Monocyte and macrophage differentiation: circulation inflammatory monocyte as biomarker for inflammatory diseases
Open accessAbstract
Monocytes express various receptors, which monitor and sense environmental changes. Monocytes are highly plastic and heterogeneous, and change their functional phenotype in response to environmental stimulation. Evidence from murine and human studies has suggested that monocytosis can be an indicator of various inflammatory diseases. Monocytes can differentiate into inflammatory or anti-inflammatory subsets. Upon tissue damage or infection, monocytes are rapidly recruited to the tissue, where they can differentiate into tissue macrophages or dendritic cells. Given the rapid progress in monocyte research from broad spectrum of inflammatory diseases, there is a need to summarize our knowledge in monocyte heterogeneity and its impact in human disease. In this review, we describe the current understanding of heterogeneity of human and murine monocytes, the function of distinct subsets of monocytes, and a potential mechanism for monocyte differentiation. We emphasize that inflammatory monocyte subsets are valuable biomarkers for inflammatory diseases, including cardiovascular diseases.
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CD14+/CD16- monocytes in humans are the functional counterpart to immature/inflammatory Ly6C hi monocytes in mice.
“CD14 + /CD16 -monocytes in humans are the functional counterpart to immature/ inflammatory Ly6C hi monocytes in mice (Yang et al, 2014).”
From Repeated Social Defeat, Neuroinflammation, and Behavior: Monocytes Carry the Signal (2017) · cites this paper as Yang et al, 2014
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References 62 · Cited by 1,099
- Authors
- Yang, J., Zhang, L., Yu, C., Yang, X.-F., & Wang, H.
- Affiliations
- Temple University (US)
- Corresponding author
- Wang, Hong
- ORCID
- Wang, Hong
- Venue
- Biomarker Research
- Published
- 2014-01-07
- Volume
- 2
- Issue
- 1
- Pages
- 1-1
- ISSN
- 2050-7771 (ISSN-L)
- PMC
- PMC3892095
- OpenAlex
- W2124392720
- Cited by
- 1,099
- References
- 62
- Citations by year
- 2026: 55 · 2025: 77 · 2024: 123 · 2023: 103 · 2022: 129 · 2021: 103 · 2020: 118 · 2019: 107 · 2018: 101 · 2017: 79 · 2016: 57 · 2015: 37 · 2014: 10
- FWCI
- 27.88
- Type
- journal article
- Language
- en
- Open access
- gold
- doi.org
- Licence
- cc-by
- Locations
- Biomarker Research (publishedVersion, cc-by)
- Europe PMC (PubMed Central) (publishedVersion, cc-by)
- PubMed Central (publishedVersion, cc-by)
- PubMed (publishedVersion)
- Funders
- National Institutes of Health (HL9445, HL-110764, HL117654)
- National Heart, Lung, and Blood Institute (R01HL067033, R01HL117654, R01HL116917, R01HL108910, R01HL110764, R01HL077288, R01HL082774)
- Topics
- Life Sciences › Immunology and Microbiology › Immunology › Immune cells in cancer
- Life Sciences › Immunology and Microbiology › Immunology › Atherosclerosis and Cardiovascular Diseases
- Life Sciences › Immunology and Microbiology › Immunology › Inflammation biomarkers and pathways
- Keywords
- monocyte heterogeneity, inflammatory monocytes, monocyte differentiation, macrophage differentiation, dendritic cells, monocytosis, biomarkers of inflammation, inflammatory diseases, cardiovascular disease, monocyte plasticity
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