CoChat
Sign Up
Cited by 38Asthma and respiratory diseasesAllergic Rhinitis and SensitizationAir Quality and Health Impacts

Prenatal allergen and diesel exhaust exposure and their effects on allergy in adult offspring mice

Open access
Corson, Lin, Zhu, Huaijie, Quan, Chunli, Grunig, Gabriele, Ballaney, Manisha, Jin, Ximei, Perera, Frederica P, Factor, Phillip H +2 more·2010·Allergy, Asthma & Clinical Immunology
DOI 10.1186/1710-1492-6-7PMC PMC2875211
Open this paper in CoChat — free accountOpen PDF

Abstract

Background: Multiple studies have suggested that prenatal exposure to either allergens or air pollution may increase the risk for the development of allergic immune responses in young offspring. However, the effects of prenatal environmental exposures on adult offspring have not been well-studied. We hypothesized that combined prenatal exposure to Aspergillus fumigatus (A. fumigatus) allergen and diesel exhaust particles will be associated with altered IgE production, airway inflammation, airway hyperreactivity (AHR), and airway remodeling of adult offspring. Methods: Following sensitization via the airway route to A. fumigatus and mating, pregnant BALB/c mice were exposed to additional A. fumigatus and/or diesel exhaust particles. At age 9-10 weeks, their offspring were sensitized and challenged with A. fumigatus. Results: We found that adult offspring from mice that were exposed to A. fumigatus or diesel exhaust particles during pregnancy experienced decreases in IgE production. Adult offspring of mice that were exposed to both A. fumigatus and diesel exhaust particles during pregnancy experienced decreases in airway eosinophilia. Conclusion: These results suggest that, in this model, allergen and/or diesel administration during pregnancy may be associated with protection from developing systemic and airway allergic immune responses in the adult offspring.

The claims and statistics of this paper haven’t been checked yet.

Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.

A few free checks a day · papers already verified open instantly · results are public

Integrity signals

Registry

Crossref · 10.1186/1710-1492-6-7

Cites

Statistics

Claims the paper makes

The claims and statistics of this paper haven’t been checked yet.

Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.

A few free checks a day · papers already verified open instantly · results are public

Claims other papers make about this one

Each is checked against this paper’s own text: does it say what the citing paper says it does?

Self-check

Percentages, sums and reported differences re-computed from the paper’s own numbers.

The self-check needs the paper’s full text.

Cites

No references could be resolved yet.

Research works printed but not linked: 43

  1. Miller RL Garfinkel R Horton M Camann D Perera FP Whyatt RM Kinney PL Polycyclic aromatic hydrocarbons, environmental tobacco smoke, and respiratory symptoms in an inner-city birth cohort Chest 2004 126 1071 1078 10.1378/chest.126.4.1071 15486366 PMC2223076 · DOI
  2. Hamada K Suzaki Y Leme A Ito T Miyamoto K Kobzik L Kimura H Exposure of pregnant mice to an air pollutant aerosol increases asthma susceptibility in offspring J Toxicol Environ Health A 2007 70 688 695 10.1080/15287390600974692 17365623 · DOI · Paper page
  3. Moshammer H Bartonova A Hanke W Hazel P van den Koppe JG Kramer U Ronchetti R Sram RJ Wallis M Wallner P Zuurbier M Air pollution: A threat to the health of our children Acta Paediatr Suppl 2006 95 93 105 10.1080/08035320600886620 17000576 · DOI
  4. Jedrychowski W Flak E Maternal smoking during pregnancy and postnatal exposure to environmental tobacco smoke as predisposition factors to acute respiratory infections Environ Health Perspect 1997 105 302 306 10.2307/3433267 9171991 PMC1470010 · DOI
  5. Fedulov AV Leme A Yang Z Dahl M Lim R Mariani TJ Kobzik L Pulmonary exposure to particles during pregnancy causes increased neonatal asthma susceptibility Am J Respir Cell Mol Biol 2008 38 57 67 10.1165/rcmb.2007-0124OC 17656681 PMC2176127 · DOI · Paper page
  6. Hollingsworth JW Maruoka S Boon K Garantziotis S Li Z Tomfohr J Bailey N Potts EN Whitehead G Brass DM Schwartz DA In utero supplementation with methyl donors enhances allergic airway disease in mice J Clin Invest 2008 118 3462 3469 18802477 PMC2542847
  7. Blumer N Herz U Wegmann M Renz H Prenatal lipopolysaccharide-exposure prevents allergic sensitization and airway inflammation, but not airway responsiveness in a murine model of experimental asthma Clin Exp Allergy 2005 35 397 402 10.1111/j.1365-2222.2005.02184.x 15784121 · DOI
  8. Gerhold K Avagyan A Seib C Frei R Steinle J Ahrens B Dittrich AM Blumchen K Lauener R Hamelmann E Prenatal initiation of endotoxin airway exposure prevents subsequent allergen-induced sensitization and airway inflammation in mice J Allergy Clin Immunol 2006 118 666 673 10.1016/j.jaci.2006.05.022 16950286 · DOI
  9. Douwes J Cheng S Travier N Cohet C Niesink A McKenzie J Cunningham C Le Gros G von Mutius E Pearce N Farm exposure in utero may protect against asthma, hay fever and eczema Eur Respir J 2008 32 603 611 10.1183/09031936.00033707 18448493 · DOI
  10. Fusaro AE Maciel M Victor JR Oliveira CR Duarte AJ Sato MN Influence of maternal murine immunization with dermatophagoides pteronyssinus extract on the type I hypersensitivity response in offspring Int Arch Allergy Immunol 2002 127 208 216 10.1159/000053865 11979046 · DOI
  11. Patel MM Miller RL Air pollution and childhood asthma: Recent advances and future directions Current Opinions in Pediatrics 2009 21 235 242 10.1097/MOP.0b013e3283267726 PMC2740858 19663041 · DOI
  12. Wang J Visness CM Calatroni A Gergen PJ Mitchell HE Sampson HA Effect of environmental allergen sensitization on asthma morbidity in inner-city asthmatic children Clin Exp Allergy 2009 39 9 1381 89 10.1111/j.1365-2222.2009.03225.x 19489919 PMC4785875 · DOI
  13. Daley E Emson C Guignabert C de Waal Malefyt R Louten J Kurup VP Hogaboam C Taraseviciene-Stewart L Voelkel NF Rabinovitch M Grunig E Grunig G Pulmonary arterial remodeling induced by a Th2 immune response J Exp Med 2008 205 361 372 10.1084/jem.20071008 18227220 PMC2271018 · DOI
  14. Liu J Ballaney M Al-alem U Quan C Jin X Perera F Chen LC Miller RL Combined inhaled diesel exhaust particles and allergen exposure alter methylation of t helper genes and IgE production in vivo Toxicological Sciences 2008 102 76 81 10.1093/toxsci/kfm290 18042818 PMC2268643 · DOI
  15. McDonald JD Barr EB White RK Design, characterization, and evaluation of a small-scale diesel exhaust exposure system Aerosol Science and Technology 2004 38 62 78 10.1080/02786820490247623 · DOI
  16. Liu J Ballaney M Al-alem U Quan C Jin X Perera F Chen LC Miller RL Combined inhaled diesel exhaust particles and allergen exposure alter methylation of t helper genes and ige production in vivo Toxicol Sci 2008 102 76 81 10.1093/toxsci/kfm290 18042818 PMC2268643 · DOI
  17. Matson AP Zhu L Lingenheld EG Schramm CM Clark RB Selander DM Thrall RS Breen E Puddington L Maternal transmission of resistance to development of allergic airway disease J Immunol 2007 179 1282 1291 17617621 PMC3155847
  18. Oldenburg PJ Wyatt TA Factor PH Sisson JH Alcohol feeding blocks methacholine-induced airway responsiveness in mice Am J Physiol Lung Cell Mol Physiol 2008 296 1 L109 14 10.1152/ajplung.00487.2007 18931055 PMC2636948 · DOI
  19. Lu FL Johnston RA Flynt L Theman TA Terry RD Schwartzman IN Lee A Shore SA Increased pulmonary responses to acute ozone exposure in obese db/db mice Am J Physiol Lung Cell Mol Physiol 2006 290 L856 865 10.1152/ajplung.00386.2005 16373670 · DOI
  20. Padula SJ Lingenheld EG Stabach PR Chou CH Kono DH Clark RB Identification of encephalitogenic v beta-4-bearing T cells in sjl mice. Further evidence for the v region disease hypothesis? J Immunol 1991 146 879 883 1703184
  21. Sur S Wild JS Choudhury BK Sur N Alam R Klinman DM Long term prevention of allergic lung inflammation in a mouse model of asthma by CpG oligodeoxynucleotides J Immunol 1999 162 6284 6293 10229876
  22. Verhasselt V Milcent V Cazareth J Kanda A Fleury S Dombrowicz D Glaichenhaus N Julia V Breast milk-mediated transfer of an antigen induces tolerance and protection from allergic asthma Nat Med 2008 14 170 175 10.1038/nm1718 18223654 · DOI
  23. Fusaro AE Brito CAd Taniguchi EF Muniz BP Victor JR Orii NM Duarte AJdS Sato MN Balance between early life tolerance and sensitization in allergy: Dependence on the timing and intensity of prenatal and postnatal allergen exposure of the mother Immunology 2009 128 10.1111/j.1365-2567.2008.03028.x PMC2753947 19740315 · DOI
  24. Yoshino S Yamaki K Li X Sai T Yanagisawa R Takano H Taneda S Hayashi H Mori Y Prenatal exposure to bisphenol a up-regulates immune responses, including T helper 1 and t helper 2 responses, in mice Immunology 2004 112 489 495 10.1111/j.1365-2567.2004.01900.x 15196218 PMC1782504 · DOI
  25. Inal A Karakoc GB Altintas DU Pinar M Ceter T Yilmaz M Kendirli SG Effect of outdoor fungus concentrations on symptom severity of children with asthma and/or rhinitis monosensitized to molds Asian Pac J Allergy Immunol 2008 26 11 17 18595525
  26. Harley KG Macher JM Lipsett M Duramad P Holland NT Prager SS Ferber J Bradman A Eskenazi B Tager IB Fungi and pollen exposure in the first months of life and risk of early childhood wheezing Thorax 2009 64 353 358 10.1136/thx.2007.090241 19240083 PMC3882001 · DOI
  27. Hagmolen of Ten Have W Berg NJ van den Palen J van der van Aalderen WM Bindels PJ Residential exposure to mould and dampness is associated with adverse respiratory health Clin Exp Allergy 2007 37 1827 1832 10.1111/j.1365-2222.2007.02841.x 17919308 · DOI
  28. Schram-Bijkerk D Doekes G Boeve M Douwes J Riedler J Ublagger E von Mutius E Benz M Pershagen G Wickman M Alfven T Braun-Fahrlander C Waser M Brunekreef B Exposure to microbial components and allergens in population studies: A comparison of two house dust collection methods applied by participants and fieldworkers Indoor Air 2006 16 414 425 10.1111/j.1600-0668.2006.00435.x 17100663 · DOI
  29. Schram-Bijkerk D Doekes G Douwes J Boeve M Riedler J Ublagger E von Mutius E Benz MR Pershagen G van Hage M Scheynius A Braun-Fahrlander C Waser M Brunekreef B Bacterial and fungal agents in house dust and wheeze in children: The parsifal study Clin Exp Allergy 2005 35 1272 1278 10.1111/j.1365-2222.2005.02339.x 16238785 · DOI
  30. Matsui EC Eggleston PA Breysse PN Rand CS Diette GB Mouse allergen-specific antibody responses in inner-city children with asthma J Allergy Clin Immunol 2007 119 910 915 10.1016/j.jaci.2006.12.663 17337296 · DOI
  31. Nordling E Berglind N Melén E Emenius G Hallberg J Nyberg F Pershagen G Svartengren M Wickman M Bellander T Traffic-related air pollution and childhood respiratory symptoms, function and allergies Epidemiology 2008 19 401 408 10.1097/EDE.0b013e31816a1ce3 18379426 · DOI
  32. Dai J Xie C Vincent R Churg A Air pollution particles produce airway wall remodeling in rat tracheal explants Am J Respir Cell Mol Biol 2003 29 352 358 10.1165/rcmb.2002-0318OC 12649123 · DOI
  33. Gao FS Qiao JO Zhang Y Jin XQ Chronic intranasal administration of aspergillus fumigatus spores leads to aggravation of airway inflammation and remodelling in asthmatic rats Respirology 2009 14 3 360 370 10.1111/j.1440-1843.2009.01482.x 19207119 · DOI
  34. Temelkovski J Hogan SP Shepherd DP Foster PS Kumar RK An improved murine model of asthma: Selective airway inflammation, epithelial lesions and increased methacholine responsiveness following chronic exposure to aerosolised allergen Thorax 1998 53 849 856 10.1136/thx.53.10.849 10193371 PMC1745083 · DOI
  35. Leigh R Ellis R Wattie J Southam DS De Hoogh M Gauldie J O'Byrne PM Inman MD Dysfunction and remodeling of the mouse airway persist after resolution of acute allergen-induced airway inflammation Am J Respir Cell Mol Biol 2002 27 526 535 12397011
  36. Fulkerson PC Rothenberg ME Hogan SP Building a better mouse model: Experimental models of chronic asthma Clin Exp Allergy 2005 35 1251 1253 10.1111/j.1365-2222.2005.02354.x 16238782 · DOI
  37. Blacquiere MJ Timens W Melgert BN Geerlings M Postma DS Hylkema MN Maternal smoking during pregnancy induces airway remodeling in mice offspring Eur Respir J 2009 33 5 1131 40 10.1183/09031936.00129608 19129273 · DOI
  38. Geerts CC Bots ML Grobbee DE Uiterwaal CS Parental smoking and vascular damage in young adult offspring: Is early life exposure critical? The atherosclerosis risk in young adults study Arterioscler Thromb Vasc Biol 2008 28 2296 2302 10.1161/ATVBAHA.108.173229 19020316 · DOI
  39. Rastogi D Wang C Mao X Lendor C Rothman PB Miller RL Antigen-specific immune responses to influenza vaccine in utero J Clin Invest 2007 117 1637 1646 10.1172/JCI29466 17549258 PMC1878514 · DOI
  40. Hamada K Suzaki Y Goldman A Ning YY Goldsmith C Palecanda A Coull B Hubeau C Kobzik L Allergen-independent maternal transmission of asthma susceptibility J Immunol 2003 170 1683 1689 12574331
  41. Frederica Perera W-yT Herbstman Julie Tang DeIIang Levin Linda Miller Rachel Shuk-mei Ho Relation of DNA methylation of 59-CpG island of ACSL3 to transplacental exposure to airborne polycyclic aromatic hydrocarbons and childhood asthma PLoS 2009 4 2 e4488 doi:10.1371/journal.pone.0004488 PMC2637989 19221603 · DOI
  42. Jarrett EE Hall E IgE suppression by maternal IgG Immunology 1983 48 49 58 6848454 PMC1454004
  43. Kips JC Anderson GP Fredberg JJ Herz U Inman MD Jordana M Kemeny DM Lotvall J Pauwels RA Plopper CG Schmidt D Sterk PJ Van Oosterhout AJ Vargaftig BB Chung KF Murine models of asthma Eur Respir J 2003 22 374 382 10.1183/09031936.03.00026403 12952276 · DOI

Cited by

Sorted by citations

Authors
Corson, L., Zhu, H., Quan, C., Grunig, G., Ballaney, M., Jin, X., Perera, F. P., Factor, P. H., Chen, L.-C., & Miller, R. L.
Affiliations
  • Columbia University Irving Medical Center (US)
  • New York University (US)
  • Columbia University (US)
Corresponding author
Miller, Rachel L
ORCID
Venue
Allergy, Asthma & Clinical Immunology
Publisher
Springer Science and Business Media LLC
Published
2010-05-11
Volume
6
Issue
1
Pages
7-7
ISSN
  • 1710-1484 (ISSN-L)
  • 1710-1492
DOI
10.1186/1710-1492-6-7
PMC
PMC2875211
OpenAlex
W2113925336
Cited by
38
References
0
Citations by year
2025: 1 · 2023: 1 · 2022: 1 · 2021: 2 · 2020: 4 · 2019: 5 · 2016: 2 · 2015: 2 · 2014: 2 · 2013: 9 · 2012: 2
FWCI
3.90
Type
journal article
Language
en
Open access
Licence
cc-by
Locations
  • Allergy Asthma and Clinical Immunology (publishedVersion, cc-by)
  • PubMed Central (publishedVersion, cc-by)
  • PubMed (publishedVersion)
  • DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion, cc-by-sa)
Funders
National Institute of Environmental Health Sciences (P50ES015905, R21ES013063)
Topics
  • Health Sciences › Medicine › Physiology › Asthma and respiratory diseases
  • Health Sciences › Medicine › Immunology and Allergy › Allergic Rhinitis and Sensitization
  • Physical Sciences › Environmental Science › Health, Toxicology and Mutagenesis › Air Quality and Health Impacts
Keywords
diesel exhaust particles, Aspergillus fumigatus, airway allergy, IgE production, airway eosinophilia, airway hyperresponsiveness, airway remodeling, airway inflammation, maternal exposure, air pollution

About these checks

Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.

Statistics and arithmetic are recomputed, not judged.

Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.

What counts as a claim ›How we measure confidence ›How we check this ›

Are you an author, or do you see a problem with this page? Request a review