Comparative analysis of Klebsiella pneumoniae genomes identifies a phospholipase D family protein as a novel virulence factor

Gapped BLAST and PSI-BLAST: a new generation of protein database search programs

Altschul, S. (1997) · Nucleic Acids Research · doi:10.1093/nar/25.17.3389 · Cited by 73,302 · see citing works

A RAPID METHOD OF TOTAL LIPID EXTRACTION AND PURIFICATION

Bligh, E. G., & Dyer, W. J. (1959) · Canadian Journal of Biochemistry and Physiology · doi:10.1139/o59-099 · Cited by 54,751 · see citing works

The RAST Server: Rapid Annotations using Subsystems Technology

Aziz, R. K., Bartels, D., Best, A. A., DeJongh, M., Disz, T. L., Edwards, R. A., Formsma, K., Gerdes, S., Glass, E. M., Kubal, M., et al. (2008) · BMC Genomics · doi:10.1186/1471-2164-9-75 · Cited by 11,777 · see citing works

Klebsiella spp. as Nosocomial Pathogens: Epidemiology, Taxonomy, Typing Methods, and Pathogenicity Factors

Podschun, R., & Ullmann, U. (1998) · Clinical Microbiology Reviews · doi:10.1128/cmr.11.4.589 · Cited by 2,701 · see citing works

The lipocalin protein family: structure and function

FLOWER, D. R. (1996) · Biochemical Journal · doi:10.1042/bj3180001 · Cited by 1,679 · see citing works

Klebsiella pneumoniae liver abscess: a new invasive syndrome

Siu, L.-K. K., Yeh, K., Lin, J., Fung, C., & Chang, F. (2012) · The Lancet Infectious Diseases · doi:10.1016/s1473-3099(12)70205-0 · Cited by 907 · see citing works

An Endonuclease Allows Streptococcus pneumoniae to Escape from Neutrophil Extracellular Traps

Beiter, K., Wartha, F., Albiger, B., Normark, S. J., Zychlinsky, A., & Henriques‐Normark, B. (2006) · Current Biology · doi:10.1016/j.cub.2006.01.056 · Cited by 588 · see citing works

Dissecting the bacterial type VI secretion system by a genome wide in silico analysis: what can be learned from available microbial genomic resources?

Boyer, F., Fichant, G. A., Berthod, J., Vandenbrouck, Y., & Attrée, I. (2009) · BMC Genomics · doi:10.1186/1471-2164-10-104 · Cited by 575 · see citing works

Capsule Polysaccharide Mediates Bacterial Resistance to Antimicrobial Peptides

Campos, M. A. L., Vargas, M. A., Regueiro, V., Llompart, C. M., Albertí, S., & Bengoechea, J. A. (2004) · Infection and Immunity · doi:10.1128/iai.72.12.7107-7114.2004 · Cited by 515 · see citing works

Virulent Clones of Klebsiella pneumoniae: Identification and Evolutionary Scenario Based on Genomic and Phenotypic Characterization

Brisse, S., Fèvre, C., Passet, V., Issenhuth-Jeanjean, S., Tournebize, R., Diancourt, L., & Grimont, P. A. D. (2009) · PLoS ONE · doi:10.1371/journal.pone.0004982 · Cited by 493 · see citing works

Interleukin-17 and Lung Host Defense against Klebsiella pneumoniae Infection

Ye, P., Garvey, P. B., Zhang, P., Nelson, S., Bagby, G. J., Summer, W. R., Schwarzenberger, P. O., Shellito, J. E., & Kolls, J. K. (2001) · American Journal of Respiratory Cell and Molecular Biology · doi:10.1165/ajrcmb.25.3.4424 · Cited by 459 · see citing works

A global emerging disease of Klebsiella pneumoniae liver abscess: is serotype K1 an important factor for complicated endophthalmitis?

Fung, C.-P., Chang, F.-Y., Lee, S.-C., Hu, B.-S., Kuo, B. I.-T., Liu, C.-Y., Ho, M.-W., & Siu, L.-K. K. (2002) · Gut · doi:10.1136/gut.50.3.420 · Cited by 420 · see citing works

Diverse type VI secretion phospholipases are functionally plastic antibacterial effectors

Russell, A. B., LeRoux, M., Hathazi, K., Agnello, D. M., Ishikawa, T., Wiggins, P. A., Wai, S. N., & Mougous, J. D. (2013) · Nature · doi:10.1038/nature12074 · Cited by 415 · see citing works

Thematic Review Series: Glycerolipids. Cardiolipin synthesis for the assembly of bacterial and mitochondrial membranes

Schlame, M. (2008) · Journal of Lipid Research · doi:10.1194/jlr.r700018-jlr200 · Cited by 388 · see citing works

Pathogenicity islands: a molecular toolbox for bacterial virulence

Gal‐Mor, O., & Finlay, B. B. (2006) · Cellular Microbiology · doi:10.1111/j.1462-5822.2006.00794.x · Cited by 383 · see citing works

Genome Sequencing and Comparative Analysis of Klebsiella pneumoniae NTUH-K2044, a Strain Causing Liver Abscess and Meningitis

Wu, K.-M., Li, L.-H., Yan, J.-J., Tsao, N., Liao, T.-L., Tsai, H.-C., Fung, C., Chen, H.-J., Liu, Y.-M., Wang, J.-T., et al. (2009) · Journal of Bacteriology · doi:10.1128/jb.00315-09 · Cited by 381 · see citing works

A novel family of phospholipase D homologues that includes phospholipid synthases and putative endonucleases: Identification of duplicated repeats and potential active site residues

Ponting, C. P., & Kerr, I. D. (1996) · Protein Science · doi:10.1002/pro.5560050513 · Cited by 328 · see citing works

Genetic Structure and Distribution of the Colibactin Genomic Island among Members of the Family Enterobacteriaceae

Putze, J., Hennequin, C., Nougayrède, J., Zhang, W., Homburg, S., Karch, H., Bringer, M.-A., Fayolle, C., Carniel, É., Rabsch, W., et al. (2009) · Infection and Immunity · doi:10.1128/iai.00522-09 · Cited by 319 · see citing works

NDM-1 — A Cause for Worldwide Concern

Moellering, R. C. (2010) · New England Journal of Medicine · doi:10.1056/nejmp1011715 · Cited by 313 · see citing works

Capsule polysaccharide is a bacterial decoy for antimicrobial peptides

Llobet, E., Tomás, J. M., & Bengoechea, J. A. (2008) · Microbiology · doi:10.1099/mic.0.2008/022301-0 · Cited by 311 · see citing works

Capsular Serotype K1 or K2, Rather than magA and rmpA , Is a Major Virulence Determinant for Klebsiella pneumoniae Liver Abscess in Singapore and Taiwan

Yeh, K., Kurup, A., Siu, L.-K. K., Koh, Y. L., Fung, C., Lin, J., Chen, T.-L., Chang, F., & Koh, T. H. (2006) · Journal of Clinical Microbiology · doi:10.1128/jcm.01150-06 · Cited by 296 · see citing works

Regulatory Circuitry of the CsrA/CsrB and BarA/UvrY Systems ofEscherichia coli

Suzuki, K., Wang, X., Weilbacher, T., Pernestig, A.-K., Melefors, Ö., Georgellis, D., Babitzke, P., & Romeo, T. (2002) · Journal of Bacteriology · doi:10.1128/jb.184.18.5130-5140.2002 · Cited by 287 · see citing works

Physiological Osmotic Induction of Leptospira interrogans Adhesion: LigA and LigB Bind Extracellular Matrix Proteins and Fibrinogen

Choy, H. A., Kelley, M. M., Chen, T. L., Møller, A. K., Matsunaga, J., & Haake, D. A. (2007) · Infection and Immunity · doi:10.1128/iai.01635-06 · Cited by 283 · see citing works

Correlation of the virulence of Klebsiella pneumoniae K1 and K2 with the presence of a plasmid encoding aerobactin

Nassif, X., & Sansonetti, P. J. (1986) · Infection and Immunity · doi:10.1128/iai.54.3.603-608.1986 · Cited by 276 · see citing works

Mucoid phenotype of Klebsiella pneumoniae is a plasmid-encoded virulence factor

Nassif, X., Fournier, J. M., Arondel, J., & Sansonetti, P. J. (1989) · Infection and Immunity · doi:10.1128/iai.57.2.546-552.1989 · Cited by 276 · see citing works

Identification of Klebsiella pneumoniae virulence determinants using an intranasal infection model

Lawlor, M. S., Hsu, J., Rick, P. D., & Miller, V. L. (2005) · Molecular Microbiology · doi:10.1111/j.1365-2958.2005.04918.x · Cited by 243 · see citing works

The Opportunistic Pathogen Serratia marcescens Utilizes Type VI Secretion To Target Bacterial Competitors

Murdoch, S. L., Trunk, K., English, G., Fritsch, M. J., Pourkarimi, E., & Coulthurst, S. J. (2011) · Journal of Bacteriology · doi:10.1128/jb.05671-11 · Cited by 238 · see citing works

The role of Klebsiella pneumoniae rmpA in capsular polysaccharide synthesis and virulence revisited

Hsu, C., Lin, T., Chen, Y.-C., Chou, H.-C., & Wang, J. (2011) · Microbiology · doi:10.1099/mic.0.050336-0 · Cited by 233 · see citing works

Characterization of Type 2 Quorum Sensing in Klebsiella pneumoniae and Relationship with Biofilm Formation

Balestrino, D., Haagensen, J. A. J., Rich, C., & Forestier, C. (2005) · Journal of Bacteriology · doi:10.1128/jb.187.8.2870-2880.2005 · Cited by 226 · see citing works

Klebsiella pneumoniae type 3 pili facilitate adherence and biofilm formation on abiotic surfaces

Martino, P. D., Cafferini, N., Joly, B., & Darfeuille–Michaud, A. (2003) · Research in Microbiology · doi:10.1016/s0923-2508(02)00004-9 · Cited by 191 · see citing works

Isolation of Genes Involved in Biofilm Formation of a Klebsiella pneumoniae Strain Causing Pyogenic Liver Abscess

Wu, M.-C., Lin, T., Hsieh, P., Yang, H.-C., & Wang, J. (2011) · PLoS ONE · doi:10.1371/journal.pone.0023500 · Cited by 183 · see citing works

Virulence for mice of Klebsiella strains belonging to the O1 group: relationship to their capsular (K) types

Mizuta, K., Ohta, M., Mori, M., Hasegawa, T., Nakashima, I., & Kato, N. (1983) · Infection and Immunity · doi:10.1128/iai.40.1.56-61.1983 · Cited by 182 · see citing works

Emerging Severe and Fatal Infections Due to Klebsiella pneumoniae in Two University Hospitals in France

Decré, D., Verdet, C., Emirian, A., Gourrierec, T. L., Petit, J., Offenstadt, G., Maury, É., Brisse, S., & Arlet, G. (2011) · Journal of Clinical Microbiology · doi:10.1128/jcm.00676-11 · Cited by 182 · see citing works

The Genus Klebsiella

Brisse, S., Grimont, F., & Grimont, P. A. D. (2006) · Springer eBooks · doi:10.1007/0-387-30746-x_8 · Cited by 179 · see citing works

Leptospiral Immunoglobulin-like Proteins Interact With Human Complement Regulators Factor H, FHL-1, FHR-1, and C4BP

Valencia, M. M. C., Fraga, T. R., da Silva, L. B., Monaris, D., Abreu, P. A. E., Strobel, S., Józsi, M., Isaac, L., & Barbosa, A. S. (2012) · The Journal of Infectious Diseases · doi:10.1093/infdis/jir875 · Cited by 179 · see citing works

Identification and Functional Characterization of Gene Components of Type VI Secretion System in Bacterial Genomes

Shrivastava, S., & Mande, S. S. (2008) · PLoS ONE · doi:10.1371/journal.pone.0002955 · Cited by 171 · see citing works

Interaction of lipocalin 2, transferrin, and siderophores determines the replicative niche of Klebsiella pneumoniae during pneumonia

Bachman, M. A., Lenio, S., Schmidt, L., Oyler, J. E., & Weiser, J. N. (2012) · mBio · doi:10.1128/mbio.00224-11 · Cited by 168 · see citing works

Expression of the Rickettsia prowazekii pld or tlyC Gene in Salmonella enterica Serovar Typhimurium Mediates Phagosomal Escape

Whitworth, T., Popov, V. L., Yu, X., Walker, D. H., & Bouyer, D. H. (2005) · Infection and Immunity · doi:10.1128/iai.73.10.6668-6673.2005 · Cited by 158 · see citing works

Lipocalin 2 deactivates macrophages and worsens pneumococcal pneumonia outcomes

Warszawska, J. M., Gawish, R., Sharif, O., Sigel, S., Doninger, B., Lakovits, K., Mesteri, I., Nairz, M., Boon, L., Spiel, A., et al. (2013) · Journal of Clinical Investigation · doi:10.1172/jci67911 · Cited by 148 · see citing works

The changing face of Klebsiella pneumoniae infections in the community

Keynan, Y., & Rubinstein, E. (2007) · International Journal of Antimicrobial Agents · doi:10.1016/j.ijantimicag.2007.06.019 · Cited by 146 · see citing works

Dynamic regulation of cardiolipin by the lipid pump Atp8b1 determines the severity of lung injury in experimental pneumonia

Ray, N. B., Durairaj, L., Chen, B. B., McVerry, B. J., Ryan, A. J., Donahoe, M. P., Waltenbaugh, A. K., O'Donnell, C. P., Henderson, F. C., Etscheidt, C. A., et al. (2010) · Nature Medicine · doi:10.1038/nm.2213 · Cited by 145 · see citing works

Phosphatidylserine synthase and phosphatidylserine decarboxylase are essential for cell wall integrity and virulence in <i>Candida albicans</i>

Chen, Y., Montedonico, A. E., Kauffman, S., Dunlap, J. R., Menn, F., & Reynolds, T. B. (2010) · Molecular Microbiology · doi:10.1111/j.1365-2958.2009.07018.x · Cited by 144 · see citing works

Characterization of Integrative and Conjugative Element ICEKp1-Associated Genomic Heterogeneity in aKlebsiella pneumoniaeStrain Isolated from a Primary Liver Abscess

Lin, T., Lee, C., Hsieh, P., Tsai, S., & Wang, J. (2007) · Journal of Bacteriology · doi:10.1128/jb.01219-07 · Cited by 128 · see citing works

Differential Binding of Escherichia coli O157:H7 to Alfalfa, Human Epithelial Cells, and Plastic Is Mediated by a Variety of Surface Structures

Torres, A. G., Jeter, C., Langley, W. A., & Matthysse, A. G. (2005) · Applied and Environmental Microbiology · doi:10.1128/aem.71.12.8008-8015.2005 · Cited by 122 · see citing works

Correlation between Klebsiella pneumoniae carrying pLVPK-derived loci and abscess formation

Tang, H., Chiang, M., Liou, W.-J., Chen, Y.-T., Peng, H.-L., Chiou, C., Liu, K. S., Lu, M., Tung, K., & Lai, Y. (2010) · European Journal of Clinical Microbiology & Infectious Diseases · doi:10.1007/s10096-010-0915-1 · Cited by 118 · see citing works

Spatial Periodicity of Escherichia coli K-12 Biofilm Microstructure Initiates during a Reversible, Polar Attachment Phase of Development and Requires the Polysaccharide Adhesin PGA

Игоревич, А. К., Wang, X., & Romeo, T. (2005) · Journal of Bacteriology · doi:10.1128/jb.187.24.8237-8246.2005 · Cited by 115 · see citing works

Hypervirulent Klebsiella pneumoniae: the Next Superbug?

Shon, A. S. Y., & Russo, T. A. (2012) · Future Microbiology · doi:10.2217/fmb.12.43 · Cited by 112 · see citing works

Positive control of colanic acid synthesis in Escherichia coli by rmpA and rmpB, two virulence‐plasmid genes of Kiebsiella pneumoniae

Nassrf, X., Honoré, N., Vasselon, T., Cole, S. T., & Sansonetti, P. J. (1989) · Molecular Microbiology · doi:10.1111/j.1365-2958.1989.tb00116.x · Cited by 108 · see citing works

Targeted mutagenesis of the phospholipase D gene results in decreased virulence of Corynebacterium pseudotuberculosis

McNamara, P. J., Bradley, G. A., & Songer, J. G. (1994) · Molecular Microbiology · doi:10.1111/j.1365-2958.1994.tb01080.x · Cited by 107 · see citing works

Klebsiella pneumoniae Capsule Polysaccharide Impedes the Expression of β-Defensins by Airway Epithelial Cells

Moranta, D., Regueiro, V., March, C., Llobet, E., Margareto, J., Larrate, E., Garmendia, J., & Bengoechea, J. A. (2009) · Infection and Immunity · doi:10.1128/iai.00940-09 · Cited by 106 · see citing works

Synthesis of phosphatidylcholine, a typical eukaryotic phospholipid, is necessary for full virulence of the intracellular bacterial parasite Brucella abortus

Conde-Álvarez, R., Grilló, M. J., Salcedo, S. P., de Miguel, M. J., Fugier, E., Gorvel, J., Moriyón, I., & Iriarte, M. (2006) · Cellular Microbiology · doi:10.1111/j.1462-5822.2006.00712.x · Cited by 103 · see citing works

The Type II Secretion System and Its Ubiquitous Lipoprotein Substrate, SslE, Are Required for Biofilm Formation and Virulence of Enteropathogenic Escherichia coli

Baldi, D. L., Higginson, E. E., Hocking, D. M., Praszkier, J., Cavaliere, R., James, C. E., Bennett-Wood, V. R., Azzopardi, K. I., Turnbull, L., Lithgow, T. J., et al. (2012) · Infection and Immunity · doi:10.1128/iai.06160-11 · Cited by 98 · see citing works

Enhancement of extracapsular polysaccharide synthesis in Klebsiella pneumoniae by RmpA2, which shows homology to NtrC and FixJ

Wacharotayankun, R., Arakawa, Y., Ohta, M., Tanaka, K., Akashi, T., Mori, M., & Kato, N. (1993) · Infection and Immunity · doi:10.1128/iai.61.8.3164-3174.1993 · Cited by 97 · see citing works

A Gene, uge , Is Essential for Klebsiella pneumoniae Virulence

Regué, M., Hita, B., Piqué, N., Izquierdo, L., Merino, S., Fresno, S., Benedi, V. J., & Tomás, J. M. (2003) · Infection and Immunity · doi:10.1128/iai.72.1.54-61.2004 · Cited by 96 · see citing works

Contribution of the SirA regulon to biofilm formation in Salmonella enterica serovar Typhimurium

Teplitski, M., Alagely, A., & Ahmer, B. M. M. (2006) · Microbiology · doi:10.1099/mic.0.29118-0 · Cited by 95 · see citing works

The Klebsiella pneumoniae wabG Gene: Role inBiosynthesis of the Core Lipopolysaccharide andVirulence

Izquierdo, L., Coderch, N., Piqué, N., Bedini, E., Corsaro, M. M., Merino, S., Fresno, S., Tomás, J. M., & Regué, M. (2003) · Journal of Bacteriology · doi:10.1128/jb.185.24.7213-7221.2003 · Cited by 94 · see citing works

Sel1 Repeat Protein LpnE Is a Legionella pneumophila Virulence Determinant That Influences Vacuolar Trafficking

Newton, H. J., Sansom, F. M., Dao, J., McAlister, A. D., Sloan, J., Cianciotto, N. P., & Hartland, E. L. (2007) · Infection and Immunity · doi:10.1128/iai.00443-07 · Cited by 92 · see citing works

Murine toxin of Yersinia pestis shows phospholipase D activity but is not required for virulence in mice

Hinnebusch, J., Cherepanov, P., Du, Y., Rudolph, A. E., Dixon, J. E., Schwan, T. G., & Försberg, Å. (2000) · International Journal of Medical Microbiology · doi:10.1016/s1438-4221(00)80070-3 · Cited by 91 · see citing works

Expression of phospholipase D, the major virulence factor of Corynebacterium pseudotuberculosis, is regulated by multiple environmental factors and plays a role in macrophage death

McKean, S. C., Davies, J. K., & Moore, R. J. (2007) · Microbiology · doi:10.1099/mic.0.2007/005926-0 · Cited by 89 · see citing works

Polyamine biosynthesis and transport mechanisms are crucial for fitness and pathogenesis of Streptococcus pneumoniae

Shah, P., Nanduri, B., Swiatlo, E., Ma, Y., & Pendarvis, K. (2010) · Microbiology · doi:10.1099/mic.0.042564-0 · Cited by 86 · see citing works

Actividad proteinasa y fosfolipasa como factores de virulencia en especies de Candida aisladas de sangre

Das, V. M., & Ballal, M. (2008) · Revista Iberoamericana de Micología · doi:10.1016/s1130-1406(08)70050-0 · Cited by 78 · see citing works

Alteration of phospholipid composition by combined defects in phosphatidylserine and cardiolipin synthases and physiological consequences in Escherichia coli

Shibuya, I., Miyazaki, C., & Ohta, A. (1985) · Journal of Bacteriology · doi:10.1128/jb.161.3.1086-1092.1985 · Cited by 75 · see citing works

Novel Virulence-Associated Type II Secretion System Unique to High-PathogenicityYersinia enterocolitica

Iwobi, A. N., Heesemann, J., García, E. G., Igwe, E. I., Nölting, C., & Rakin, A. (2003) · Infection and Immunity · doi:10.1128/iai.71.4.1872-1879.2003 · Cited by 69 · see citing works

Polyamines are required for the expression of key Hms proteins important for Yersinia pestis biofilm formation

Wortham, B. W., Oliveira, M., Fetherston, J. D., & Perry, R. D. (2010) · Environmental Microbiology · doi:10.1111/j.1462-2920.2010.02219.x · Cited by 62 · see citing works

Community-Acquired Liver Abscess Caused by Serotype K1 Klebsiella pneumoniae with CTX-M-15-Type Extended-Spectrum β-Lactamase

Su, S., Siu, L.-K. K., Ma, L., Yeh, K., Fung, C., Lin, J., & Chang, F. (2007) · Antimicrobial Agents and Chemotherapy · doi:10.1128/aac.01269-07 · Cited by 59 · see citing works

Fumarate reductase is essential for Helicobacter pylori colonization of the mouse stomach

Ge, Z., Feng, Y., Dangler, C. A., Xu, S., Taylor, N. S., & Fox, J. G. (2000) · Microbial Pathogenesis · doi:10.1006/mpat.2000.0391 · Cited by 58 · see citing works

Distribution of the putative type VI secretion system core genes in Klebsiella spp.

Sarris, P. F., Zoumadakis, C., Panopoulos, N. J., & Scoulica, E. V. (2010) · Infection Genetics and Evolution · doi:10.1016/j.meegid.2010.09.006 · Cited by 58 · see citing works

Finishing genomes with limited resources: lessons from an ensemble of microbial genomes

Nagarajan, N., Cook, C., Bonaventura, M. P. D., Ge, H., Richards, A. L., Bishop‐Lilly, K. A., DeSalle, R., Read, T. D., & Pop, M. (2010) · BMC Genomics · doi:10.1186/1471-2164-11-242 · Cited by 58 · see citing works

Streptococcus pyogenesGlycoprotein-Binding Strepadhesin Activity Is Mediated by a Surface-Associated Carbohydrate-Degrading Enzyme, Pullulanase

Hytönen, J., Haataja, S., & Finne, J. (2003) · Infection and Immunity · doi:10.1128/iai.71.2.784-793.2003 · Cited by 55 · see citing works

CAAT-Box, contigs-Assembly and Annotation Tool-Box for genome sequencing projects

Frangeul, L., Glaser, P., Rusniok, C., Buchrieser, C., Duchaud, É., Dehoux, P., & Kunst, F. (2004) · Bioinformatics · doi:10.1093/bioinformatics/btg490 · Cited by 53 · see citing works

Biofilm Formation In Vitro and Virulence In Vivo of Mutants of Klebsiella pneumoniae

Lavender, H. F., Jagnow, J., & Clegg, S. (2004) · Infection and Immunity · doi:10.1128/iai.72.8.4888-4890.2004 · Cited by 51 · see citing works

A Salmonella enterica Serovar Typhimurium Succinate Dehydrogenase/Fumarate Reductase Double Mutant Is Avirulent and Immunogenic in BALB/c Mice

Mercado–Lubo, R., Gauger, E. J., Leatham, M. P., Conway, T., & Cohen, P. S. (2007) · Infection and Immunity · doi:10.1128/iai.01226-07 · Cited by 49 · see citing works

Analysis of theActinobacillus pleuropneumoniaeArcA Regulon Identifies Fumarate Reductase as a Determinant of Virulence

Buettner, F. F. R., Bendallah, I. M., Bossé, J. T., Dreckmann, K., Nash, J. H. E., Langford, P. R., & Gerlach, G.-F. (2008) · Infection and Immunity · doi:10.1128/iai.01540-07 · Cited by 49 · see citing works

Liver abscess due to Klebsiella pneumoniae: Risk factors for metastatic infection

Yoon, J. H., Kim, Y. J., Jun, Y. H., Kim, S.-I., Kang, J. Y., Suk, K. T., & Kim, D. J. (2013) · Scandinavian Journal of Infectious Diseases · doi:10.3109/00365548.2013.851414 · Cited by 46 · see citing works

Virulence of Klebsiella strains in experimentally induced skin lesions in the mouse

Simoons‐Smit, A. M., Vught, A. M. J. J. V.-V., Kanis, I. Y. R., & MacLaren, D. M. (1984) · Journal of Medical Microbiology · doi:10.1099/00222615-17-1-67 · Cited by 41 · see citing works

The Vibrio Cholerae Type VI Secretion System: Evaluating its Role in the Human Disease Cholera

Miyata, S. T., Kitaoka, M., Wieteska, Ł., Frech, C., Chen, N., & Pukatzki, S. U. (2010) · Frontiers in Microbiology · doi:10.3389/fmicb.2010.00117 · Cited by 41 · see citing works

Identification of Escherichia coli Genes That Are Specifically Expressed in a Murine Model of Septicemic Infection

Khan, M. A., & Isaacson, R. E. (2002) · Infection and Immunity · doi:10.1128/iai.70.7.3404-3412.2002 · Cited by 35 · see citing works

Pathogenicity Islands and Their Role in Bacterial Virulence and Survival

Hochhut, B., Dobrindt, U., & Hacker, J. (2004) · KARGER eBooks · doi:10.1159/000081698 · Cited by 28 · see citing works

A novel murine model of rhinoscleroma identifies Mikulicz cells, the disease signature, as IL‐10 dependent derivatives of inflammatory monocytes

Fèvre, C., Almeida, A. S., Taront, S., Pédron, T., Huerre, M., Prévost, M., Kieusseian, A., Cumano, A., Brisse, S., Sansonetti, P. J., et al. (2013) · EMBO Molecular Medicine · doi:10.1002/emmm.201202023 · Cited by 26 · see citing works

Improved model systems for bacterial membranes from differing species: Theimportance of varying composition in PE/PG/cardiolipin ternary mixtures

Lopes, S. C. D. N., Neves, C., Eaton, P. J., & Gameiro, P. (2012) · Molecular Membrane Biology · doi:10.3109/09687688.2012.700491 · Cited by 26 · see citing works

Characterization of genes differentially expressed within macrophages by virulent and attenuated Mycobacterium tuberculosis identifies candidate genes involved in intracellular growth

Li, A. H., Lam, W. L., & Stokes, R. W. (2008) · Microbiology · doi:10.1099/mic.0.2008/019661-0 · Cited by 25 · see citing works

Contribution of AmyA, an extracellular α‐glucan degrading enzyme, to group A streptococcal host–pathogen interaction

Shelburne, S. A., Keith, D. B., Davenport, M. T., Beres, S. B., Carroll, R. K., & Musser, J. M. (2009) · Molecular Microbiology · doi:10.1111/j.1365-2958.2009.06858.x · Cited by 21 · see citing works

Legionella Phospholipases Implicated in Virulence

Kuhle, K., & Flieger, A. (2013) · Current topics in microbiology and immunology · doi:10.1007/82_2013_348 · Cited by 18 · see citing works

Acylation of the lipid a region of a Klebsiella pneumoniae LPS controls the alternative pathway activation of human complement

Mey, A., Ponard, D., Colomb, M. G., Normier, G., Binz, H., & Revillard, J. (1994) · Molecular Immunology · doi:10.1016/0161-5890(94)90074-4 · Cited by 17 · see citing works

Primary structure and function of a cytotoxic outer-membrane protein (ComP) of Plesiomonas shigelloides

Tsugawa, H., Ogawa, A., Takehara, S., Kimura, M., & Okawa, Y. (2008) · FEMS Microbiology Letters · doi:10.1111/j.1574-6968.2007.01041.x · Cited by 16 · see citing works

Microbiological and clinical characteristics of bacteraemia caused by the hypermucoviscosity phenotype of Klebsiella pneumoniae in Korea

Bialek-Davenet, S., Nicolas-Chanoine, M.-H., Decré, D., & Brisse, S. (2012) · Epidemiology and Infection · doi:10.1017/s0950268812002051 · Cited by 14 · see citing works

Probing the heat shock response of Corynebacterium pseudotuberculosis: The major virulence factor, phospholipase D, is downregulated at 43 °C

McKean, S. C., Davies, J. K., & Moore, R. J. (2007) · Research in Microbiology · doi:10.1016/j.resmic.2006.12.006 · Cited by 11 · see citing works

Evolution of prokaryotic homologues of the eukaryotic SEFIR protein domain

Wu, B., Gong, J., Liu, L., Li, T., Wei, T., & Bai, Z. (2011) · Gene · doi:10.1016/j.gene.2011.10.033 · Cited by 10 · see citing works

Klebsiella pneumoniae: Going on the Offense with a Strong Defense

Paczosa, M., & Mecsas, J. (2016) · Microbiology and Molecular Reviews · doi:10.1128/mmbr.00078-15 · Cited by 1,769 · see citing works

Hypervirulent Klebsiella pneumoniae

Russo, T. A., & Marr, C. M. (2019) · Clinical Microbiology Reviews · doi:10.1128/cmr.00001-19 · Cited by 1,332 · see citing works

Population genomics of Klebsiella pneumoniae

Wyres, K. L., Lam, M. M. C., & Holt, K. E. (2020) · Nature Reviews Microbiology · doi:10.1038/s41579-019-0315-1 · Cited by 1,175 · see citing works

Colonization, Infection, and the Accessory Genome of Klebsiella pneumoniae

Martin, R. M., & Bachman, M. A. (2018) · Frontiers in Cellular and Infection Microbiology · doi:10.3389/fcimb.2018.00004 · Cited by 1,067 · see citing works

Hypervirulent Klebsiella pneumoniae – clinical and molecular perspectives

Choby, J. E., Howard-Anderson, J. R., & Weiss, D. S. (2019) · Journal of Internal Medicine · doi:10.1111/joim.13007 · Cited by 719 · see citing works

Functional and Genomic Variation between Human-Derived Isolates of Lachnospiraceae Reveals Inter- and Intra-Species Diversity

Sorbara, M. T., Littmann, E. R., Fontana, E., Moody, T. U., Kohout, C. E., Gjonbalaj, M., Eaton, V. P., Seok, R., Leiner, I. M., & Pamer, E. G. (2020) · Cell Host & Microbe · doi:10.1016/j.chom.2020.05.005 · Cited by 406 · see citing works

Mapping the Evolution of Hypervirulent Klebsiella pneumoniae

Struve, C., Roe, C. C., Stegger, M., Stahlhut, S. G., Hansen, D. S., Engelthaler, D. M., Andersen, P. S., Driebe, E. M., Keim, P., & Krogfelt, K. A. (2015) · mBio · doi:10.1128/mbio.00630-15 · Cited by 367 · see citing works

Hypervirulence and hypermucoviscosity: Two different but complementary Klebsiella spp. phenotypes?

Catalán-Nájera, J. C., Garza–Ramos, U., & Barrios-Camacho, H. (2017) · Virulence · doi:10.1080/21505594.2017.1317412 · Cited by 364 · see citing works

Virulence Factors in Hypervirulent Klebsiella pneumoniae

Zhu, J., Wang, T., Chen, L., & Du, H. (2021) · Frontiers in Microbiology · doi:10.3389/fmicb.2021.642484 · Cited by 324 · see citing works

Genetic diversity, mobilisation and spread of the yersiniabactin-encoding mobile element ICEKp in Klebsiella pneumoniae populations

Lam, M. M. C., Wick, R. R., Wyres, K. L., Gorrie, C. L., Judd, L. M., Jenney, A. W. J., Brisse, S., & Holt, K. E. (2018) · Microbial Genomics · doi:10.1099/mgen.0.000196 · Cited by 317 · see citing works

Carbapenem Resistance-Encoding and Virulence-Encoding Conjugative Plasmids in Klebsiella pneumoniae

Yang, X., Dong, N., Chan, E. W., Zhang, R., & Chen, S. (2020) · Trends in Microbiology · doi:10.1016/j.tim.2020.04.012 · Cited by 290 · see citing works

Tracking key virulence loci encoding aerobactin and salmochelin siderophore synthesis in Klebsiella pneumoniae

Lam, M. M. C., Wyres, K. L., Judd, L. M., Wick, R. R., Jenney, A. W. J., Brisse, S., & Holt, K. E. (2018) · Genome Medicine · doi:10.1186/s13073-018-0587-5 · Cited by 274 · see citing works

Type VI secretion and anti-host effectors

Hachani, A., Wood, T. E., & Filloux, A. (2015) · Current Opinion in Microbiology · doi:10.1016/j.mib.2015.11.006 · Cited by 270 · see citing works

The staphylococcal exopolysaccharide PIA – Biosynthesis and role in biofilm formation, colonization, and infection

Nguyen, T. T. H., Nguyen, T. D., & Otto, M. J. (2020) · Computational and Structural Biotechnology Journal · doi:10.1016/j.csbj.2020.10.027 · Cited by 244 · see citing works

VgrG, Tae, Tle, and beyond: the versatile arsenal of Type VI secretion effectors

Durand, É., Cambillau, C., Cascalès, E., & Journet, L. (2014) · Trends in Microbiology · doi:10.1016/j.tim.2014.06.004 · Cited by 239 · see citing works

Genomic Analysis of the Emergence and Rapid Global Dissemination of the Clonal Group 258 Klebsiella pneumoniae Pandemic

Bowers, J. R., Kitchel, B., Driebe, E. M., MacCannell, D., Roe, C. C., Lemmer, D., de Man, T. J. B., Rasheed, J. K., Engelthaler, D. M., Keim, P., et al. (2015) · PLoS ONE · doi:10.1371/journal.pone.0133727 · Cited by 203 · see citing works

Bacterial Sphingomyelinases and Phospholipases as Virulence Factors

Flores-Dı́az, M., Monturiol‐Gross, L., Naylor, C. E., Alape‐Girón, A., & Flieger, A. (2016) · Microbiology and Molecular Biology Reviews · doi:10.1128/mmbr.00082-15 · Cited by 208 · see citing works

A Klebsiella pneumoniae Regulatory Mutant Has Reduced Capsule Expression but Retains Hypermucoviscosity

Walker, K. A., Miner, T. A., Palacios, M., Trzilova, D., Frederick, D. R., Broberg, C. A., Sepúlveda, V. E., Quinn, J. D., & Miller, V. L. (2019) · mBio · doi:10.1128/mbio.00089-19 · Cited by 200 · see citing works

A promising bioconjugate vaccine against hypervirulent Klebsiella pneumoniae

Feldman, M. F., Bridwell, A. E. M., Scott, N. E., VINOGRADOV, E. V., McKee, S. R., Chavez, S. M., Twentyman, J., Stallings, C. L., Rosen, D. A., & Harding, C. M. (2019) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1907833116 · Cited by 192 · see citing works

SecReT6 : a web‐based resource for type VI secretion systems found in bacteria

Li, J., Yao, Y., Xu, H. H., Hao, L., Deng, Z., Rajakumar, K., & Ou, H. (2015) · Environmental Microbiology · doi:10.1111/1462-2920.12794 · Cited by 186 · see citing works

The intersection of capsule gene expression, hypermucoviscosity and hypervirulence in Klebsiella pneumoniae

Walker, K. A., & Miller, V. L. (2020) · Current Opinion in Microbiology · doi:10.1016/j.mib.2020.01.006 · Cited by 181 · see citing works

Current status and development prospects of aquatic vaccines

Du, Y., Hu, X., Liang, M., & Chen, J. (2022) · Frontiers in Immunology · doi:10.3389/fimmu.2022.1040336 · Cited by 175 · see citing works

A phospholipase A1 antibacterial Type VI secretion effector interacts directly with the C‐terminal domain of the VgrG spike protein for delivery

Flaugnatti, N., Le, T. T., Canaan, S., Aschtgen, M., Nguyen, V. S., Blangy, S., Kellenberger, C., Roussel, A., Cambillau, C., Cascalès, E., et al. (2015) · Molecular Microbiology · doi:10.1111/mmi.13292 · Cited by 173 · see citing works

Molecular weaponry: diverse effectors delivered by the Type VI secretion system

Diniz, J. A., Liu, Y., & Coulthurst, S. J. (2015) · Cellular Microbiology · doi:10.1111/cmi.12532 · Cited by 172 · see citing works

A Klebsiella pneumoniae antibiotic resistance mechanism that subdues host defences and promotes virulence

Kidd, T. J., Mills, G., Sá‐Pessoa, J., Dumigan, A., Frank, C. G., Insua, J. L., Ingram, R. J., Hobley, L., & Bengoechea, J. A. (2017) · EMBO Molecular Medicine · doi:10.15252/emmm.201607336 · Cited by 174 · see citing works

Revisiting ESKAPE Pathogens: virulence, resistance, and combating strategies focusing on quorum sensing

Venkateswaran, P., Vasudevan, S., David, H., Shaktivel, A., Shanmugam, K., Neelakantan, P., & Solomon, A. P. (2023) · Frontiers in Cellular and Infection Microbiology · doi:10.3389/fcimb.2023.1159798 · Cited by 165 · see citing works

Activity, delivery, and diversity of Type VI secretion effectors

Jurėnas, D., & Journet, L. (2020) · Molecular Microbiology · doi:10.1111/mmi.14648 · Cited by 152 · see citing works

An Overview of Anti-Eukaryotic T6SS Effectors

Feria, J. M., & Valvano, M. A. (2020) · Frontiers in Cellular and Infection Microbiology · doi:10.3389/fcimb.2020.584751 · Cited by 148 · see citing works

Klebsiella pneumoniae type VI secretion system-mediated microbial competition is PhoPQ controlled and reactive oxygen species dependent

Storey, D., McNally, A., Åstrand, M., Santos, J. S.-P. G., Rodríguez‐Escudero, I., Elmore, B., Palacios-Chaves, L., Marshall, H., Hobley, L., Molina, M., et al. (2020) · PLoS Pathogens · doi:10.1371/journal.ppat.1007969 · Cited by 143 · see citing works

Clinical detection and characterization of bacterial pathogens in the genomics era

Fournier, P., Dubourg, G., & Raoult, D. (2014) · Genome Medicine · doi:10.1186/s13073-014-0114-2 · Cited by 135 · see citing works

Clinical Implications of Genomic Adaptation and Evolution of Carbapenem-Resistant Klebsiella pneumoniae

Gomez‐Simmonds, A., & Uhlemann, A. (2017) · The Journal of Infectious Diseases · doi:10.1093/infdis/jiw378 · Cited by 130 · see citing works

Hybrid Resistance and Virulence Plasmids in “High-Risk” Clones of Klebsiella pneumoniae, Including Those Carrying blaNDM-5

Turton, J. F., Davies, F., Turton, J. A., Perry, C., Payne, Z., & Pike, R. (2019) · Microorganisms · doi:10.3390/microorganisms7090326 · Cited by 122 · see citing works

Deciphering tissue-induced Klebsiella pneumoniae lipid A structure

Llobet, E., Martínez-Moliner, V., Moranta, D., Dahlström, K. M., Regueiro, V., Tomás, A., Cano, V., Pérez-Gutiérrez, C., Frank, C. G., Fernández‐Carrasco, H., et al. (2015) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1508820112 · Cited by 107 · see citing works

Klebsiella pneumoniae Type VI Secretion System Contributes to Bacterial Competition, Cell Invasion, Type-1 Fimbriae Expression, and In Vivo Colonization

Hsieh, P., Lu, Y.-R., Lin, T., Lai, L.-Y., & Wang, J. (2018) · The Journal of Infectious Diseases · doi:10.1093/infdis/jiy534 · Cited by 104 · see citing works

The making of hypervirulent Klebsiella pneumoniae

Dai, P., & Hu, D. (2022) · Journal of Clinical Laboratory Analysis · doi:10.1002/jcla.24743 · Cited by 102 · see citing works

Genomic surveillance for multidrug-resistant or hypervirulent Klebsiella pneumoniae among United States bloodstream isolates

Kochan, T. J., Nozick, S., Medernach, R. L., Cheung, B. H., Gatesy, S. W. M., Lebrun-Corbin, M., Mitra, S. D., Khalatyan, N., Krapp, F., Qi, C., et al. (2022) · BMC Infectious Diseases · doi:10.1186/s12879-022-07558-1 · Cited by 91 · see citing works

Gut bacterial phospholipase Ds support disease-associated metabolism by generating choline

Chittim, C. L., Campo, A. M.-D., & Balskus, E. P. (2018) · Nature Microbiology · doi:10.1038/s41564-018-0294-4 · Cited by 92 · see citing works

Natural killer cell-intrinsic type I IFN signaling controls Klebsiella pneumoniae growth during lung infection

Ivin, M., Dumigan, A., Vasconcelos, F., Ebner, F., Borroni, M., Kavirayani, A. M., Przybyszewska, K., Ingram, R. J., Lienenklaus, S., Kalinke, U., et al. (2017) · PLoS Pathogens · doi:10.1371/journal.ppat.1006696 · Cited by 85 · see citing works

Opposing roles of IL-10 in acute bacterial infection

Peñaloza, H. F., Schultz, B. M., Nieto, P. A., Salazar, G. A., Suazo, I. D., González, P. A., Riedel, C. A., Álvarez-Lobos, M. M., Kalergis, A. M., & Bueno, S. M. (2016) · Cytokine & Growth Factor Reviews · doi:10.1016/j.cytogfr.2016.07.003 · Cited by 88 · see citing works

Diversity of virulence level phenotype of hypervirulent Klebsiella pneumoniae from different sequence type lineage

Shi, Q., Lan, P., Huang, D., Hua, X., Jiang, Y., Zhou, J., & Yu, Y. (2018) · BMC Microbiology · doi:10.1186/s12866-018-1236-2 · Cited by 84 · see citing works

An Assessment of Siderophore Production, Mucoviscosity, and Mouse Infection Models for Defining the Virulence Spectrum of Hypervirulent Klebsiella pneumoniae

Russo, T. A., MacDonald, U., Hassan, S., Camanzo, E., Lebreton, F., Corey, B. W., & McGann, P. (2021) · mSphere · doi:10.1128/msphere.00045-21 · Cited by 76 · see citing works

Genomic Epidemiology of Klebsiella pneumoniae in Italy and Novel Insights into the Origin and Global Evolution of Its Resistance to Carbapenem Antibiotics

Gaiarsa, S., Comandatore, F., Gaibani, P., Corbella, M., Valle, C. D., Epis, S., Scaltriti, E., Carretto, E., Farina, C., Labonia, M., et al. (2014) · Antimicrobial Agents and Chemotherapy · doi:10.1128/aac.04224-14 · Cited by 72 · see citing works

Tracking Nosocomial Klebsiella pneumoniae Infections and Outbreaks by Whole-Genome Analysis: Small-Scale Italian Scenario within a Single Hospital

Onori, R., Gaiarsa, S., Comandatore, F., Pongolini, S., Brisse, S., Colombo, A., Cassani, G., Marone, P., Grossi, P., Minoja, G., et al. (2015) · Journal of Clinical Microbiology · doi:10.1128/jcm.00545-15 · Cited by 69 · see citing works

Virulence Characteristics of Carbapenem-Resistant Klebsiella pneumoniae Strains from Patients with Necrotizing Skin and Soft Tissue Infections

Krapp, F., Morris, A. R., Ozer, E. A., & Hauser, A. R. (2017) · Scientific Reports · doi:10.1038/s41598-017-13524-8 · Cited by 65 · see citing works

Bacterial type VI secretion system (T6SS): an evolved molecular weapon with diverse functionality

Singh, R. P., & Kumari, K. (2023) · Biotechnology Letters · doi:10.1007/s10529-023-03354-2 · Cited by 64 · see citing works

A trans-kingdom T6SS effector induces the fragmentation of the mitochondrial network and activates innate immune receptor NLRX1 to promote infection

Sá‐Pessoa, J., López-Montesino, S., Przybyszewska, K., Rodríguez‐Escudero, I., Marshall, H., Ova, A. B., Schroeder, G. N., Barabás, P., Molina, M., Curtis, T. M., et al. (2023) · Nature Communications · doi:10.1038/s41467-023-36629-3 · Cited by 60 · see citing works

Identification and Characterization of an Antibacterial Type VI Secretion System in the Carbapenem-Resistant Strain Klebsiella pneumoniae HS11286

Liu, L., Ye, M., Li, X., Li, J., Deng, Z., Yao, Y., & Ou, H. (2017) · Frontiers in Cellular and Infection Microbiology · doi:10.3389/fcimb.2017.00442 · Cited by 63 · see citing works

Potential therapeutic targets of Klebsiella pneumoniae: a multi-omics review perspective

Ali, S., Alam, M., Hasan, G. M., & Hassan, M. I. (2021) · Briefings in Functional Genomics · doi:10.1093/bfgp/elab038 · Cited by 62 · see citing works

Modelling the Gastrointestinal Carriage of Klebsiella pneumoniae Infections

Calderón-Gonzalez, R., Lee, A., López-Campos, G., Hancock, S. J., Sá-Pessoa, J., Dumigan, A., McMullan, R., Campbell, E. L., & Bengoechea, J. (2022) · bioRxiv · doi:10.1128/mbio.03121-22 · Cited by 53 · see citing works

Functional Genomic Screen Identifies Klebsiella pneumoniae Factors Implicated in Blocking Nuclear Factor κB (NF-κB) Signaling

Tomás, A., Lery, L. M. S., Regueiro, V., Pérez-Gutiérrez, C., Martínez-Moliner, V., Moranta, D., Llobet, E., González-Nicolau, M., Insua, J. L., Tomás, J. M., et al. (2015) · Journal of Biological Chemistry · doi:10.1074/jbc.m114.621292 · Cited by 57 · see citing works

Insights into Klebsiella pneumoniae type VI secretion system transcriptional regulation

Barbosa, V. A. A., & Lery, L. M. S. (2019) · BMC Genomics · doi:10.1186/s12864-019-5885-9 · Cited by 57 · see citing works

In vivo single‐cell transcriptomics reveal Klebsiella pneumoniae skews lung macrophages to promote infection

Dumigan, A., Cappa, O., Morris, B., Sá‐Pessoa, J., Calderón-González, R., Mills, G., Lancaster, R., Simpson, D. A. C., Kissenpfennig, A., & Bengoechea, J. A. (2022) · EMBO Molecular Medicine · doi:10.15252/emmm.202216888 · Cited by 51 · see citing works

Klebsiella pneumoniaeFimK Promotes Virulence in Murine Pneumonia

Rosen, D. A., Hilliard, J. K., Tiemann, K. M., Todd, E. M., Morley, S. C., & Hunstad, D. A. (2015) · The Journal of Infectious Diseases · doi:10.1093/infdis/jiv440 · Cited by 52 · see citing works

Klebsiella pneumoniae Asparagine tDNAs Are Integration Hotspots for Different Genomic Islands Encoding Microcin E492 Production Determinants and Other Putative Virulence Factors Present in Hypervirulent Strains

Marcoleta, A. E., Berríos-Pastén, C., Núñez, G., Monasterio, O., & Lagos, R. (2016) · Frontiers in Microbiology · doi:10.3389/fmicb.2016.00849 · Cited by 50 · see citing works

Role of Klebsiella pneumoniae Type VI secretion system (T6SS) in long-term gastrointestinal colonization

Merciecca, T., Bornes, S., Nakusi, L., Theil, S., Rendueles, O., Forestier, C., & Miquel, S. (2022) · Scientific Reports · doi:10.1038/s41598-022-21396-w · Cited by 48 · see citing works

Klebsiella pneumoniae hijacks the Toll-IL-1R protein SARM1 in a type I IFN-dependent manner to antagonize host immunity

Feriotti, C., Sá‐Pessoa, J., Calderón-González, R., Gu, L., Morris, B., Sugisawa, R., Insua, J. L., Carty, M., Dumigan, A., Ingram, R. J., et al. (2022) · Cell Reports · doi:10.1016/j.celrep.2022.111167 · Cited by 46 · see citing works

Prevalence and characteristics of pks genotoxin gene cluster-positive clinical Klebsiella pneumoniae isolates in Taiwan

Chen, Y.-T., Lai, Y., Tan, M.-C., Hsieh, L.-Y., Wang, J., Shiau, Y., Wang, H., Lin, A.-C., Lai, J., Huang, I., et al. (2017) · Scientific Reports · doi:10.1038/srep43120 · Cited by 46 · see citing works

Klebsiella pneumoniae Reduces SUMOylation To Limit Host Defense Responses

Sá‐Pessoa, J., Przybyszewska, K., Vasconcelos, F., Dumigan, A., Frank, C. G., Hobley, L., & Bengoechea, J. A. (2020) · mBio · doi:10.1128/mbio.01733-20 · Cited by 45 · see citing works

Siderophore-mediated iron acquisition by <i>Klebsiella pneumoniae</i>

Kumar, A., Chakravorty, S., Yang, T., Russo, T. A., Newton, S. M., & Klebba, P. E. (2024) · Journal of Bacteriology · doi:10.1128/jb.00024-24 · Cited by 42 · see citing works

Clinical and laboratory insights into the threat of hypervirulent Klebsiella pneumoniae

Han, X., Yao, J., He, J., Liu, H., Jiang, Y., Zhao, D., Shi, Q., Zhou, J., Hu, H., Lan, P., et al. (2024) · International Journal of Antimicrobial Agents · doi:10.1016/j.ijantimicag.2024.107275 · Cited by 43 · see citing works

From Welfare to Warfare: The Arbitration of Host-Microbiota Interplay by the Type VI Secretion System

Wood, T. E., Aksoy, E., & Hachani, A. (2020) · Frontiers in Cellular and Infection Microbiology · doi:10.3389/fcimb.2020.587948 · Cited by 37 · see citing works

Development of a multiplex PCR assay for identification of Klebsiella pneumoniae hypervirulent clones of capsular serotype K2

Bialek-Davenet, S., Criscuolo, A., Ailloud, F., Passet, V., Nicolas-Chanoine, M.-H., Decré, D., & Brisse, S. (2014) · Journal of Medical Microbiology · doi:10.1099/jmm.0.081448-0 · Cited by 36 · see citing works

Clinical and Bacterial Characteristics of Klebsiella pneumoniae Affecting 30-Day Mortality in Patients With Bloodstream Infection

Wu, X., Shi, Q., Shen, S., Huang, C., & Wu, H. (2021) · Frontiers in Cellular and Infection Microbiology · doi:10.3389/fcimb.2021.688989 · Cited by 35 · see citing works

Third generation cephalosporin-resistant Klebsiella pneumoniae thriving in patients and in wastewater: what do they have in common?

da Rocha, J. A., Ferreira, C., Mil‐Homens, D., Busquets, A., Fialho, A. M., Henriques, I. S., Gomila, M., & Manaia, C. M. (2022) · BMC Genomics · doi:10.1186/s12864-021-08279-6 · Cited by 35 · see citing works

Multiple bacterial virulence factors focused on adherence and biofilm formation associate with outcomes in cirrhosis

Bajaj, J. S., Shamsaddini, A., Acharya, C., Fagan, A., Sikaroodi, M., Gavis, E. A., McGeorge, S., Khoruts, A., Fuchs, M. A., Sterling, R. K., et al. (2021) · Gut Microbes · doi:10.1080/19490976.2021.1993584 · Cited by 31 · see citing works

Pan-Resistome Insights into the Multidrug Resistance of Acinetobacter baumannii

Rodrigues, D. L. N., Morais-Rodrigues, F., Raquel Hurtado, C., dos Santos, R. G., Costa, D. C., Barh, D., Ghosh, P., Alzahrani, K. J., Soares, S. D. C., Ramos, R. T. J., et al. (2021) · Antibiotics · doi:10.3390/antibiotics10050596 · Cited by 32 · see citing works

Identification of novel zinc-binding inhibitors against key microbial metallohydrolase DapE in Klebsiella pneumoniae: an integrated ligand-based virtual screening, molecular docking, molecular dynamics, and MM/PBSA approach

Biswas, R., & Anbarasu, A. (2025) · Integrative Biology · doi:10.1093/intbio/zyaf018 · Cited by 31 · see citing works

Dissociation between the critical role of ClpB of Francisella tularensis for the heat shock response and the DnaK interaction and its important role for efficient type VI secretion and bacterial virulence

Alam, A., Golovliov, I. R., Javed, E., Kumar, R., Ådén, J., & Sjöstedt, A. B. (2020) · PLoS Pathogens · doi:10.1371/journal.ppat.1008466 · Cited by 31 · see citing works

The intrinsic resistome of Klebsiella pneumoniae

Bernardini, A., Cuesta, T., Tomás, A., Bengoechea, J. A., Martínez, J. L., & Sánchez, M. B. (2018) · International Journal of Antimicrobial Agents · doi:10.1016/j.ijantimicag.2018.09.012 · Cited by 30 · see citing works

A Porcine Ex Vivo Lung Perfusion Model To Investigate Bacterial Pathogenesis

Dumigan, A., Fitzgerald, M., Sá‐Pessoa, J., Hamid, U. I., O’Kane, C. M., McAuley, D. F., & Bengoechea, J. A. (2019) · mBio · doi:10.1128/mbio.02802-19 · Cited by 29 · see citing works

Fluorescent sensors of siderophores produced by bacterial pathogens

Kumar, A., Yang, T., Chakravorty, S., Majumdar, A., Nairn, B. L., Six, D. A., Marcondes dos Santos, N., Price, S. L., Lawrenz, M. B., Actis, L. A., et al. (2022) · Journal of Biological Chemistry · doi:10.1016/j.jbc.2022.101651 · Cited by 28 · see citing works

Virulence factors of Klebsiella pneumoniae: Insights into canonical and emerging mechanisms driving pathogenicity and drug resistance

Singh, R. P., Kapoor, A., Sinha, A., Ma, Y., & Shankar, M. (2025) · The Microbe · doi:10.1016/j.microb.2025.100289 · Cited by 27 · see citing works

The reasons why Klebsiella pneumoniae becomes a leading opportunistic pathogen

Chebotar, I. V., Bocharova, Y. A., Podoprigora, I. V., & Shagin, D. A. (2020) · Clinical Microbiology and Antimicrobial Chemotherapy · doi:10.36488/cmac.2020.1.4-19 · Cited by 27 · see citing works

Endogenous Endophthalmitis Caused by ST66-K2 Hypervirulent Klebsiella pneumoniae , United States

Kamau, E. T., Allyn, P. R., Beaird, O. E., Ward, K. W., Kwan, N., Garner, O. B., & Yang, S. (2021) · Emerging infectious diseases · doi:10.3201/eid2708.210234 · Cited by 26 · see citing works

Generation and Validation of the iKp1289 Metabolic Model for Klebsiella pneumoniae KPPR1

Henry, C. S., Rotman, E. R., Lathem, W. W., Tyo, K. E. J., Hauser, A. R., & Mandel, M. J. (2016) · The Journal of Infectious Diseases · doi:10.1093/infdis/jiw465 · Cited by 25 · see citing works

Functional eubacteria species along with trans-domain gut inhabitants favour dysgenic diversity in oxalate stone disease

Suryavanshi, M. V., Bhute, S. S., Gune, R. P., & Shouche, Y. S. (2018) · Scientific Reports · doi:10.1038/s41598-018-33773-5 · Cited by 25 · see citing works

Community-acquired infection caused by the uncommon hypervirulent Klebsiella pneumoniae ST66-K2 lineage

Rodrigues, C., d’Humières, C., Papin, G., Passet, V., Ruppé, É., & Brisse, S. (2020) · Microbial Genomics · doi:10.1099/mgen.0.000419 · Cited by 25 · see citing works

Virulence genes and previously unexplored gene clusters in four commensal Neisseria spp. isolated from the human throat expand the neisserial gene repertoire

Calder, A., Menkiti, C. J., Çağdaş, A., Santos, J. L., Streich, R., Wong, A., Avini, A. H., Bojang, E., Yogamanoharan, K., Sivanesan, N., et al. (2020) · Microbial Genomics · doi:10.1099/mgen.0.000423 · Cited by 25 · see citing works

Hypervirulent Klebsiella pneumoniae of Lineage ST66-K2 Caused Tonsillopharyngitis in a German Patient

Klaper, K., Wendt, S., Lübbert, C., Lippmann, N., Pfeifer, Y., & Werner, G. (2021) · Microorganisms · doi:10.3390/microorganisms9010133 · Cited by 25 · see citing works

Clinical and virulence factors related to the 30-day mortality of Klebsiella pneumoniae bacteremia at a tertiary hospital: a case–control study

Namikawa, H., Niki, M., Niki, M., Yamada, K., Nakaie, K., Sakiyama, A., Oinuma, K.-I., Tsubouchi, T., Tochino, Y., Takemoto, Y., et al. (2019) · European Journal of Clinical Microbiology & Infectious Diseases · doi:10.1007/s10096-019-03676-y · Cited by 21 · see citing works

Phytophthora infestans small phospholipase D‐like proteins elicit plant cell death and promote virulence

Meijer, H. J. G., Schoina, C., Wang, S., Bouwmeester, K., Hua, C., & Govers, F. (2018) · Molecular Plant Pathology · doi:10.1111/mpp.12746 · Cited by 21 · see citing works

The Biological and Regulatory Role of Type VI Secretion System of Klebsiella pneumoniae

Liu, W., Li, M., Cao, S., Ishaq, H. M., Zhao, H., Yang, F., & Liu, L. (2023) · Infection and Drug Resistance · doi:10.2147/idr.s426657 · Cited by 20 · see citing works

Virulence and genomic features of a blaCTX-M-3 and blaCTX-M-14 coharboring hypermucoviscous Klebsiella pneumoniae of serotype K2 and ST65

Fu, Y., Xu, M., Liu, Y., Li, A., & Zhou, J. (2019) · Infection and Drug Resistance · doi:10.2147/idr.s187289 · Cited by 19 · see citing works

Capsular type K54, clonal group 29 and virulence plasmids: an analysis of K54 and non-K54 closely related isolates ofKlebsiella pneumoniae

Turton, J. F., Payne, Z., Micah, K., & Turton, J. A. (2018) · Epidemiology and Infection · doi:10.1017/s0950268818001826 · Cited by 18 · see citing works

The phospholipase effector Tle1 Vc promotes Vibrio cholerae virulence by killing competitors and impacting gene expression

Liu, M., Wang, H., Liu, Y., Tian, M., Wang, Z., Shu, R., Zhao, M.-Y., Chen, W.-D., Wang, H., Wang, H., et al. (2023) · Gut Microbes · doi:10.1080/19490976.2023.2241204 · Cited by 17 · see citing works

In vivo single-cell high-dimensional mass cytometry analysis to track the interactions between Klebsiella pneumoniae and myeloid cells

Calderón-González, R., Dumigan, A., Sá‐Pessoa, J., Kissenpfennig, A., & Bengoechea, J. A. (2024) · PLoS Pathogens · doi:10.1371/journal.ppat.1011900 · Cited by 17 · see citing works

T le distribution and diversity in metagenomic datasets reveal niche specialization

Egan, F., Reen, F. J., & O’Gara, F. (2014) · Environmental Microbiology Reports · doi:10.1111/1758-2229.12222 · Cited by 17 · see citing works

Identification and Comparative Genomic Analysis of Type VI Secretion Systems and Effectors in Klebsiella pneumoniae

Li, W., Liu, X., Tsui, W., Xu, A., Li, D., Zhang, X., Li, P. Z., Bian, X., & Zhang, J. (2022) · Frontiers in Microbiology · doi:10.3389/fmicb.2022.853744 · Cited by 16 · see citing works

Molecular Epidemiology of Hypervirulent K. pneumoniae and Problems of Health-Care Associated Infections

Tutelyan, A. V., Shlykova, D. S., Voskanyan, S. L., Михайлович, Г. А., & Писарев, В. М. (2022) · Bulletin of Experimental Biology and Medicine · doi:10.1007/s10517-022-05424-3 · Cited by 16 · see citing works

Comparative genomics and virulome analysis reveal unique features associated with clinical strains of Klebsiella pneumoniae and Klebsiella quasipneumoniae from Trinidad, West Indies

Pustam, A., Jayaraman, J., & Ramsubhag, A. (2023) · PLoS ONE · doi:10.1371/journal.pone.0283583 · Cited by 15 · see citing works

Cultivation and Genomic DNA Extraction of Klebsiella pneumoniae

Pariseau, D. A., Ring, B. E., Khadka, S., & Mike, L. A. (2024) · Current Protocols · doi:10.1002/cpz1.932 · Cited by 15 · see citing works

Selection or drift: The population biology underlying transposon insertion sequencing experiments

Mahmutovic, A., Wiesch, P. A. Z., & Abel, S. (2020) · Computational and Structural Biotechnology Journal · doi:10.1016/j.csbj.2020.03.021 · Cited by 14 · see citing works

Molecular characterization and pathogenicity determination of hypervirulent Klebsiella pneumoniae clinical isolates serotype K2 in Mexico

Catalán-Nájera, J. C., Barrios-Camacho, H., Dúran-Bedolla, J., Sagal-Prado, A., Hernández‐Castro, R., García-Méndez, J., Morfín-OteroMorfín-Otero, R., Velázquez-Larios, M. D. R., Ortiz-Navarrete, V. F., Gutiérrez‐Xicoténcatl, L., et al. (2019) · Diagnostic Microbiology and Infectious Disease · doi:10.1016/j.diagmicrobio.2019.01.013 · Cited by 15 · see citing works

Genetic and Functional Characterization of a Conjugative KpVP-2-Type Virulence Plasmid From a Clinical Klebsiella pneumoniae Strain

Yang, X., Liu, X., Xu, Y., Yang, C., Chan, E. W., Shum, H., & Chen, S. (2022) · Frontiers in Microbiology · doi:10.3389/fmicb.2022.914884 · Cited by 14 · see citing works

PYHIN protein IFI207 regulates cytokine transcription and IRF7 and contributes to the establishment of K. pneumoniae infection

Baran, M., Feriotti, C., McGinley, A. M., Carlile, S. R., Jiang, Z., Calderón-González, R., Dumigan, A., Sá‐Pessoa, J., Sutton, C. E., Kearney, J., et al. (2023) · Cell Reports · doi:10.1016/j.celrep.2023.112341 · Cited by 12 · see citing works

Characterization of hypervirulent Klebsiella pneumoniae isolates in Belgium

Anantharajah, A., Deltombe, M., de Barsy, M., Evrard, S., Denis, O., Bogaerts, P., Hallin, M., Deyi, V. Y. M., Piérard, D., Bruynseels, P., et al. (2022) · European Journal of Clinical Microbiology & Infectious Diseases · doi:10.1007/s10096-022-04438-z · Cited by 12 · see citing works

A mutagenesis-based approach identifies amino acids in the N-terminal part ofFrancisella tularensisIglE that critically control Type VI system-mediated secretion

Bröms, J. E., Meyer, L., & Sjöstedt, A. B. (2016) · Virulence · doi:10.1080/21505594.2016.1258507 · Cited by 12 · see citing works

A fatal case of liver abscess caused by hypervirulent Klebsiella pneumoniae in a diabetic adolescent: A clinical and laboratory study

Li, Y., Li, Z., Qian, S., Dong, F., Wang, Q., Zhang, P., & Yao, K. (2021) · Pediatric Investigation · doi:10.1002/ped4.12238 · Cited by 12 · see citing works

Universal fluorescent sensors of high-affinity iron transport, applied to ESKAPE pathogens

Chakravorty, S., Shipelskiy, Y., Kumar, A., Majumdar, A., Yang, T., Nairn, B. L., Newton, S. M., & Klebba, P. E. (2019) · Journal of Biological Chemistry · doi:10.1074/jbc.ra118.006921 · Cited by 11 · see citing works

A novel virulence plasmid encoding yersiniabactin, salmochelin, and RmpADC from hypervirulent Klebsiella pneumoniae of distinct genetic backgrounds

Huang, L., Li, Y., Xu, C., Zhou, M., Wang, T., Wang, T., Wang, J., Tang, J., Li, Y., & Dong, N. (2023) · Antimicrobial Agents and Chemotherapy · doi:10.1128/aac.00935-23 · Cited by 11 · see citing works

Modulation of pld1-dependent virulence factors in Klebsiella pneumoniae

de Carvalho, M. D. M. L. (2023) · Arca - Repositório Institucional da Fiocruz

Dual Role for Pld1 in Klebsiella pneumoniae Virulence: Transcriptomics and Proteomics Provide Insights into Direct and Indirect Effects

de Carvalho, M. D. M. L., do Nascimento, T. S., Rocha, G. M., Barbosa, L. C., Bisch, P. M., Delporte, C., Antwerpen, P. V., Ruysschaert, J., Batista, P. R., & Lery, L. M. S. (2025) · Journal of Proteome Research · doi:10.1021/acs.jproteome.4c01146 · Cited by 2 · see citing works

Caracterização do Papel da Proteína PLDkp na Virulência de Klebsiella pneumoniae

de Carvalho, M. D. M. L. (2018) · Americanae (AECID Library)

Coexistence of c-rmpA with p-rmpA and p-rmpA2 rather than excessive siderophores confers higher virulence in K1 Klebsiella pneumoniae

Hu, D., Chen, W., Wu, J., Luo, X., Yu, L., Qu, Y., Zhang, X., Zhang, J., & Ma, B. (2023) · Pathology · doi:10.1016/j.pathol.2023.07.007 · Cited by 9 · see citing works

Comparative analysis of the complete genome of KPC-2-producing Klebsiella pneumoniae Kp13 reveals remarkable genome plasticity and a wide repertoire of virulence and resistance mechanisms

Ramos, P. I. P., Picão, R. C., de Almeida, L. G. P., Lima, N. C. B., Girardello, R., Vivan, A. C. P., Xavier, D. E., Barcellos, F. G., Pelisson, M., Vespero, E. C., et al. (2014) · BMC Genomics · doi:10.1186/1471-2164-15-54 · Cited by 114 · see citing works