Targeting aspartate aminotransferase in breast cancer

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Items 101–200 of 297

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3. Methyl 3-(3-(4-(2,4,4-Trimethylpentan-2-yl)phenoxy)-propanamido)benzoate as a Novel and Dual Malate Dehydrogenase (MDH) 1/2 Inhibitor Targeting Cancer Metabolism
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4. NMR and MS-based Stable Isotope-Resolved Metabolomics and applications in cancer metabolism
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8. Glutamine Deprivation Enhances Antitumor Activity of 3-Bromopyruvate through the Stabilization of Monocarboxylate Transporter-1
   Simone Cardaci, Salvatore Rizza, Giuseppe Filomeni, Roberta Bernardini, Fabio Bertocchi, Maurizio Mattei, Maurizio Paci, Giuseppe Rotilio, Maria Rosa Ciriolo · 2012 · Cancer Research
9. Assessment of the low inhibitory specificity of oxamate, aminooxyacetate and dichloroacetate on cancer energy metabolism
   Rafael Moreno‐Sánchez, Álvaro Marín‐Hernández, Isis Del Mazo‐Monsalvo, Emma Saavedra, Sara Rodríguez‐Enríquez · 2016 · Biochimica et Biophysica Acta (BBA) - General Subjects
10. Oxamate Improves Glycemic Control and Insulin Sensitivity via Inhibition of Tissue Lactate Production in db/db Mice
    Weiran Ye, Yijia Zheng, Shanshan Zhang, Li Yan, Hua Cheng, Muchao Wu · 2016 · PLoS ONE
11. Intron 4 VNTR (4a/b) Polymorphism of the Endothelial Nitric Oxide Synthase Gene Is Associated with Breast Cancer in Mexican Women
    Ramiro Ramírez-Patiño, Luis Eduardo Figuera, Ana María Puebla‐Pérez, Jorge Ivan Delgado-Saucedo, María Magdalena Legazpí-Macias, Rocío Patricia Mariaud-Schmidt, Adriana Ramos-Silva, Itzae Adonaí Gutiérrez-Hurtado, Liliana Gómez‐Flores‐Ramos, Guillermo Moisés Zúñiga‐González et al. · 2013 · Journal of Korean Medical Science
12. Resveratrol enhances HBV replication through activating Sirt1-PGC-1α-PPARα pathway
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13. Development of novel human lactate dehydrogenase A inhibitors: High-throughput screening, synthesis, and biological evaluations
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14. Targeting Metabolic Remodeling in Triple Negative Breast Cancer in a Murine Model
    Verónica García-Castillo, Eduardo López–Urrutia, Octavio Villanueva-Sánchez, Miguel A. Ávila‐Rodríguez, Alejandro Zentella‐Dehesa, Carlo César Cortés-González, César López‐Camarillo, Nadia Judith Jacobo-Herrera, Carlos Pérez‐Plasencia · 2017 · Journal of Cancer
15. Targeting fuel pocket of cancer cell metabolism: A focus on glutaminolysis
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16. Mitochondria Deregulations in Cancer Offer Several Potential Targets of Therapeutic Interventions
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17. Targeting lactate dehydrogenase‑A promotes docetaxel‑induced cytotoxicity predominantly in castration‑resistant prostate cancer cells
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18. Inhibitors of glucose transport and glycolysis as novel anticancer therapeutics
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19. Biochemical Characterization and Structure-Based Mutational Analysis Provide Insight into the Binding and Mechanism of Action of Novel Aspartate Aminotransferase Inhibitors
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20. D-2-Hydroxyglutarate does not mimic all the IDH mutation effects, in particular the reduced etoposide-triggered apoptosis mediated by an alteration in mitochondrial NADH
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21. Perspectives of Reprogramming Breast Cancer Metabolism
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22. Is the interaction between fatty acids and tryptophan responsible for the efficacy of a ketogenic diet in epilepsy? The new hypothesis of action
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23. Therapeutic potential of endogenous hydrogen sulfide inhibition in breast cancer (Review)
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24. Warburg and Krebs and related effects in cancer
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25. Expression, purification and preliminary crystallographic studies of human glutamate oxaloacetate transaminase 1 (GOT1)
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26. Malate–aspartate shuttle promotes l ‐lactate oxidation in mitochondria
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27. Glutamine metabolism regulates FLIP expression and sensitivity to TRAIL in triple-negative breast cancer cells
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28. Oxamate potentiates taxol chemotherapeutic efficacy in experimentally-induced solid ehrlich carcinoma (SEC) in mice
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29. Urinary malate dehydrogenase 2 is a new biomarker for early detection of non‐small‐cell lung cancer
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30. Proteomic analysis of the proteins that are associated with the resistance to paclitaxel in human breast cancer cells
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31. Identification of N-acylhydrazone derivatives as novel lactate dehydrogenase A inhibitors
    Sebastiano Rupiani, Rosa Buonfiglio, Marcella Manerba, Lorenza Di Ianni, Marina Vettraino, Elisa Giacomini, Matteo Masetti, Federico Falchi, Giuseppina Di Stefano, Marinella Roberti et al. · 2015 · European Journal of Medicinal Chemistry
32. Influence of Preoperative Serum Aspartate Aminotransferase (AST) Level on the Prognosis of Patients with Non-Small Cell Lung Cancer
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33. Analisis Molekular dan Karakteristik Hidrogen Sianida (HCN)
    Aulia Dinul Husna, Rahadian Zainul · 2019
34. Using Machine Learning to Measure Relatedness Between Genes: A Multi-Features Model
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35. A Nomogram Based on Aspartate Aminotransferase/Alanine Aminotransferase (AST/ALT) Ratio to Predict Prognosis After Surgery in Gastric Cancer Patients
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36. Effect of LDHA Inhibition on TNF-α-Induced Cell Migration in Esophageal Cancers
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37. Metabolic and Amino Acid Alterations of the Tumor Microenvironment
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38. Structural and functional analysis of disease-associated mutations in GOT1 gene: An in silico study
    Sidharth Saxena, Sai Achyuth B, T. P. Krishna Murthy, Vivek Chandramohan, Arvind Kumar Yadav, Tiratha Raj Singh · 2021 · Computers in Biology and Medicine
39. Parafilm-assisted microdissection: a sampling method for mass spectrometry-based identification of differentially expressed prostate cancer protein biomarkers
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40. Analyzing the differentially expressed genes and pathway cross‐talk in aggressive breast cancer
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41. From Prokaryotes to Cancer: Glutamine Flux in Multicellular Units
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42. Metabolic pathways underlying GATA6 regulating Trastuzumab resistance in Gastric Cancer cells based on untargeted metabolomics
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43. The Role of Host-Generated H2S in Microbial Pathogenesis: New Perspectives on Tuberculosis
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44. Discovery of novel human lactate dehydrogenase inhibitors: Structure-based virtual screening studies and biological assessment
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45. Glutamic oxaloacetic transaminase 1 as a potential target in human cancer
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46. Shotgun proteomic analysis to study the decrease of xenograft tumor growth after rosemary extract treatment
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47. Screening of lactate dehydrogenase inhibitor from bioactive compounds in natural products by electrophoretically mediated microanalysis
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48. Metabolic Heterogeneity, Plasticity, and Adaptation to “Glutamine Addiction” in Cancer Cells: The Role of Glutaminase and the GTωA [Glutamine Transaminase—ω-Amidase (Glutaminase II)] Pathway
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49. Crystal structure of wild-type (WT) human Glutamate oxaloacetate transaminase 1 (GOT1)
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50. Targeting androgen receptor-independent pathways in therapy-resistant prostate cancer
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51. The prognostic value of De Ritis (AST/ALT) ratio in patients after surgery for urothelial carcinoma: a systematic review and meta-analysis
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52. In vitro and in vivo effects of 3-bromopyruvate against Echinococcus metacestodes
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53. REDOX proteomics reveals energy metabolism alterations in the liver of M. spretus mice exposed to p, p′-DDE
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54. Label-free quantitative proteomics unravels the importance of RNA processing in glioma malignancy
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55. Malate-Aspartate Shuttle Inhibitor Aminooxyacetate Acid Induces Apoptosis and Impairs Energy Metabolism of Both Resting Microglia and LPS-Activated Microglia
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56. GLUL Ablation Can Confer Drug Resistance to Cancer Cells via a Malate-Aspartate Shuttle-Mediated Mechanism
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57. High aspartate transaminase/alanine transaminase ratio predicts poor prognosis in patients with localized upper tract urothelial cancer: a propensity score-matched study in a large Chinese center
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58. Effects of three modifiers of glycolysis on ATP, lactate, hypoxia, and growth in human tumor cell lines in vivo
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59. Enhancing doxorubicin efficacy through inhibition of aspartate transaminase in triple-negative breast cancer cells
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60. Aberrant Metabolism as Inductor of Epigenetic Changes in Breast Cancer: Therapeutic Opportunities
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61. Glutamine metabolism controls amphiregulin-facilitated chemoresistance to cisplatin in human chondrosarcoma
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62. Identification of a potent inhibitor targeting human lactate dehydrogenase A and its metabolic modulation for cancer cell line
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63. The Prognostic Value of the De Ritis Ratio for Progression-Free Survival in Patients with NET Undergoing [177Lu]Lu-DOTATOC-PRRT: A Retrospective Analysis
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64. Pretreatment Aspartate Aminotransferase-to-Alanine Aminotransferase (De Ritis) Ratio Predicts the Prognosis of Nonmetastatic Nasopharyngeal Carcinoma
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65. The effect of lactate dehydrogenase inhibitors on proliferation, motility and invasion of breast cancer cells in vitro highlights a new role for lactate
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66. Customizing Functionalized Cofactor Mimics to Study the Human Pyridoxal 5′-Phosphate-Binding Proteome
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67. The De Ritis (Aspartate Transaminase/Alanine Transaminase) Ratio as a Prognosticator in Patients With End-stage Renal Disease–associated Renal Cell Carcinoma
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68. Kinetic modeling of glucose central metabolism in hepatocytes and hepatoma cells
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69. A Proteomic Approach for the Identification of Up-Regulated Proteins Involved in the Metabolic Process of the Leiomyoma
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70. The association between serum liver enzymes and cancer mortality
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71. Synthesis, structural and spectroscopic characterization, in vitro cytotoxicity and in vivo activity as free radical scavengers of chlorido(p-cymene) complexes of ruthenium(II) containing N-alkylphenothiazines
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72. Breast Cancer Cell Subtypes Display Different Metabolic Phenotypes That Correlate with Their Clinical Classification
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77. Aspartate in tumor microenvironment and beyond: Metabolic interactions and therapeutic perspectives
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80. Triple Isozyme Lactic Acid Dehydrogenase Inhibition in Fully Viable MDA-MB-231 Cells Induces Cytostatic Effects That Are Not Reversed by Exogenous Lactic Acid
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86. Lactate metabolic pathway regulates tumor cell metastasis and its use as a new therapeutic target
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87. Identification of Proteins Differentially Expressed in Gastric Cancer Cells with High Metastatic Potential for Invasion to Lymph Nodes
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88. Frex and FrexH
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89. Potential Clinical Value of Pretreatment De Ritis Ratio as a Prognostic Biomarker for Renal Cell Carcinoma
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93. Metabolism, a Blossoming Target for Small-Molecule Anticancer Drugs
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98. A patent review of lactate dehydrogenase inhibitors (2014–present)
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99. The metabolic importance of the overlooked asparaginase II pathway
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100. Secondary metabolites of Mirabilis jalapa structurally inhibit Lactate Dehydrogenase A in silico: a potential cancer treatment
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