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The Changing Microbial Environment and Chronic Inflammatory Disorders

Rook, Graham A.W.·2008·Allergy, Asthma & Clinical Immunology
DOI 10.1186/1710-1492-4-3-117PMC PMC2868866
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Abstract

There is much to be gained from examining human diseases within the expanding framework of Darwinian medicine. This is particularly true of those conditions that change in frequency as populations develop from the human "environment of evolutionary adaptedness" to the living conditions of the rich industrialized countries. This development entails major changes in lifestyle, leading to reductions in contact with environmental microorganisms and helminths that have evolved a physiologic role as drivers of immunoregulatory circuits. It is suggested that a deficit in immunoregulation in rich countries is contributing not only to increases in the incidence of allergic disorders but also to increases in other chronic inflammatory conditions that are exacerbated by a failure to terminate inappropriate inflammatory reponses. These include autoimmunity, neuroinflammatory disorders, atherosclerosis, depression associated with raised inflammatory cytokines, and some cancers.

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Metadata

Authors
Rook, G. A. W.
Venue
Allergy, Asthma & Clinical Immunology
Publisher
Springer Science and Business Media LLC
Published
2008-09
Volume
4
Issue
3
ISSN
1710-1492
DOI
10.1186/1710-1492-4-3-117
PMC
PMC2868866
Cited by
9
References
6
Language
en
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