Why do general practitioners prescribe antidepressants to their patients? A pilot study
Open accessAbstract
BACKGROUND: The frequency of antidepressant (ADs) prescription is high, with general practitioners (GPs) responsible for about 80% of the prescriptions. Some studies considered prescriptions meet DSM criteria, while others stress inadequate use. The importance of biological and psychosocial determinants of GP prescription behaviour remains little explored. We aimed to describe the importance of these biological and psychosocial determinants and their weight in the daily practice of GPs'. METHODS: During a week chosen at random, 28 GPs collected the AD prescriptions made within the previous six months, regardless of the reason for the patient contact. Bio psychosocial and AD treatment characteristics were recorded for all patients. In a random sample of 50 patients, patient characteristics were assessed via a structured face-to-face interview with the GP. RESULTS: The frequency of AD prescription was 8.90% [3.94 -17.02]. The GPs initiated 65.6% [60.1-70.8] of the prescriptions. The rate of AD prescription for non-psychiatric conditions was 18%. Patients had from 1 to 9 conditions, showing a high level of multi-morbidity. There was a strong influence of past medical history and contextual problems, such as work related problems. CONCLUSION: AD prescription is related to complex contextual situations and multi-morbid patients. GPs use a bio psycho social approach, rather than a purely biological assessment. Awareness of these influences could improve prescription by GPs.
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Integrity signals
Registry
Cites
Statistics
Claims the paper makes
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
Expert-reviewed systematic frameworks for evaluating such apps have found inconsistent and/or contradictory results.
“Furthermore, expert-reviewed systematic frameworks for evaluating such apps have found inconsistent and/or contradictory results.”
From Digital health technologies and major depressive disorder (2023) · cites this paper as [155]
Self-check
Percentages, sums and reported differences re-computed from the paper’s own numbers.
The self-check needs the paper’s full text.
Cites
Guidelines on male sexual dysfunction: erectile dysfunction and premature ejaculation
Hatzimouratidis, K., Amar, E., Eardley, I., Giuliano, F., Hatzichristou, D., Montorsi, F., Vardi, Y., & Wespes, E. (2010) · European Urology · doi:10.1016/j.eururo.2010.02.020 · Cited by 1,223 · see citing works
The current status of urban‐rural differences in psychiatric disorders
Peen, J., Schoevers, R. A., Beekman, A. T. F., & Dekker, J. (2009) · Acta Psychiatrica Scandinavica · doi:10.1111/j.1600-0447.2009.01438.x · Cited by 1,068 · see citing works
The Loss of Sadness: How Psychiatry Transformed Normal Sorrow into Depressive Disorder
(2009) · PsycEXTRA Dataset · doi:10.1037/e671332011-001 · Cited by 752 · see citing works
Tobacco use and cessation in psychiatric disorders: National Institute of Mental Health report
Ziedonis, D., Hitsman, B., Beckham, J. C., Zvolensky, M., Adler, L. E., Audrain-McGovern, J., Breslau, N., Brown, R. A., George, T. P., Williams, J., et al. (2008) · Nicotine & Tobacco Research · doi:10.1080/14622200802443569 · Cited by 735 · see citing works
National Patterns in Antidepressant Medication Treatment
Olfson, M., & Marcus, S. C. (2009) · Archives of General Psychiatry · doi:10.1001/archgenpsychiatry.2009.81 · Cited by 730 · see citing works
(1998) · PubMed · Cited by 460 · see citing works
Bulking agents, antispasmodics and antidepressants for the treatment of irritable bowel syndrome
Ruepert, L., Quartero, A. O., de Wit, N. J., van der Heijden, G. J., Rubin, G., & Muris, J. W. (2011) · Cochrane Database of Systematic Reviews · doi:10.1002/14651858.cd003460.pub3 · Cited by 389 · see citing works
Efficacy of Antidepressants as Analgesics: A Review
Dharmshaktu, P., Tayal, V., & Kalra, B. S. (2011) · The Journal of Clinical Pharmacology · doi:10.1177/0091270010394852 · Cited by 326 · see citing works
Moore, M., Yuen, H. M., Dunn, N., Mullee, M. A., Maskell, J., & Kendrick, T. (2009) · BMJ · doi:10.1136/bmj.b3999 · Cited by 287 · see citing works
Ohayon, M. M., & Lader, M. H. (2002) · The Journal of Clinical Psychiatry · doi:10.4088/jcp.v63n0912 · Cited by 271 · see citing works
Proportion Of Antidepressants Prescribed Without A Psychiatric Diagnosis Is Growing
Mojtabai, R., & Olfson, M. (2011) · Health Affairs · doi:10.1377/hlthaff.2010.1024 · Cited by 252 · see citing works
Pizzi, C., Rutjes, A. W. S., Costa, G. M., Fontana, F., Mezzetti, A., & Manzoli, L. (2011) · The American Journal of Cardiology · doi:10.1016/j.amjcard.2010.11.017 · Cited by 203 · see citing works
Tricyclic antidepressants and headaches: systematic review and meta-analysis
Jackson, J. L., Shimeall, W. T., Sessums, L. L., DeZee, K. J., Becher, D. A., Diemer, M. M., Berbano, E. P., & O’Malley, P. G. (2010) · BMJ · doi:10.1136/bmj.c5222 · Cited by 199 · see citing works
Lepine, J., Gasquet, I., Kovess, V., Arbabzadeh-Bouchez, S., Negre-pages, L., Nachbaur, G., & Gaudin, A. (2005) · L Encéphale · doi:10.1016/s0013-7006(05)82385-1 · Cited by 189 · see citing works
Mojtabai, R., & Olfson, M. (2008) · The Journal of Clinical Psychiatry · doi:10.4088/jcp.v69n0704 · Cited by 185 · see citing works
Understanding the prescription of antidepressants: a Qualitative study among French GPs
Mercier, A., Aubin-Auger, I., Lebeau, J., Royen, P. V., & Peremans, L. (2011) · BMC Family Practice · doi:10.1186/1471-2296-12-99 · Cited by 156 · see citing works
Self-citationThe Loss of Sadness: How Psychiatry Transformed Normal Sorrow Into Depressive Disorder
Seritan, A. L. (2007) · American Journal of Psychiatry · doi:10.1176/appi.ajp.2007.07081263 · Cited by 146 · see citing works
Clinical factors influencing the prescription of antidepressants and benzodiazepines:
Demyttenaere, K., Bonnewyn, A., Bruffaerts, R., de Girolamo, G., Gasquet, I., Kovess–Masféty, V., Haro, J. M., & Alonso, J. (2008) · Journal of Affective Disorders · doi:10.1016/j.jad.2008.01.011 · Cited by 145 · see citing works
Patient perspectives on once-weekly fluoxetine.
Judge, R. (2001) · PubMed · Cited by 144 · see citing works
Survey among 78 studies showed that Lasagna's law holds in Dutch primary care research
van der Wouden, J. C., Blankenstein, A. H., Huibers, M. J. H., van der Windt, D. A. W. M., Stalman, W. A. B., & Verhagen, A. P. (2007) · Journal of Clinical Epidemiology · doi:10.1016/j.jclinepi.2006.11.010 · Cited by 122 · see citing works
Gasquet, I., Nègre‐Pagès, L., Fourrier, A., Nachbaur, G., El-Hasnaoui, A., Kovess–Masféty, V., & Lépine, J. (2005) · L Encéphale · doi:10.1016/s0013-7006(05)82386-3 · Cited by 92 · see citing works
Sociological influences on antidepressant prescribing
Sleath, B. L., & Shih, Y. T. (2003) · Social Science & Medicine · doi:10.1016/s0277-9536(02)00132-6 · Cited by 83 · see citing works
Mercier, A., Aubin-Auger, I., Lebeau, J., Schuers, M., Boulet, P., Hermil, J.-L., Royen, P. V., & Peremans, L. (2013) · BMC Family Practice · doi:10.1186/1471-2296-14-55 · Cited by 81 · see citing works
Self-citationThe Edinburgh Primary Care Depression Study: Personality Disorder and Outcome
Patience, D. A., McGuire, R. J., Scott, A. I. F., & Freeman, C. P. L. (1995) · The British Journal of Psychiatry · doi:10.1192/bjp.167.3.324 · Cited by 63 · see citing works
[Antidepressants consumption in the global population in France].
Olié, J., Elomari, F., Spadone, C., & Lépine, J. (2002) · PubMed · Cited by 62 · see citing works
Lecadet, J., Bidal, P., Baris, B., Vallier, N., Fender, P., & Allemand, H. (2003) · Revue médicale de l'assurance maladie · Cited by 52 · see citing works
Ornstein, S. M., Stuart, G., & Jenkins, R. (2000) · PubMed · Cited by 47 · see citing works
Lamboy, B., Léon, C., & Guilbert, P. (2007) · Revue d Épidémiologie et de Santé Publique · doi:10.1016/j.respe.2006.11.005 · Cited by 42 · see citing works
Piek, E., van der Meer, K., Hoogendijk, W. J. G., Penninx, B. W. J. H., & Nolen, W. A. (2011) · PLoS ONE · doi:10.1371/journal.pone.0014784 · Cited by 36 · see citing works
Tardieu, S., Bottéro, A., Blin, P., Bohbot, M., Goni, S., Gérard, A., & Gasquet, I. (2006) · BMC Family Practice · doi:10.1186/1471-2296-7-5 · Cited by 28 · see citing works
Os, T. W. D. P. V., van den Brink, R. H. S., Tiemens, B. G., Jenner, J. A., van der Meer, K., & Ormel, J. (2003) · Journal of Affective Disorders · doi:10.1016/s0165-0327(03)00074-0 · Cited by 25 · see citing works
Treatment with Antidepressant Medications in Private Health Plans
Larson, M. J., Miller, K., & Fleming, K. J. (2006) · Administration and Policy in Mental Health and Mental Health Services Research · doi:10.1007/s10488-006-0088-5 · Cited by 24 · see citing works
Recours aux soins et adéquation des traitements de l’épisode dépressif majeur en France
Briffault, X., Morvan, Y., Rouillon, F., Dardennes, R. M., & Lamboy, B. (2009) · L Encéphale · doi:10.1016/j.encep.2008.10.011 · Cited by 23 · see citing works
Serna, C., Cruz, I., Galván, L., Real, J., Eguíluz, E. G., & Soler-González, J. (2010) · PubMed Central · Cited by 21 · see citing works
Amselle, F. (2011) · HAL (Le Centre pour la Communication Scientifique Directe) · Cited by 7 · see citing works
Flagged first, then by citations
Research works printed but not linked: 1
- Sleath B Shih Y-CT Sociological influences on antidepressant prescribing Soc Sci Med 1982 56 6 1335 1344 12600369
Cited by
Sorted by citations
Digital health technologies and major depressive disorder
McIntyre, R. S., Greenleaf, W., Bulaj, G., Taylor, S. T., Mitsi, G., Saliu, D., Czysz, A., Silvesti, G., Garcia, M., & Jain, R. (2023) · CNS Spectrums · doi:10.1017/s1092852923002225 · Cited by 38 · see citing works
Aarts, N., Noordam, R., Albert Hofman, D., Tiemeier, H. W., Stricker, B. H. C., & Visser, L. E. (2016) · International Journal of Clinical Pharmacy · doi:10.1007/s11096-016-0371-9 · Cited by 24 · see citing works
Šištík, P., Turjap, M., Iordache, A. M., Saldanha, H. M. E. B., Lemr, K., & Bednář, P. (2016) · Biomedical Papers · doi:10.5507/bp.2015.065 · Cited by 23 · see citing works
The long-term financial consequences of breast cancer: a Danish registry-based cohort study
Jensen, L. S., Overgaard, C., Bøggild, H., Garne, J. P., Lund, T., Overvad, K., & Fonager, K. (2017) · BMC Public Health · doi:10.1186/s12889-017-4839-x · Cited by 16 · see citing works
Jensen, L. S., Overgaard, C., Garne, J. P., Bøggild, H., & Fonager, K. (2017) · Scandinavian Journal of Public Health · doi:10.1177/1403494817722291 · Cited by 11 · see citing works
Management of Current Psychiatric Disorders
Engberink, A. O., Carbonnel, F., David, M., Norton, J. L., Bourrel, G., Boulenger, J., & Capdevielle, D. (2016) · The Canadian Journal of Psychiatry · doi:10.1177/0706743716639922 · Cited by 7 · see citing works
Goswami, P., & Chaudhuri, A. (2020) · Springer eBooks · doi:10.1007/978-981-15-4514-6_13 · Cited by 4 · see citing works
Asmussen, F., Hjorth, C. F., Plana‐Ripoll, O., Mailhac, A. C., & Cronin-Fenton, D. P. (2024) · Cancer Epidemiology · doi:10.1016/j.canep.2024.102733 · Cited by 3 · see citing works
Ethical Issues in Neuropsychopharmacotherapy: US Perspective
Menconi, M. J., & Dubljević, V. (2022) · Springer eBooks · doi:10.1007/978-3-030-62059-2_380 · Cited by 2 · see citing works
Ethical Issues in Neuropsychopharmacotherapy: US Perspective
Menconi, M. J., & Dubljević, V. (2020) · Springer eBooks · doi:10.1007/978-3-319-56015-1_380-1
Le patient souffrant de pathologies psychiatriques chroniques ou récurrentes prévalentes
Mercier, A. (2022) · Elsevier eBooks · doi:10.1016/b978-2-294-76710-4.00022-x
Self-citationGonzález‐Blanch, C., Medrano, L. A., Ruiz‐Rodríguez, P., Muñoz‐Navarro, R., Moriana, J. A., & Vindel, A. C. (2023) · Cognitive Therapy and Research · doi:10.1007/s10608-023-10360-1
Inconsistency of Antidepressant Prescription for Anxiety and Depression Among U.S. Older AdultsPreprint
Gain, E. P., Yu, X., Kedia, S., Naser, A. M., Ajoku, M. J., & Mou, X. (2025) · SSRN Electronic Journal · doi:10.2139/ssrn.5162665
- Authors
- Mercier, A., Auger-Aubin, I., Lebeau, J.-P., Schuers, M., Boulet, P., Van Royen, P., & Peremans, L.
- Affiliations
- Inserm (FR)
- Université de Tours (FR)
- Vrije Universiteit Brussel (BE)
- Corresponding author
- Mercier, Alain
- Venue
- BioPsychoSocial Medicine
- Published
- 2014
- Volume
- 8
- Issue
- 1
- Pages
- 17
- ISSN
- 1751-0759 (ISSN-L)
- PMC
- PMC4126991
- OpenAlex
- W2141823974
- Cited by
- 14
- References
- 35
- Citations by year
- 2025: 1 · 2024: 1 · 2023: 2 · 2022: 2 · 2020: 2 · 2017: 2 · 2016: 3 · 2015: 1
- FWCI
- 2.97
- Type
- journal article
- Language
- en
- Open access
- gold
- doi.org
- Licence
- cc-by
- Locations
- BioPsychoSocial Medicine (publishedVersion, cc-by)
- Europe PMC (PubMed Central) (publishedVersion, cc-by)
- PubMed Central (publishedVersion, cc-by)
- PubMed (publishedVersion)
- VUBIR (Vrije Universiteit Brussel) (submittedVersion, public-domain)
- HAL (submittedVersion, other-oa)
- Funders
- Institut National de la Santé et de la Recherche Médicale
- Topics
- Social Sciences › Psychology › Social Psychology › Mental Health Treatment and Access
- Health Sciences › Medicine › Pharmacology › Treatment of Major Depression
- Health Sciences › Health Professions › General Health Professions › Primary Care and Health Outcomes
- Keywords
- antidepressant prescribing, general practitioners, prescription behavior, psychosocial factors, biological determinants, multimorbidity, work-related problems, medical history, biopsychosocial model
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review