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Cited by 74Sleep and related disordersSleep and Wakefulness ResearchGenetic Syndromes and Imprinting

The DOI matches its Crossref record; 67 of the 67 references it cites were found in a registry or an index.

A cross-syndrome cohort comparison of sleep disturbance in children with Smith-Magenis syndrome, Angelman syndrome, autism spectrum disorder and tuberous sclerosis complex

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Trickett, J., Heald, M., Oliver, C., Richards, C.·2018·Journal of Neurodevelopmental Disorders
DOI 10.1186/s11689-018-9226-0PMC PMC5831859
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Abstract

BACKGROUND: Sleep disturbance is common in children with neurodevelopmental disorders, with high rates identified in children with Smith-Magenis syndrome (SMS), Angelman syndrome (AS), autism spectrum disorder (ASD) and tuberous sclerosis complex (TSC). Phenotypic sleep profiles for these groups may implicate different pathways to sleep disturbance. At present, cross-group comparisons that might elucidate putative phenotypic sleep characteristics are limited by measurement differences between studies. In this study, a standardised questionnaire was administered across groups affording comparison of the prevalence and profile of sleep disturbance between groups and contrast to chronologically age-matched typically developing (TD) peers. METHODS: The modified version of Simonds and Parraga's sleep questionnaire, adapted for use in children with intellectual disabilities, was employed to assess sleep disturbance profiles in children aged 2-15 years with SMS (n = 26), AS (n = 70), ASD (n = 30), TSC (n = 20) and a TD contrast group (n = 47). Associations between sleep disturbance and age, obesity, health conditions and overactivity/impulsivity were explored for each neurodevelopmental disorder group. RESULTS: Children with SMS displayed severe night waking (81%) and early morning waking (73%). In contrast, children with ASD experienced difficulties with sleep onset (30%) and sleep maintenance (43%). Fewer children with ASD (43%) and AS (46%) experienced severe night waking compared to children with SMS (both p < .01). Higher sleep-disordered breathing scores were identified for children with SMS (p < .001) and AS (p < .001) compared to the TD group. Sleep disturbance in children with AS and TSC was associated with poorer health. Children experiencing symptoms indicative of gastro-oesophageal reflux had significantly higher sleep-disordered breathing scores in the AS, SMS and ASD groups (all p < .01). A number of associations between overactivity, impulsivity, gastro-oesophageal reflux, age and sleep disturbance were found for certain groups. CONCLUSIONS: These data reveal syndrome-specific profiles of sleep disturbance. The divergent associations between sleep parameters and person characteristics, specifically symptoms of gastro-oesophageal reflux, overactivity and impulsivity and age, implicate aetiology-specific mechanisms underpinning sleep disturbance. The differences in prevalence, severity and mechanisms implicated in sleep disturbance between groups support a syndrome-sensitive approach to assessment and treatment of sleep disturbance in children with neurodevelopmental disorders.

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  • ASD children with gastroesophageal reflux have higher comorbidity with sleep disorders.

    “ASD children with gastroesophageal reflux, which is also associated with GI discomfort, have higher comorbidity with sleep disorders 30.”

    From Gastrointestinal Issues and Autism Spectrum Disorder (2020) · cites this paper as [30]

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Research works printed but not linked: 2

  1. Oliver C, Wilkie L. Gastro-oesophageal Distress Questionnaire. Birmingham: University of Birmingham; 2005.
  2. Oliver C, Wilde L, Eden K. Pain in children with severe intellectual disability: a guide for parents. 2015.

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Metadata

Authors
Trickett, J., Heald, M., Oliver, C., & Richards, C.
Affiliations
  • University of Leicester (GB)
  • University of Birmingham (GB)
Corresponding author
Trickett, J.
ORCID
Venue
Journal of Neurodevelopmental Disorders
Publisher
Springer Science and Business Media LLC
Published
2018-03-01
Volume
10
Issue
1
Pages
9-9
ISSN
  • 1866-1947 (ISSN-L)
  • 1866-1955
DOI
10.1186/s11689-018-9226-0
PMC
PMC5831859
OpenAlex
W2793962042
Cited by
74
References
67
Citations by year
2026: 2 · 2025: 2 · 2024: 10 · 2023: 11 · 2022: 16 · 2021: 13 · 2020: 9 · 2019: 7 · 2018: 4
FWCI
10.80
Type
journal article
Language
en
Open access
Licence
cc-by
Locations
  • Journal of Neurodevelopmental Disorders (publishedVersion, cc-by)
  • Europe PMC (PubMed Central) (publishedVersion, cc-by)
  • PubMed Central (publishedVersion, cc-by)
  • PubMed (publishedVersion)
  • DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion, cc-by-sa)
  • Figshare (submittedVersion, cc-by)
  • Leicester Research Archive (University of Leicester) (submittedVersion, cc-by)
  • University of Birmingham Research Portal (University of Birmingham) (submittedVersion, cc-by)
Funders
Cerebra
Topics
  • Social Sciences › Psychology › Experimental and Cognitive Psychology › Sleep and related disorders
  • Life Sciences › Neuroscience › Cognitive Neuroscience › Sleep and Wakefulness Research
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Genetics › Genetic Syndromes and Imprinting
Keywords
sleep disorders, Smith-Magenis syndrome, Angelman syndrome, autism spectrum disorder, tuberous sclerosis complex, neurodevelopmental disorders, nocturnal awakenings, sleep onset difficulty, sleep maintenance, sleep-disordered breathing, gastroesophageal reflux, obesity, typically developing children, sleep questionnaires, children with intellectual disabilities, age differences in sleep
MeSH terms
Autism Spectrum Disorder, Child, Female, Humans, Male, Surveys and Questionnaires, Sleep Wake Disorders, Tuberous Sclerosis, Cohort Studies, Angelman Syndrome, Smith-Magenis Syndrome

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