The DOI matches its Crossref record; 2 of the 2 references it cites were found in a registry or an index.
The role of tumor necrosis factor-alpha in systemic lupus erythematosus
Open accessAbstract
Murine models of systemic lupus erythematosus (SLE) have shown apparently contradictory evidence in that either (a) tumor necrosis factor (TNF) expression was low and TNF administration helpful or (b) TNF was high and TNF blockade of therapeutic benefit, depending on the mouse model investigated. In fact, TNF apparently has both effects, checking autoimmunity, at least to some degree, and fostering inflammation. TNF blockade regularly, but transiently, induces or increases autoantibodies to chromatin and to phospholipids. At the same time, open-label data suggest that TNF blockade suppresses inflammatory manifestations of SLE, and long-term benefit was seen in patients with lupus nephritis. A controlled clinical trial is under way.
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Vermeire, S., Noman, M., Van Assche, G., Baert, F., Van Steen, K., Esters, N., Joossens, S., Bossuyt, X., & Rutgeerts, P. (2003) · Gastroenterology · doi:10.1016/s0016-5085(03)00701-7 · Cited by 327
Cope, A. P., Londei, M., Chu, N. R., Cohen, S. B., Elliott, M. J., Brennan, F. M., Maini, R. N., & Feldmann, M. (1994) · Journal of Clinical Investigation · doi:10.1172/jci117394 · Cited by 243
Cited by
Urbonaviciute, V., Fürnrohr, B. G., Meister, S., Munoz, L., Heyder, P., De Marchis, F., Bianchi, M. E., Kirschning, C., Wagner, H., Manfredi, A. A., et al. (2008) · The Journal of Experimental Medicine · doi:10.1084/jem.20081165 · Cited by 517
Seillet, C., Laffont, S., Trémollières, F., Rouquié, N., Ribot, C., Arnal, J.-F., Douin-Echinard, V., Gourdy, P., & Guéry, J.-C. (2012) · Blood · doi:10.1182/blood-2011-08-371831 · Cited by 332
Metadata
- Authors
- Aringer, M., & Smolen, J. S.
- Venue
- Arthritis Research & Therapy
- Published
- 2008
- Volume
- 10
- Issue
- 1
- Pages
- 202
- ISSN
- 1478-6354 (ISSN-L)
- OpenAlex
- W2089737288
- Cited by
- 177
- References
- 2
- FWCI
- 10.89
- Type
- journal article
- Language
- en
- Open access
- gold
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- Aringer, M., & Smolen, J. S. (2008). The role of tumor necrosis factor-alpha in systemic lupus erythematosus. Arthritis Research & Therapy. https://doi.org/10.1186/ar2341
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
