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Functional and molecular characterisation of mammary side population cells
Open accessAbstract
BACKGROUND: Breast cancer is thought to arise in mammary epithelial stem cells. However, the identity of these stem cells is unknown. METHODS: Studies in the haematopoetic and muscle systems show that stem cells have the ability to efflux the dye Hoechst 33342. Cells with this phenotype are referred to as the side population (SP). We have adapted the techniques from the haematopoetic and muscle systems to look for a mammary epithelial SP. RESULTS: Of mammary epithelial cells isolated from both the human and mouse mammary epithelia, 0.2-0.45% formed a distinct SP. The SP was relatively undifferentiated but grew as typical differentiated epithelial clones when cultured. Transplantation of murine SP cells at limiting dilution into cleared mammary fat pads generated epithelial ductal and lobuloalveolar structures. CONCLUSION: These data demonstrate the existence of an undifferentiated SP in human and murine mammary epithelium. Purified SP cells are a live single-cell population that retain the ability to differentiate in vitro and in vivo. Studies of haematopoetic cells have suggested that the SP phenotype constitutes a universal stem cell marker. This work therefore has implications for mammary stem cell biology.
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Extension of Life-Span by Introduction of Telomerase into Normal Human Cells
Bodnar, A. G., Ouellette, M., Frolkis, M., Holt, S. E., Chiu, C.-P., Morin, G. B., Harley, C. B., Shay, J. W., Lichtsteiner, S., & Wright, W. E. (1998) · Science · doi:10.1126/science.279.5349.349 · Cited by 4,975
Zhou, S., Schuetz, J. D., Bunting, K. D., Colapietro, A.-M., Sampath, J., Morris, J. J., Lagutina, I., Grosveld, G. C., Osawa, M., Nakauchi, H., et al. (2001) · Nature Medicine · doi:10.1038/nm0901-1028 · Cited by 2,280
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Tumour stem cells and drug resistance
Dean, M., Fojo, T., & Bates, S. (2005) · Nature reviews. Cancer · doi:10.1038/nrc1590 · Cited by 3,668
Generation of a functional mammary gland from a single stem cell
Shackleton, M., Vaillant, F., Simpson, K. J., Stingl, J., Smyth, G. K., Asselin-Labat, M.-L., Wu, L., Lindeman, G. J., & Visvader, J. E. (2006) · Nature · doi:10.1038/nature04372 · Cited by 2,005
Stem cell divisions, somatic mutations, cancer etiology, and cancer prevention
Tomasetti, C., Li, L., & Vogelstein, B. (2017) · Science · doi:10.1126/science.aaf9011 · Cited by 1,113
Identification of Gastric Cancer Stem Cells Using the Cell Surface Marker CD44
Takaishi, S., Okumura, T., Tu, S., Wang, S. S. W., Shibata, W., Vigneshwaran, R., Gordon, S. A. K., Shimada, Y., & Wang, T. C. (2009) · Stem Cells · doi:10.1002/stem.30 · Cited by 1,039
Tackling the cancer stem cells — what challenges do they pose?
Pattabiraman, D. R., & Weinberg, R. A. (2014) · Nature Reviews Drug Discovery · doi:10.1038/nrd4253 · Cited by 990
Metadata
- Authors
- Alvi, A. J., Clayton, H., Joshi, C., Enver, T., Ashworth, A., Vivanco, M. A. M., Dale, T. C., & Smalley, M. J.
- Venue
- Breast Cancer Research
- Published
- 2002-12-04
- Volume
- 5
- Issue
- 1
- Pages
- R1-8
- ISSN
- 1465-5411 (ISSN-L)
- 1465-542X
- OpenAlex
- W1483319410
- Cited by
- 289
- References
- 2
- FWCI
- 6.99
- Type
- journal article
- Language
- en
- Open access
- gold
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- Alvi, A. J., Clayton, H., Joshi, C., Enver, T., Ashworth, A., Vivanco, M. A. M., Dale, T. C., & Smalley, M. J. (2002). Functional and molecular characterisation of mammary side population cells. Breast Cancer Research. https://doi.org/10.1186/bcr547
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