The DOI matches its Crossref record; 15 of the 15 references it cites were found in a registry or an index.
Elevated serum levels of interleukin-17A in children with autism
Open accessAbstract
BACKGROUND: The T-helper (Th)1/Th2 dichotomy dominated the field of immune regulation until interleukin (IL)-17-expressing T cells (Th17) were proposed to be a third lineage of helper T cells, the key players in the pathogenesis of autoimmune disorders. Autoimmunity to brain tissue may play a pathogenic role in autism. IL-17A is a pro-inflammatory cytokine that has been shown to play an important role in various autoimmune neuroinflammatory diseases. The aim of this study was to measure serum levels of IL-17A in relation to the degree of the severity of autism. METHODS: Serum IL-17A levels were measured by ELISA in 45 children with autism and 40 matched healthy controls. RESULTS: Children with autism had significantly higher serum IL-17A levels than healthy controls (P <0.001), with increased serum levels of IL-17A found in 48.9% of the autism group. Patients with severe autism had significantly higher serum IL-17A levels than those with mild to moderate autism (P=0.01), and raised serum IL-17A levels were significantly more common in children with severe autism (67.9%) than in those with mild to moderate autism (17.6%), P=0.001. CONCLUSIONS: Serum IL-17A levels were raised in the group with autism, and the levels correlated significantly with the severity of autism. This is the first study to measure levels of IL-17A in relation to the severity of autism, to our knowledge. Further research, with a larger subject population, is warranted to determine whether the increase of serum IL-17A levels plasma has a pathogenic role in autism, and whether anti- IL-17A therapy could be useful.
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A distinct lineage of CD4 T cells regulates tissue inflammation by producing interleukin 17
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Transforming growth factor-β induces development of the TH17 lineage
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Th17: An Effector CD4 T Cell Lineage with Regulatory T Cell Ties
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“Macrophages and DCs express IL-17A receptors, and can respond to IL-17, producing cytokines and chemokines [58,59].”
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Circulating autoantibodies to neuronal and glial filament proteins in autism
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Cited by
The maternal interleukin-17a pathway in mice promotes autism-like phenotypes in offspring
Choi, G. B., Yim, Y. S., Wong, H., Kim, S., Kim, H., Kim, S. V., Hoeffer, C. A., Littman, D. R., & Huh, J. R. (2016) · Science · doi:10.1126/science.aad0314 · Cited by 1,214
“For example, elevated levels of IL-17a, the predominant TH17 cytokine, have been detected in the serum of a subset of autistic children (14, 15).”
BackgroundThe Role of the Immune System in Autism Spectrum Disorder
Meltzer, A., & Van de Water, J. (2017) · Neuropsychopharmacology · doi:10.1038/npp.2016.158 · Cited by 533
Cytokine aberrations in autism spectrum disorder: a systematic review and meta-analysis
Masi, A., Quintana, D. S., Glozier, N., Lloyd, A. R., Hickie, I. B., & Guastella, A. J. (2015) · Molecular Psychiatry · doi:10.1038/mp.2014.59 · Cited by 466
Tsilioni, I., Taliou, A., Francis, K., & Theoharides, T. C. (2015) · Translational Psychiatry · doi:10.1038/tp.2015.142 · Cited by 199
Beurel, E., & Lowell, J. A. (2018) · Brain, Behavior, and Immunity · doi:10.1016/j.bbi.2017.08.001 · Cited by 187
Metadata
- Authors
- AL-Ayadhi, L. Y., & Mostafa, G. A.
- Venue
- Journal of Neuroinflammation
- Published
- 2012-07-02
- Volume
- 9
- Issue
- 1
- Pages
- 158-158
- ISSN
- 1742-2094 (ISSN-L)
- OpenAlex
- W2164938398
- Cited by
- 193
- References
- 15
- FWCI
- 3.68
- Type
- journal article
- Language
- en
- Open access
- gold
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