extracellular matrix = ECM) of the tumor microenvironment will eventually lead to a loss of tissue homeostasis and promote tumor development and progression. Thus, interactions of genetically altered tumor cells and the ECM on the one hand and reactive non-neoplastic cells on the other hand essentially control most aspects of tumorigenesis such as epithelial-mesenchymal-transition (EMT), migration, invasion (i.e. migration through connective tissue), metastasis formation, neovascularisation, apoptosis and chemotherapeutic drug resistance. In this mini-review we will focus on these issues that were recently raised by two review articles in CCS.

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  • Interactions among reactive non-neoplastic cells, genetically altered tumor cells, and ECM control the majority of stages of tumorigenesis, including clonal evolution, cancer heterogeneity, epithelial-mesenchymal transition, migration, invasion, metastasis, neovascularization, apoptosis, and chemotherapeutic drug resistance.

    “Therefore, on the other side of the argument, interactions in reactive non-neoplastic cells, genetically-altered tumor cells, and ECM control the majority of the stages of tumorigenesis effectively including clonal evolution, cancer heterogeneity, epithelial-mesenchymal-transition (EMT), migration, invasion, development of metastasis, neovascularization, apoptosis and chemotherapeutic drug resist”

    From Tumor microenvironment complexity and therapeutic implications at a glance (2020) · cites this paper as [11]

    The Abstract states that interactions among genetically altered tumor cells, reactive non-neoplastic cells, and the ECM control most aspects of tumorigenesis, and lists EMT, migration, invasion, metastasis, neovascularization, apoptosis, and chemotherapeutic drug resistance. It does not include clonal evolution or cancer heterogeneity; searches for those terms found no supporting passage in our copy. No page number is provided. (LLM, conf=0.90)

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References 62 · Cited by 333

Research works printed but not linked: 58

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Authors
Ungefroren, H., Sebens, S., Seidl, D., Lehnert, H., & Hass, R.
Affiliations
  • University Hospital Schleswig-Holstein (DE)
  • Medizinische Hochschule Hannover (DE)
Corresponding author
Ungefroren, Hendrik
ORCID
Venue
Cell Communication and Signaling
Publisher
Springer Science and Business Media LLC
Published
2011
Volume
9
Issue
1
Pages
18
ISSN
1478-811X (ISSN-L)
DOI
10.1186/1478-811x-9-18
PMC
PMC3180438
OpenAlex
W2034855235
Cited by
333
References
62
Citations by year
2026: 7 · 2025: 12 · 2024: 15 · 2023: 22 · 2022: 32 · 2021: 37 · 2020: 28 · 2019: 23 · 2018: 18 · 2017: 23 · 2016: 28 · 2015: 23 · 2014: 20 · 2013: 17 · 2012: 25
FWCI
10.09
Type
journal article
Language
en
Open access
Licence
cc-by
Locations
  • Cell Communication and Signaling (publishedVersion, cc-by)
  • Europe PMC (PubMed Central) (publishedVersion, cc-by)
  • PubMed Central (publishedVersion, cc-by)
  • PubMed (publishedVersion)
  • DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion)
Topics
  • Health Sciences › Medicine › Oncology › Cancer Cells and Metastasis
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Cell Biology › Cellular Mechanics and Interactions
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › TGF-β signaling in diseases
Keywords
tumor microenvironment, tumor stroma, extracellular matrix, tumor cell-microenvironment interactions, epithelial-mesenchymal transition, tumor invasion, metastasis, neovascularization, apoptosis, chemoresistance, tissue homeostasis, tumor progression

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