Construction of a polycystic ovarian syndrome (PCOS) pathway based on the interactions of PCOS-related proteins retrieved from bibliomic data
Open accessAbstract
Polycystic ovary syndrome (PCOS) is a complex but frequently occurring endocrine abnormality. PCOS has become one of the leading causes of oligo-ovulatory infertility among premenopausal women. The definition of PCOS remains unclear because of the heterogeneity of this abnormality, but it is associated with insulin resistance, hyperandrogenism, obesity and dyslipidaemia. The main purpose of this study was to identify possible candidate genes involved in PCOS. Several genomic approaches, including linkage analysis and microarray analysis, have been used to look for candidate PCOS genes. To obtain a clearer view of the mechanism of PCOS, we have compiled data from microarray analyses. An extensive literature search identified seven published microarray analyses that utilized PCOS samples. These were published between the year of 2003 and 2007 and included analyses of ovary tissues as well as whole ovaries and theca cells. Although somewhat different methods were used, all the studies employed cDNA microarrays to compare the gene expression patterns of PCOS patients with those of healthy controls. These analyses identified more than a thousand genes whose expression was altered in PCOS patients. Most of the genes were found to be involved in gene and protein expression, cell signaling and metabolism. We have classified all of the 1081 identified genes as coding for either known or unknown proteins. Cytoscape 2.6.1 was used to build a network of protein and then to analyze it. This protein network consists of 504 protein nodes and 1408 interactions among those proteins. One hypothetical protein in the PCOS network was postulated to be involved in the cell cycle. BiNGO was used to identify the three main ontologies in the protein network: molecular functions, biological processes and cellular components. This gene ontology analysis identified a number of ontologies and genes likely to be involved in the complex mechanism of PCOS. These include the insulin receptor signaling pathway, steroid biosynthesis, and the regulation of gonadotropin secretion among others.
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Integrity signals
Registry
Cites
Statistics
Claims the paper makes
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
PCOS reflects interactions among multiple proteins and genes influenced by epigenetic and environmental factors.
“PCOS reflects the interactions among multiple proteins and genes influenced by epigenetic and environmental factors (Fig. 1) [5].”
From Polycystic Ovary Syndrome: Pathophysiology, Presentation, and Treatment With Emphasis on Adolescent Girls (2019) · cites this paper as [5]
Self-check
Percentages, sums and reported differences re-computed from the paper’s own numbers.
The self-check needs the paper’s full text.
Cites
Cytoscape: A software Environment for integrated models of biomolecular interaction networks
Shannon, P., Markiel, A., Ozier, O., Baliga, N. S., Wang, J. T., Ramage, D., Amin, N., Schwikowski, B., & Ideker, T. (2003) · Genome Research · doi:10.1101/gr.1239303 · Cited by 51,888 · see citing works
(2004) · Fertility and Sterility · doi:10.1016/j.fertnstert.2003.10.004 · Cited by 9,050 · see citing works
Maere, S., Heymans, K., & Kuiper, M. (2005) · Bioinform. · doi:10.1093/bioinformatics/bti551 · Cited by 4,251 · see citing works
Franks, S. (1995) · New England Journal of Medicine · doi:10.1056/nejm199509283331307 · Cited by 2,463 · see citing works
Men at risk: occupation and male infertility.
Claman, P. (2004) · Fertility and Sterility · doi:10.1016/s0015-0282(03)01188-9 · Cited by 2,219 · see citing works
Amenorrhea associated with bilateral polycystic ovaries
Stein, I. F., & Leventhal, M. L. (1935) · American Journal of Obstetrics and Gynecology · doi:10.1016/s0002-9378(15)30642-6 · Cited by 2,121 · see citing works
A quantitative atlas of mitotic phosphorylation
Dephoure, N., Zhou, C., Villén, J., Beausoleil, S. A., Bakalarski, C. E., Elledge, S. J., & Gygi, S. P. (2008) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0805139105 · Cited by 1,608 · see citing works
Mitotic kinases as regulators of cell division and its checkpoints
Nigg, E. A. (2001) · Nature Reviews Molecular Cell Biology · doi:10.1038/35048096 · Cited by 1,541 · see citing works
Mammalian cyclin-dependent kinases
Malumbres, M., & Barbacid, M. (2005) · Trends in Biochemical Sciences · doi:10.1016/j.tibs.2005.09.005 · Cited by 1,294 · see citing works
Casein kinase 2: An ‘eminence grise’ in cellular regulation?
Pinna, L. A. (1990) · Biochimica et Biophysica Acta (BBA) - Molecular Cell Research · doi:10.1016/0167-4889(90)90098-x · Cited by 920 · see citing works
Franks, S. (1997) · Archives of Disease in Childhood · doi:10.1136/adc.77.1.89 · Cited by 802 · see citing works
Evidence for Distinctive and Intrinsic Defects in Insulin Action in Polycystic Ovary Syndrome
Dunaif, A. E., Segal, K. R., Shelley, D., Green, G., Dobrjansky, A., & Licholai, T. (1992) · Diabetes · doi:10.2337/diab.41.10.1257 · Cited by 544 · see citing works
Infrastructure for the life sciences: design and implementation of the UniProt website
Jain, E., Bairoch, A., Duvaud, S., Phan, I. Q., Redaschi, N., Süzek, B. E., Martin, M. J., McGarvey, P. B., & Gasteiger, E. (2009) · BMC Bioinformatics · doi:10.1186/1471-2105-10-136 · Cited by 485 · see citing works
Urbanek, M., Legro, R. S., Driscoll, D. A., Azziz, R., Ehrmann, D. A., Norman, R. J., Strauss, J. F., Spielman, R. S., & Dunaif, A. E. (1999) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.96.15.8573 · Cited by 477 · see citing works
Carey, A. H., Waterworth, D. M., Patel, K., White, D. M., Little, J., Novelli, P., Franks, S., & Williamson, R. (1994) · Human Molecular Genetics · doi:10.1093/hmg/3.10.1873 · Cited by 462 · see citing works
p53 regulates a G 2 checkpoint through cyclin B1
Innocente, S. A., Abrahamson, J., Cogswell, J. P., & Lee, J. M. (1999) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.96.5.2147 · Cited by 435 · see citing works
Mitotic regulation of the human anaphase‐promoting complex by phosphorylation
Kraft, C., Herzog, F., Gieffers, C., Mechtler, K., Hagting, A., Pines, J., & Peters, J. (2003) · The EMBO Journal · doi:10.1093/emboj/cdg627 · Cited by 421 · see citing works
Kishimoto, A., Nishiyama, K., Nakanishi, H., Uratsuji, Y., Nomura, H., Takeyama, Y., & Nishizuka, Y. (1985) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(17)38898-1 · Cited by 417 · see citing works
Linkage and association of insulin gene VNTR regulatory polymorphism with polycystic ovary syndrome
Waterworth, D. M., Bennett, S. T., Gharani, N., McCarthy, M. I., Hague, S., Batty, S., Conway, G. S., White, D. M., Todd, J. A., Franks, S., et al. (1997) · The Lancet · doi:10.1016/s0140-6736(96)08368-7 · Cited by 316 · see citing works
Wood, J. R., Dumesic, D. A., Abbott, D. H., & Strauss, J. F. (2006) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jc.2006-2123 · Cited by 307 · see citing works
Association of the Steroid Synthesis Gene Cyp11a with Polycystic Ovary Syndrome and Hyperandrogenism
Gharani, N., Waterworth, D. M., Batty, S., White, D. M., Gilling‐Smith, C., Conway, G. S., McCarthy, M. I., Franks, S., & Williamson, R. (1997) · Human Molecular Genetics · doi:10.1093/hmg/6.3.397 · Cited by 290 · see citing works
Wood, J. R., Nelson-DeGrave, V. L., Ho, C. K. M., Jansen, E., Wang, C. Y., Urbanek, M., McAllister, J. M., Mosselman, S., & Strauss, J. F. (2003) · Journal of Biological Chemistry · doi:10.1074/jbc.m300688200 · Cited by 259 · see citing works
Cortón, M., Botella-Carretero, J. I., Benguría, A., Villuendas, G., Zaballos, Á., Millán, J. L. S., Escobar-Morreale, H. F., & Peral, B. (2006) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jc.2006-1665 · Cited by 174 · see citing works
Abnormal Gene Expression Profiles in Human Ovaries from Polycystic Ovary Syndrome Patients
Jansen, E., Laven, J. S. E., Dommerholt, H. B. R., Polman, J. E. M., de Westerlo, C. V. R.-V., van den Hurk, C., Westland, J. A., Mosselman, S., & Fauser, B. C. J. M. (2004) · Molecular Endocrinology · doi:10.1210/me.2004-0074 · Cited by 172 · see citing works
Diagnosis, epidemiology, and genetics of the polycystic ovary syndrome
Goodarzi, M. O., & Azziz, R. (2006) · Best Practice & Research Clinical Endocrinology & Metabolism · doi:10.1016/j.beem.2006.02.005 · Cited by 170 · see citing works
Evidence for distinctive and intrinsic defects in insulin action in polycystic ovary syndrome
Dunaif, A. E., Segal, K. R., Shelley, D. R., et al. (1992) · Diabetes · doi:10.2337/diabetes.41.10.1257 · Cited by 141 · see citing works
The genetics of polycystic ovary syndrome
Amato, P., & Simpson, J. L. (2004) · Best Practice & Research Clinical Obstetrics & Gynaecology · doi:10.1016/j.bpobgyn.2004.05.002 · Cited by 122 · see citing works
Diao, F., Xu, M., Hu, Y., Li, J., Xu, Z., Lin, M., Wang, L., Zhou, Y., Zhou, Z., Liu, J., et al. (2004) · Journal of Molecular Endocrinology · doi:10.1677/jme.0.0330059 · Cited by 99 · see citing works
Wood, J. R., Nelson-DeGrave, V. L., Jansen, E., McAllister, J. M., Mosselman, S., & Strauss, J. F. (2004) · Physiological Genomics · doi:10.1152/physiolgenomics.00193.2004 · Cited by 77 · see citing works
Looking for Polycystic Ovary Syndrome Genes: Rational and Best Strategy
Goodarzi, M. O. (2008) · Seminars in Reproductive Medicine · doi:10.1055/s-2007-992919 · Cited by 75 · see citing works
BioNetBuilder: automatic integration of biological networks
Avila-Campillo, I., Drew, K., Lin, J., Reiss, D. J., & Bonneau, R. (2006) · Bioinformatics · doi:10.1093/bioinformatics/btl604 · Cited by 69 · see citing works
Effect of masoprocol on carbohydrate and lipid metabolism in a rat model of Type II diabetes
Reed, M. J., Meszaros, K., Entes, L. J., Claypool, M. D., Pinkett, J. G., Brignetti, D., Luo, J., Khandwala, A. S., & Reaven, G. M. (1999) · Diabetologia · doi:10.1007/s001250051121 · Cited by 58 · see citing works
Molecular profiling of polycystic ovaries for markers of cell invasion and matrix turnover
Oksjoki, S., Söderström, M., Inki, P., Vuorio, E., & Anttila, L. (2005) · Fertility and Sterility · doi:10.1016/j.fertnstert.2004.10.037 · Cited by 38 · see citing works
Coqueret, O. (2003) · Cell Cycle · doi:10.4161/cc.2.4.427 · Cited by 14 · see citing works
Structure of the conserved hypothetical protein MAL13P1.257 fromPlasmodium falciparum
Holmes, M. A., C, F. S. B. A., A, W. C. V. V., Mehlin, C., Boni, E., Earnest, T. N., DeTitta, G. T., Luft, J. R., Lauricella, A. M., Anderson, L., et al. (2006) · Acta Crystallographica Section F Structural Biology and Crystallization Communications · doi:10.1107/s1744309106005847 · Cited by 9 · see citing works
Flagged first, then by citations
Cited by
Sorted by citations
Witchel, S. F., Oberfield, S. E., & Peña, A. S. (2019) · Journal of the Endocrine Society · doi:10.1210/js.2019-00078 · Cited by 653 · see citing works
PCOS Forum: research in polycystic ovary syndrome today and tomorrow
Pasquali, R., Stener‐Victorin, E., Yıldız, B. O., Dulęba, A. J., Hoeger, K. M., Mason, H. D., Homburg, R., Hickey, T. E., Franks, S., Tapanainen, J. S., et al. (2010) · Clinical Endocrinology · doi:10.1111/j.1365-2265.2010.03956.x · Cited by 188 · see citing works
Baranova, A. V., Tran, T., Birerdinc, A., & Younossi, Z. M. (2011) · Alimentary Pharmacology & Therapeutics · doi:10.1111/j.1365-2036.2011.04579.x · Cited by 146 · see citing works
Diamanti‐Kandarakis, E. (2009) · Best Practice & Research Clinical Obstetrics & Gynaecology · doi:10.1016/j.bpobgyn.2009.09.005 · Cited by 91 · see citing works
Aberrant expression of long noncoding RNAs in cumulus cells isolated from PCOS patients
Huang, X. Y., Hao, C., Bao, H., Wang, M., & Dai, H. (2015) · Journal of Assisted Reproduction and Genetics · doi:10.1007/s10815-015-0630-z · Cited by 81 · see citing works
Reyes-Muñoz, E., Sathyapalan, T., Rossetti, P., Shah, M., Long, M., Buscema, M., Valenti, G., Rosa, V. L. L., Cianci, S., & Vitale, S. G. (2018) · Advances in Therapy · doi:10.1007/s12325-018-0810-1 · Cited by 75 · see citing works
Huang, X. Y., Liu, C., Hao, C., Tang, Q., Liu, R., Lin, S., Zhang, L., & Yan, W. (2016) · Reproduction · doi:10.1530/rep-16-0071 · Cited by 64 · see citing works
Huang, X. Y., Pan, J., Wu, B., & Teng, X. (2018) · Reproductive Biology and Endocrinology · doi:10.1186/s12958-018-0392-4 · Cited by 60 · see citing works
Branavan, U., Muneeswaran, K., Wijesundera, S., Jayakody, S., Chandrasekharan, V., & Wijeyaratne, C. N. (2018) · PLoS ONE · doi:10.1371/journal.pone.0209830 · Cited by 46 · see citing works
Vonica, C. L., Ilie, I. R. P., Socaciu, C., Moraru, C., Georgescu, B., Fărcaș, A. D., Román, G., Mureşan, A. A., & Georgescu, C. E. (2019) · Scandinavian Journal of Clinical and Laboratory Investigation · doi:10.1080/00365513.2019.1658215 · Cited by 29 · see citing works
Pan, M.-L., Chen, L.-R., & Chen, K.-H. (2021) · International Journal of Environmental Research and Public Health · doi:10.3390/ijerph18168253 · Cited by 24 · see citing works
Pan, M.-L., Chen, L.-R., Tsao, H.-M., & Chen, K.-H. (2017) · Menopause The Journal of The North American Menopause Society · doi:10.1097/gme.0000000000000832 · Cited by 20 · see citing works
Harnessing Expression Data to Identify Novel Candidate Genes in Polycystic Ovary Syndrome
Jones, M. R., Chua, A. K., Chen, Y. I., Li, X., Krauss, R. M., Rotter, J. I., Legro, R. S., Azziz, R., & Goodarzi, M. O. (2011) · PLoS ONE · doi:10.1371/journal.pone.0020120 · Cited by 20 · see citing works
Systematic Analysis of Protein Interaction Network Associated with Azoospermia
Sabetian, S., & Shamsir, M. S. (2016) · International Journal of Molecular Sciences · doi:10.3390/ijms17111857 · Cited by 18 · see citing works
Mokhtar, H. M., Giribabu, N., & Salleh, N. (2018) · Sains Malaysiana · doi:10.17576/jsm-2018-4710-28 · Cited by 15 · see citing works
Construction and Analysis of the Cell Surface’s Protein Network for Human Sperm-Egg Interaction
Sabetian, S., & Shamsir, M. S. (2013) · ISRN Bioinformatics · doi:10.1155/2013/962760 · Cited by 13 · see citing works
PCOSDB: PolyCystic Ovary Syndrome DataBase for manually curated genes associated with the disease
Mary, M. J., Vetrivel, U., Deecaraman, M., & Melanathuru, V. (2016) · Bioinformation · doi:10.6026/97320630012004 · Cited by 13 · see citing works
Pan, M.-L., Chen, L.-R., Tsao, H.-M., & Chen, K.-H. (2020) · International Journal of Environmental Research and Public Health · doi:10.3390/ijerph17103657 · Cited by 13 · see citing works
Analyzing the Impact of FSHR Variants on Polycystic Ovary Syndrome—a Case-Control Study in Punjab
Kaur, M., Singh, S., Kaur, R., Beri, A., & Kaur, A. (2023) · Reproductive Sciences · doi:10.1007/s43032-023-01194-z · Cited by 11 · see citing works
Association between β2‐adrenoceptor ( ADRB 2) haplotypes and insulin resistance in PCOS
Tellechea, M. L., Muzzio, D. O., Molli, A. E. I., Belli, S., Graffigna, M. N., Levalle, O. A., Frechtel, G. D., & Cerrone, G. E. (2012) · Clinical Endocrinology · doi:10.1111/cen.12019 · Cited by 11 · see citing works
Polycystic οvary syndrome revisited: An interactions network approach
Geronikolou, S. A., Pavlopoulou, A., Cokkinos, D. V., Bacopoulou, F., & Chrousos, G. P. (2021) · European Journal of Clinical Investigation · doi:10.1111/eci.13578 · Cited by 9 · see citing works
Gollapalli, P., Kumari, S., Shetty, P. K., & Gnanasekaran, T. S. (2022) · Beni-Suef University Journal of Basic and Applied Sciences · doi:10.1186/s43088-022-00200-8 · Cited by 8 · see citing works
Youssef, H. M. G., Marei, E. S., & Rashed, L. A. (2019) · Clinical and Experimental Obstetrics & Gynecology · doi:10.12891/ceog4774.2019 · Cited by 7 · see citing works
Harun, S., & Zulkifle, N. (2018) · Sains Malaysiana · doi:10.17576/jsm-2018-4712-01 · Cited by 6 · see citing works
Pan, M.-L., Chen, L.-R., & Chen, K.-H. (2022) · International Journal of Environmental Research and Public Health · doi:10.3390/ijerph19095470 · Cited by 4 · see citing works
Юрьевна, П. В., Сергеевна, А. О., & Sosna, N. A. (2021) · Russian Journal of Human Reproduction · doi:10.17116/repro20212704197 · Cited by 4 · see citing works
Computational Systems Analysis on Polycystic Ovarian Syndrome (PCOS)
Afiqah‐Aleng, N., & Mohamed‐Hussein, Z. (2020) · IntechOpen eBooks · doi:10.5772/intechopen.89490 · Cited by 4 · see citing works
Polycystic Ovary Syndrome Till Date and Possibilities in Coming Years
Agrawal, P. K., Garg, R., Chauhan, V., & Kumari, S. (2024) · Journal of South Asian Federation of Obstetrics and Gynaecology · doi:10.5005/jp-journals-10006-2371 · Cited by 3 · see citing works
Polycystic Ovarian Syndrome: A Complex Affair Centered on Ovarian Hyperandrogenism
Crum, C. P., & Meserve, E. E. K. (2014) · Elsevier eBooks · doi:10.1016/b978-0-12-386456-7.03912-5 · Cited by 2 · see citing works
Zhou, C., Teng, W., Yang, J., Hu, Z., Wang, C., Qin, B., Lv, Q.-L., Liu, Z.-W., & Sun, C. (2014) · Asian Pacific Journal of Cancer Prevention · doi:10.7314/apjcp.2014.15.13.5325 · Cited by 2 · see citing works
Sun, C., Cao, X., Zhou, C., Liu, L. J., Feng, F., Liu, R.-R., Zhuang, J., & Li, Y. J. (2015) · Genetics and Molecular Research · doi:10.4238/2015.december.8.1 · Cited by 2 · see citing works
Rahaman, S. N. A., Yusop, J. M., Mohamed‐Hussein, Z., Ho, K. L., Teh, A.-H., Waterman, J., & Ng, C. L. (2016) · Acta Crystallographica Section F Structural Biology Communications · doi:10.1107/s2053230x16002016 · Cited by 1 · see citing works
Polycystic Ovary Syndrome: Pathophysiology, Presentation and Treatment a Mini-Review Article
Simic, D., Stefanovic, K., Djurić, D., & Turnić, T. N. (2021) · Serbian Journal of Experimental and Clinical Research · doi:10.2478/sjecr-2020-0053 · Cited by 1 · see citing works
Integrative approaches for the management of PCOS: A review
Joshi, A., Muthal, A., Namdeo, A. G., & Shinde, V. M. (2023) · International Journal of Herbal Medicine · doi:10.22271/flora.2023.v11.i2a.856 · Cited by 1 · see citing works
Adolesanda Polikistik Over Sendromu
Şahi̇n, L., & Aygün, B. (2013) · DergiPark (Istanbul University) · Cited by 1 · see citing works
Genetic factors responsible for ovarian hyperandrogenism in women
Семенюк, Л. М., & Яроцький, М. Є. (2016) · Clinical endocrinology and endocrine surgery · doi:10.24026/1818-1384.2(54).2016.75858 · Cited by 1 · see citing works
Ayurvedic management of Polycystic Ovarian Disorder - A case study
Mishra, K., Changade, J., & Sonalkar, A. D. (2023) · International Journal of Ayurvedic Medicine · doi:10.47552/ijam.v14i2.3464
A Case Study of Ayurvedic Therapies for Polycystic Ovarian Disorder
-, S. S. (2023) · International Journal For Multidisciplinary Research · doi:10.36948/ijfmr.2023.v05i05.8024
Joshi, S., Sharma, V., Bhandari, S., Joshi, P., & Mondal, S. (2024) · Research Square · doi:10.21203/rs.3.rs-4384391/v1
Revolutionizing Infertility Management through Novel Peptide-based Targets
Kumar, V., & Doshi, G. (2024) · Current Protein and Peptide Science · doi:10.2174/0113892037304433240430144106 · Cited by 1 · see citing works
Fazilat, A., Majidzadeh‐A, K., Gilany, K., Moghadam, F. M., Valilo, M., & Wajid, S. (2025) · The Protein Journal · doi:10.1007/s10930-025-10295-4
Gollapalli, P., Kumari, N. S., Shetty, P., & Gnanasekaran, T. S. (2022) · Figshare · doi:10.6084/m9.figshare.19174147
MicroRNA Crossroads in PCOS and Endometriosis
Sambath, G., Kalai, J., Usha Rani, G., Osborne, J. W., Sumitha, R., & Parvathi, V. D. (2025) · Reproductive Sciences · doi:10.1007/s43032-025-02037-9
Senthilkumar, H., Vijaikumar, E., Manikandan, M., Jeyaraman, J., & Arumugam, M. (2026) · In Silico Research in Biomedicine · doi:10.1016/j.insi.2026.100488
Correlation between age, BMI and sexual hormones levels among PCOS women
Imran, R. E., & Faris, R. A. (2026) · AIP conference proceedings · doi:10.1063/5.0330242
- Authors
- Mohamed-Hussein, Z.-A., & Harun, S.
- Affiliations
- National University of Malaysia (MY)
- ORCID
- Harun, Sarahani
- Venue
- Theoretical Biology and Medical Modelling
- Published
- 2009-09-01
- Volume
- 6
- Issue
- 1
- Pages
- 18-18
- ISSN
- 1742-4682 (ISSN-L)
- PMC
- PMC2743649
- OpenAlex
- W2054839236
- Cited by
- 46
- References
- 35
- Citations by year
- 2026: 2 · 2025: 2 · 2024: 3 · 2023: 4 · 2022: 3 · 2021: 4 · 2020: 2 · 2019: 3 · 2018: 6 · 2017: 1 · 2016: 5 · 2015: 2 · 2014: 2 · 2013: 2 · 2012: 1
- FWCI
- 1.97
- Type
- journal article
- Language
- en
- Open access
- hybrid
- doi.org
- Licence
- Locations
- Theoretical Biology and Medical Modelling (publishedVersion, cc-by)
- PubMed Central (publishedVersion, cc-by)
- PubMed (publishedVersion)
- DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion)
- Greater South Information System
- Funders
- National Science Foundation
- Kementerian Sains, Teknologi dan Inovasi
- Ministério da Ciência, Tecnologia e Inovação
- Topics
- Health Sciences › Medicine › Reproductive Medicine › Ovarian function and disorders
- Health Sciences › Medicine › Public Health, Environmental and Occupational Health › Reproductive Biology and Fertility
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Genetics › Genetic and Kidney Cyst Diseases
- Keywords
- polycystic ovary syndrome, protein-protein interaction network, gene expression profiling, microarray data integration, insulin receptor signaling, steroidogenesis, gonadotropin secretion, cell cycle, Gene Ontology, theca cells, insulin resistance, hyperandrogenism
- MeSH terms
- Female, Humans, Polycystic Ovary Syndrome, Protein Binding, Proteins, Software, Bibliometrics, Oligonucleotide Array Sequence Analysis
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
