The DOI matches its Crossref record; 1 of the 1 references it cites were found in a registry or an index.
Role of cytochrome P450 in drug interactions
Open accessAbstract
Drug-drug interactions have become an important issue in health care. It is now realized that many drug-drug interactions can be explained by alterations in the metabolic enzymes that are present in the liver and other extra-hepatic tissues. Many of the major pharmacokinetic interactions between drugs are due to hepatic cytochrome P450 (P450 or CYP) enzymes being affected by previous administration of other drugs. After coadministration, some drugs act as potent enzyme inducers, whereas others are inhibitors. However, reports of enzyme inhibition are very much more common. Understanding these mechanisms of enzyme inhibition or induction is extremely important in order to give appropriate multiple-drug therapies. In future, it may help to identify individuals at greatest risk of drug interactions and adverse events.
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Terfenadine-Ketoconazole Interaction: Pharmacokinetic and Electrocardiographic Consequences
Honig, P. K. (1993) · JAMA · doi:10.1001/jama.1993.03500120051025 · Cited by 664
Cited by
Network-based prediction of drug combinations
Cheng, F., Kovács, I. A., & Barabási, A.-L. (2019) · Nature Communications · doi:10.1038/s41467-019-09186-x · Cited by 800
Sengupta, S., Johnson, B., Seirup, M., Ardalani, H., Duffin, B., Barrett-Wilt, G. A., Stewart, R., & Thomson, J. A. (2020) · Current Research in Toxicology · doi:10.1016/j.crtox.2020.08.001 · Cited by 9
Metadata
- Authors
- Bibi, Z.
- Venue
- Nutrition & Metabolism
- Published
- 2008-10-18
- Volume
- 5
- Issue
- 1
- Pages
- 27-27
- ISSN
- 1743-7075 (ISSN-L)
- OpenAlex
- W2087826156
- Cited by
- 197
- References
- 1
- FWCI
- 3.86
- Type
- journal article
- Language
- en
- Status
- Retracted
- Open access
- gold
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- Bibi, Z. (2008). Role of cytochrome P450 in drug interactions. Nutrition & Metabolism. https://doi.org/10.1186/1743-7075-5-27
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Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
