The DOI matches its Crossref record; 39 of the 39 references it cites were found in a registry or an index.
Vitamin D Deficiency Causes Deficits in Lung Function and Alters Lung Structure
Open accessAbstract
RATIONALE: The prevalence of vitamin D deficiency is increasing and has been linked to obstructive lung diseases including asthma and chronic obstructive pulmonary disease. Recent studies suggest that vitamin D deficiency is associated with reduced lung function. The relationship between vitamin D deficiency and lung function is confounded by the association between physical activity levels and vitamin D status. Thus, causal data confirming a relationship between vitamin D and lung function are lacking. OBJECTIVES: To determine if vitamin D deficiency alters lung structure and function. METHODS: A physiologically relevant BALB/c mouse model of vitamin D deficiency was developed by dietary manipulation. Offspring from deficient and replete colonies of mice were studied for somatic growth, lung function, and lung structure at 2 weeks of age. MEASUREMENTS AND MAIN RESULTS: Lung volume and function were measured by plethysmography and the forced oscillation technique, respectively. Lung structure was assessed histologically. Vitamin D deficiency did not alter somatic growth but decreased lung volume. There were corresponding deficits in lung function that could not be entirely explained by lung volume. The volume dependence of lung mechanics was altered by deficiency suggesting altered tissue structure. However, the primary histologic difference between groups was lung size rather than an alteration in architecture. CONCLUSIONS: Vitamin D deficiency causes deficits in lung function that are primarily explained by differences in lung volume. This study is the first to provide direct mechanistic evidence linking vitamin D deficiency and lung development, which may explain the association between obstructive lung disease and vitamin D status.
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Cites
Holick, M. F. (2007) · New England Journal of Medicine · doi:10.1056/nejmra070553 · Cited by 13,720
Yoshizawa, T., Handa, Y., Uematsu, Y., Takeda, S., Sekine, K., Yoshihara, Y., Kawakami, T., Arioka, K., Sato, H., Uchiyama, Y., et al. (1997) · Nature Genetics · doi:10.1038/ng0897-391 · Cited by 1,177
Demographic Differences and Trends of Vitamin D Insufficiency in the US Population, 1988-2004
Ginde, A. A., Liu, M. C., & Camargo, C. A. (2009) · Archives of Internal Medicine · doi:10.1001/archinternmed.2008.604 · Cited by 1,120
Hsia, C. C. W., Hyde, D. M., Ochs, M., & Weibel, E. R. (2010) · American Journal of Respiratory and Critical Care Medicine · doi:10.1164/rccm.200809-1522st · Cited by 902
Maternal intake of vitamin D during pregnancy and risk of recurrent wheeze in children at 3 y of age
Camargo, C. A., Rifas-Shiman, S. L., Litonjua, A. A., Rich-Edwards, J. W., Weiss, S. T., Gold, D. R., Kleinman, K., & Gillman, M. W. (2007) · The American Journal of Clinical Nutrition · doi:10.1093/ajcn/85.3.788 · Cited by 676
Panda, D. K., Miao, D., Tremblay, M. L., Sirois, J., Farookhi, R., Hendy, G. N., & Goltzman, D. (2001) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.131029498 · Cited by 641
Serum Vitamin D Levels and Markers of Severity of Childhood Asthma in Costa Rica
Brehm, J. M., Celedón, J. C., Soto-Quiros, M. E., Avila, L., Hunninghake, G. M., Forno, E., Laskey, D., Sylvia, J. S., Hollis, B. W., Weiss, S. T., et al. (2009) · American Journal of Respiratory and Critical Care Medicine · doi:10.1164/rccm.200808-1361oc · Cited by 636
Mathieu, C., Gysemans, C., Giulietti, A., & Bouillon, R. (2005) · Diabetologia · doi:10.1007/s00125-005-1802-7 · Cited by 612
Black, P. N., & Scragg, R. (2005) · Chest · doi:10.1378/chest.128.6.3792 · Cited by 598
Maternal vitamin D intake during pregnancy and early childhood wheezing
Devereux, G., Litonjua, A. A., Turner, S. W., Craig, L. C., McNeill, G., Martindale, S., Helms, P. J., Seaton, A., & Weiss, S. T. (2007) · The American Journal of Clinical Nutrition · doi:10.1093/ajcn/85.3.853 · Cited by 581
Cited by
Modulation of the immune system by UV radiation: More than just the effects of vitamin D?
Hart, P. H., Gorman, S., & Finlay-Jones, J. J. (2011) · Nature Reviews Immunology · doi:10.1038/nri3045 · Cited by 465
Self-citationEarly lung development: lifelong effect on respiratory health and disease
Stocks, J., Hislop, A., & Sonnappa, S. (2013) · The Lancet Respiratory Medicine · doi:10.1016/s2213-2600(13)70118-8 · Cited by 390
Raiten, D. J., Ashour, F. A. S., Ross, A. C., Meydani, S. N., Dawson, H. D., Stephensen, C. B., Brabin, B. J., Suchdev, P. S., & van Ommen, B. (2015) · The Journal of Nutrition · doi:10.3945/jn.114.194571 · Cited by 234
Maternal vitamin D levels and the autism phenotype among offspring
Whitehouse, A. J. O., Holt, B. J., Serralha, M., Holt, P. G., Hart, P. H., & Kusel, M. M. H. (2013) · Journal of Autism and Developmental Disorders · doi:10.1007/s10803-012-1676-8 · Cited by 100
Self-citationHussien, N. I., El-kerdasy, H. I., Sorour, S. M., & Shoman, A. A. (2022) · Archives of Physiology and Biochemistry · doi:10.1080/13813455.2019.1676262 · Cited by 11
Metadata
- Authors
- Zosky, G. R., Berry, L. J., Elliot, J. G., James, A. L., Gorman, S., & Hart, P. H.
- Venue
- American Journal of Respiratory and Critical Care Medicine
- Publisher
- Oxford University Press (OUP)
- Published
- 2011-05-15
- Volume
- 183
- Issue
- 10
- Pages
- 1336-1343
- ISSN
- 1073-449X (ISSN-L)
- 1535-4970
- OpenAlex
- W2097467471
- Cited by
- 334
- References
- 39
- FWCI
- 22.61
- Type
- journal article
- Language
- en
- Open access
- green
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