The DOI matches its Crossref record; 3 of the 3 references it cites were found in a registry or an index.
Antiangiogenic and antiapoptotic effects of green-synthesized zinc oxide nanoparticles using Sargassum muticum algae extraction
Open accessAbstract
BACKGROUND: Algae are one of the natural materials used to green synthesis of nanoparticles. This method leads to minimize the toxicity of the chemical materials used to nanoparticle synthesis. METHODS: algae extraction used to evaluate its cytotoxicity and apoptotic properties on human liver cancer cell line (HepG2). RESULTS: Trypan blue assay results demonstrate a concentration-dependent decrease in cell viability and MTT assay shows increased growth inhibition in time and dose-dependent manner. In addition, CAM assay confirmed the ability of ZnO NPs to inhibit angiogenesis, but chick morphology (both the CR and weight) was not changed. Apoptotic tests (annexin V/PI and AO/PI) show that green-synthesized ZnO NPs induce apoptosis in all three time points (24, 48 and 72h). CONCLUSIONS: Our results confirm the beneficial cytotoxic effects of green-synthesized ZnO NPs on Human liver cancer cell. This nanoparticle decreased angiogenesis and induces apoptosis, so we conclude that these nanoparticles can be used as a supplemental drug in cancer treatments.
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Siegel, R. L., Miller, K. D., & Jemal, A. (2017) · CA: A Cancer Journal for Clinicians · doi:10.3322/caac.21387 · Cited by 14,712
Martin, S. J., Reutelingsperger, C. P., McGahon, A. J., Rader, J. A., van Schie, R. C., LaFace, D. M., & Green, D. R. (1995) · The Journal of experimental medicine · doi:10.1084/jem.182.5.1545 · Cited by 2,824
Milledge, J. J., Nielsen, B. V., & Bailey, D. (2016) · Reviews in Environmental Science and Bio/Technology · doi:10.1007/s11157-015-9381-7 · Cited by 193
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Nguyen, D. D., & Lai, J.-Y. (2022) · Chemical Engineering Journal · doi:10.1016/j.cej.2022.134970 · Cited by 178
Metadata
- Authors
- Sanaeimehr, Z., Javadi, I., & Namvar, F.
- Venue
- Cancer Nanotechnology
- Published
- 2018-04-02
- Volume
- 9
- Issue
- 1
- Pages
- 3-3
- ISSN
- 1868-6958 (ISSN-L)
- 1868-6966
- OpenAlex
- W2797469574
- Cited by
- 257
- References
- 3
- FWCI
- 8.49
- Type
- journal article
- Language
- en
- Open access
- gold
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- Sanaeimehr, Z., Javadi, I., & Namvar, F. (2018). Antiangiogenic and antiapoptotic effects of green-synthesized zinc oxide nanoparticles using Sargassum muticum algae extraction. Cancer Nanotechnology. https://doi.org/10.1186/s12645-018-0037-5
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