Cellular uptake and localization of inhaled gold nanoparticles in lungs of mice with chronic obstructive pulmonary disease
Open accessAbstract
BACKGROUND: Inhalative nanocarriers for local or systemic therapy are promising. Gold nanoparticles (AuNP) have been widely considered as candidate material. Knowledge about their interaction with the lungs is required, foremost their uptake by surface macrophages and epithelial cells. METHODS: Scnn1b-Tg and Wt mice inhaled a 21-nm AuNP aerosol for 2 h. Immediately (0 h) or 24 h thereafter, bronchoalveolar lavage (BAL) macrophages and whole lungs were prepared for stereological analysis of AuNP by electron microscopy. RESULTS: AuNP were mainly found as singlets or small agglomerates of ≤ 100 nm diameter, at the epithelial surface and within lung-surface structures. Macrophages contained also large AuNP agglomerates (> 100 nm). At 0 h after aerosol inhalation, 69.2±4.9% AuNP were luminal, i.e. attached to the epithelial surface and 24.0±5.9% in macrophages in Scnn1b-Tg mice. In Wt mice, 35.3±32.2% AuNP were on the epithelium and 58.3±41.4% in macrophages. The percentage of luminal AuNP decreased from 0 h to 24 h in both groups. At 24 h, 15.5±4.8% AuNP were luminal, 21.4±14.2% within epithelial cells and 63.0±18.9% in macrophages in Scnn1b-Tg mice. In Wt mice, 9.5±5.0% AuNP were luminal, 2.2±1.6% within epithelial cells and 82.8±0.2% in macrophages. BAL-macrophage analysis revealed enhanced AuNP uptake in Wt animals at 0 h and in Scnn1b-Tg mice at 24 h, confirming less efficient macrophage uptake and delayed clearance of AuNP in Scnn1b-Tg mice. CONCLUSIONS: Inhaled AuNP rapidly bound to the alveolar epithelium in both Wt and Scnn1b-Tg mice. Scnn1b-Tg mice showed less efficient AuNP uptake by surface macrophages and concomitant higher particle internalization by alveolar type I epithelial cells compared to Wt mice. This likely promotes AuNP depth translocation in Scnn1b-Tg mice, including enhanced epithelial targeting. These results suggest AuNP nanocarrier delivery as successful strategy for therapeutic targeting of alveolar epithelial cells and macrophages in COPD.
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Integrity signals
Registry
Cites
Statistics
Claims the paper makes
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
Metallic NPs such as Au and TiO2 have been suggested as potential nanocarriers for COPD treatment.
“Based on several investigations, metallic NPs such as Au and TiO2 have been suggested as potential nanocarriers for COPD treatment.187,188”
From Targeted therapy in chronic diseases using nanomaterial-based drug delivery vehicles (2019) · cites this paper as [188]
Self-check
Percentages, sums and reported differences re-computed from the paper’s own numbers.
The self-check needs the paper’s full text.
Cites
Shukla, R., Bansal, V., Chaudhary, M., Basu, A., Bhonde, R. R., & Sastry, M. (2005) · Langmuir · doi:10.1021/la0513712 · Cited by 1,689 · see citing works
Geiser, M., Rothen‐Rutishauser, B., Kapp, N., Schürch, S., Kreyling, W. G., Schulz, H., Semmler, M., Hof, V. I., Heyder, J., & Gehr, P. (2005) · Environmental Health Perspectives · doi:10.1289/ehp.8006 · Cited by 1,408 · see citing works
Self-citationA simple method for volumetry of organs in quantitative stereology.
Scherle, W. F. (1970) · PubMed · Cited by 1,059 · see citing works
Increased airway epithelial Na+ absorption produces cystic fibrosis-like lung disease in mice
Mall, M. A., Grubb, B. R., Harkema, J. R., O’Neal, W. K., & Boucher, R. C. (2004) · Nature Medicine · doi:10.1038/nm1028 · Cited by 911 · see citing works
Self-citationDeposition and biokinetics of inhaled nanoparticles
Geiser, M., & Kreyling, W. G. (2010) · Particle and Fibre Toxicology · doi:10.1186/1743-8977-7-2 · Cited by 747 · see citing works
Self-citationNanoparticles: Health Effects—Pros and Cons
Gwinn, M. R., & Vallyathan, V. (2006) · Environmental Health Perspectives · doi:10.1289/ehp.8871 · Cited by 570 · see citing works
Allometric Relationships of Cell Numbers and Size in the Mammalian Lung
Stone, K. C., Mercer, R. R., Gehr, P., Stockstill, B. L., & Crapo, J. D. (1992) · American Journal of Respiratory Cell and Molecular Biology · doi:10.1165/ajrcmb/6.2.235 · Cited by 550 · see citing works
Oxidative stress in asthma and COPD: Antioxidants as a therapeutic strategy
Kirkham, P., & Rahman, I. (2006) · Pharmacology & Therapeutics · doi:10.1016/j.pharmthera.2005.10.015 · Cited by 462 · see citing works
Chronic obstructive pulmonary disease
室, 繁. (2012) · 臨床免疫・アレルギー科 · Cited by 407 · see citing works
Deposition of aerosol in the respiratory tract.
Brain, J. D., & Valberg, P. A. (1979) · PubMed · doi:10.1164/arrd.1979.120.6.1325 · Cited by 384 · see citing works
Möller, W., Felten, K., Sommerer, K., Scheuch, G., Meyer, G., Meyer, P., Häussinger, K., & Kreyling, W. G. (2008) · American Journal of Respiratory and Critical Care Medicine · doi:10.1164/rccm.200602-301oc · Cited by 367 · see citing works
Self-citationUpdate on Macrophage Clearance of Inhaled Micro- and Nanoparticles
Geiser, M. (2010) · Journal of Aerosol Medicine and Pulmonary Drug Delivery · doi:10.1089/jamp.2009.0797 · Cited by 364 · see citing works
Self-citationSmoking Alters Alveolar Macrophage Recognition and Phagocytic Ability
Hodge, S. J., Hodge, G. L., Ahern, J., Jersmann, H. P. A., Holmes, M., & Reynolds, P. N. (2007) · American Journal of Respiratory Cell and Molecular Biology · doi:10.1165/rcmb.2007-0025oc · Cited by 357 · see citing works
Brandenberger, C., Mühlfeld, C., Ali, Z., Lenz, A., Schmid, O., Parak, W. J., Gehr, P., & Rothen‐Rutishauser, B. (2010) · Small · doi:10.1002/smll.201000528 · Cited by 356 · see citing works
A simple tool for stereological assessment of digital images: the STEPanizer
Tschanz, S. A., Burri, P. H., & Weibel, E. R. (2011) · Journal of Microscopy · doi:10.1111/j.1365-2818.2010.03481.x · Cited by 280 · see citing works
Morphometric characteristics of cells in the alveolar region of mammalian lungs.
Crapo, J. D., Young, S. L., Fram, E. K., Pinkerton, K. E., Barry, B. E., & Crapo, R. O. (1983) · PubMed · doi:10.1164/arrd.1983.128.2p2.s42 · Cited by 236 · see citing works
Mall, M. A. (2008) · Journal of Aerosol Medicine and Pulmonary Drug Delivery · doi:10.1089/jamp.2007.0659 · Cited by 212 · see citing works
Self-citationDevelopment of Chronic Bronchitis and Emphysema in β-Epithelial Na+ Channel–Overexpressing Mice
Mall, M. A., Harkema, J. R., Trojanek, J., Treis, D., Livraghi-Butrico, A., Schubert, S., Zhou, Z., Kreda, S. M., Tilley, S. L., Hudson, E. J., et al. (2007) · American Journal of Respiratory and Critical Care Medicine · doi:10.1164/rccm.200708-1233oc · Cited by 200 · see citing works
Self-citationBrandenberger, C., Rothen‐Rutishauser, B., Mühlfeld, C., Schmid, O., FERRON, G. A., Maier, K., Gehr, P., & Lenz, A. (2009) · Toxicology and Applied Pharmacology · doi:10.1016/j.taap.2009.09.014 · Cited by 195 · see citing works
Distribution Pattern of Inhaled Ultrafine Gold Particles in the Rat Lung
Takenaka, S., Karg, E. W., Kreyling, W. G., Lentner, B., Möller, W., Behnke-Semmler, M., Jennen, L., Walch, A. K., Michalke, B., Schramel, P., et al. (2006) · Inhalation Toxicology · doi:10.1080/08958370600748281 · Cited by 182 · see citing works
Self-citationThe ENaC-overexpressing mouse as a model of cystic fibrosis lung disease
Zhou, Z., Duerr, J., Jóhannesson, B., Schubert, S., Treis, D., Harm, M., Graeber, S. Y., Dalpke, A. H., Schultz, C., & Mall, M. A. (2011) · Journal of Cystic Fibrosis · doi:10.1016/s1569-1993(11)60021-0 · Cited by 167 · see citing works
Self-citationTranslocation and cellular entering mechanisms of nanoparticles in the respiratory tract
Mühlfeld, C. (2008) · Swiss Medical Weekly · doi:10.4414/smw.2008.12153 · Cited by 142 · see citing works
Chronic Obstructive Pulmonary Disease
JA (1986) · Thorax · doi:10.1136/thx.41.6.495 · Cited by 81 · see citing works
Lung deposition and biokinetics of inhaled nanoparticles
Kreyling, W. (2013) · Pneumologie · doi:10.1055/s-0033-1357051 · Cited by 51 · see citing works
Self-citationMühlfeld, C., Mayhew, T. M., Gehr, P., & Rothen‐Rutishauser, B. (2007) · Journal of Aerosol Medicine · doi:10.1089/jam.2007.0624 · Cited by 50 · see citing works
In vivomonitoring of cystic fibrosis-like lung disease in mice by volumetric computed tomography
Wielpütz, M. O., Eichinger, M., Zhou, Z., Leotta, K., Hirtz, S., Bartling, S. H., Semmler, W., Kauczor, H.-U., Puderbach, M., & Mall, M. A. (2011) · European Respiratory Journal · doi:10.1183/09031936.00149810 · Cited by 49 · see citing works
Self-citationBiodistribution of Inhaled Gold Nanoparticles in Mice and the Influence of Surfactant Protein D
Schleh, C., Holzwarth, U., Hirn, S., Wenk, A., Simonelli, F., Schäffler, M., Möller, W., Gibson, P. N., & Kreyling, W. G. (2012) · Journal of Aerosol Medicine and Pulmonary Drug Delivery · doi:10.1089/jamp.2011.0951 · Cited by 45 · see citing works
Self-citationTakenaka, S., Möller, W., Semmler‐Behnke, M., Karg, E. W., Wenk, A., Schmid, O., Stoeger, T., Jennen, L., Aichler, M., Walch, A. K., et al. (2012) · Nanomedicine · doi:10.2217/nnm.11.152 · Cited by 45 · see citing works
Self-citationTechniques for the Determination of Particle Deposition in Lungs of Hamsters
Hof, V. I., Scheuch, G., Geiser, M., Gebhart, J., Gehr, P., & Heyder, J. (1989) · Journal of Aerosol Medicine · doi:10.1089/jam.1989.2.247 · Cited by 29 · see citing works
Self-citationKreyling, W. G., Biswas, P., Messing, M. E., Gibson, P. N., Geiser, M., Wenk, A., Sahu, M., Deppert, K., Cydzik, I., Wigge, C., et al. (2010) · Journal of Nanoparticle Research · doi:10.1007/s11051-010-0081-5 · Cited by 27 · see citing works
Self-citationGeiser, M., Serra, A., Cruz-Orive, L. M., Baumann, M. H., Hof, V. I., & Gehr, P. (1995) · European Respiratory Journal · doi:10.1183/09031936.95.08101712 · Cited by 20 · see citing works
Self-citationGold nanoparticle aerosols for rodent inhalation and translocation studies
Möller, W., Gibson, P. N., Geiser, M., Pokhrel, S., Wenk, A., Takenaka, S., Schmid, O., Bulgheroni, A., Simonelli, F., Kozempel, J., et al. (2013) · Journal of Nanoparticle Research · doi:10.1007/s11051-013-1574-9 · Cited by 19 · see citing works
Self-citationDOES LACK OF Cftr GENE LEAD TO DEVELOPMENTAL ABNORMALITIES IN THE LUNG?
Geiser, M. (2000) · Experimental Lung Research · doi:10.1080/019021400750048090 · Cited by 18 · see citing works
Self-citationChronic obstructive pulmonary disease.
Ferrara, A. R. (2011) · PubMed · Cited by 10 · see citing works
Flagged first, then by citations
Research works printed but not linked: 2
- The European Commission Commission recommendation of 18 October 2011 on the definition of nanomaterial Official Journal of the European Union 2011 2011/696/EU. http://eur-lex.europa.eu/LexUriServ/LexUriServ.do?uri=OJ:L:2011:275:0038:0040:EN:PDF
- Snedecor GW Cochran WG Statistical methods 1989 8 Ames, Iowa, 50014, USA: Iowa State Universisty Press
Cited by
Sorted by citations
Targeted therapy in chronic diseases using nanomaterial-based drug delivery vehicles
Singh, A. P., Biswas, A., Shukla, A., & Maiti, P. (2019) · Signal Transduction and Targeted Therapy · doi:10.1038/s41392-019-0068-3 · Cited by 645 · see citing works
Particle toxicology and health - where are we?
Riediker, M., Zink, D., Kreyling, W. G., Oberdörster, G., Elder, A. C. P., Graham, U. M., Lynch, I., Duschl, A., Ichihara, G., Ichihara, S., et al. (2019) · Particle and Fibre Toxicology · doi:10.1186/s12989-019-0302-8 · Cited by 222 · see citing works
Self-citationZhou-Suckow, Z., Duerr, J., Hagner, M., Agrawal, R., & Mall, M. A. (2017) · Cell and Tissue Research · doi:10.1007/s00441-016-2562-z · Cited by 186 · see citing works
Self-citationEffect of particle agglomeration in nanotoxicology
Bruinink, A., Wang, J., & Wick, P. (2015) · Archives of Toxicology · doi:10.1007/s00204-015-1460-6 · Cited by 183 · see citing works
Medical nanoparticles for next generation drug delivery to the lungs
van Rijt, S., Bein, T., & Meiners, S. (2014) · European Respiratory Journal · doi:10.1183/09031936.00212813 · Cited by 156 · see citing works
Quantitative biokinetics of titanium dioxide nanoparticles after oral application in rats: Part 2
Kreyling, W. G., Holzwarth, U., Schleh, C., Kozempel, J., Wenk, A., Haberl, N., Hirn, S., Schäffler, M., Lipka, J., Semmler‐Behnke, M., et al. (2017) · Nanotoxicology · doi:10.1080/17435390.2017.1306893 · Cited by 152 · see citing works
Self-citationCigarette Smoke-Induced Respiratory Response: Insights into Cellular Processes and Biomarkers
Cha, S.-R., Jang, J., Park, S., Ryu, S. M., Cho, S.-J., & Yang, S. (2023) · Antioxidants · doi:10.3390/antiox12061210 · Cited by 132 · see citing works
Advanced Therapeutic Strategies for Chronic Lung Disease Using Nanoparticle-Based Drug Delivery
Yhee, J. Y., Im, J., & Nho, R. S. (2016) · Journal of Clinical Medicine · doi:10.3390/jcm5090082 · Cited by 122 · see citing works
Inhalable nanotherapeutics to improve treatment efficacy for common lung diseases
Anderson, C. F., Grimmett, M. E., Domalewski, C. J., & Cui, H. (2019) · Wiley Interdisciplinary Reviews Nanomedicine and Nanobiotechnology · doi:10.1002/wnan.1586 · Cited by 111 · see citing works
Xu, Y., Liu, H., & Song, L. (2020) · Journal of Nanobiotechnology · doi:10.1186/s12951-020-00703-5 · Cited by 104 · see citing works
Dealing with nanosafety around the globe—Regulation vs. innovation
Wacker, M. G., Proykova, A., & Santos, G. M. L. (2016) · International Journal of Pharmaceutics · doi:10.1016/j.ijpharm.2016.05.015 · Cited by 95 · see citing works
Kreyling, W. G., Möller, W., Holzwarth, U., Hirn, S., Wenk, A., Schleh, C., Schäffler, M., Haberl, N., Gibson, P. N., & Schittny, J. C. (2018) · ACS Nano · doi:10.1021/acsnano.8b01826 · Cited by 93 · see citing works
Self-citationA Review of Non-Invasive Drug Delivery through Respiratory Routes
Zhang, Y., Xu, D. W., Bai, L., Zhou, Y.-M., Zhang, H., & Cui, Y. (2022) · Pharmaceutics · doi:10.3390/pharmaceutics14091974 · Cited by 77 · see citing works
Nanotherapeutics for pulmonary drug delivery: An emerging approach to overcome respiratory diseases
Kole, E. B., Jadhav, K., Shirsath, N. R., Dudhe, P. B., Verma, R. K., Chatterjee, A., & Naik, J. (2023) · Journal of Drug Delivery Science and Technology · doi:10.1016/j.jddst.2023.104261 · Cited by 73 · see citing works
New perspectives in nanotherapeutics for chronic respiratory diseases
da Silva, A. L., Cruz, F. F., Rocco, P. R. M., & Morales, M. M. (2017) · Biophysical Reviews · doi:10.1007/s12551-017-0319-x · Cited by 72 · see citing works
Chou, W., Cheng, Y., Riviere, J. E., Monteiro-Riviere, N. A., Kreyling, W. G., & Lin, Z. (2022) · Particle and Fibre Toxicology · doi:10.1186/s12989-022-00489-4 · Cited by 70 · see citing works
Self-citationPassi, M., Shahid, S., Chockalingam, S., Sundar, I. K., & Packirisamy, G. (2020) · International Journal of Nanomedicine · doi:10.2147/ijn.s242516 · Cited by 65 · see citing works
Kreyling, W. G., Holzwarth, U., Schleh, C., Hirn, S., Wenk, A., Schäffler, M., Haberl, N., Semmler‐Behnke, M., & Gibson, P. N. (2019) · Particle and Fibre Toxicology · doi:10.1186/s12989-019-0303-7 · Cited by 62 · see citing works
Self-citationHussain, M. S., Sharma, P., Dhanjal, D. S., Khurana, N., Vyas, M., Sharma, N., Mehta, M., Tambuwala, M. M., Satija, S., Sohal, S. S., et al. (2021) · Chemico-Biological Interactions · doi:10.1016/j.cbi.2021.109637 · Cited by 57 · see citing works
Pulmonary delivery of cationic gold nanoparticles boost antigen-specific CD4 + T Cell Proliferation
Seydoux, E., Rodríguez‐Lorenzo, L., Blom, R. A. M., Stumbles, P. A., Petri‐Fink, A., Rothen‐Rutishauser, B., Blank, F., & von Garnier, C. (2016) · Nanomedicine Nanotechnology Biology and Medicine · doi:10.1016/j.nano.2016.02.020 · Cited by 55 · see citing works
Durantie, E., Vanhecke, D., Rodríguez‐Lorenzo, L., Delhaes, F., Balog, S., Septiadi, D., Bourquin, J., Petri‐Fink, A., & Rothen‐Rutishauser, B. (2017) · Particle and Fibre Toxicology · doi:10.1186/s12989-017-0231-3 · Cited by 55 · see citing works
Aerosol pulmonary immune engineering
Sudduth, E. R., Trautmann-Rodriguez, M., Gill, N. A., Bomb, K., & Fromen, C. A. (2023) · Advanced Drug Delivery Reviews · doi:10.1016/j.addr.2023.114831 · Cited by 49 · see citing works
Rubis, G. D., Paudel, K. R., Corrie, L., Mehndiratta, S., Patel, V. K., Kumbhar, P., Manjappa, A. S., Disouza, J., Patravale, V. B., Gupta, G., et al. (2023) · Naunyn-Schmiedeberg s Archives of Pharmacology · doi:10.1007/s00210-023-02830-w · Cited by 49 · see citing works
Varma, J. R., Kumar, T., Boddu, P., & Ratna, J. (2015) · Indian Journal of Pharmaceutical Sciences · doi:10.4103/0250-474x.159602 · Cited by 49 · see citing works
Geiser, M., Stoeger, T., Casaulta, M., Chen, S., Semmler‐Behnke, M., Bolle, I., Takenaka, S., Kreyling, W. G., & Schulz, H. (2014) · Particle and Fibre Toxicology · doi:10.1186/1743-8977-11-19 · Cited by 47 · see citing works
Self-citationAerosolizable gold nano-in-micro dry powder formulations for theragnosis and lung delivery
Silva, A. S., Sousa, A. M. L., Cabral, R. P., Silva, M. C., Costa, C., Miguel, S. P., Bonifácio, V. D. B., Casimiro, T., Correia, I. J., & Aguiar‐Ricardo, A. (2017) · International Journal of Pharmaceutics · doi:10.1016/j.ijpharm.2017.01.032 · Cited by 47 · see citing works
Current views in chronic obstructive pulmonary disease pathogenesis and management
Alfahad, A. J., Alzaydi, M. M., Aldossary, A. M., Alshehri, A. A., Almughem, F. A., Zaidan, N. M., & Tawfik, E. A. (2021) · Saudi Pharmaceutical Journal · doi:10.1016/j.jsps.2021.10.008 · Cited by 46 · see citing works
Sustainable strategies for nano-in-micro particle engineering for pulmonary delivery
Silva, A. S., Tavares, M. T., & Aguiar‐Ricardo, A. (2014) · Journal of Nanoparticle Research · doi:10.1007/s11051-014-2602-0 · Cited by 45 · see citing works
Selective inhibitory effects of 50-nm gold nanoparticles on mouse macrophage and spleen cells
Kingston, M., Pfau, J. C., Gilmer, J., & Brey, R. R. (2015) · Journal of Immunotoxicology · doi:10.3109/1547691x.2015.1035819 · Cited by 45 · see citing works
Use of Silica Nanoparticles for Drug Delivery in Cardiovascular Disease
Kirla, H., Henry, D. J., Jansen, S. J., Thompson, P. L., & Hamzah, J. (2023) · Clinical Therapeutics · doi:10.1016/j.clinthera.2023.08.017 · Cited by 44 · see citing works
Berardis, B. D., Marchetti, M., Risuglia, A., Ietto, F., Fanizza, C., & Superti, F. (2020) · Journal of Nanoparticle Research · doi:10.1007/s11051-020-04966-9 · Cited by 38 · see citing works
Peng, Y., Yang, Z., Sun, H., Li, J., Lan, X., & Liu, S. (2024) · Aging and Disease · doi:10.14336/ad.2024.0206-1 · Cited by 37 · see citing works
Schwotzer, D., Niehof, M., Schaudien, D., Kock, H., Hansen, T., Dasenbrock, C., & Creutzenberg, O. (2018) · Journal of Nanobiotechnology · doi:10.1186/s12951-018-0343-4 · Cited by 35 · see citing works
Biodegradable micro-sized discoidal polymeric particles for lung-targeted delivery system
Park, J. Y., Park, S.-H., Lee, T. S., Hwang, Y. H., Kim, J. Y., Kang, W. J., & Key, J. (2019) · Biomaterials · doi:10.1016/j.biomaterials.2019.119331 · Cited by 33 · see citing works
Biokinetics and clearance of inhaled gold ultrasmall-in-nano architectures
Mapanao, A. K., Giannone, G., Summa, M., Ermini, M. L., Zamborlin, A., Santi, M., Cassano, D., Bertorelli, R., & Voliani, V. (2020) · Nanoscale Advances · doi:10.1039/d0na00521e · Cited by 33 · see citing works
Liu, C., Liu, Y., Xi, L. F., He, Y., Liang, Y., Mak, J., Mao, S., Wang, Z., & Zheng, Y. (2022) · ACS Applied Materials & Interfaces · doi:10.1021/acsami.2c17660 · Cited by 33 · see citing works
Novel drug targets for asthma and COPD: Lessons learned from in vitro and in vivo models
Baker, K. E., Bonvini, S. J., Donovan, C., Foong, R. E., Han, B., Jha, A., Shaifta, Y., Smit, M., Johnson, J. R., & Moir, L. M. (2014) · Pulmonary Pharmacology & Therapeutics · doi:10.1016/j.pupt.2014.05.008 · Cited by 33 · see citing works
Holáň, V., Javorková, E., Vrbova, K., Večeřa, Z., Mikuška, P., Coufalík, P., Kulich, P., Skoupý, R., Machala, M., Zajı́cová, A., et al. (2019) · Nanotoxicology · doi:10.1080/17435390.2019.1602679 · Cited by 30 · see citing works
Supramolecular nanoscale assemblies for cancer diagnosis and therapy
Coelho, S. C., Pereira, M. D. C., Juzeniene, A., Juzenas, P., & Coelho, M. A. N. (2015) · Journal of Controlled Release · doi:10.1016/j.jconrel.2015.06.034 · Cited by 30 · see citing works
Gold nanomaterials in the management of lung cancer
Guinart, A., Perry, H. L., Wilton‐Ely, J. D. E. T., & Tetley, T. D. (2020) · Emerging Topics in Life Sciences · doi:10.1042/etls20200332 · Cited by 29 · see citing works
Yokel, R. A., Unrine, J. M., Wu, P., Wang, B., & Grulke, E. A. (2014) · Environmental Science Nano · doi:10.1039/c4en00035h · Cited by 28 · see citing works
Lewis, B. W., Sultana, R., Sharma, R., Noël, A., Langohr, I. M., Patial, S., Penn, A. L., & Saini, Y. (2017) · The Journal of Immunology · doi:10.4049/jimmunol.1700144 · Cited by 28 · see citing works
Nanoparticle-Based Drug Delivery for Chronic Obstructive Pulmonary Disorder and Asthma
Wadhwa, R., Aggarwal, T., Thapliyal, N., Chellappan, D. K., Gupta, G., Gulati, M., Collet, T., Oliver, B. G. G., Williams, K. A., Hansbro, P. M., et al. (2019) · Elsevier eBooks · doi:10.1016/b978-0-12-818823-1.00005-3 · Cited by 25 · see citing works
Nanotechnology-Based Therapeutics for Targeting Inflammatory Lung Diseases
Loo, C., & Lee, W. (2022) · Nanomedicine · doi:10.2217/nnm-2021-0447 · Cited by 24 · see citing works
Zhou, H., Yao, L., Jiang, X., Sumayyah, G., Tu, B., Cheng, S., Qin, X., Zhang, J., Zou, Z., & Chen, C. (2021) · Neurotoxicity Research · doi:10.1007/s12640-021-00358-6 · Cited by 23 · see citing works
Vysloužil, J., Kulich, P., Zeman, T., Vaculovič, T., Tvrdoňová, M., Mikuška, P., Večeřa, Z., Stráská, J., Moravec, P., Balcar, V. J., et al. (2020) · Journal of Trace Elements in Medicine and Biology · doi:10.1016/j.jtemb.2020.126511 · Cited by 23 · see citing works
Wang, Y., Xuan, W., Mao, C., & Liu, Y. (2025) · Acta Biomaterialia · doi:10.1016/j.actbio.2025.07.068 · Cited by 22 · see citing works
Immunopathology of Airway Surface Liquid Dehydration Disease
Lewis, B. W., Patial, S., & Saini, Y. (2019) · Journal of Immunology Research · doi:10.1155/2019/2180409 · Cited by 21 · see citing works
The Impact of Air Pollution on the Course of Cystic Fibrosis: A Review
Blayac, M., Coll, P., Urbach, V., Fanen, P., Epaud, R., & Lanone, S. (2022) · Frontiers in Physiology · doi:10.3389/fphys.2022.908230 · Cited by 20 · see citing works
Geiser, M., Wigge, C., Conrad, M. L., Eigeldinger‐Berthou, S., Künzi, L., Garn, H., Renz, H., & Mall, M. A. (2014) · BMC Pulmonary Medicine · doi:10.1186/1471-2466-14-116 · Cited by 20 · see citing works
Self-citationSoto, M. R., Lewis, M. M., Leal, J., Pan, Y., Mohanty, R. P., Veyssi, A., Maier, E. Y., Heiser, B. J., & Ghosh, D. (2024) · Molecular Therapy — Nucleic Acids · doi:10.1016/j.omtn.2024.102375 · Cited by 19 · see citing works
Cova, E., Inghilleri, S., Pandolfi, L., Morosini, M., Magni, S., Colombo, M., Piloni, D., Finetti, C., Ceccarelli, G., Benedetti, L., et al. (2017) · Nanotoxicology · doi:10.1080/17435390.2017.1317862 · Cited by 16 · see citing works
Choudhary, I., Vo, T., Paudel, K., Yadav, R., Mao, Y., Patial, S., & Saini, Y. (2021) · The Journal of Immunology · doi:10.4049/jimmunol.2001286 · Cited by 13 · see citing works
Endotracheal Nebulization of Gold Nanoparticles for Noninvasive Pulmonary Drug Delivery
Urso, A., Meloni, F., Malatesta, M., Latorre, R., Damoci, C. B., Crapanzano, J. P., Pandolfi, L., Giustra, M., Pearson, M., Colombo, M., et al. (2023) · Nanomedicine · doi:10.2217/nnm-2022-0179 · Cited by 13 · see citing works
Advances and Opportunities In Nanoimaging Agents for the Diagnosis of Inflammatory Lung Diseases
Masanam, H. B., Perumal, G., Krishnan, S., Singh, S. K., Jha, N. K., Chellappan, D. K., Dua, K., Gupta, P. K., & Narasimhan, A. K. (2022) · Nanomedicine · doi:10.2217/nnm-2021-0427 · Cited by 11 · see citing works
Mayhew, T. M. (2014) · Cell and Tissue Research · doi:10.1007/s00441-014-2038-y · Cited by 10 · see citing works
Jin, X., Song, L., Ma, C., Zhang, Y.-C., & Yu, S. (2020) · Saudi Pharmaceutical Journal · doi:10.1016/j.jsps.2020.10.012 · Cited by 9 · see citing works
RetractedSato, K., & Kawakami, H. (2023) · Oxygen · doi:10.3390/oxygen3040026 · Cited by 8 · see citing works
Applications of Nanomaterials for Water Quality
der Bruggen, B. V. (2013) · doi:10.4155/9781909453074 · Cited by 8 · see citing works
Nanoparticles in bodily tissues: predicting their equilibrium distributions
Nolte, T. M., Lu, B., & Hendriks, A. J. (2022) · Environmental Science Nano · doi:10.1039/d2en00469k · Cited by 8 · see citing works
Applications of Nanoparticles in Treatment of Respiratory Disorders
Deeba, F., Umer, F., & Nainan, D. (2021) · Life and Science · doi:10.37185/lns.1.1.186 · Cited by 8 · see citing works
NOVEL NANOPARTICULATE SYSTEMS FOR IDIOPATHIC PULMONARY FIBROSIS: A REVIEW
Dudhat, K. R., & Patel, H. V. (2020) · Asian Journal of Pharmaceutical and Clinical Research · doi:10.22159/ajpcr.2020.v13i11.39035 · Cited by 7 · see citing works
Formulation and role of polymeric and inorganic nanoparticles in respiratory diseases
Chakraborty, A., & Selomulya, C. (2020) · Elsevier eBooks · doi:10.1016/b978-0-12-820658-4.00012-1 · Cited by 7 · see citing works
Applications of Nanomaterials in Medicine: Current Status and Future Scope
Kakodkar, S., Dhawal, P. P., & Kadam, J. (2023) · Springer eBooks · doi:10.1007/978-981-99-5281-6_4 · Cited by 7 · see citing works
Elkady, O. A., Saleh, L. M., Tadros, M. I., & El-Laithy, H. M. (2021) · AAPS PharmSciTech · doi:10.1208/s12249-021-02078-8 · Cited by 6 · see citing works
Beeraka, N. M., Zhou, R., Wang, X., R, H. V. P., Kumar, T. P., Liu, J., Greeshma, M. V., Mandal, S. P., Gurupadayya, B., & Fan, R. (2022) · International Journal of Nanomedicine · doi:10.2147/ijn.s364693 · Cited by 5 · see citing works
Maurya, S., Srivastava, R., Arfin, S., Hawthorne, S. J., Jha, N. K., Agrawal, K., Raj, S., Rathi, B., Kumar, A. J., Raj, R., et al. (2022) · Nanomedicine · doi:10.2217/nnm-2021-0437 · Cited by 4 · see citing works
Tiralosi, A., Cambria, M., Campanella, M., Paratore, V., Russo, C., Malaguarnera, L., Valle, M. S., & Cambria, M. T. (2025) · International Journal of Molecular Sciences · doi:10.3390/ijms26168025 · Cited by 4 · see citing works
Pulmonary Delivery for miRs: Present and Future Potential
Shrestha, A., Haque, M. A., & Mattheolabakis, G. (2023) · Processes · doi:10.3390/pr11061788 · Cited by 4 · see citing works
Blayac, M., Yegen, C.-H., Marj, E. A., Rodriguez, J. C. M., Cazaunau, M., Bergé, A., Epaud, R., Coll, P., & Lanone, S. (2023) · Journal of Hazardous Materials · doi:10.1016/j.jhazmat.2023.133340 · Cited by 4 · see citing works
Radiation Safety Aspects of Nanotechnology
Los Alamos National Lab. (LANL), L. A., Hoover, M., USDOE, Myers, D., Cash, L. J., Guilmette, R. A., Kreyling, W. G., Oberdörster, G., & Smith, R. R. (2017) · doi:10.2172/1351238 · Cited by 4 · see citing works
Self-citationPollutant distribution in vertebrates across scales: Organs, cells, and organelles
Ren, B., Zhao, Y., Wang, X., Wang, M., Wang, Y., Li, X., & Fan, W. (2025) · Environmental Pollution · doi:10.1016/j.envpol.2025.126680 · Cited by 3 · see citing works
Polymeric and Inorganic Nanoparticles Targeting Chronic Respiratory Diseases
Chan, Y., Ng, S. W., & Soon, L. (2022) · Springer eBooks · doi:10.1007/978-981-16-4392-7_18 · Cited by 3 · see citing works
Nanomedicine - a boon for respiratory disease management
Deepika, B., Lavanya, S., Girigoswami, A., & Girigoswami, K. (2023) · Archives of Materials Science and Engineering · doi:10.5604/01.3001.0053.4743 · Cited by 3 · see citing works
Vo, T., Patial, S., & Saini, Y. (2025) · Frontiers in Toxicology · doi:10.3389/ftox.2025.1540468 · Cited by 2 · see citing works
Yang, M., Yeh, N.-C., Wu, C., Shiau, A., & Chen, Y. (2025) · International Journal of Biological Macromolecules · doi:10.1016/j.ijbiomac.2025.147558 · Cited by 1 · see citing works
Ntolia, A., Matisioudis, N., Dimitriou, E., Rouptsiou, K., Chatzigiannakou, T., Manglaris, C., Kalis, M., Triantafillou, E., Evangelopoulou, G., Liakopoulou-Kyriakides, M. T., et al. (2026) · Journal of Functional Biomaterials · doi:10.3390/jfb17030120 · Cited by 1 · see citing works
Hydrodynamic elements of aerosol flows for targeted drug delivery into the respiratory tract
Антонов, Д. В., Kerimbekova, S. A., Nagatkina, O. V., & Suvorova, O. (2026) · Journal of Aerosol Science · doi:10.1016/j.jaerosci.2026.106762 · Cited by 1 · see citing works
Kolling, J. (2014) · Cited by 1 · see citing works
Utility of nanomedicine and nanocarriers for noninfectious disease treatment
Tuteja, J., Vyas, A., & Sand, A. (2023) · Elsevier eBooks · doi:10.1016/b978-0-323-95325-2.00014-6 · Cited by 1 · see citing works
ALHALILL, Z., ZAILA, A., Sanderson, B. J. S., & Shapter, J. G. (2017) · International Journal of Pharma and Bio Sciences · doi:10.22376/ijpbs.2017.8.1.p260-269
Targeted and nanoparticle therapies for lung diseases
Trivedi, R. (2014) · doi:10.25677/ehjq-jy57
Environmental and health concerns of nanomaterials
Wang, C., & Valiyaveettil, S. (2013) · doi:10.4155/ebo.13.453
Current challenges and future scope of nanoparticles in chronic obstructive pulmonary disease
Pandey, S., Garg, R., Kant, S., Verma, A., Gaur, P., & Agarwal, M. (2021) · Eurasian Journal of Pulmonology · doi:10.4103/ejop.ejop_57_19
Rafidah, S. F., Rahmanto, I., & Pratiska, A. B. (2022) · Qanun Medika - Medical Journal Faculty of Medicine Muhammadiyah Surabaya · doi:10.30651/jqm.v6i2.11227
Advanced nanomedicine-based therapeutics for targeting airway inflammatory diseases
Chan, Y., Lim, J. S., Cui, X., Ng, S. W., Lim, X. W., Chellappan, D. K., & Dua, K. (2023) · Elsevier eBooks · doi:10.1016/b978-0-323-99988-5.00007-3
Nanomedicine Applied to Inflammatory and Infectious Pulmonary Diseases
Kaur, A., Sharma, R., Sundar, I. K., & Packirisamy, G. (2023) · Interdisciplinary biotechnological advances · doi:10.1007/978-981-19-8342-9_11
Metal and Metal Oxide Nanoparticles for the Management of Allergic Airway Diseases
Castillo, F., & Zacconi, F. C. M. (2024) · Springer eBooks · doi:10.1007/978-981-97-1953-2_6
Nano-engineered biomaterials: An Alternative Route for Drug Delivery in Lung Bioengineering
Siddiqua, A., Ali, P., Rehman, S., Ullah, S., Kholik, K., Munawaroh, M., Sukri, A., Pradana, M., Ullah, S., Dharmawibawa, I. D., et al. (2025) · Research Journal of Pharmacy and Technology · doi:10.52711/0974-360x.2025.00735
Chou, W.-C., Cheng, Y.-H., Riviere, J. E., Monteiro-Riviere, N. A., Kreyling, W. G., & Lin, Z. (2022) · Figshare · doi:10.6084/m9.figshare.20279306
Self-citationIntroduction to chronic obstructive pulmonary disease
Lahoti, S. R., Sakle, N. S., Saifee, M., & Bawangoanwala, A. (2026) · Elsevier eBooks · doi:10.1016/b978-0-443-43946-9.00009-4
Challenges associated with nanotechnology and future directions in the management of COPD
Chugh, S., Sharma, M., & Prasher, P. (2026) · Elsevier eBooks · doi:10.1016/b978-0-443-43946-9.00022-7
Jeon, S., Kim, G. T., & Cho, W. (2026) · Particle and Fibre Toxicology · doi:10.1186/s12989-026-00687-4
Jafari, A., Manzari‐Tavakoli, A., Tavakoli, M. M., Hashemian, S. M., Jamaati, H., Akhtari, M., Tabarsi, P., & Omrani, M. (2026) · Expert Review of Molecular Diagnostics · doi:10.1080/14737159.2026.2714060
- Authors
- Geiser, M., Quaile, O., Wenk, A., Wigge, C., Eigeldinger-Berthou, S., Hirn, S., Schäffler, M., Schleh, C., Möller, W., Mall, M. A., & Kreyling, W. G.
- Affiliations
- University of Bern (CH)
- Helmholtz Munich (DE)
- Heidelberg University (DE)
- Corresponding author
- Geiser, Marianne
- Venue
- Particle and Fibre Toxicology
- Published
- 2013
- Volume
- 10
- Issue
- 1
- Pages
- 19
- ISSN
- 1743-8977 (ISSN-L)
- PMC
- PMC3660288
- OpenAlex
- W2159440345
- Cited by
- 97
- References
- 34
- Citations by year
- 2026: 6 · 2025: 6 · 2024: 3 · 2023: 15 · 2022: 12 · 2021: 7 · 2020: 10 · 2019: 9 · 2018: 2 · 2017: 9 · 2016: 3 · 2015: 4 · 2014: 9 · 2013: 2
- FWCI
- 4.89
- Type
- journal article
- Language
- en
- Open access
- gold
- doi.org
- Licence
- cc-by
- Locations
- Particle and Fibre Toxicology (publishedVersion, cc-by)
- Europe PMC (PubMed Central) (publishedVersion, cc-by)
- PubMed Central (publishedVersion, cc-by)
- PubMed (publishedVersion)
- heiDOK (Heidelberg University) (acceptedVersion, other-oa)
- Bern Open Repository and Information System (University of Bern) (submittedVersion, cc-by)
- Site cant be reached (submittedVersion, cc-by)
- Open Access CRIS of the University of Bern
- Funders
- National Science Foundation (310030)
- University of Bern
- European Commission (228789)
- Deutsche Forschungsgemeinschaft (SPP1313)
- Schweizerischer Nationalfonds zur Förderung der Wissenschaftlichen Forschung (214547, 120763, 310030)
- Bundesministerium für Bildung und Forschung (82DZL00401)
- Topics
- Health Sciences › Medicine › Pulmonary and Respiratory Medicine › Inhalation and Respiratory Drug Delivery
- Physical Sciences › Materials Science › Biomaterials › Nanoparticle-Based Drug Delivery
- Physical Sciences › Materials Science › Materials Chemistry › Nanoparticles: synthesis and applications
- Keywords
- gold nanoparticles, inhaled nanoparticles, nanoparticle uptake, alveolar macrophages, chronic obstructive pulmonary disease, nanoparticle clearance, nanoparticle agglomeration, aerosol inhalation
- MeSH terms
- Administration, Inhalation, Aerosols, Animals, Disease Models, Animal, Drug Carriers, Female, Gold, Lung, Mice, Inbred C3H, Mice, Inbred C57BL, Mice, Transgenic, Particle Size, Tissue Distribution, Macrophages, Alveolar, Pulmonary Disease, Chronic Obstructive, Microscopy, Electron, Transmission, Epithelial Sodium Channels, Metal Nanoparticles
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
