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Cited by 144Bone Metabolism and DiseasesRheumatoid Arthritis Research and TherapiesOsteomyelitis and Bone Disorders Research

Negative regulation of osteoclastogenesis and bone resorption by cytokines and transcriptional repressors

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Zhao, Baohong, Ivashkiv, Lionel B·2011·Arthritis Research & Therapy
DOI 10.1186/ar3379PMC PMC3239342
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Abstract

Bone remodeling in physiological and pathological conditions represents a balance between bone resorption mediated by osteoclasts and bone formation by osteoblasts. Bone resorption is tightly and dynamically regulated by multiple mediators, including cytokines that act directly on osteoclasts and their precursors, or indirectly by modulating osteoblast lineage cells that in turn regulate osteoclast differentiation. The critical role of cytokines in inducing and promoting osteoclast differentiation, function and survival is covered by the accompanying review by Zwerina and colleagues. Recently, it has become clear that negative regulation of osteoclastogenesis and bone resorption by inflammatory factors and cytokines, downstream signaling pathways, and a newly described network of transcriptional repressors plays a key role in bone homeostasis by fine tuning bone remodeling and restraining excessive bone resorption in inflammatory settings. In this review we discuss negative regulators of osteoclastogenesis and mechanisms by which these factors suppress bone resorption.

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  • IL-4 limits bone resorption by promoting OPG expression and suppressing expression of RANKL, RANK, NF-κB, c-Fos, NFATc1, MAPK, and calcium signaling during osteoclast formation.

    “Furthermore, Zhao and Ivashkiv reported that IL-4 limits bone resorption by promoting OPG expression and suppressing the expression of RANKL, RANK, NF-κB, c-Fos, NFATc1, MAPK, and calcium signaling during osteoclast formation [42].”

    From Osteoclasts and Microgravity (2020) · cites this paper as [42]

  • IL-10 limits osteoclast formation by inhibiting expression of c-Fos, c-Jun, TREM2, and NFATc1 in osteoclast precursors.

    “Additionally, Zhao and Ivashkiv reported that IL-10 limits osteoclast formation by inhibiting the expression of c-Fos, c-Jun, TREM2, and NFATc1 in osteoclast precursors [42].”

    From Osteoclasts and Microgravity (2020) · cites this paper as [42]

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References 67 · Cited by 144

Research works printed but not linked: 63

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Authors
Zhao, B., & Ivashkiv, L. B.
Affiliations
Hospital for Special Surgery (US)
Corresponding author
Ivashkiv, Lionel B
ORCID
Venue
Arthritis Research & Therapy
Publisher
Springer Science and Business Media LLC
Published
2011
Volume
13
Issue
4
Pages
234
ISSN
1478-6354 (ISSN-L)
DOI
10.1186/ar3379
PMC
PMC3239342
OpenAlex
W2149827038
Cited by
144
References
67
Citations by year
2026: 9 · 2025: 6 · 2024: 8 · 2023: 10 · 2022: 13 · 2021: 7 · 2020: 12 · 2019: 11 · 2018: 9 · 2017: 11 · 2016: 10 · 2015: 13 · 2014: 11 · 2013: 6 · 2012: 7
FWCI
0.73
Type
journal article
Language
en
Open access
Locations
  • Arthritis Research & Therapy (publishedVersion)
  • Europe PMC (PubMed Central) (publishedVersion)
  • PubMed Central (publishedVersion)
  • PubMed (publishedVersion)
Funders
  • Arthritis Foundation
  • National Institutes of Health
  • National Institute of Arthritis and Musculoskeletal and Skin Diseases (K99AR062047, R01AR050401, R01AR046713)
  • National Institute of Dental and Craniofacial Research (R01DE019420)
Topics
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Bone Metabolism and Diseases
  • Health Sciences › Medicine › Rheumatology › Rheumatoid Arthritis Research and Therapies
  • Health Sciences › Medicine › Rheumatology › Osteomyelitis and Bone Disorders Research
Keywords
osteoclastogenesis, bone resorption, negative regulation, cytokines, transcriptional repressor, bone remodeling, bone homeostasis, osteoblasts, inflammatory mediators, osteoclast survival
MeSH terms
Animals, Bone Resorption, Cell Differentiation, Humans, Osteoclasts, Transcription, Genetic, Signal Transduction, Cytokines

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