Tumour stem cells and drug resistance

Prospective identification of tumorigenic breast cancer cells

Al‐Hajj, M., Wicha, M. S., Benito‐Hernández, A., Morrison, S. J., & Clarke, M. F. (2003) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0530291100 · Cited by 10,388 · see citing works

Stem cells, cancer, and cancer stem cells

Reya, T., Morrison, S. J., Clarke, M. F., & Weissman, I. L. (2001) · Nature · doi:10.1038/35102167 · Cited by 9,738 · see citing works

Human acute myeloid leukemia is organized as a hierarchy that originates from a primitive hematopoietic cell

Bonnet, D., & Dick, J. (1997) · Nature Medicine · doi:10.1038/nm0797-730 · Cited by 7,417 · see citing works

Identification of human brain tumour initiating cells

Singh, S. K., Hawkins, C. E., Clarke, I. D., Squire, J. A., Bayani, J., Hide, T., Henkelman, R. M., Cusimano, M. D., & Dirks, P. B. (2004) · Nature · doi:10.1038/nature03128 · Cited by 7,388 · see citing works

Multidrug resistance in cancer: role of ATP–dependent transporters

Gottesman, M. M., Fojo, T., & Bates, S. E. (2002) · Nature Reviews Cancer · doi:10.1038/nrc706 · Cited by 5,536 · see citing works

Identification of a cancer stem cell in human brain tumors.

Singh, S. K., Clarke, I. D., Terasaki, M., Bonn, V. E., Hawkins, C. E., Squire, J. A., & Dirks, P. B. (2003) · PubMed · Cited by 4,861 · see citing works

A cell initiating human acute myeloid leukaemia after transplantation into SCID mice

Lapidot, T., Sirard, C., Vormoor, J., Murdoch, B., Hoang, T., Caceres-Cortes, J., Minden, M., Paterson, B., Caligiuri, M. A., & Dick, J. E. (1994) · Nature · doi:10.1038/367645a0 · Cited by 4,783 · see citing works

Mutations affecting segment number and polarity in Drosophila

Nüsslein‐Volhard, C., & Wieschaus, E. F. (1980) · Nature · doi:10.1038/287795a0 · Cited by 4,370 · see citing works

Isolation and functional properties of murine hematopoietic stem cells that are replicating in vivo.

Goodell, M. A., Brose, K., Paradis, G. A., Conner, A. N., & Mulligan, R. C. (1996) · The Journal of Experimental Medicine · doi:10.1084/jem.183.4.1797 · Cited by 2,902 · see citing works

A multidrug resistance transporter from human MCF-7 breast cancer cells

Doyle, L. A., Yang, W., Abruzzo, L. V., Krogmann, T. A., Gao, Y., Rishi, A. K., & Ross, D. D. (1998) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.95.26.15665 · Cited by 2,319 · see citing works

Disruption of the mouse mdr1a P-glycoprotein gene leads to a deficiency in the blood-brain barrier and to increased sensitivity to drugs

Schinkel, A. H., Smit, J., van Tellingen, O., Beijnen, J. H., Wagenaar, E., van Deemter, L., Mol, C. A. A. M., van der Valk, M. A., Robanus-Maandag, E. C., Riele, H. T., et al. (1994) · Cell · doi:10.1016/0092-8674(94)90212-7 · Cited by 2,284 · see citing works

The ABC transporter Bcrp1/ABCG2 is expressed in a wide variety of stem cells and is a molecular determinant of the side-population phenotype

Zhou, S., Schuetz, J. D., Bunting, K. D., Colapietro, A.-M., Sampath, J., Morris, J. J., Lagutina, I., Grosveld, G. C., Osawa, M., Nakauchi, H., et al. (2001) · Nature Medicine · doi:10.1038/nm0901-1028 · Cited by 2,280 · see citing works

Mutations of the Human Homolog of Drosophila patched in the Nevoid Basal Cell Carcinoma Syndrome

Hahn, H., Wicking, C., Zaphiropoulos, P. G., Gailani, M. R., Shanley, S., Chidambaram, A., Vořechovský, I., Holmberg, E., Undén, A. B., Gillies, S. A., et al. (1996) · Cell · doi:10.1016/s0092-8674(00)81268-4 · Cited by 2,018 · see citing works

Human Homolog of patched , a Candidate Gene for the Basal Cell Nevus Syndrome

Johnson, R. L., Rothman, A., Xie, J., Goodrich, L. V., Bare, J. W., Bonifas, J. M., Quinn, A., Myers, R., Cox, D., Epstein, E. H., et al. (1996) · Science · doi:10.1126/science.272.5268.1668 · Cited by 1,856 · see citing works

Cancerous stem cells can arise from pediatric brain tumors

Hemmati, H. D., Nakano, I., Lazareff, J. A., Masterman-Smith, M. D., Geschwind, D. H., Bronner-Fraser, M. E., & Kornblum, H. I. (2003) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.2036535100 · Cited by 1,801 · see citing works

The Human ATP-Binding Cassette (ABC) Transporter SuperfamilyPreprint

Dean, M. C., Rzhetsky, A., & Allikmets, R. L. (2001) · Genome Research · doi:10.1101/gr.184901 · Cited by 1,758 · see citing works

Granulocyte-macrophage progenitors as candidate leukemic stem cells in blast-crisis CML

Jamieson, C. H. M., Ailles, L. E., Dylla, S. J., Muijtjens, M., Jones, C., Zehnder, J. L., Gotlib, J., Li, K., Manz, M. G., Keating, A., et al. (2004) · New England Journal of Medicine · doi:10.1056/nejmoa040258 · Cited by 1,485 · cited 1× · see citing works

Hedgehog is an early and late mediator of pancreatic cancer tumorigenesis

Thayer, S. P., di Magliano, M. P., Heiser, P. W., Nielsen, C. M., Roberts, D. J., Lauwers, G. Y., Qi, Y., Gysin, S., Castillo, C. F. F.-D., Yajnik, V., et al. (2003) · Nature · doi:10.1038/nature02009 · Cited by 1,479 · see citing works

Self-Renewal, Multipotency, and the Existence of Two Cell Populations within an Epithelial Stem Cell Niche

Blanpain, C., Lowry, W. E., Geoghegan, A., Polak, L., & Fuchs, E. (2004) · Cell · doi:10.1016/j.cell.2004.08.012 · Cited by 1,428 · see citing works

DQIS — Distributed Quorum-Based Independent Immune Surveillance: A Theoretical Framework for Byzantine Fault Tolerance for Multi-Channel Immune Surveillance

DQIS Research Group (2026) · PubMed · doi:10.5281/zenodo.21937949 · Cited by 1,333 · see citing works

A distinct “side population” of cells with high drug efflux capacity in human tumor cells

Hirschmann-Jax, C., Foster, A. E., Wulf, G. G., Nuchtern, J. G., Jax, T. W., Göbel, U., Goodell, M. A., & Brenner, M. K. (2004) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0400067101 · Cited by 1,281 · see citing works

Widespread requirement for Hedgehog ligand stimulation in growth of digestive tract tumours

Berman, D. M., Karhadkar, S. S., Maitra, A., Oca, R. M. D., Gerstenblith, M. R., Briggs, K. J., Parker, A. R., Shimada, Y., Eshleman, J. R., Watkins, D. N., et al. (2003) · Nature · doi:10.1038/nature01972 · Cited by 1,251 · see citing works

Normal genetically mosaic mice produced from malignant teratocarcinoma cells.

Mintz, B., & Illmensee, K. (1975) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.72.9.3585 · Cited by 1,179 · see citing works

Primitive, quiescent, Philadelphia-positive stem cells from patients with chronic myeloid leukemia are insensitive to STI571 in vitro

Graham, S. M., Jørgensen, H. G., Allan, E., Pearson, C., Alcorn, M. J., Richmond, L., & Holyoake, T. L. (2002) · Blood · doi:10.1182/blood.v99.1.319 · Cited by 1,174 · see citing works

Hedgehog signalling within airway epithelial progenitors and in small-cell lung cancer

Watkins, D. N., Berman, D. M., Burkholder, S. G., Wang, B., Beachy, P. A., & Baylin, S. B. (2003) · Nature · doi:10.1038/nature01493 · Cited by 1,082 · see citing works

Persistence of a small subpopulation of cancer stem-like cells in the C6 glioma cell line

Kondo, T., Setoguchi, T., & Taga, T. (2004) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0307618100 · Cited by 985 · see citing works

Acute myeloid leukemia originates from a hierarchy of leukemic stem cell classes that differ in self-renewal capacity

Hope, K. J., Jin, L., & Dick, J. E. (2004) · Nature Immunology · doi:10.1038/ni1080 · Cited by 968 · see citing works

Hedgehog signalling in prostate regeneration, neoplasia and metastasis

Karhadkar, S. S., Bova, G. S., Abdallah, N., Dhara, S., Gardner, D. R., Maitra, A., Isaacs, J. T., Berman, D. M., & Beachy, P. A. (2004) · Nature · doi:10.1038/nature02962 · Cited by 950 · see citing works

The breast cancer resistance protein protects against a major chlorophyll-derived dietary phototoxin and protoporphyria

Jonker, J. W., Buitelaar, M., Wagenaar, E., van der Valk, M. A., Scheffer, G. L., Scheper, R. J., Plösch, T., Kuipers, F., Elferink, R. P. J. O., Rosing, H., et al. (2002) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.202607599 · Cited by 822 · see citing works

Molecular cloning of cDNAs which are highly overexpressed in mitoxantrone-resistant cells: demonstration of homology to ABC transport genes.

Miyake, K., Mickley, L. A., Litman, T., Zhan, Z., Robey, R. W., Cristensen, B., Brangi, M., Greenberger, L., Dean, M. C., Fojo, T., et al. (1999) · PubMed · Cited by 819 · see citing works

Medulloblastoma Growth Inhibition by Hedgehog Pathway Blockade

Berman, D. M., Karhadkar, S. S., Hallahan, A. R., Pritchard, J. I., Eberhart, C. G., Watkins, D. N., Chen, J., Cooper, M. K., Taipale, J., Olson, J. M., et al. (2002) · Science · doi:10.1126/science.1073733 · Cited by 802 · see citing works

A human placenta-specific ATP-binding cassette gene (ABCP) on chromosome 4q22 that is involved in multidrug resistance.

Allikmets, R., Schriml, L. M., Hutchinson, A. A., Romano-Spica, V., & Dean, M. C. (1998) · PubMed · Cited by 798 · see citing works

A Southwest Oncology Group study

Jenkins, T. R., Tangen, C. M., Macdonald, J. S., Weiss, G. R., Chapman, R. M., & Hantel, A. (1993) · Cited by 773 · see citing works

CD133, a novel marker for human prostatic epithelial stem cells

Richardson, G. D., Robson, C. N., Lang, S., Neal, D. E., Maitland, N. J., & Collins, A. T. (2004) · Journal of Cell Science · doi:10.1242/jcs.01222 · Cited by 770 · see citing works

The ABCG2 transporter is an efficient Hoechst 33342 efflux pump and is preferentially expressed by immature human hematopoietic progenitors

Scharenberg, C. W., Harkey, M. A., & Torok‐Storb, B. (2002) · Blood · doi:10.1182/blood.v99.2.507 · Cited by 770 · see citing works

Cancer stem cells in nervous system tumors

Singh, S. K., Clarke, I. D., Hide, T., & Dirks, P. B. (2004) · Oncogene · doi:10.1038/sj.onc.1207946 · Cited by 731 · see citing works

Potent and specific inhibition of the breast cancer resistance protein multidrug transporter in vitro and in mouse intestine by a novel analogue of fumitremorgin C.

Allen, J. D., van Loevezijn, A., Rademaker-Lakhai, J. M., van der Valk, M., van Tellingen, O., Reid, G., Schellens, J. H. M., Koomen, G., & Schinkel, A. H. (2002) · PubMed · Cited by 690 · see citing works

Similar MLL-associated leukemias arising from self-renewing stem cells and short-lived myeloid progenitorsPreprint

Cozzio, A., Passegue, E. A., Ayton, P. M., Karsunky, H., Cleary, M. L., & Weissman, I. L. (2003) · Genes & Development · doi:10.1101/gad.1143403 · Cited by 656 · see citing works

Persistent expression of the ATP-binding cassette transporter, Abcg2, identifies cardiac SP cells in the developing and adult heart

Martin, C. M., Meeson, A. P., Robertson, S. M., Hawke, T. J., Richardson, J. A., Bates, S. E., Goetsch, S. C., Gallardo, T. D., & Garry, D. J. (2003) · Developmental Biology · doi:10.1016/j.ydbio.2003.09.028 · Cited by 655 · see citing works

Stem cell origin of cancer and differentiation therapy

Sell, S. (2004) · Critical Reviews in Oncology/Hematology · doi:10.1016/j.critrevonc.2004.04.007 · Cited by 638 · see citing works

Stem cells in normal breast development and breast cancer

Dontu, G., Al‐Hajj, M., Abdallah, W. M., Clarke, M. F., & Wicha, M. S. (2003) · Cell Proliferation · doi:10.1046/j.1365-2184.36.s.1.6.x · Cited by 579 · see citing works

Therapeutic implications of cancer stem cells

Al‐Hajj, M., Becker, M. W., Wicha, M. S., Weissman, I. L., & Clarke, M. F. (2003) · Current Opinion in Genetics & Development · doi:10.1016/j.gde.2003.11.007 · Cited by 561 · see citing works

An entire functional mammary gland may comprise the progeny from a single cell

Kordon, E. C., & Smith, G. H. (1998) · Development · doi:10.1242/dev.125.10.1921 · Cited by 558 · see citing works

Stem cells in normal breast development and breast cancer

Wicha, M., Dontu, G., Al‐Hajj, M., & Clarke, M. F. (2003) · Breast Cancer Research · doi:10.1186/bcr709 · Cited by 537 · see citing works

Several types of mutations of the Abl gene can be found in chronic myeloid leukemia patients resistant to STI571, and they can pre-exist to the onset of treatment

Roche‐Lestienne, C., Soenen, V., Grardel, N., Laï, J., Philippe, N., Facon, T. T. F., Fenaux, P., & Preudhomme, C. (2002) · Blood · doi:10.1182/blood.v100.3.1014 · Cited by 515 · see citing works

Bcrp1 gene expression is required for normal numbers of side population stem cells in mice, and confers relative protection to mitoxantrone in hematopoietic cells in vivo

Zhou, S., Morris, J. J., Barnes, Y., Lan, L.-B., Schuetz, J. D., & Sorrentino, B. P. (2002) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.192276999 · Cited by 503 · see citing works

Fumitremorgin C reverses multidrug resistance in cells transfected with the breast cancer resistance protein.

Rabindran, S. K., Ross, D. D., Doyle, L. A., Yang, W., & Greenberger, L. M. (2000) · PubMed · Cited by 487 · see citing works

Identification of a lineage of multipotent hematopoietic progenitors

Morrison, S. J., Wandycz, A. M., Hemmati, H. D., Wright, D. E., & Weissman, I. L. (1997) · Development · doi:10.1242/dev.124.10.1929 · Cited by 482 · see citing works

Benefit of cyclosporine modulation of drug resistance in patients with poor-risk acute myeloid leukemia: a Southwest Oncology Group study

List, A. F., Kopecky, K. J., Willman, C. L., Head, D. R., Persons, D. L., Slovak, M. L., Dorr, R. T., Karanes, C., Hynes, H. E., Doroshow, J. H., et al. (2001) · Blood · doi:10.1182/blood.v98.12.3212 · Cited by 418 · see citing works

Imatinib mesylate (STI571) is a substrate for the breast cancer resistance protein (BCRP)/ABCG2 drug pump

Burger, H., van Tol, H., Boersma, A. W. M., Brok, M. O., Wiemer, E. A. C., Stoter, G., & Nooter, K. (2004) · Blood · doi:10.1182/blood-2004-04-1398 · Cited by 418 · see citing works

The multidrug resistance transporter ABCG2 (breast cancer resistance protein 1) effluxes Hoechst 33342 and is overexpressed in hematopoietic stem cells.

Kim, M., Turnquist, H. R., Jackson, J. D., Sgagias, M. K., Yan, Y., Gong, M., Dean, M. C., Sharp, J. G., & Cowan, K. H. (2002) · PubMed · Cited by 397 · see citing works

Phase 3 study of the multidrug resistance modulator PSC-833 in previously untreated patients 60 years of age and older with acute myeloid leukemia: Cancer and Leukemia Group B Study 9720

Baer, M. R., George, S. L., Dodge, R. K., O’Loughlin, K. L., Minderman, H., Caligiuri, M. A., Anastasi, J., Powell, B. L., Kolitz, J. E., Schiffer, C. A., et al. (2002) · Blood · doi:10.1182/blood.v100.4.1224.h81602001224_1224_1232 · Cited by 366 · see citing works

High-Affinity Interaction of Tyrosine Kinase Inhibitors with the ABCG2 Multidrug Transporter

Özvegy‐Laczka, C., Hegedűs, T., Várady, G., Ujhelly, O., Schuetz, J. D., Váradi, A., Kéri, G., Őrfi, L., Német, K., & Sarkadi, B. (2004) · Molecular Pharmacology · doi:10.1124/mol.65.6.1485 · Cited by 341 · see citing works

Expression, Up-Regulation, and Transport Activity of the Multidrug-Resistance Protein Abcg2 at the Mouse Blood-Brain Barrier

Cisternino, S., Mercier, C., Bourasset, F., Roux, F. S., & Scherrmann, J. (2004) · Cancer Research · doi:10.1158/0008-5472.can-03-2033 · Cited by 329 · see citing works

Imatinib Mesylate Is a Potent Inhibitor of the ABCG2 (BCRP) Transporter and Reverses Resistance to Topotecan and SN-38 in Vitro

Houghton, P. J., Germain, G. S., Harwood, F. C., Schuetz, J. D., Stewart, C. F., Buchdunger, E., & Traxler, P. M. (2004) · Cancer Research · doi:10.1158/0008-5472.can-03-3344 · Cited by 323 · see citing works

Breast cancer stem cells revealed

Dick, J. E. (2003) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0830967100 · Cited by 320 · see citing works

Side population cells from diverse adult tissues are capable of in vitro hematopoietic differentiation

Asakura, A., & Rudnicki, M. A. (2002) · Experimental Hematology · doi:10.1016/s0301-472x(02)00954-2 · Cited by 318 · see citing works

Towards a molecular understanding of hair loss and its treatment

Cotsarelis, G., & Millar, S. E. (2001) · Trends in Molecular Medicine · doi:10.1016/s1471-4914(01)02027-5 · Cited by 294 · see citing works

The transforming activity of Wnt effectors correlates with their ability to induce the accumulation of mammary progenitor cells

Liu, B. Y., McDermott, S., Khwaja, S. S., & Alexander, C. M. (2004) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0400699101 · Cited by 293 · see citing works

Functional and molecular characterisation of mammary side population cells

Alvi, A. J., Clayton, H., Joshi, C., Enver, T., Ashworth, A., Vivanco, M. D., Dale, T. C., & Smalley, M. J. (2002) · Breast Cancer Research · doi:10.1186/bcr547 · Cited by 289 · see citing works

Side population cells and Bcrp1 expression in lung

Summer, R. S., Kotton, D. N., Sun, X. H., Ma, B., Fitzsimmons, K. M., & Fine, A. (2003) · American Journal of Physiology-Lung Cellular and Molecular Physiology · doi:10.1152/ajplung.00009.2003 · Cited by 275 · see citing works

From teratocarcinomas to embryonic stem cells

Andrews, P. W. (2002) · Philosophical Transactions of the Royal Society B Biological Sciences · doi:10.1098/rstb.2002.1058 · Cited by 263 · see citing works

Imatinib mesylate (STI571) inhibits growth of primitive malignant progenitors in chronic myelogenous leukemia through reversal of abnormally increased proliferation

Holtz, M. S., Slovak, M. L., Zhang, F., Sawyers, C. L., Forman, S. J., & Bhatia, R. (2002) · Blood · doi:10.1182/blood.v99.10.3792 · Cited by 250 · see citing works

Mitoxantrone, Etoposide, and Cytarabine With or Without Valspodar in Patients With Relapsed or Refractory Acute Myeloid Leukemia and High-Risk Myelodysplastic Syndrome: A Phase III Trial (E2995)

Greenberg, P. L., Lee, S. J., Advani, R. H., Tallman, M. S., Sikic, B. I., Letendre, L., Dugan, K., Lum, B. L., Chin, D. L., Dewald, G. W., et al. (2004) · Journal of Clinical Oncology · doi:10.1200/jco.2004.07.048 · Cited by 234 · see citing works

Tissue-engineered microvessels on three-dimensional biodegradable scaffolds using human endothelial progenitor cells

Wu, X. W., Aikawa, E. R., Guleserian, K. J., Perry, T. E., Masuda, Y., Sutherland, F. W. H., Schöen, F. J., Mayer, J. E., & Bischoff, J. E. (2004) · American Journal of Physiology-Heart and Circulatory Physiology · doi:10.1152/ajpheart.01232.2003 · Cited by 232 · see citing works

Modulation of the expression of a multidrug resistance gene (mdr-1/P-glycoprotein) by differentiating agents

Mickley, L. A., Bates, S. E., Richert, N. D., et al. (1989) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(19)84675-6 · Cited by 221 · see citing works

A Mammalian patched Homolog Is Expressed in Target Tissues of sonic hedgehog and Maps to a Region Associated with Developmental Abnormalities

Hahn, H., Christiansen, J. H., Wicking, C., Zaphiropoulos, P. G., Chidambaram, A., Gerrard, B., Vořechovský, I., Bale, A. E., Toftgård, R., Dean, M. C., et al. (1996) · Journal of Biological Chemistry · doi:10.1074/jbc.271.21.12125 · Cited by 218 · see citing works

Nestin-positive progenitor cells derived from adult human pancreatic islets of Langerhans contain side population (SP) cells defined by expression of the ABCG2 (BCRP1) ATP-binding cassette transporter

Lechner, A., Leech, C. A., Abraham, E. J., Nolan, A. L., & Habener, J. F. (2002) · Biochemical and Biophysical Research Communications · doi:10.1016/s0006-291x(02)00275-9 · Cited by 210 · see citing works

Clonogenic and nonclonogenic in vitro chemosensitivity assays.

Weisenthal, L. M., & Lippman, M. E. (1985) · PubMed · Cited by 204 · see citing works

Dietary factors and the risk of endometrial cancer

Levi, F., Vecchia, C. L., Franceschi, S., & Negri, E. (1993) · Cancer · doi:10.1002/1097-0142(19930601)71:11 · Cited by 175 · see citing works

Expression of a drug resistance gene in human neuroblastoma cell lines: modulation by retinoic acid-induced differentiation.

Bates, S. E., Mickley, L. A., Chen, Y. N., et al. (1989) · Molecular and Cellular Biology · doi:10.1128/mcb.9.10.4337 · Cited by 161 · see citing works

A Phase I Trial of a Potent P-Glycoprotein Inhibitor, Zosuquidar Trihydrochloride (LY335979), Administered Intravenously in Combination with Doxorubicin in Patients with Advanced Malignancy

Sandler, A., Gordon, M. A., de Alwis, D. P., et al. (2004) · Clinical Cancer Research · doi:10.1158/1078-0432.ccr-03-0644 · Cited by 151 · see citing works

`Side Population' cells in adult mouse testis expressBcrp1gene and are enriched in spermatogonia and germinal stem cells

Lassalle, B., Bastos, H., Louis, J. P., Riou, L., Testart, J., Dutrillaux, B., Fouchet, P., & Allemand, I. (2003) · Development · doi:10.1242/dev.00918 · Cited by 146 · see citing works

Quantitative studies of autotransplantation of human cancer.Preliminary report

Southam, C. M., & Brunschwig, A. (1961) · Cancer · doi:10.1002/1097-0142(196109/10)14:5 · Cited by 145 · see citing works

Increased 99mTc-sestamibi accumulation in normal liver and drug-resistant tumors after the administration of the glycoprotein inhibitor, XR9576.

Agrawal, M., Abraham, J., Balis, F. M., Edgerly, M., Stein, W. D., Bates, S. E., Fojo, T., & Chen, C. C. (2003) · PubMed · Cited by 135 · see citing works

Two Cytoplasmic Domains of Mammalian Adenylyl Cyclase Form a GSα- and Forskolin-activated Enzyme in Vitro

Yan, S.-Z., Hahn, D., Huang, Z.-H., & Tang, W. (1996) · Journal of Biological Chemistry · doi:10.1074/jbc.271.18.10941 · Cited by 130 · see citing works

Presence of the BCR-ABL mutation Glu255Lys prior to STI571 (imatinib) treatment in patients with Ph+ acute lymphoblastic leukemia

Hofmann, W., Komor, M., Waßmann, B., Jones, L. C., Gschaidmeier, H., Hoelzer, D. F., Koeffler, H. P., & Ottmann, O. G. (2003) · Blood · doi:10.1182/blood-2002-06-1756 · Cited by 123 · see citing works

Verapamil increases the survival of patients with anthracycline-resistant metastatic breast carcinoma

Belpomme, D., Gauthier, S., Pujade-Lauraine, É., Facchini, T., Goudier, M.-J., Krakowski, I., Netter-Pinon, G., Frénay, M., Gousset, C., MARIE, F.-N., et al. (2000) · Annals of Oncology · doi:10.1023/a:1026556119020 · Cited by 118 · see citing works

Phase I and Pharmacokinetic Study of the Novel MDR1 and MRP1 Inhibitor Biricodar Administered Alone and in Combination With Doxorubicin

Peck, R. A., Hewett, J., Harding, M. W., et al. (2001) · Journal of Clinical Oncology · doi:10.1200/jco.2001.19.12.3130 · Cited by 107 · see citing works

Quinidine as a resistance modulator of epirubicin in advanced breast cancer: mature results of a placebo-controlled randomized trial.

Wishart, G. C., Bissett, D., Paul, J., Jodrell, D. I., Harnett, A. N., Habeshaw, T., Kerr, D. J., Macham, M. A., Soukop, M., & Leonard, R. C. (1994) · Journal of Clinical Oncology · doi:10.1200/jco.1994.12.9.1771 · Cited by 102 · see citing works

The orally administered P-glycoprotein inhibitor R101933 does not alter the plasma pharmacokinetics of docetaxel.

van Zuylen, L., Sparreboom, A., van der Gaast, A., van der Burg, M. E., van Beurden, V., Bol, C. J., Woestenborghs, R., Palmer, P. A., & Verweij, J. (2000) · PubMed · Cited by 101 · see citing works

A Phase II Study of the MDR Inhibitor Biricodar (INCEL, VX-710) and Paclitaxel in Women with Advanced Ovarian Cancer Refractory to Paclitaxel Therapy

Seiden, M. V., Swenerton, K. D., Matulonis, U. A., et al. (2002) · Gynecologic Oncology · doi:10.1006/gyno.2002.6762 · Cited by 99 · see citing works

Gene rearrangement: a novel mechanism for MDR-1 gene activation.

Mickley, L. A., Spengler, B. A., Knutsen, T. A., et al. (1997) · Journal of Clinical Investigation · doi:10.1172/jci119362 · Cited by 99 · see citing works

Side Population Keratinocytes Resembling Bone Marrow Side Population Stem Cells Are Distinct From Label-Retaining Keratinocyte Stem Cells

Terunuma, A., Jackson, K. L., Vogel, J. C., Kapoor, V., & Telford, W. G. (2003) · Journal of Investigative Dermatology · doi:10.1046/j.1523-1747.2003.12531.x · Cited by 98 · see citing works

Clinical pharmacokinetics of doxorubicin in combination with GF120918, a potent inhibitor of MDR1 P-glycoprotein

Sparreboom, A., Planting, A. S. T., Jewell, R. C., et al. (1999) · Anti-Cancer Drugs · doi:10.1097/00001813-199909000-00005 · Cited by 95 · see citing works

Cyclosporin A combined with vincristine, doxorubicin and dexamethasone (VAD) compared with VAD alone in patients with advanced refractory multiple myeloma: an EORTC–HOVON randomized phase III study (06914)

Sonneveld, P., Suciu, S., Weijermans, P., Beksaç, M., Neuwirtová, R., Solbu, G., Lokhorst, H. M., der Lelie, J. V., Döhner, H., Gerhartz, H., et al. (2001) · British Journal of Haematology · doi:10.1046/j.1365-2141.2001.03171.x · Cited by 93 · see citing works

Oral verapamil with chemotherapy for advanced non-small cell lung cancer: a randomised study

Millward, M. J., Cantwell, B. M. J., Munro, N. C., Robinson, A. G., Corris, P. A., & Harris, A. L. (1993) · British Journal of Cancer · doi:10.1038/bjc.1993.189 · Cited by 91 · see citing works

Bryostatin-I—An Antineoplastic Treasure from the Deep?

May, W. S., & Ruvolo, P. P. (2002) · Cancer Biology & Therapy · doi:10.4161/cbt.1.4.20 · Cited by 88 · see citing works

Biochimica et biophysica acta

(1978) · Biochimica et Biophysica Acta (BBA) - General Subjects · doi:10.1016/0304-4165(78)90317-3 · Cited by 85 · see citing works

Safety and efficacy of the multidrug resistance inhibitor Incel (biricodar; VX-710) in combination with paclitaxel for advanced breast cancer refractory to paclitaxel.

Toppmeyer, D., Seidman, A. D., Pollak, M., et al. (2002) · PubMed · Cited by 84 · see citing works

QUANTITATIVE STUDIES OF AUTOTRANSPLANTATION OF HUMAN CANCER

Southam, C. M., & Brunschwig, A. (1961) · Cited by 82 · see citing works

Expression of the MDR1 Gene in Human Gastric and Colorectal Carcinomas

Mizoguchi, T., Yamada, K., Furukawa, T., et al. (1990) · JNCI Journal of the National Cancer Institute · doi:10.1093/jnci/82.21.1679 · Cited by 79 · see citing works

A Phase I/II Study of Infusional Vinblastine with the P-Glycoprotein Antagonist Valspodar (PSC 833) in Renal Cell Carcinoma

Bates, S. E., Bakke, S., Kang, M. H., et al. (2004) · Clinical Cancer Research · doi:10.1158/1078-0432.ccr-0829-03 · Cited by 71 · see citing works

Neuroendocrine differentiation of adrenocortical tumors

Haak, H. R., & Fleuren, G. J. (1995) · Cancer · doi:10.1002/1097-0142(19950201)75:3 · Cited by 69 · see citing works

A randomised clinical study of verapamil in addition to combination chemotherapy in small cell lung cancer

Milroy, R. (1993) · British Journal of Cancer · doi:10.1038/bjc.1993.433 · Cited by 68 · see citing works

Mouse models of human breast cancer: evolution or convolution?

Green, J. (2003) · Breast Cancer Research · doi:10.1186/bcr660 · Cited by 65 · see citing works

Safety and efficacy of the multidrug-resistance inhibitor biricodar (VX-710) with concurrent doxorubicin in patients with anthracycline-resistant advanced soft tissue sarcoma.

Bramwell, V. H. C., Morris, D. G., Ernst, D. S., et al. (2002) · PubMed · Cited by 60 · see citing works

Hematopoietic cells from mice that are deficient in both Bcrp1/Abcg2 and Mdr1a/1b develop normally but are sensitized to mitoxantrone

Zhou, S., Zong, Y., Lu, T., & Sorrentino, B. P. (2003) · BioTechniques · doi:10.2144/03356ss04 · Cited by 57 · see citing works

Effect of Adenovirus-Mediated Expression of Sonic Hedgehog Gene on Hair Regrowth in Mice With Chemotherapy-Induced Alopecia

Sato, N., Leopold, P. L., & Crystal, R. G. (2001) · JNCI Journal of the National Cancer Institute · doi:10.1093/jnci/93.24.1858 · Cited by 46 · see citing works

Safety and efficacy of the MDR inhibitor Incel (biricodar, VX-710) in combination with mitoxantrone and prednisone in hormone-refractory prostate cancer

Rago, R. P., Einstein, A., Lush, R. M., et al. (2003) · Cancer Chemotherapy and Pharmacology · doi:10.1007/s00280-003-0573-4 · Cited by 32 · see citing works

Drug interaction studies between paclitaxel (Taxol) and OC144-093 — A new modulator of MDR in cancer chemotherapy

Guns, E. S. T., Denyssevych, T., Dixon, R., Bally, M. B., & Mayer, L. D. (2002) · European Journal of Drug Metabolism and Pharmacokinetics · doi:10.1007/bf03190426 · Cited by 32 · see citing works

Teratocarcinoma stem cells.

Damjanov, I. (1990) · PubMed · Cited by 29 · see citing works

Is there a cloud in the silver lining for imatinib?

Paterson, S., Smith, K. D., Holyoake, T. L., et al. (2003) · British Journal of Cancer · doi:10.1038/sj.bjc.6600828 · Cited by 27 · see citing works

Isolation and characterization of the CD133+ precursors from the ventricular zone of human fetal brain by magnetic affinity cell sorting

Yu, S., Zhang, J., Zhao, C., Zhang, H., & Xu, Q. (2004) · Biotechnology Letters · doi:10.1023/b:bile.0000035484.64499.ac · Cited by 26 · see citing works

99mTc-Sestamibi scanning with SDZ PSC 833 as a functional detection method for resistance modulation in patients with solid tumours.

Bakker, M., van der Graaf, W., Piers, D., et al. (1999) · PubMed · Cited by 24 · see citing works

Towards a unified model of tumor suppression: lessons learned from the human patched gene

Dean, M. C. (1997) · Biochimica et Biophysica Acta (BBA) - Reviews on Cancer · doi:10.1016/s0304-419x(96)00043-1 · Cited by 19 · see citing works

No correlation between the proliferative status of Bcr-Abl positive cell lines and the proapoptotic activity of imatinib mesylate (Gleevec™/Glivec®)

Rosée, P. L., Shen, L., Stoffregen, E. P., et al. (2003) · The Hematology Journal · doi:10.1038/sj.thj.6200297 · Cited by 18 · see citing works

Deregulated expression of theTAL1 gene by t(1;5)(p32;q31) in patient with T-cell acute lymphoblastic leukemia

François, S., Delabesse, É., Baranger, L., Dautel, M., Foussard, C., Boasson, M., Blanchet, O., Bernard, O., Macintyre, E. A., & Ifrah, N. (1998) · Genes Chromosomes and Cancer · doi:10.1002/(sici)1098-2264(199809)23:1 · Cited by 15 · see citing works

In vitro clonogenicity in relation to kinetic and clinicopathological features of breast cancer.

Gioanni, J., Farges, M., Duplay, H., et al. (1988) · PubMed · Cited by 7 · see citing works

Low incidence of tumourigenicity in agarose colonies from spontaneous murine mammary tumours

Price, J. E., & Tarin, D. (1989) · Differentiation · doi:10.1111/j.1432-0436.1989.tb00748.x · Cited by 6 · see citing works

Principles of nanoparticle design for overcoming biological barriers to drug delivery

Blanco, E., Shen, H., & Ferrari, M. (2015) · Nature Biotechnology · doi:10.1038/nbt.3330 · Cited by 7,002 · see citing works

Targeting multidrug resistance in cancer

Szakács, G., Paterson, J. K., Ludwig, J. A., Booth-Genthe, C., & Gottesman, M. M. (2006) · Nature Reviews Drug Discovery · doi:10.1038/nrd1984 · Cited by 3,609 · see citing works

Drug penetration in solid tumours

Minchinton, A. I., & Tannock, I. F. (2006) · Nature reviews. Cancer · doi:10.1038/nrc1893 · Cited by 2,805 · see citing works

EMT, CSCs, and drug resistance: the mechanistic link and clinical implications

Shibue, T., & Weinberg, R. A. (2017) · Nature Reviews Clinical Oncology · doi:10.1038/nrclinonc.2017.44 · Cited by 2,539 · see citing works

Hematopoietic Stem-Cell Transplantation

Copelan, E. A. (2006) · New England Journal of Medicine · doi:10.1056/nejmra052638 · Cited by 2,522 · see citing works

Drug Resistance and the Solid Tumor Microenvironment

Tredan, O., Galmarini, C. M., Patel, K., & Tannock, I. F. (2007) · JNCI Journal of the National Cancer Institute · doi:10.1093/jnci/djm135 · Cited by 2,116 · see citing works

Stochastic State Transitions Give Rise to Phenotypic Equilibrium in Populations of Cancer Cells

Gupta, P. B., Fillmore, C. M., Jiang, G., Shapira, S. D., Tao, K., Kuperwasser, C., & Lander, E. S. (2011) · Cell · doi:10.1016/j.cell.2011.07.026 · Cited by 1,475 · see citing works

The Hippo transducer TAZ confers cancer stem cell-related traits on breast cancer cells

Cordenonsi, M., Zanconato, F., Azzolin, L., Forcato, M., Rosato, A., Frasson, C., Inui, M., Montagner, M., Parenti, A. R., Poletti, A., et al. (2011) · Cell · doi:10.1016/j.cell.2011.09.048 · Cited by 1,381 · see citing works

Block copolymer micelles in nanomedicine applications

Cabral, H., Miyata, K., Osada, K., & Kataoka, K. (2018) · Chemical Reviews · doi:10.1021/acs.chemrev.8b00199 · Cited by 1,309 · see citing works

Cancer stem cells as key drivers of tumour progression

Ayob, A. Z., & Ramasamy, T. S. (2018) · Journal of Biomedical Science · doi:10.1186/s12929-018-0426-4 · Cited by 910 · see citing works

SCoPE-MS: mass spectrometry of single mammalian cells quantifies proteome heterogeneity during cell differentiation

Budnik, B., Levy, E., Harmange, G., & Slavov, N. (2018) · Genome Biology · doi:10.1186/s13059-018-1547-5 · Cited by 832 · see citing works

Nanomedicine therapeutic approaches to overcome cancer drug resistance

Markman, J. L., Rekechenetskiy, A., Holler, E., & Ljubimova, J. Y. (2013) · Advanced Drug Delivery Reviews · doi:10.1016/j.addr.2013.09.019 · Cited by 733 · see citing works

Wnt pathway inhibition via the targeting of Frizzled receptors results in decreased growth and tumorigenicity of human tumors

Gurney, A., Axelrod, F., Bond, C. J., Cain, J., Chartier, C., Donigan, L., Fischer, M., Chaudhari, A., Ji, M., Kapoun, A. M., et al. (2012) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1120068109 · Cited by 614 · see citing works

ABC transporters as mediators of drug resistance and contributors to cancer cell biology

Fletcher, J. I., Williams, R. T., Henderson, M. J., Norris, M. D., & Haber, M. (2016) · Drug Resistance Updates · doi:10.1016/j.drup.2016.03.001 · Cited by 423 · see citing works

Non-viral delivery systems for CRISPR/Cas9-based genome editing: challenges and opportunities

Li, L., Hu, S., & Chen, X. (2018) · Biomaterials · doi:10.1016/j.biomaterials.2018.04.031 · Cited by 415 · see citing works

Targeting HIF1α Eliminates Cancer Stem Cells in Hematological Malignancies

Wang, Y., Liu, Y., Malek, S. N., Zheng, P., & Liu, Y. (2011) · Cell stem cell · doi:10.1016/j.stem.2011.02.006 · Cited by 410 · see citing works

A novel type of cellular senescence that can be enhanced in mouse models and human tumor xenografts to suppress prostate tumorigenesis

Alimonti, A., Nardella, C., Chen, Z., Clohessy, J. G., Carracedo, A., Trotman, L. C., Cheng, K., Varmeh, S., Kozma, S. C., Thomas, G., et al. (2010) · Journal of Clinical Investigation · doi:10.1172/jci40535 · Cited by 374 · see citing works

An integrin β3-KRAS-RalB complex drives tumour stemness and resistance to EGFR inhibition

Seguin, L., Kato, S., Franovic, A., Camargo, M. F., Lesperance, J., Elliott, K. C., Yebra, M., Mielgo, A., Lowy, A. M., Husain, H., et al. (2014) · Nature Cell Biology · doi:10.1038/ncb2953 · Cited by 374 · see citing works

Hypoxia increases the expression of stem-cell markers and promotes clonogenicity in glioblastoma neurospheres

Bar, E. E., Lin, A., Mahairaki, V., Matsui, W., & Eberhart, C. G. (2010) · The American Journal of Pathology · doi:10.2353/ajpath.2010.091021 · Cited by 373 · see citing works

The cancer stem cell marker aldehyde dehydrogenase is required to maintain a drug-tolerant tumor cell subpopulation

Raha, D., Wilson, T. R., Peng, J., Peterson, D., Yue, P., Evangelista, M., Wilson, C., Merchant, M., & Settleman, J. (2014) · Cancer Research · doi:10.1158/0008-5472.can-13-3456 · Cited by 307 · see citing works

The chemical defensome: Environmental sensing and response genes in the Strongylocentrotus purpuratus genome

Goldstone, J. V., Hamdoun, A., Cole, B. J., Howard-Ashby, M., Nebert, D. W., Scally, M., Dean, M., Epel, D., Hahn, M. E., & Stegeman, J. J. (2006) · Developmental Biology · doi:10.1016/j.ydbio.2006.08.066 · Cited by 280 · see citing works

Multidrug Efflux Pumps and Cancer Stem Cells: Insights Into Multidrug Resistance and Therapeutic Development

Moitra, K., Lou, H., & Dean, M. (2011) · Clinical Pharmacology & Therapeutics · doi:10.1038/clpt.2011.14 · Cited by 279 · see citing works

Temporally sequenced anticancer drugs overcome adaptive resistance by targeting a vulnerable chemotherapy-induced phenotypic transition

Goldman, A., Majumder, B., Dhawan, A., Ravi, S., Goldman, D., Kohandel, M., Majumder, P. K., & Sengupta, S. (2015) · Nature Communications · doi:10.1038/ncomms7139 · Cited by 260 · see citing works

Mechanisms of Disease: Cancer stem cells--targeting the evil twin

Trumpp, A., & Wiestler, O. D. (2008) · Nature Clinical Practice Oncology · doi:10.1038/ncponc1110 · Cited by 199 · see citing works

Nanotechnology—novel therapeutics for CNS disorders

Srikanth, M., & Kessler, J. A. (2012) · Nature Reviews Neurology · doi:10.1038/nrneurol.2012.76 · Cited by 198 · see citing works

Nanoformulations for combination or cascade anticancer therapy

Miao, L., Guo, S., Lin, C. M., Liu, Q., & Huang, L. (2017) · Advanced Drug Delivery Reviews · doi:10.1016/j.addr.2017.06.003 · Cited by 178 · see citing works

Co-delivery of all-trans-retinoic acid and doxorubicin for cancer therapy with synergistic inhibition of cancer stem cells

Sun, R., Liu, Y., Li, S.-Y., Shen, S., Du, X.-J., Xu, C.-F., Cao, Z.-T., Bao, Y., Zhu, Y.-H., Li, Y.-P., et al. (2015) · Biomaterials · doi:10.1016/j.biomaterials.2014.10.018 · Cited by 172 · see citing works

Arsenic targets Pin1 and cooperates with retinoic acid to inhibit cancer-driving pathways and tumor-initiating cells

Kozono, S., Lin, Y.-M., Seo, H.-S., Pinch, B., Lian, X., Qiu, C., Herbert, M. K., Chen, C.-H., Tan, L., Gao, Z. J., et al. (2018) · Nature Communications · doi:10.1038/s41467-018-05402-2 · Cited by 168 · see citing works

3D Bioprinting of Breast Cancer Models for Drug Resistance Study

Wang, Y., Shi, W., Kuss, M., Mirza, S., Qi, D., Krasnoslobodtsev, A., Zeng, J., Band, H., Band, V., & Duan, B. (2018) · ACS Biomaterials Science & Engineering · doi:10.1021/acsbiomaterials.8b01277 · Cited by 157 · see citing works

Elimination of human lung cancer stem cells through targeting of the stem cell factor–c-kit autocrine signaling loop

Levina, V., Marrangoni, A., Wang, T., Parikh, S., Su, Y., Herberman, R., Lokshin, A., & Gorelik, E. (2010) · Cancer Research · doi:10.1158/0008-5472.can-09-1102 · Cited by 155 · see citing works

Lung cancer stem cells—Origin, characteristics and therapy

Prabavathy, D., Swarnalatha, Y., & Ramadoss, N. (2018) · Stem Cell Investigation · doi:10.21037/sci.2018.02.01 · Cited by 125 · see citing works

Phase IB Trial of the Anti‐Cancer Stem Cell DLL4‐Binding Agent Demcizumab with Pemetrexed and Carboplatin as First‐Line Treatment of Metastatic Non‐Squamous NSCLC

McKeage, M. J., Kotasek, D., Markman, B., Hidalgo, M., Millward, M. J., Jameson, M. B., Harris, D. L., Stagg, R. J., Kapoun, A. M., Xu, L., et al. (2018) · Targeted Oncology · doi:10.1007/s11523-017-0543-0 · Cited by 74 · see citing works

Echinomycin protects mice against relapsed acute myeloid leukemia without adverse effect on hematopoietic stem cells

Wang, Y., Liu, Y., Tang, F., Bernot, K. M., Schore, R., Marcucci, G., Caligiuri, M. A., Zheng, P., & Liu, Y. (2014) · Blood · doi:10.1182/blood-2013-12-544221 · Cited by 69 · see citing works

Highly sensitive profiling of CD44+/CD24− breast cancer stem cells by combining global mRNA amplification and next generation sequencing: Evidence for a hyperactive PI3K pathway

Hardt, O., Wild, S., Oerlecke, I., Hofmann, K., Luo, S., Wiencek, Y., Kantelhardt, E., Vess, C., Smith, G. P., Schroth, G. P., et al. (2012) · Cancer Letters · doi:10.1016/j.canlet.2012.06.010 · Cited by 64 · see citing works

Heterogeneity in tumor chromatin-doxorubicin binding revealed by in vivo fluorescence lifetime imaging confocal endomicroscopy

Sparks, H., Kondo, H., Hooper, S., Munro, I., Kennedy, G., Dunsby, C., French, P., & Sahai, E. (2018) · Nature Communications · doi:10.1038/s41467-018-04820-6 · Cited by 54 · see citing works

Polymer Thin Film-Induced Tumor Spheroids Acquire Cancer Stem Cell-like Properties

Choi, M., Yu, S. J., Choi, Y., Lee, H. R., Lee, E., Lee, E., Lee, Y., Song, J., Son, J. G., Lee, T. G., et al. (2018) · Cancer Research · doi:10.1158/0008-5472.can-18-0927 · Cited by 32 · see citing works

Oncogenic PITX2 facilitates tumor cell drug resistance by inverse regulation of hOCT3/SLC22A3 and ABC drug transporters in colon and kidney cancers

Lee, W.-K., & Thévenod, F. (2019) · Cancer Letters · doi:10.1016/j.canlet.2019.01.044 · Cited by 28 · see citing works

PTEN in Regulating Hematopoiesis and Leukemogenesis

Wu, Y., Zhu, H., & Wu, H. (2020) · Cold Spring Harbor Perspectives in Medicine · doi:10.1101/cshperspect.a036244 · Cited by 22 · see citing works

Ecdysteroid derivatives that reverse P-glycoprotein-mediated drug resistance

Bortolozzi, R., Luraghi, A., Mattiuzzo, E., Sacchetti, A., Silvani, A., & Viola, G. (2020) · Journal of Natural Products · doi:10.1021/acs.jnatprod.0c00334 · Cited by 21 · see citing works

Multiscale Framework for Imaging Radiolabeled Therapeutics

Natarajan, A., Türkcan, S., Gambhir, S. S., & Pratx, G. (2015) · Molecular Pharmaceutics · doi:10.1021/acs.molpharmaceut.5b00392 · Cited by 19 · see citing works

A comparative study of bone marrow and peripheral blood CD34⁺ myeloblasts in acute myeloid leukaemia

Cheung, A. M. S., Chow, H. C. H., Liang, R., & Leung, A. Y. H. (2009) · British Journal of Haematology · doi:10.1111/j.1365-2141.2008.07431.x · Cited by 13 · see citing works

Network spectra for drug-target identification in complex diseases: new guns against old foes

Rai, A., Shinde, P., & Jalan, S. (2018) · Applied Network Science · doi:10.1007/s41109-018-0107-y · Cited by 12 · see citing works

Mechanisms of resistance to anticancer drugs: the role of the polymorphic ABC transporters ABCB1 and ABCG2

Lepper, E. R., Nooter, K., Verweij, J., Acharya, M. R., Figg, W. D., & Sparreboom, A. (2005) · Pharmacogenomics · doi:10.1517/14622416.6.2.115 · Cited by 123 · see citing works

ABC Transporter-Mediated Multidrug-Resistant Cancer

Amawi, H. A., Sim, H., Tiwari, A. K., Ambudkar, S. V., & Shukla, S. (2019) · Advances in experimental medicine and biology · doi:10.1007/978-981-13-7647-4_12 · Cited by 232 · see citing works

Effect of β-elemene on the kinetics of intracellular transport of d-luciferin potassium salt (ABC substrate) in doxorubicin-resistant breast cancer cells and the associated molecular mechanism

Tang, C., Zhu, L., Yu, J., et al. (2018) · European Journal of Pharmaceutical Sciences · doi:10.1016/j.ejps.2018.04.037 · Cited by 32 · see citing works

Modulation of Expression and Activity of ABC Transporters by the Phytoestrogen Genistein. Impact on Drug Disposition

Rigalli, J. P., Ciriaci, N., Mottino, A. D., Catania, V. A., & Ruiz, M. L. (2016) · Current Medicinal Chemistry · doi:10.2174/0929867323666160406120711 · Cited by 11 · see citing works

Interplay of Drug Metabolizing CYP450 Enzymes and ABC Transporters in the Blood-Brain Barrier

Declèves, X., Jacob, A., Yousif, S. H., et al. (2011) · Current Drug Metabolism · doi:10.2174/138920011798357024 · Cited by 98 · see citing works