Cited by 145Advanced Proteomics Techniques and ApplicationsRetinal Diseases and TreatmentsMass Spectrometry Techniques and Applications

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Proteomic analysis of human vitreous humor

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Murthy, Krishna R, Goel, Renu, Subbannayya, Yashwanth, Jacob, Harrys KC, Murthy, Praveen R, Manda, Srikanth Srinivas, Patil, Arun H, Sharma, Rakesh, Sahasrabuddhe, Nandini A, Parashar, Arun, Nair, Bipin G, Krishna, Venkatarangaiah, Prasad, TS Keshava, Gowda, Harsha, Pandey, Akhilesh·2014·Clinical Proteomics

DOI 10.1186/1559-0275-11-29PMC PMC4106660

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Abstract

BACKGROUND: The vitreous humor is a transparent, gelatinous mass whose main constituent is water. It plays an important role in providing metabolic nutrient requirements of the lens, coordinating eye growth and providing support to the retina. It is in close proximity to the retina and reflects many of the changes occurring in this tissue. The biochemical changes occurring in the vitreous could provide a better understanding about the pathophysiological processes that occur in vitreoretinopathy. In this study, we investigated the proteome of normal human vitreous humor using high resolution Fourier transform mass spectrometry. RESULTS: The vitreous humor was subjected to multiple fractionation techniques followed by LC-MS/MS analysis. We identified 1,205 proteins, 682 of which have not been described previously in the vitreous humor. Most proteins were localized to the extracellular space (24%), cytoplasm (20%) or plasma membrane (14%). Classification based on molecular function showed that 27% had catalytic activity, 10% structural activity, 10% binding activity, 4% cell and 4% transporter activity. Categorization for biological processes showed 28% participate in metabolism, 20% in cell communication and 13% in cell growth. The data have been deposited to the ProteomeXchange with identifier PXD000957. CONCLUSION: This large catalog of vitreous proteins should facilitate biomedical research into pathological conditions of the eye including diabetic retinopathy, retinal detachment and cataract.

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Figure 1 Experimental design for proteomic characterization of vitreous humor. Pooled vitreous humor samples were depleted of abundant proteins using Agilent’s MARS 14 column followed by in-gel digestion, in-solution digestion and OFFGEL electrophoresis. The samples were analyzed on LTQ-Orbitrap Velos mass spectrometer.CC BY · PubMed Central

Figure 2 Representative MS/MS spectra of known proteins in vitreous that were identified in this study. A. peptide YLAEFATGNDR belongs to 14-3-3 protein epsilon. B. Peptide EVPDEYEVGSFMEEVR belongs to dickkopf-related protein 3. C. Peptide TFHEASEDCISR belongs to tetranectin. D. Peptide IDLSNNLISSIDNDAFR belongs to opticin.CC BY · PubMed Central

Figure 3 Representative MS/MS spectra of novel proteins identified in this study. A. Peptide FAGIDGTSTYTSGDQK belongs to Transforming growth factor beta-2 (TGFB2). B. Peptide YILDGISALR belongs to Interleukin-6 Precursor (IL-6).CC BY · PubMed Central

Figure 4 Subcellular localization and functional annotation of proteins identified in vitreous humor. A. Gene Ontology analysis for subcellular localization of identified proteins. B. Molecular functions of identified proteins. C. Biological processes of the identified proteins. The data regarding proteins was obtained from Human Protein Reference Database (HPRD: http://www.hprd.org).CC BY · PubMed Central

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Authors: Murthy, K. R., Goel, R., Subbannayya, Y., Jacob, H. K., Murthy, P. R., Manda, S. S., Patil, A. H., Sharma, R., Sahasrabuddhe, N. A., Parashar, A., Nair, B. G., Krishna, V., Prasad, T. K., Gowda, H., & Pandey, A.
Affiliations: Institute of Bioinformatics (IN)
Kuvempu University (IN)
Pondicherry University (IN)
National Institute of Mental Health and Neurosciences (IN)
Armed Forces Medical College (IN)
Amrita Vishwa Vidyapeetham (IN)
Johns Hopkins University (US)
Corresponding author: Murthy, Krishna R
ORCID: Subbannayya, Yashwanth
Jacob, Harrys KC
Manda, Srikanth Srinivas
Patil, Arun H
Sharma, Rakesh
Parashar, Arun
Nair, Bipin G
Gowda, Harsha
Pandey, Akhilesh
Venue: Clinical Proteomics
Publisher: Springer Science and Business Media LLC
Published: 2014-07-14
Volume: 11
Issue: 1
Pages: 29-29
ISSN: 1542-6416 (ISSN-L)
1559-0275
DOI: 10.1186/1559-0275-11-29
PMC: PMC4106660
OpenAlex: W2164518567
Cited by: 145
References: 76
Citations by year: 2026: 6 · 2025: 10 · 2024: 14 · 2023: 12 · 2022: 9 · 2021: 10 · 2020: 21 · 2019: 8 · 2018: 18 · 2017: 15 · 2016: 14 · 2015: 6 · 2014: 2
FWCI: 5.29
Type: journal article
Language: en
Open access: gold
doi.org
Licence: cc-by
Locations: Clinical Proteomics (publishedVersion, cc-by)
PubMed Central (publishedVersion, cc-by)
PubMed (publishedVersion)
Funders: Wellcome Trust
Department of Biotechnology, Ministry of Science and Technology, India
University Grants Commission
The Wellcome Trust DBT India Alliance
Topics: Physical Sciences › Chemistry › Spectroscopy › Advanced Proteomics Techniques and Applications
Health Sciences › Medicine › Ophthalmology › Retinal Diseases and Treatments
Physical Sciences › Chemistry › Spectroscopy › Mass Spectrometry Techniques and Applications
Keywords: vitreous humor, vitreous proteome, vitreoretinopathy, vitreous proteins, extracellular proteins, protein function classification, diabetic retinopathy, retinal detachment, cataract

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Proteomic analysis of human vitreous humor

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