The DOI matches its Crossref record; 33 of the 33 references it cites were found in a registry or an index.
Sex differences in rheumatoid arthritis: more than meets the eye
Open accessAbstract
Sex differences in the prevalence of autoimmune diseases such as rheumatoid arthritis (RA) are well described, but the literature is not as clear about sex differences in RA disease course and prognosis. A recent study from a very large cross-sectional international cohort demonstrated slightly worse levels of disease activity and function in female patients with RA, compared with men. These findings are discussed in the context of our evolving knowledge of sex differences in the expression of this prototypic autoimmune disease, both in terms of the actual disease activity level, the effects that the disease has on physical function, and our ability accurately to measure these aspects.
Overview
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Integrity signals
Registry
Cites
Statistics
Figures

Verification
Claims the paper makes
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
The cited source says what the claim attributes to it.
In the citing paper
“Besides, the sample size of included studies consisted mostly of female participants, which is generally reflective of prevalence rates in rheumatic conditions (Van Vollenhoven, 2009).”
From Guided internet-based cognitive-behavioral therapy for patients with rheumatic conditions: A systematic review (2021) · cites this paper as Van Vollenhoven, 2009
Self-check
Percentages, sums and reported differences re-computed from the paper’s own numbers.
The self-check needs the paper’s full text.
Citations
Cites
Prevoo, M. L. L., Hof, M. A. V., Kuper, H. H., Leeuwen, M. A. V., van de Putte, L. B. A., & van Riel, P. L. C. M. (1995) · Arthritis & Rheumatism · doi:10.1002/art.1780380107 · Cited by 6,250
Preliminary criteria for the classification of systemic sclerosis (scleroderma)
Masi, A. T. (1980) · Arthritis & Rheumatism · doi:10.1002/art.1780230510 · Cited by 4,925
American college of rheumatology preliminary definition of improvement in rheumatoid arthritis
Felson, D. T., Anderson, J. J., Boers, M., Bombardier, C., Fürst, D. E., Goldsmith, C. H., Katz, L. M. G., Lightfoot, R. W., Paulus, H. E., Strand, V., et al. (1995) · Arthritis & Rheumatism · doi:10.1002/art.1780380602 · Cited by 2,825
van Gestel, A. M., Prevoo, M. L. L., Hof, M. A. V., van Rijswijk, M. H., van de Putte, L. B. A., & van Riel, P. L. C. M. (1996) · Arthritis & Rheumatism · doi:10.1002/art.1780390105 · Cited by 1,568
Gender variations in clinical pain experience
Unruh, A. M. (1996) · Pain · doi:10.1016/0304-3959(95)00214-6 · Cited by 1,550
Aviña-Zubieta, J. A., Choi, H. K., Sadatsafavi, M., Etminan, M., Esdaile, J. M., & Lacaille, D. V. (2008) · Arthritis Care & Research · doi:10.1002/art.24092 · Cited by 1,461
Moll, J. M. H., & Wright, V. A. (1973) · Seminars in Arthritis and Rheumatism · doi:10.1016/0049-0172(73)90035-8 · Cited by 1,263
Sex differences in the perception of noxious experimental stimuli: a meta-analysis
Riley, J. L., Robinson, M. E., Wise, E. A., Myers, C. D., & Fillingim, R. B. (1998) · Pain · doi:10.1016/s0304-3959(97)00199-1 · Cited by 1,085
Development of a disease activity score based on judgment in clinical practice by rheumatologists.
van der Heijde, D. M. F. M., Hof, M. V. '., van Riel, P. L., & van de Putte, L. B. (1993) · PubMed · Cited by 787
A meta-analytic review of pain perception across the menstrual cycle
Riley, J. L., Robinson, M. E., Wise, E. A., & Price, D. D. (1999) · Pain · doi:10.1016/s0304-3959(98)00258-9 · Cited by 591
Fransen, J. (2004) · British journal of rheumatology · doi:10.1093/rheumatology/keh297 · Cited by 487
Sokka, T., Toloza, S., Cutolo, M., Kautiainen, H., Mäkinen, H., Gogus, F. N., Skakić, V., Badsha, H., Peets, T., Baranauskaitė, A., et al. (2009) · Arthritis Research & Therapy · doi:10.1186/ar2591 · Cited by 476
Wj, F. (1974) · Archives of Internal Medicine · doi:10.1001/archinte.134.6.1027 · Cited by 430
Sex hormones influence on the immune system: basic and clinical aspects in autoimmunity
Cutolo, M., Sulli, A., Capellino, S., Villaggio, B., Montagna, P., SERIOLO, B., & Straub, R. H. (2004) · Lupus · doi:10.1191/0961203304lu1094oa · Cited by 407
Linos, A., Worthington, J. W., O'Fallon, M. W., & Kurland, L. T. (1980) · American Journal of Epidemiology · doi:10.1093/oxfordjournals.aje.a112878 · Cited by 402
Smith, Y. R., Stohler, C. S., Nichols, T. E., Bueller, J. A., Koeppe, R. A., & Zubieta, J. (2006) · Journal of Neuroscience · doi:10.1523/jneurosci.5223-05.2006 · Cited by 386
Bingefors, K., & Isacson, D. (2004) · European Journal of Pain · doi:10.1016/j.ejpain.2004.01.005 · Cited by 380
Epidemiology of rheumatoid arthritis: determinants of onset, persistence and outcome
Symmons, D. P. M. (2002) · Best Practice & Research Clinical Rheumatology · doi:10.1053/berh.2002.0257 · Cited by 319
Familial occurrence of psoriatic arthritis.
Moll, J. M. H., & Wright, V. A. (1973) · Annals of the Rheumatic Diseases · doi:10.1136/ard.32.3.181 · Cited by 305
Hormones, Pregnancy, and Autoimmune Diseases
Wilder, R. L. (1998) · Annals of the New York Academy of Sciences · doi:10.1111/j.1749-6632.1998.tb09547.x · Cited by 268
Sex: a major predictor of remission in early rheumatoid arthritis?
Forslind, K., Hafström, I., Ahlmén, M., & Svensson, B. (2006) · Annals of the Rheumatic Diseases · doi:10.1136/ard.2006.056937 · Cited by 223
Tengstrand, B., Ahlmén, M., & Hafström, I. (2004) · PubMed · Cited by 127
Influence of sex, age, and menopausal state on the course of early rheumatoid arthritis.
Kuiper, S., van Gestel, A. M., Swinkels, H. L., de Boo, T. M., da Silva, J. A. P., & van Riel, P. L. C. M. (2001) · PubMed · Cited by 119
Why do people with rheumatoid arthritis still die prematurely?
Gabriel, S. E. (2008) · Annals of the Rheumatic Diseases · doi:10.1136/ard.2008.098038 · Cited by 116
Impact of Gender and Menstrual Cycle Phase on Plasma Cytokine Concentrations
O’Brien, S. M., Fitzgerald, P., Scully, P., Landers, A., Scott, L. V., & Dinan, T. G. (2007) · NeuroImmunoModulation · doi:10.1159/000107423 · Cited by 109
Is there sexual inequality in ankylosing spondylitis? A study of 498 women and 1202 men.
Will, R., Edmunds, L., Elswood, J., & Călin, A. (1990) · PubMed · Cited by 105
Synovial fluid estrogens in rheumatoid arthritis
Cutolo, M., Villaggio, B., SERIOLO, B., Montagna, P., Capellino, S., Straub, R. H., & Sulli, A. (2003) · Autoimmunity Reviews · doi:10.1016/j.autrev.2003.08.003 · Cited by 98
The effects of gender and sex hormones on outcome in rheumatoid arthritis
da Silva, J. A. P., & Hall, G. M. (1992) · Baillière s Clinical Rheumatology · doi:10.1016/s0950-3579(05)80344-9 · Cited by 95
Estrogen, progesterone, and testosterone: Can they be used to treat autoimmune diseases?
van Vollenhoven, R., & McGuire, J. L. (1994) · Cleveland Clinic Journal of Medicine · doi:10.3949/ccjm.61.4.276 · Cited by 91
SJÖGREN’S SYNDROME: HISTORICAL OVERVIEW AND CLINICAL SPECTRUM OF DISEASE
Talal, N. (1992) · Rheumatic Disease Clinics of North America · doi:10.1016/s0889-857x(21)00313-6 · Cited by 89
Hormones, pregnancy, and rheumatoid arthritis.
Olsen, N. J., & Kovacs, W. J. (2003) · PubMed · Cited by 64
The epidemiology of rheumatoid arthritis: a review. II. Incidence and diagnostic criteria.
Wolfe, A. M., Kellgren, J., & Masi, A. T. (1968) · PubMed · Cited by 47
The Prognosis of Rheumatoid Arthritis
Reah, T. G. (1963) · Proceedings of the Royal Society of Medicine · doi:10.1177/003591576305600924 · Cited by 34
Research works printed but not linked: 1
- Joelsson J, Van Vollenhoven RF: RA: different for her than for him? – Gender differences in RA therapeutics. Oral presentation, International Congress on Gender Medicine. 2008
Cited by
Sorted by citations
Lim, E., Ahn, Y., Jang, E.-S., Lee, S., Lee, S., & Son, C. (2020) · Journal of Translational Medicine · doi:10.1186/s12967-020-02269-0 · Cited by 489
Shah, S. C., Khalili, H., Gower-Rousseau, C., Olen, O., Benchimol, E. I., Lynge, E., Nielsen, K. R., Brassard, P., Vutcovici, M., Bitton, A., et al. (2018) · Gastroenterology · doi:10.1053/j.gastro.2018.06.043 · Cited by 286
O’Donovan, A., Cohen, B. E., Seal, K. H., Bertenthal, D., Margaretten, M. E., Nishimi, K. M., & Neylan, T. C. (2014) · Biological Psychiatry · doi:10.1016/j.biopsych.2014.06.015 · Cited by 302
Autoimmune Disease in Women: Endocrine Transition and Risk Across the Lifespan
Desai, M. K., & Brinton, R. D. (2019) · Frontiers in Endocrinology · doi:10.3389/fendo.2019.00265 · Cited by 293
Dana, R., Bradley, J. L., Guérin, A., Pivneva, I., Stillman, I. Ö., Evans, A., & Schaumberg, D. A. (2019) · American Journal of Ophthalmology · doi:10.1016/j.ajo.2019.01.026 · Cited by 229
Metadata
- Authors
- van Vollenhoven, R. F.
- Venue
- BMC Medicine
- Published
- 2009-03-30
- Volume
- 7
- Issue
- 1
- Pages
- 12-12
- ISSN
- 1741-7015 (ISSN-L)
- PMC
- PMC2670321
- OpenAlex
- W2090929542
- Cited by
- 326
- References
- 33
- Citations by year
- 2026: 22 · 2025: 23 · 2024: 35 · 2023: 33 · 2022: 38 · 2021: 43 · 2020: 39 · 2019: 31 · 2018: 25 · 2017: 9 · 2016: 6 · 2015: 5 · 2014: 5 · 2013: 1 · 2012: 5
- FWCI
- 2.59
- Type
- journal article
- Language
- en
- Open access
- gold
- doi.org
- Licence
- Locations
- BMC Medicine (publishedVersion, cc-by)
- PubMed Central (publishedVersion, cc-by)
- PubMed (publishedVersion)
- DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion, cc-by-sa)
- Topics
- Health Sciences › Medicine › Rheumatology › Rheumatoid Arthritis Research and Therapies
- Health Sciences › Medicine › Public Health, Environmental and Occupational Health › Sex and Gender in Healthcare
- Health Sciences › Medicine › Hematology › Autoimmune and Inflammatory Disorders Research
- Keywords
- rheumatoid arthritis, sex differences, disease activity, physical function, prognosis, autoimmune disease, clinical course, sex differences in disease expression
- MeSH terms
- Arthritis, Rheumatoid, Cross-Sectional Studies, Female, Humans, Male, Severity of Illness Index, Sex Characteristics, Cohort Studies, Prevalence
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review