The DOI matches its Crossref record; 157 of the 157 references it cites were found in a registry or an index.
Chromatin accessibility: a window into the genome
Open accessAbstract
Transcriptional activation throughout the eukaryotic lineage has been tightly linked with disruption of nucleosome organization at promoters, enhancers, silencers, insulators and locus control regions due to transcription factor binding. Regulatory DNA thus coincides with open or accessible genomic sites of remodeled chromatin. Current chromatin accessibility assays are used to separate the genome by enzymatic or chemical means and isolate either the accessible or protected locations. The isolated DNA is then quantified using a next-generation sequencing platform. Wide application of these assays has recently focused on the identification of the instrumental epigenetic changes responsible for differential gene expression, cell proliferation, functional diversification and disease development. Here we discuss the limitations and advantages of current genome-wide chromatin accessibility assays with especial attention on experimental precautions and sequence data analysis. We conclude with our perspective on future improvements necessary for moving the field of chromatin profiling forward.
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The prevalence, evolution and chromatin signatures of plant regulatory elements
Lu, Z., Marand, A. P., Ricci, W. A., Ethridge, C. L., Zhang, X., & Schmitz, R. J. (2019) · Nature Plants · doi:10.1038/s41477-019-0548-z · Cited by 384
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Metadata
- Authors
- Tsompana, M., & Buck, M. J.
- Venue
- Epigenetics & Chromatin
- Published
- 2014-11-20
- Volume
- 7
- Issue
- 1
- Pages
- 33-33
- ISSN
- 1756-8935 (ISSN-L)
- OpenAlex
- W2133557974
- Cited by
- 447
- References
- 157
- FWCI
- 7.79
- Type
- journal article
- Language
- en
- Open access
- gold
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