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Cited by 571

The DOI matches its Crossref record; 5 of the 5 references it cites were found in a registry or an index.

Pathogenesis of tendinopathies: inflammation or degeneration?

Open access
Abate, Michele, Gravare-Silbernagel, Karin, Siljeholm, Carl, Di Iorio, Angelo, De Amicis, Daniele, Salini, Vincenzo, Werner, Suzanne, Paganelli, Roberto·2009·Arthritis Research & Therapy

Abstract

The intrinsic pathogenetic mechanisms of tendinopathies are largely unknown and whether inflammation or degeneration has the prominent role is still a matter of debate. Assuming that there is a continuum from physiology to pathology, overuse may be considered as the initial disease factor; in this context, microruptures of tendon fibers occur and several molecules are expressed, some of which promote the healing process, while others, including inflammatory cytokines, act as disease mediators. Neural in-growth that accompanies the neovessels explains the occurrence of pain and triggers neurogenic-mediated inflammation. It is conceivable that inflammation and degeneration are not mutually exclusive, but work together in the pathogenesis of tendinopathies.

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Crossref · 10.1186/ar2723

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Metadata

Authors
Abate, M., Gravare-Silbernagel, K., Siljeholm, C., Di Iorio, A., De Amicis, D., Salini, V., Werner, S., & Paganelli, R.
Venue
Arthritis Research & Therapy
Published
2009
Volume
11
Issue
3
Pages
235
ISSN
1478-6354 (ISSN-L)
OpenAlex
W1986818994
Cited by
571
References
5
FWCI
16.00
Type
journal article
Language
en
Open access
gold

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CoChat. (2026). Citation check: Pathogenesis of tendinopathies: inflammation or degeneration? https://app.cochat.ai/papers/10.1186/ar2723
The paper
Abate, M., Gravare-Silbernagel, K., Siljeholm, C., Di Iorio, A., De Amicis, D., Salini, V., Werner, S., & Paganelli, R. (2009). Pathogenesis of tendinopathies: inflammation or degeneration? Arthritis Research & Therapy. https://doi.org/10.1186/ar2723

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Bibliographic data: Semantic Scholar, OpenAlex, Crossref.

Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).

Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.