The DOI matches its Crossref record; 32 of the 32 references it cites were found in a registry or an index.
Environmental risk factors differ between rheumatoid arthritis with and without auto-antibodies against cyclic citrullinated peptides
Open accessAbstract
The aim of this study was to evaluate new and previously hypothesised non-genetic risk factors for serologic subtypes of rheumatoid arthritis (RA) defined by the presence or absence of auto-antibodies to cyclic citrullinated peptides (CCP). In a national case-control study, we included 515 patients recently diagnosed with RA according to the American College of Rheumatology 1987 classification criteria and 769 gender- and age-matched population controls. Telephone interviews provided information about non-genetic exposures, and serum samples for patients were tested for anti-CCP-antibodies. Associations between exposure variables and risk of anti-CCP-positive and anti-CCP-negative RA were evaluated using logistic regression. A series of RA subtype-specific risk factors were identified. Tobacco smoking (odds ratio [OR] = 1.65; 95% confidence interval: 1.03–2.64, for >20 versus 0 pack-years) was selectively associated with risk of anti-CCP-positive RA, whereas alcohol consumption exhibited an inverse dose-response association with this RA subtype (OR = 1.98, 1.22–3.19, for 0 versus >0–5 drinks per week). Furthermore, coffee consumption (OR = 2.18; 1.07–4.42, for >10 versus 0 cups per day), ever use of oral contraceptives (OR = 1.65; 1.06–2.57) and having a first-degree relative with schizophrenia (OR = 4.18; 1.54–11.3) appeared more strongly associated with risk of anti-CCP-positive RA. Obesity was selectively associated with risk of anti-CCP-negative RA, with obese individuals being at more than 3-fold increased risk of this subtype compared with normal-weight individuals (OR = 3.45; 1.73–6.87). Age at menarche was the only examined factor that was significantly associated with both serologic subtypes of RA (p-trends = 0.01); women with menarche at age ≥ 15 years had about twice the risk of either RA subtype compared with women with menarche at age ≤ 12 years. Major differences in risk factor profiles suggest distinct etiologies for anti-CCP-positive and anti-CCP-negative RA.
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Revised Criteria for the Classification of Rheumatoid Arthritis
Arnett, F. C. (1990) · Orthopaedic Nursing · doi:10.1097/00006416-199003000-00011 · Cited by 7,723
Klareskog, L., Stolt, P., Lundberg, K., Källberg, H., Bengtsson, C., Grunewald, J., Rönnelid, J., Erlandsson Harris, H., Ulfgren, A., Rantapää‐Dahlqvist, S., et al. (2006) · Arthritis & Rheumatism · doi:10.1002/art.21575 · Cited by 1,515
Padyukov, L., Silva, C., Stolt, P., Alfredsson, L., & Klareskog, L. (2004) · Arthritis & Rheumatism · doi:10.1002/art.20553 · Cited by 682
Stolt, P., Bengtsson, C., Nordmark, B., Lindblad, S., Lundberg, I., Klareskog, L., & Alfredsson, L. (2003) · Annals of the Rheumatic Diseases · doi:10.1136/ard.62.9.835 · Cited by 648
Huizinga, T. W. J., Amos, C. I., van der Helm‐van Mil, A. H. M., Chen, W., van Gaalen, F. A., Jawaheer, D., Schreuder, G. M. T., Wener, M., Breedveld, F. C., Ahmad, N., et al. (2005) · Arthritis & Rheumatism · doi:10.1002/art.21385 · Cited by 593
Association of Schizophrenia and Autoimmune Diseases: Linkage of Danish National Registers
Eaton, W. W., Byrne, M., Ewald, H., Mors, O., Chen, C.-Y., Agerbo, E., & Mortensen, P. B. (2006) · American Journal of Psychiatry · doi:10.1176/appi.ajp.163.3.521 · Cited by 527
Molecular Mimicry and Autoimmunity
Albert, L. J., & Inman, R. D. (1999) · New England Journal of Medicine · doi:10.1056/nejm199912303412707 · Cited by 516
MacGregor, R. R. (1986) · JAMA: The Journal of the American Medical Association · doi:10.1001/jama.1986.03380110080031 · Cited by 439
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Cited by
Klareskog, L., Catrina, A. I., & Paget, S. (2009) · The Lancet · doi:10.1016/s0140-6736(09)60008-8 · Cited by 787
Obesity in autoimmune diseases: Not a passive bystander
Versini, M., Jeandel, P.-Y., Rosenthal, E., & Shoenfeld, Y. (2014) · Autoimmunity Reviews · doi:10.1016/j.autrev.2014.07.001 · Cited by 694
Sugiyama, D., Nishimura, K., Tamaki, K., Tsuji, G., Nakazawa, T., Morinobu, A., & Kumagai, S. (2010) · Annals of the Rheumatic Diseases · doi:10.1136/ard.2008.096487 · Cited by 667
Genetic and environmental risk factors for rheumatoid arthritis
Deane, K. D., Demoruelle, M. K., Kelmenson, L. B., Kuhn, K. A., Norris, J. M., & Holers, V. M. (2017) · Best Practice & Research Clinical Rheumatology · doi:10.1016/j.berh.2017.08.003 · Cited by 666
Myasoedova, E., Davis, J., Matteson, E. L., & Crowson, C. S. (2020) · Annals of the Rheumatic Diseases · doi:10.1136/annrheumdis-2019-216694 · Cited by 253
Metadata
- Authors
- Pedersen, M., Jacobsen, S., Klarlund, M., Pedersen, B. V., Wiik, A., Wohlfahrt, J., & Frisch, M.
- Venue
- Arthritis Research & Therapy
- Published
- 2006-07-27
- Volume
- 8
- Issue
- 4
- Pages
- R133-R133
- ISSN
- 1478-6354 (ISSN-L)
- OpenAlex
- W1831078481
- Cited by
- 358
- References
- 32
- FWCI
- 7.37
- Type
- journal article
- Language
- en
- Open access
- gold
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- Pedersen, M., Jacobsen, S., Klarlund, M., Pedersen, B. V., Wiik, A., Wohlfahrt, J., & Frisch, M. (2006). Environmental risk factors differ between rheumatoid arthritis with and without auto-antibodies against cyclic citrullinated peptides. Arthritis Research & Therapy. https://doi.org/10.1186/ar2022
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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