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Cited by 76Inflammatory Bowel DiseaseMental Health Treatment and AccessPsychosomatic Disorders and Their Treatments

Psychological problems in gastroenterology outpatients: A South Australian experience. Psychological co-morbidity in IBD, IBS and hepatitis C

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Mikocka-Walus, Antonina A, Turnbull, Deborah A, Andrews, Jane M, Moulding, Nicole T, Wilson, Ian G, Harley, Hugh AJ, Hetzel, David J, Holtmann, Gerald J·2008·Clinical Practice and Epidemiology in Mental Health
DOI 10.1186/1745-0179-4-15PMC PMC2430958
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Abstract

BACKGROUND: In independent studies, IBD, IBS and HCV have each been associated with a substantially increased risk of psychological problems such as depression and anxiety and impairment of quality of life compared to the general healthy population. However, the relative psychological burden for each of these diagnoses is unknown as it has never been compared contemporaneously at one institution. Current local data are therefore needed to enable an evidence-based allocation of limited clinical psychological resources. METHODS: Overall, 139 outpatients (64 IBD, 41 HCV, and 34 IBS) were enrolled in this cross-sectional study. The HADS, SCL90, SF-12 and appropriate disease-specific activity measures were administered. Differences between groups were assesed with ANOVA, the Chi-Square test and the independent samples t-test (two-tailed). RESULTS: Each of the three groups had significantly lower quality of life than the general population (p < 0.05). Overall, a total of 58 (42%) participants met HADS screening criteria for anxiety and 26 (19%) participants for depression. The HCV group had a significantly higher prevalence of depression than either of the other groups (HCV = 34%, IBS = 15% and IBD = 11%, p = 0.009). In the SCL90, the three disease groups differed on 7 out of 12 subscales. On each of these subscales, the HCV group were most severely affected and differed most from the general population. CONCLUSION: Patients with these common chronic gastrointestinal diseases have significant impairment of quality of life. Anxiety is a greater problem than depression, although patients with HCV in particular, should be regularly monitored and treated for co-morbid depression. Evaluation of specific psychological interventions targeting anxiety is warranted.

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Crossref · 10.1186/1745-0179-4-15

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  • Pooled from five studies including 1244 patients, the risk of developing a flare of disease activity was no higher among those with symptoms of anxiety at baseline (RR = 1.20; 95% CI 0.93-1.55), with moderate heterogeneity (I2 = 53.7%).

    “When data were pooled from five studies,[20, 26, 27, 29, 30] containing 1244 patients, the risk of developing a flare of disease activity was no higher among those with symptoms of anxiety at baseline (RR = 1.20; 95% CI 0.93-1.55), with moderate heterogeneity between studies ( I 2 =53.7%).”

    From Bidirectional brain-gut axis effects influence mood and prognosis in IBD: A systematic review and meta-analysis (2022) · cites this paper as [29]

  • Pooled from eight studies including 7606 patients, symptoms of depression at baseline were associated with a significantly increased risk of flare of disease activity during longitudinal follow-up (RR = 1.60; 95% CI 1.21-2.12), with high heterogeneity (I2 = 73.5%).

    “When data were pooled from eight studies,[20-23, 26, 27, 29, 30] which included 7606 patients, symptoms of depression at baseline were associated with a significantly increased risk of flare of disease activity during longitudinal follow-up (RR = 1.60; 95% CI 1.212.12), with high heterogeneity between studies ( I 2 =73.5%)”

    From Bidirectional brain-gut axis effects influence mood and prognosis in IBD: A systematic review and meta-analysis (2022) · cites this paper as [29]

  • Clinically active disease at baseline had a significant effect on future symptoms of depression (RR = 1.49; 95% CI 1.11-1.98) in three studies with 642 patients, with no heterogeneity (I2 = 0%).

    “Similarly, the effect of clinically active disease at baseline on future symptoms of depression was also significant (RR = 1.49; 95% CI 1.11-1.98), with no heterogeneity ( I 2 =0%).[11, 26, 29]”

    From Bidirectional brain-gut axis effects influence mood and prognosis in IBD: A systematic review and meta-analysis (2022) · cites this paper as [29]

  • Original investigators were contacted and additional data were obtained from six studies to maximise the number of eligible studies for analysis.

    “We also contacted original investigators and obtained additional data from six studies,[26-30, 33] to maximise the number of eligible studies for analysis.”

    From Bidirectional brain-gut axis effects influence mood and prognosis in IBD: A systematic review and meta-analysis (2022) · cites this paper as [29]

  • Clinically active disease at baseline had a significant impact on future development of symptoms of anxiety (RR = 2.24; 95% CI 1.25-4.01) in two studies with 249 patients, with no heterogeneity (I2 = 0%).

    “There was a significant impact of clinically active disease at baseline on the future development of symptoms of anxiety (RR = 2.24; 95% CI 1.25-4.01), with no heterogeneity between studies ( I 2 =0%).[26, 29]”

    From Bidirectional brain-gut axis effects influence mood and prognosis in IBD: A systematic review and meta-analysis (2022) · cites this paper as [29]

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  1. Derogartis LR SCL-90-R Symptom Checklist-90-R. Administration, Scoring, and Procedures Manual 1994 Minneapolis: NCS Pearson

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Authors
Mikocka-Walus, A. A., Turnbull, D. A., Andrews, J. M., Moulding, N. T., Wilson, I. G., Harley, H. A., Hetzel, D. J., & Holtmann, G. J.
Affiliations
  • The University of Adelaide (AU)
  • Royal Adelaide Hospital (AU)
  • University of South Australia (AU)
  • Western Sydney University (AU)
ORCID
Venue
Clinical Practice and Epidemiology in Mental Health
Publisher
Bentham Science Publishers Ltd.
Published
2008
Volume
4
Issue
1
Pages
15
ISSN
1745-0179 (ISSN-L)
DOI
10.1186/1745-0179-4-15
PMC
PMC2430958
OpenAlex
W2074841505
Cited by
76
References
37
Citations by year
2026: 1 · 2025: 2 · 2024: 4 · 2023: 1 · 2021: 3 · 2020: 4 · 2019: 6 · 2018: 9 · 2017: 4 · 2016: 9 · 2015: 5 · 2014: 8 · 2013: 5 · 2012: 8
FWCI
1.33
Type
journal article
Language
en
Open access
Licence
cc-by
Locations
  • Clinical Practice and Epidemiology in Mental Health (publishedVersion, cc-by)
  • Europe PMC (PubMed Central) (publishedVersion, cc-by)
  • PubMed Central (publishedVersion, cc-by)
  • PubMed (publishedVersion)
  • Research Online (University of Wollongong) (submittedVersion)
  • Adelaide Research & Scholarship (AR&S) (University of Adelaide) (submittedVersion, cc-by)
  • Figshare (submittedVersion, cc-by)
  • Figshare (submittedVersion)
  • UniSA Research Outputs Repository (University of South Australia) (submittedVersion, other-oa)
Funders
  • Pfizer
  • AstraZeneca
  • Deutsche Forschungsgemeinschaft
  • University of Adelaide
  • Royal Adelaide Hospital
  • AstraZeneca Australia
  • Cilag
Topics
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Genetics › Inflammatory Bowel Disease
  • Social Sciences › Psychology › Social Psychology › Mental Health Treatment and Access
  • Health Sciences › Medicine › Psychiatry and Mental health › Psychosomatic Disorders and Their Treatments
Keywords
psychological comorbidity, inflammatory bowel disease, irritable bowel syndrome, hepatitis C, depression, anxiety, quality of life, chronic gastrointestinal diseases, gastroenterology outpatients, psychological burden

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