The DOI matches its Crossref record; 1 of the 1 references it cites were found in a registry or an index.
The failure of protein cancer biomarkers to reach the clinic: why, and what can be done to address the problem?
Open accessAbstract
There is a plethora of published cancer biomarkers but the reality is that very few, if any, new circulating cancer biomarkers have entered the clinic in the last 30 years. I here try to explain this apparent oxymoron by classifying circulating cancer biomarkers into three categories: fraudulent reports (rare); true discoveries of biomarkers, that then fail to meet the demands of the clinic; and false discoveries, which represent artifactual biomarkers. I further provide examples of combinations of some known cancer biomarkers that can perform well in niche clinical applications, despite individually being not useful.
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Duff, B. R. L., & Faber, R. J. (2011) · Journal of Advertising · doi:10.2753/joa0091-3367400204 · Cited by 137
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Emerging biomarkers in head and neck cancer in the era of genomics
Kang, H., Kiess, A., & Chung, C. H. (2015) · Nature Reviews Clinical Oncology · doi:10.1038/nrclinonc.2014.192 · Cited by 310
Kim, M., Chen, C., Wang, P., Mulvey, J. J., Yang, Y., Wun, C., Antman-Passig, M., Luo, H.-B., Cho, S., Long-Roche, K., et al. (2022) · Nature Biomedical Engineering · doi:10.1038/s41551-022-00860-y · Cited by 214
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Metadata
- Authors
- Diamandis, E. P.
- Venue
- BMC Medicine
- Published
- 2012-08-09
- Volume
- 10
- Issue
- 1
- Pages
- 87-87
- ISSN
- 1741-7015 (ISSN-L)
- OpenAlex
- W2162217976
- Cited by
- 185
- References
- 1
- FWCI
- 3.96
- Type
- journal article
- Language
- en
- Open access
- gold
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- Diamandis, E. P. (2012). The failure of protein cancer biomarkers to reach the clinic: why, and what can be done to address the problem? BMC Medicine. https://doi.org/10.1186/1741-7015-10-87
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
