In utero ultrafine particulate matter exposure causes offspring pulmonary immunosuppression
Open accessAbstract
Significance: Particulate matter exposure causes infant respiratory morbidity and mortality, but the role of ultrafine particles (UFPs) with an aerodynamic diameter of less than 0.1 μm in asthma and respiratory tract infections is unclear. Limited mechanistic information is available concerning UFP influence on the etiology of childhood asthma or susceptibility to respiratory infections. Here we exposed two strains of mice (sensitive to oxidative stress or allergen exposure) to UFPs throughout gestation at concentrations relevant to human exposures. Our results reveal a window of pulmonary immunosuppression in offspring following in utero UFP exposure. A dampened host immune response during early development underlies increased childhood susceptibility to respiratory infections, highlighting the necessity to develop strategies to protect the fetus during this vulnerable period.
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Circulating IL-10 was significantly upregulated in offspring exposed to PM0.1, suggesting increased regulatory T cell expression and suppressed Th2/Th17 response.
“Circulating IL-10 was significantly upregulated in offspring exposed to PM0.1, suggesting increased regulatory T cell (Tregs) expression and suppressed Th2/Th17 response.”
From Air pollution and children’s health—a review of adverse effects associated with prenatal exposure from fine to ultrafine particulate matter (2021) · cites this paper as [68]
The systemic inflammatory response section reports significantly higher circulating IL-10 in C57BL/6 PM-HDM offspring than in FA-HDM offspring; the Discussion reports a reduced Th2/Th17 response in that comparison. The Discussion proposes that increased Treg cells likely underlie the response, but says the study could not distinguish Treg levels between exposed and unexposed groups. The claim omits the HDM challenge and presents the Treg increase more firmly than the paper establishes. Page numbers were not provided. (LLM, conf=0.88)
Experimental — accuracy not yet measuredUsing this system, Rychlik et al. reported an average mass concentration of 101.94 μg/m3, corresponding to a 24-h daily mean dose of 25 μg/m3.
“Using this system, Rychlik et al. [68] reported an average mass concentration of 101.94 μg/m3, corresponding to a 24-h daily mean dose of 25 μg/m3.”
From Air pollution and children’s health—a review of adverse effects associated with prenatal exposure from fine to ultrafine particulate matter (2021) · cites this paper as [68]
Particle size ranged from 20 to 220 nm, with a peak diameter of 50 nm in the Zhang et al. ultrafine PM mixture.
“Particle size ranged from 20 to 220 nm, with a peak diameter of 50 nm.”
From Air pollution and children’s health—a review of adverse effects associated with prenatal exposure from fine to ultrafine particulate matter (2021) · cites this paper as [68]
In a mouse model of prenatal PM0.1 exposure, offspring from the exposed group showed a dampened response to HDM challenge.
“Likewise, in a mouse model of prenatal exposure to PM0.1, Rychlik et al. [68] demonstrated a dampened response to HDM challenge in offspring from the exposed group.”
From Air pollution and children’s health—a review of adverse effects associated with prenatal exposure from fine to ultrafine particulate matter (2021) · cites this paper as [68]
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- Authors
- Rychlik, K. A., Secrest, J. R., Lau, C., Pulczinski, J., Zamora, M. L., Leal, J., Langley, R., Myatt, L. G., Raju, M., Chang, R. C.-A., Li, Y., Golding, M. C., Rodrigues-Hoffmann, A., Molina, M. J., Zhang, R., & Johnson, N. M.
- Affiliations
- Texas A&M University (US)
- Department of Veterinary Pathobiology, Texas A&M University, College Station, TX 77843;
- University of California San Diego (US)
- Corresponding author
- Molina, Mario J.
- Johnson, Natalie M.
- ORCID
- Venue
- Proceedings of the National Academy of Sciences
- Publisher
- National Academy of Sciences
- Published
- 2019-02-11
- Volume
- 116
- Issue
- 9
- Pages
- 3443-3448
- ISSN
- 0027-8424 (ISSN-L)
- 1091-6490
- PMC
- PMC6397543
- OpenAlex
- W2913752795
- Cited by
- 98
- References
- 47
- Citations by year
- 2026: 10 · 2025: 2 · 2024: 8 · 2023: 10 · 2022: 16 · 2021: 21 · 2020: 23 · 2019: 8
- FWCI
- 7.34
- Type
- journal article
- Language
- en
- Open access
- hybrid
- doi.org
- Licence
- Locations
- Proceedings of the National Academy of Sciences (publishedVersion, cc-by-nc-nd)
- Europe PMC (PubMed Central) (publishedVersion, cc-by-nc-nd)
- PubMed Central (publishedVersion, cc-by-nc-nd)
- PubMed (publishedVersion)
- eScholarship (California Digital Library) (submittedVersion)
- eScholarship (California Digital Library) (submittedVersion, cc-by-nc-nd)
- Funders
- National Institute of environmental health sciences (R01ES028866)
- The Robert A. Welch Foundation (A-1417)
- Topics
- Physical Sciences › Environmental Science › Health, Toxicology and Mutagenesis › Air Quality and Health Impacts
- Health Sciences › Medicine › Physiology › Asthma and respiratory diseases
- Physical Sciences › Environmental Science › Health, Toxicology and Mutagenesis › Indoor Air Quality and Microbial Exposure
- Keywords
- ultrafine particles, prenatal exposure, prenatal air pollution exposure, house dust mite allergens, allergic airway inflammation, regulatory T cells, IL-13, IL-17, IL-10, bronchoalveolar lavage, respiratory infection susceptibility, mouse strain differences, oxidative stress
- MeSH terms
- Allergens, Animals, Asthma, Bronchoalveolar Lavage Fluid, Female, Hypersensitivity, Immunosuppression Therapy, Lung, Pregnancy, Prenatal Exposure Delayed Effects, Cytokines, Th2 Cells, Pyroglyphidae, Mice, Particulate Matter, Th17 Cells
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