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Cytotoxicity, oxidative stress, and genotoxicity in human hepatocyte and embryonic kidney cells exposed to ZnO nanoparticles
Open accessAbstract
Traces of zinc oxide nanoparticles (ZnO NPs) used may be found in the liver and kidney. The aim of this study is to determine the optimal viability assay for using with ZnO NPs and to assess their toxicity to human hepatocyte (L02) and human embryonic kidney (HEK293) cells. Cellular morphology, mitochondrial function (MTT assay), and oxidative stress markers (malondialdehyde, glutathione (GSH) and superoxide dismutase (SOD)) were assessed under control and exposed to ZnO NPs conditions for 24 h. The results demonstrated that ZnO NPs lead to cellular morphological modifications, mitochondrial dysfunction, and cause reduction of SOD, depletion of GSH, and oxidative DNA damage. The exact mechanism behind ZnO NPs toxicity suggested that oxidative stress and lipid peroxidation played an important role in ZnO NPs-elicited cell membrane disruption, DNA damage, and subsequent cell death. Our preliminary data suggested that oxidative stress might contribute to ZnO NPs cytotoxicity.
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Cited by
In vitro and in vivo toxicity assessment of nanoparticles
Kumar, V., Sharma, N., & Maitra, S. S. (2017) · International Nano Letters · doi:10.1007/s40089-017-0221-3 · Cited by 391
Sun, Q., Li, J., & Le, T. (2018) · Journal of Agricultural and Food Chemistry · doi:10.1021/acs.jafc.8b03210 · Cited by 265
Synthesis, characterization and cytotoxicity of zinc oxide nanoparticles by green synthesis method
Patrón-Romero, L., Luque, P. A., Soto-Robles, C. A., Nava, O., Vilchis-Nestor, A. R., Barajas-Carrillo, V. W., Martínez-Ramírez, C. E., Chávez Méndez, J. R., Alvelais Palacios, J. A., Leal Ávila, M. Á., et al. (2020) · Journal of Drug Delivery Science and Technology · doi:10.1016/j.jddst.2020.101925 · Cited by 33
Metadata
- Authors
- Guan, R., Kang, T., Lu, F., Zhang, Z., Shen, H., & Liu, M.
- Venue
- Nanoscale Research Letters
- Published
- 2012-10-30
- Volume
- 7
- Issue
- 1
- Pages
- 602-602
- ISSN
- 1556-276X (ISSN-L)
- OpenAlex
- W2144687899
- Cited by
- 193
- References
- 0
- FWCI
- 4.20
- Type
- journal article
- Language
- en
- Open access
- gold
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- Guan, R., Kang, T., Lu, F., Zhang, Z., Shen, H., & Liu, M. (2012). Cytotoxicity, oxidative stress, and genotoxicity in human hepatocyte and embryonic kidney cells exposed to ZnO nanoparticles. Nanoscale Research Letters. https://doi.org/10.1186/1556-276x-7-602
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