Cited by 69Systemic Lupus Erythematosus ResearchGenetic Associations and EpidemiologyRheumatoid Arthritis Research and Therapies

Risk for rheumatic disease in relation to ethnicity and admixture

Open access
Molokhia·2000·Arthritis Research

Abstract

Risk of systemic lupus erythematosus (SLE) is high in west Africans compared with Europeans, and risk of rheumatoid arthritis (RA) is high in Native Americans compared with Europeans. These differences are not accounted for by differences in allele or haplotype frequencies in the human leucocyte antigen (HLA) region or any other loci known to influence risk of rheumatic disease. Where there has been admixture between two or more ethnic groups that differ in risk of disease, studies of the relationship of disease risk to proportionate admixture can help to distinguish between genetic and environmental explanations for ethnic differences in disease risk and to map the genes underlying these differences.

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  • Differences in ethnicity between the SARD-BDB and Toronto cohorts may impact results such as incidence, prevalence, and mortality rates.

    “Such differences between two groups of patients may also impact results such as the incidence, prevalence and mortality rates (76–79).”

    From Autoantibodies in Systemic Lupus Erythematosus Target Mitochondrial RNA (2019) · cites this paper as [78]

    The section on ethnic variation in systemic lupus erythematosus reports differences in incidence and prevalence between ethnic groups, supporting the possibility that cohort composition could affect those results. It does not compare the SARD-BDB and Toronto cohorts or establish that their ethnic differences affect mortality rates; it discusses shorter survival only as a possible influence on measured prevalence. No page number is available in our copy. (LLM, conf=0.86)

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  1. Bias WB Hochberg MC Mclean RH Machan C Systemic lupus erythematosus joint report. HLA 1991: Proceedings of the Eleventh International Histocompatability Workshop and Conference.Edited by Tsuji K, Aizawa M, Sasazuki T. Oxford: Oxford University Press, 1992 740 745

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Authors
Molokhia
Venue
Arthritis Research
Published
2000
Volume
2
Issue
2
Pages
115
ISSN
1465-9905 (ISSN-L)
OpenAlex
W1525533103
Cited by
69
References
69
Citations by year
2025: 1 · 2024: 2 · 2022: 2 · 2021: 6 · 2020: 3 · 2019: 4 · 2018: 4 · 2017: 1 · 2016: 3 · 2015: 4 · 2013: 3 · 2012: 3
FWCI
0.31
Type
journal article
Language
en
Open access
Locations
  • Arthritis Research (publishedVersion)
  • Europe PMC (PubMed Central) (publishedVersion)
  • PubMed Central (publishedVersion)
  • PubMed (publishedVersion)
  • Research Portal (King's College London) (publishedVersion, cc-by)
Topics
  • Health Sciences › Medicine › Rheumatology › Systemic Lupus Erythematosus Research
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Genetics › Genetic Associations and Epidemiology
  • Health Sciences › Medicine › Rheumatology › Rheumatoid Arthritis Research and Therapies
Keywords
rheumatic diseases, ethnic differences in disease risk, admixture, systemic lupus erythematosus, rheumatoid arthritis, West Africans, Native Americans, human leucocyte antigen, genetic susceptibility, gene mapping
MeSH terms
Africa, Arthritis, Rheumatoid, Chromosome Mapping, Europe, Humans, Lupus Erythematosus, Systemic, Rheumatic Diseases, Risk Factors

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