Risk for rheumatic disease in relation to ethnicity and admixture
Open accessAbstract
Risk of systemic lupus erythematosus (SLE) is high in west Africans compared with Europeans, and risk of rheumatoid arthritis (RA) is high in Native Americans compared with Europeans. These differences are not accounted for by differences in allele or haplotype frequencies in the human leucocyte antigen (HLA) region or any other loci known to influence risk of rheumatic disease. Where there has been admixture between two or more ethnic groups that differ in risk of disease, studies of the relationship of disease risk to proportionate admixture can help to distinguish between genetic and environmental explanations for ethnic differences in disease risk and to map the genes underlying these differences.
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Differences in ethnicity between the SARD-BDB and Toronto cohorts may impact results such as incidence, prevalence, and mortality rates.
“Such differences between two groups of patients may also impact results such as the incidence, prevalence and mortality rates (76–79).”
From Autoantibodies in Systemic Lupus Erythematosus Target Mitochondrial RNA (2019) · cites this paper as [78]
The section on ethnic variation in systemic lupus erythematosus reports differences in incidence and prevalence between ethnic groups, supporting the possibility that cohort composition could affect those results. It does not compare the SARD-BDB and Toronto cohorts or establish that their ethnic differences affect mortality rates; it discusses shorter survival only as a possible influence on measured prevalence. No page number is available in our copy. (LLM, conf=0.86)
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- Authors
- Molokhia
- Venue
- Arthritis Research
- Published
- 2000
- Volume
- 2
- Issue
- 2
- Pages
- 115
- ISSN
- 1465-9905 (ISSN-L)
- DOI
- 10.1186/ar76
- PMC
- PMC129994
- OpenAlex
- W1525533103
- Cited by
- 69
- References
- 69
- Citations by year
- 2025: 1 · 2024: 2 · 2022: 2 · 2021: 6 · 2020: 3 · 2019: 4 · 2018: 4 · 2017: 1 · 2016: 3 · 2015: 4 · 2013: 3 · 2012: 3
- FWCI
- 0.31
- Type
- journal article
- Language
- en
- Open access
- diamond
- doi.org
- Locations
- Arthritis Research (publishedVersion)
- Europe PMC (PubMed Central) (publishedVersion)
- PubMed Central (publishedVersion)
- PubMed (publishedVersion)
- Research Portal (King's College London) (publishedVersion, cc-by)
- Topics
- Health Sciences › Medicine › Rheumatology › Systemic Lupus Erythematosus Research
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Genetics › Genetic Associations and Epidemiology
- Health Sciences › Medicine › Rheumatology › Rheumatoid Arthritis Research and Therapies
- Keywords
- rheumatic diseases, ethnic differences in disease risk, admixture, systemic lupus erythematosus, rheumatoid arthritis, West Africans, Native Americans, human leucocyte antigen, genetic susceptibility, gene mapping
- MeSH terms
- Africa, Arthritis, Rheumatoid, Chromosome Mapping, Europe, Humans, Lupus Erythematosus, Systemic, Rheumatic Diseases, Risk Factors
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