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Measuring the lung function in the mouse: the challenge of size
Open accessAbstract
Measurement of the effects of drugs, mediators and infectious agents on various models of lung disease, as well as assessment of lung function in the intact mouse has the potential for significantly advancing our knowledge of lung disease. However, the small size of the mouse presents significant challenges for the assessment of lung function. Because of compromises made between precision and noninvasiveness, data obtained may have an uncertain bearing on the mechanical response of the lung. Nevertheless, considerable recent progress has been made in developing valid and useful measures of mouse lung function. These advances, resulting in our current ability to measure sophisticated indices of lung function in laboratory animals, are likely to lead to important insights into the mechanisms of lung disease.
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Cited by
Jenkins, R. G., Moore, B. B., Chambers, R. C., Eickelberg, O., Königshoff, M., Kolb, M., Laurent, G. J., Nanthakumar, C. B., Olman, M. A., Pardo, A., et al. (2017) · American Journal of Respiratory Cell and Molecular Biology · doi:10.1165/rcmb.2017-0096st · Cited by 435
The Cellular and Physiological Basis for Lung Repair and Regeneration: Past, Present, and Future
Basil, M. C., Katzen, J., Engler, A. E., Guo, M., Herriges, M. J., Kathiriya, J. J., Windmueller, R., Ysasi, A. B., Zacharias, W. J., Chapman, H. A., et al. (2020) · Cell Stem Cell · doi:10.1016/j.stem.2020.03.009 · Cited by 414
SIRT1 protects against emphysema via FOXO3-mediated reduction of premature senescence in mice
Yao, H., Chung, S., Hwang, J.-W., Rajendrasozhan, S., Sundar, I. K., Dean, D. A., McBurney, M. W., Guarente, L., Gu, W., Rönty, M., et al. (2012) · Journal of Clinical Investigation · doi:10.1172/jci60132 · Cited by 358
Vitamin D Deficiency Causes Deficits in Lung Function and Alters Lung Structure
Zosky, G. R., Berry, L. J., Elliot, J. G., James, A. L., Gorman, S., & Hart, P. H. (2011) · American Journal of Respiratory and Critical Care Medicine · doi:10.1164/rccm.201010-1596oc · Cited by 334
Vanoirbeek, J. A. J., Rinaldi, M., De Vooght, V., Haenen, S., Bobic, S., Gayan-Ramirez, G., Hoet, P. H. M., Verbeken, E., Decramer, M., Nemery, B., et al. (2010) · American Journal of Respiratory Cell and Molecular Biology · doi:10.1165/rcmb.2008-0487oc · Cited by 320
Metadata
- Authors
- Irvin, C. G., & Bates, J. H.
- Venue
- Respiratory Research
- Published
- 2003-05-15
- Volume
- 4
- Issue
- 1
- Pages
- 4-4
- ISSN
- 1465-9921 (ISSN-L)
- 1465-993X
- OpenAlex
- W2117839847
- Cited by
- 407
- References
- 0
- FWCI
- 6.78
- Type
- journal article
- Language
- en
- Open access
- gold
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- Irvin, C. G., & Bates, J. H. (2003). Measuring the lung function in the mouse: the challenge of size. Respiratory Research. https://doi.org/10.1186/rr199
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Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
