Chronic exposure to tumor necrosis factor (TNF) in vitro impairs the activation of T cells through the T cell receptor/CD3 complex; reversal in vivo by anti-TNF antibodies in patients with rheumatoid arthritis

Cope, A P; Londei, M; Chu, N R; Cohen, S B; Elliott, M J; Brennan, F M; Maini, R N; Feldmann, M

doi:10.1172/jci117394

Cited by 243Rheumatoid Arthritis Research and TherapiesT-cell and B-cell ImmunologyImmunotoxicology and immune responses

Chronic exposure to tumor necrosis factor (TNF) in vitro impairs the activation of T cells through the T cell receptor/CD3 complex; reversal in vivo by anti-TNF antibodies in patients with rheumatoid arthritis

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Cope, A P, Londei, M, Chu, N R, Cohen, S B, Elliott, M J, Brennan, F M, Maini, R N, Feldmann, M·1994·Journal of Clinical Investigation

DOI 10.1172/jci117394PMC PMC296155

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Abstract

Experiments were designed to test the hypothesis that chronic exposure to tumor necrosis factor alpha (TNF) alters the function of activated T lymphocytes. Pretreatment of tetanus toxoid-specific T cell clones with TNF for up to 16 d impaired rechallenge proliferative responses to antigen in a dose- and time-dependent fashion. IL-2 and PHA responses were preserved. Prolonged treatment with TNF impaired production of IL-2, IL-10, IFN gamma, TNF, and lymphotoxin (LT) following stimulation with immobilized OKT3, and resulted in suboptimal expression of the IL-2R alpha chain (Tac) but not CD3, CD4, or HLA-DR antigens, when compared to untreated control cells. By contrast, pretreatment of T cells for prolonged periods in vitro with neutralizing anti-TNF monoclonal antibodies (mAb) enhanced proliferative responses, increased lymphokine production, and upregulated Tac expression following stimulation with OKT3. To determine whether TNF exerts immunosuppressive effects on T cells in vivo, we studied cell-mediated immunity in patients with active rheumatoid arthritis (RA), before and after treatment with a chimeric anti-TNF mAb. Treatment with anti-TNF restored the diminished proliferative responses of PBMC to mitogens and recall antigens towards normal in all patients tested. These data demonstrate that persistent expression of TNF in vitro and in vivo impairs cell-mediated immune responses.

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Inflammatory cytokines that direct T cell subtype production are altered in depressed patients.
“Since inflammatory cytokines that direct T cell subtype production are altered in depressed patients (12–14)”
From Inflammatory T helper 17 cells promote depression-like behavior in mice (2013) · cites this paper as [14]
The Results (p. 754) report altered T-cell cytokine production after TNF treatment in culture. The Introduction discusses abnormal cytokine responses in rheumatoid arthritis, not depression. Our copy does not establish that cytokines directing T-cell subtype production are altered in depressed patients. (LLM, conf=0.82)
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T cell responses in rheumatoid arthritis patients treated with TNF antagonists (107.7)
Roumanes, D., Kobie, J. J., Cavenaugh, J. S., Quataert, S. A., & Mosmann, T. R. (2011) · The Journal of Immunology · doi:10.4049/jimmunol.186.supp.107.7 · Cited by 1 · see citing works
Compromised Function of Regulatory T Cells in Rheumatoid Arthritis and Reversal by Anti-TNFα Therapy
Ehrenstein, M. R., Evans, J. G., Singh, A., Moore, S., Warnes, G., Isenberg, D. A., & Mauri, C. (2004) · The Journal of Experimental Medicine · doi:10.1084/jem.20040165 · Cited by 1,253 · see citing works
Modulation of T-cell responses by anti-tumor necrosis factor treatments in rheumatoid arthritis: a review
Davignon, J., Rauwel, B., Degboé, Y., Constantin, A., Boyer, J., Kruglov, A., & Cantagrel, A. G. (2018) · Arthritis Research & Therapy · doi:10.1186/s13075-018-1725-6 · Cited by 55 · see citing works
Compromised function of regulatory T cells in rheumatoid arthritis and reversal by anti-TNF alpha therapy
Ehrenstein, M. R., Evans, J., Singh, A., Moore, S., Warnes, G., Isenberg, D. A., & Mauri, C. (2004) · UCL Discovery (University College London)

Authors: Cope, A. P., Londei, M., Chu, N. R., Cohen, S. B., Elliott, M. J., Brennan, F. M., Maini, R. N., & Feldmann, M.
Affiliations: Kennedy Institute of Rheumatology (GB)
ORCID: Cope, A P
Feldmann, M
Venue: Journal of Clinical Investigation
Publisher: American Society for Clinical Investigation
Published: 1994-08-01
Volume: 94
Issue: 2
Pages: 749-760
ISSN: 0021-9738 (ISSN-L)
DOI: 10.1172/jci117394
PMC: PMC296155
OpenAlex: W1985680749
Cited by: 243
References: 60
Citations by year: 2026: 1 · 2024: 2 · 2023: 1 · 2022: 2 · 2021: 1 · 2019: 9 · 2018: 4 · 2017: 3 · 2016: 5 · 2015: 5 · 2014: 7 · 2013: 7 · 2012: 10
FWCI: 9.33
Type: journal article
Language: en
Open access: bronze
doi.org
Locations: Journal of Clinical Investigation (publishedVersion)
PubMed Central (publishedVersion)
PubMed (publishedVersion)
Funders: Wellcome Trust
Medical Research Council
Topics: Health Sciences › Medicine › Rheumatology › Rheumatoid Arthritis Research and Therapies
Life Sciences › Immunology and Microbiology › Immunology › T-cell and B-cell Immunology
Life Sciences › Immunology and Microbiology › Immunology › Immunotoxicology and immune responses
Keywords: TNF-α, T cell activation, T cell receptor/CD3 complex, anti-TNF monoclonal antibody, rheumatoid arthritis, cell-mediated immunity, immunosuppression, IL-2 receptor alpha chain, OKT3, lymphokine production, T cell clones
MeSH terms: Antibodies, Monoclonal, Antigen-Presenting Cells, Arthritis, Rheumatoid, Cells, Cultured, Dose-Response Relationship, Drug, HLA-DR Antigens, Humans, Interleukin-2, Lymphocyte Activation, Lymphokines, T-Lymphocytes, Tumor Necrosis Factor-alpha, CD4 Antigens, Receptor-CD3 Complex, Antigen, T-Cell

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Chronic exposure to tumor necrosis factor (TNF) in vitro impairs the activation of T cells through the T cell receptor/CD3 complex; reversal in vivo by anti-TNF antibodies in patients with rheumatoid arthritis

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