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Clinical trials for stem cell therapies
Open accessAbstract
In recent years, clinical trials with stem cells have taken the emerging field in many new directions. While numerous teams continue to refine and expand the role of bone marrow and cord blood stem cells for their vanguard uses in blood and immune disorders, many others are looking to expand the uses of the various types of stem cells found in bone marrow and cord blood, in particular mesenchymal stem cells, to uses beyond those that could be corrected by replacing cells in their own lineage. Early results from these trials have produced mixed results often showing minor or transitory improvements that may be attributed to extracellular factors. More research teams are accelerating the use of other types of adult stem cells, in particular neural stem cells for diseases where beneficial outcome could result from either in-lineage cell replacement or extracellular factors. At the same time, the first three trials using cells derived from pluripotent cells have begun.
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Dominici, M., Le Blanc, K., Mueller, I., Slaper-Cortenbach, I., Marini, F. C., Krause, D. S., Deans, R. J., Keating, A., Prockop, D. J., & Horwitz, E. M. (2006) · Cytotherapy · doi:10.1080/14653240600855905 · Cited by 17,766
Cited by
Functional heterogeneity of mesenchymal stem cells: Implications for cell therapy
Phinney, D. G. (2012) · Journal of Cellular Biochemistry · doi:10.1002/jcb.24166 · Cited by 434
De Feo, D., Merlini, A., Laterza, C., & Martino, G. (2012) · Current Opinion in Neurology · doi:10.1097/wco.0b013e328352ec45 · Cited by 181
Nano-engineered mesenchymal stem cells as targeted therapeutic carriers
Sadhukha, T., O'Brien, T. D., & Prabha, S. (2014) · Journal of Controlled Release · doi:10.1016/j.jconrel.2014.10.015 · Cited by 115
The Alpha Stem Cell Clinic: A Model for Evaluating and Delivering Stem Cell-Based Therapies
Trounson, A., DeWitt, N. D., & Feigal, E. G. (2012) · Stem Cells Translational Medicine · doi:10.5966/sctm.2011-0027 · Cited by 33
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Metadata
- Authors
- Trounson, A., Thakar, R. G., Lomax, G., & Gibbons, D.
- Venue
- BMC Medicine
- Published
- 2011-05-10
- Volume
- 9
- Issue
- 1
- Pages
- 52-52
- ISSN
- 1741-7015 (ISSN-L)
- OpenAlex
- W2149038956
- Cited by
- 445
- References
- 1
- FWCI
- 28.30
- Type
- journal article
- Language
- en
- Open access
- gold
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Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
