The DOI matches its Crossref record; 305 of the 305 references it cites were found in a registry or an index.
Aquatic ecotoxicity of glyphosate, its formulations, and co-formulants: evidence from 2010 to 2023
Open accessAbstract
Glyphosate (GLY), the most widely used herbicide active ingredient (AI) in the world, is frequently detected in aquatic environments where it can affect non-target organisms. Globally, more than 2000 commercial GLY-based herbicides (GBHs) are used to control weeds. Non-target organisms are exposed to complex pesticide formulations under real environmental conditions, but the co-formulants contained in GBHs are classified as so-called inert and inactive ingredients in terms of their biological effects. The main objective of this comprehensive review is to compile the results of aquatic ecotoxicological studies on the side-effects of GLY, GBHs, and their formulating agents. Based on the results demonstrated for a variety of plant and animal aquatic organisms, oxidative stress appears to be a major trigger for these adverse effects, affecting the integrity of DNA and other biochemical functions. Furthermore, there is evidence of impairment of various physiological and behavioral functions. Adverse effects of GLY and GBHs have been observed even at very low concentrations. There are also differences in the sensitivity of the aquatic organisms tested, even with similar lifestyles, habitats or identical taxa. The studies typically investigate the short-term effects of a single exposure to GLY/GBH on a single species, whilst in reality multiple applications of GBHs together with other pesticides are common during a cropping cycle. Moreover, the interactions between GLY/GBHs and other aquatic contaminants are rarely studied. Higher toxicity of GBHs compared to GLY alone has often been observed, demonstrating that co-formulants can be highly toxic on their own and markedly increase the toxicity of the GBH formulation. The possible impurities in GBHs, such as heavy metals, can cause additional problems for the environment and food safety. The widespread and massive use of GBHs leads to increased exposure and environmental hazards. In addition, the need for a revision of the risk assessment system is emphasized. According to the results of aquatic ecotoxicological studies, the current use and pollution of the aquatic environment by GLY/GBHs is highly problematic and cannot be considered environmentally sustainable. It is, therefore, necessary to at least tighten the permitted forms of use.
Overview
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Integrity signals
Registry
Cites
Statistics
Verification
Claims the paper makes
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
The source backs part of the claim, not all of it — or backs it for a different population, condition or comparison.
In the citing paper
“The absence of long-term biodiversity records for taxonomic groups heavily impacted by pesticides, such as insects and microbes, hinders a full understanding of GMcrop management's effects on biodiversity ( 121 -124 )”
From Environmental impacts of genetically modified crops (2024) · cites this paper as [123]
Experimental — accuracy not yet measured
Self-check
Percentages, sums and reported differences re-computed from the paper’s own numbers.
The self-check needs the paper’s full text.
Citations
Cites
Flemming, H.-C., & Wingender, J. (2010) · Nature Reviews Microbiology · doi:10.1038/nrmicro2415 · Cited by 10,137
An international database for pesticide risk assessments and management
Lewis, K. A., Tzilivakis, J., Warner, D., & Green, A. (2016) · Human and Ecological Risk Assessment An International Journal · doi:10.1080/10807039.2015.1133242 · Cited by 2,068
Trends in glyphosate herbicide use in the United States and globally
Benbrook, C. M. (2016) · Environmental Sciences Europe · doi:10.1186/s12302-016-0070-0 · Cited by 1,890
Glyphosate: a once‐in‐a‐century herbicide
Duke, S. O., & Powles, S. B. (2008) · Pest Management Science · doi:10.1002/ps.1518 · Cited by 1,821
Biofilm exopolysaccharides: a strong and sticky framework
Sutherland, I. W. (2001) · Microbiology · doi:10.1099/00221287-147-1-3 · Cited by 1,807
Herrmann, K. M., & Weaver, L. M. (1999) · Annual Review of Plant Physiology and Plant Molecular Biology · doi:10.1146/annurev.arplant.50.1.473 · Cited by 1,343
Ecotoxicological Risk Assessment for Roundup® Herbicide
Giesy, J. P., Dobson, S., & Solomon, K. R. (2000) · Reviews of Environmental Contamination and Toxicology · doi:10.1007/978-1-4612-1156-3_2 · Cited by 912
(PPR), E. P. O. P. P. P. A. T. R. (2013) · EFSA Journal · doi:10.2903/j.efsa.2013.3290 · Cited by 762
Fate of glyphosate in soil and the possibility of leaching to ground and surface waters: a review.
Borggaard, O., & Gimsing, A. (2008) · Pest Management Science · doi:10.1002/ps.1512 · Cited by 734
Tsui, M. T., & Chu, L. M. (2003) · Chemosphere · doi:10.1016/s0045-6535(03)00306-0 · Cited by 630
Research works printed but not linked: 10
- Swanson N, Leu A, Abrahamson J, Wallet B (2014) Genetically engineered crops, glyphosate and the deterioration of health in the United States of America. J Org Syst 9:6–37
- Zgurzynski MI, Lushington GH (2019) Glyphosate impact on Apis mellifera navigation: a combined behavioral and cheminformatics study. Pharmacol Toxicol 7:806–824
- Huhn C (2018) More and enhanced glyphosate analysis is needed. Anal Bioanal Chem 410:3041–3045. https://doi.org/10.1007/s00216-018-1000-3.49 · DOI
- Characklis WG, Marshall KC (1990) Physiological ecology in biofilm systems. In: Characklis WG, Marshall KC (eds) Biofilms. John Wiley & Sons, New York, pp 341–394
- MacBean C (2012) The pesticide manual, 16th edn. The British Crop Protection Council, Brighton
- Sobrero C, Martin M, Ronco A (2007) Fitotoxicidad del herbicida Roundup® Max sobre la especie no blanco Lemna gibba en estudios de campo y laboratorio. Hidrobiológica 17:31–39 (ISSN 0188-8897)
- Diagonel G, Carriel O, de Campos OR, Boas K, Branco C (2022) Effect of glyphosate-based herbicides on the photosynthetic responses of the macrophyte Egeria densa Planch. from topical lotic ecosystems. Limnetica 41:73–84. https://doi.org/10.23818/limn.23841.23806 · DOI
- Hyman LH (1940) The invertebrates. IV. Echinodermata. McGraw-Hill, New York, pp 22–43
- PAN Europe (2023) Glyphosate in the EU up to 2034? Danger to health and environment and violation of citizens will. https://www.pan-europe.info/press-releases/2023/09/glyphosate-eu-2034-danger-health-and-environment-and-violation-citizens-will. Accessed 14 Jan 2024
- Lopes AR, Moraes JS, Martins CMG (2022) Effects of the herbicide glyphosate on fish from embryos to adults: a review addressing behavior patterns and mechanisms behind them. Aquat Toxicol 251:106281. https://doi.org/10.1016/j.aquatox.2022 · DOI
Cited by
Sorted by citations
Bănăduc, D., Curtean–Bănăduc, A., Barinova, S. S., Lozano, V. L., Afanasyev, S. A., Leite, T., Branco, P., Isaza, D. F. G., Geist, J. P., Tegos, A., et al. (2024) · Water · doi:10.3390/w16111483 · Cited by 100
Environmental impacts of genetically modified crops
Noack, F., Engist, D., Gantois, J., Gaur, V., Hyjazie, B. F., Larsen, A., M’Gonigle, L. K., Missirian, A., Qaim, M., Sargent, R. D., et al. (2024) · Science · doi:10.1126/science.ado9340 · Cited by 70
Klátyik, S., Simon, G., Takács, E., Oláh, M., Zaller, J. G., Antoniou, M. N., Benbrook, C., Mesnage, R., & Székács, A. (2025) · Archives of Toxicology · doi:10.1007/s00204-025-04076-2 · Cited by 45
Self-citationBirolli, W. G., Lanças, F. M., Santos‐Neto, Á. J., & Silveira, H. C. S. (2024) · Frontiers in Public Health · doi:10.3389/fpubh.2024.1336014 · Cited by 29
Glyphosate lessons: is biodegradation of pesticides a harmless process for biodiversity?
Lozano, V. L., & Pizarro, H. N. (2024) · Environmental Sciences Europe · doi:10.1186/s12302-024-00884-y · Cited by 17
Metadata
- Authors
- Klátyik, S., Simon, G., Oláh, M., Takács, E., Mesnage, R., Antoniou, M. N., Zaller, J. G., & Székács, A.
- Affiliations
- Magyar Agrár- és Élettudományi Egyetem (HU)
- Guy's Hospital (GB)
- BOKU University (AT)
- Corresponding author
- Zaller, Johann G.
- ORCID
- Venue
- Environmental Sciences Europe
- Published
- 2024-02-06
- Volume
- 36
- Issue
- 1
- ISSN
- 2190-4715 (ISSN-L)
- OpenAlex
- W4391561638
- Cited by
- 80
- References
- 305
- Citations by year
- 2026: 40 · 2025: 24 · 2024: 16
- FWCI
- 7.91
- Type
- journal article
- Language
- en
- Open access
- gold
- doi.org
- Locations
- Environmental Sciences Europe (publishedVersion, cc-by)
- DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion)
- Funders
- Erasmus+ project Hort4EUGreen (2020-1-RO01-KA203-080398)
- University of Natural Resources and Life Sciences Vienna
- Topics
- Physical Sciences › Environmental Science › Pollution › Pesticide and Herbicide Environmental Studies
- Physical Sciences › Environmental Science › Health, Toxicology and Mutagenesis › Environmental Toxicology and Ecotoxicology
- Life Sciences › Pharmacology, Toxicology and Pharmaceutics › Toxicology › Pesticide Exposure and Toxicity
- Keywords
- glyphosate, herbicide formulation, co-formulants, aquatic toxicity, oxidative stress, DNA damage, non-target organisms, herbicide mixtures, heavy metal impurities, pesticide risk assessment, water pollution
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
