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Cited by 24Exercise and Physiological ResponsesSports Performance and TrainingMuscle metabolism and nutrition

The DOI matches its Crossref record; 14 of the 14 references it cites were found in a registry or an index.

The effects of IQPLUS Focus on cognitive function, mood and endocrine response before and following acute exercise

Open access
Parker, Adam G, Gordon, Josh, Thornton, Aaron, Byars, Allyn, Lubker, John, Bartlett, Michelle, Byrd, Mike, Oliver, Jonathan, Simbo, Sunday, Rasmussen, Chris, Greenwood, Mike, Kreider, Richard B·2011·Journal of the International Society of Sports Nutrition
DOI 10.1186/1550-2783-8-16PMC PMC3210081
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Abstract

BACKGROUND: Phosphatidylserine (PS) is a phospholipid found in cell membranes of most animals and plants. PS has been shown to reduce stress and increase performance in runners, cyclists and golfers. The purpose of this study was to investigate the effects of a PS containing formulation on cognitive function, mood and endocrine response before and after intense resistance exercise. METHODS: 18 lower body, resistance trained, college aged males ingested 14 days of supplement (IQPLUS Focus, providing 400 mg of soy-derived PS) and a Placebo (PL), in a randomized, double-blind, placebo controlled, cross-over manner. Following 14 days of supplementation, participants performed an acute bout of lower body resistance training. Mood (Profile of Mood States, POMS) and cognitive function (Serial Subtraction Test, SST) were measured prior to, 5 minutes after, and 60 minutes after exercise. Venous blood samples were collected prior to, and 5, 15, 25, 40 and 60 minutes after exercise. Blood samples were analyzed for plasma cortisol and testosterone. Data were analyzed using repeated measures ANOVA. RESULTS: PS supplementation significantly reduced the time needed for a correct calculation on the SST by 20% (reduced by 1.27 s per calculation; PL: 6.4 s, PS: 5.13 s; p = 0.001), and reduced the total amount of errors by 39% (PL: 1.28 + .69, PS: .78 + .27, p = 0.53), and increased the amount of correct calculations by 13% (PL: 22.1 + 2.24, PS: 24.9 + 1.52, p = 0.07) prior to or in response to exercise compared to PL. Following exercise, there was no difference in SST scores between PS and PL. There were no significant changes in regards to mood or endocrine response to exercise as a result of PS supplementation. CONCLUSION: PS supplementation significantly increased cognitive function prior to exercise. Improved cognitive function could benefit athletes and non-athletes alike. PS did not appear to affect mood or endocrine response prior to or following resistance exercise.

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  • Previous investigations using this population were unable to identify such changes [11,12], while studies involving older and clinically compromised populations [1] have reported the ability of A-GPC to positively impact cognitive performance.

    “Previous investigations using this population were unable to identify such changes [11,12], while studies involving older and clinically compromised populations [1] have reported the ability of A-GPC to positively impact cognitive performance.”

    From Acute Alpha-Glycerylphosphorylcholine Supplementation Enhances Cognitive Performance in Healthy Men (2024) · cites this paper as [12]

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  • The higher A-GPC dosage (HD: 630 mg) during the present study was higher than the dosages provided during both the Parker (200 mg and 400 mg) and Bunn (500 mg) investigations [11,12].

    “The higher A-GPC dosage (HD: 630 mg) during the present study was higher than the dosages provided during both the Parker (200 mg and 400 mg) and Bunn (500 mg) investigations [11,12]”

    From Acute Alpha-Glycerylphosphorylcholine Supplementation Enhances Cognitive Performance in Healthy Men (2024) · cites this paper as [12]

    The Methods (Experimental Approach to the Problem; page unavailable) say Parker’s participants received phosphatidylserine (PS), not A-GPC: two servings containing 200 mg of PS each. The 200 mg and 400 mg figures therefore refer to PS per serving and total PS, respectively, contrary to the claim that they were A-GPC dosages. (LLM, conf=0.88)

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  • The majority of studies in healthy individuals have failed to highlight cognitive benefits of A-GPC.

    “Research in healthy populations, however, is scant, and, to date, the majority of these studies have failed to highlight cognitive benefits in healthy individuals [11,12].”

    From Acute Alpha-Glycerylphosphorylcholine Supplementation Enhances Cognitive Performance in Healthy Men (2024) · cites this paper as [12]

    The Background and Conclusions discuss phosphatidylserine (PS), not A-GPC. Searches for A-GPC and for the claimed pattern across studies found no passage addressing whether most studies in healthy individuals failed to find cognitive benefits of A-GPC. The paper’s positive result for PS cannot settle a claim about a different substance. (LLM, conf=0.76)

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  • No changes in vertical jump performance were reported after A-GPC supplementation in healthy men and women.

    “Alternatively, no changes in vertical jump performance were reported in an abstract presented as part of conference proceedings by Parker et al. [12]”

    From Acute Alpha-Glycerylphosphorylcholine Supplementation Enhances Cognitive Performance in Healthy Men (2024) · cites this paper as [12]

    The Methods (Experimental Approach to the Problem; no page available) describe phosphatidylserine supplementation in 18 men, not A-GPC supplementation in men and women. Searches for A-GPC and vertical jump performance found no passage reporting a vertical-jump result in our copy. (LLM, conf=0.78)

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Research works printed but not linked: 1

  1. Scholey AB, 2009, Journal of Psychopharmacology

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Metadata

Authors
Parker, A. G., Gordon, J., Thornton, A., Byars, A., Lubker, J., Bartlett, M., Byrd, M., Oliver, J., Simbo, S., Rasmussen, C., Greenwood, M., & Kreider, R. B.
Affiliations
  • Angelo State University (US)
  • West Texas A&M University (US)
  • University of Notre Dame (US)
  • Texas A&M University (US)
Corresponding author
Parker, Adam G
ORCID
Venue
Journal of the International Society of Sports Nutrition
Publisher
Informa UK Limited
Published
2011-02-04
Volume
8
Issue
1
Pages
16-16
ISSN
1550-2783 (ISSN-L)
DOI
10.1186/1550-2783-8-16
PMC
PMC3210081
OpenAlex
W2104128091
Cited by
24
References
14
Citations by year
2026: 1 · 2024: 1 · 2023: 3 · 2022: 3 · 2021: 2 · 2019: 1 · 2018: 2 · 2017: 2 · 2016: 1 · 2015: 2 · 2014: 2 · 2013: 3 · 2012: 1
FWCI
1.95
Type
journal article
Language
en
Open access
Licence
Locations
  • Journal of the International Society of Sports Nutrition (publishedVersion, cc-by)
  • Europe PMC (PubMed Central) (publishedVersion, cc-by)
  • PubMed Central (publishedVersion, cc-by)
  • PubMed (publishedVersion)
  • DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion, cc-by-sa)
  • OakTrust (Texas A&M University Libraries) (submittedVersion)
Topics
  • Health Sciences › Medicine › Physiology (medical) › Exercise and Physiological Responses
  • Health Sciences › Medicine › Orthopedics and Sports Medicine › Sports Performance and Training
  • Health Sciences › Nursing › Nutrition and Dietetics › Muscle metabolism and nutrition
Keywords
phosphatidylserine, cognitive function, mood, resistance training, acute exercise, plasma cortisol, testosterone, Profile of Mood States, dietary supplementation

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