The challenges of explainable AI in biomedical data science
Open accessAbstract
With the surge of biomedical data science, more and more AI techniques are employed to discover knowledge, unveil latent data behavior, generate new insight, and seek optimal strategies in decision making.Different AI methods have been proposed and developed in almost all different biomedical data science fields that range from drug discovery, electronic medical records (EMRs) data automation, single-cell RNA sequencing, early disease diagnosis, COVID research, and healthcare analytics.The AI methods and systems also generate a massive amount of data or big data that not only bring unpreceded progress in biomedical fields but also new challenges for AI.One of the key challenges should be the explainability of AI in biomedical data science problem-solving.It refers to that an AI method or system should not only bring good results but also have good interpretability, i.e., let users know why this way is the optimal one rather than the others.The existing AI methods employed in biomedical data science generally lack good explainability and may not create trustworthiness and transparency in usage well.For example, a deep learning model may bring good accuracy in disease diagnosis by analyzing corresponding bioimages, but it can be hard to explain well about the setting of thousands of parameters in the model.It can be possible that some small perturbations of the parameters may generate totally different learning results and challenge the robustness and stability of the deep learning model.Since AI models cannot explain themselves well, it is likely to encounter a high risk to make an incorrect decision making and decrease its trustworthiness and reliability, even if it has the advantage in accuracy, speed, or complicate data relationship revealing.On the other hand, the AI interpretation issue has been raised almost ten years ago in some subfield of biomedical data science such as bioinformatics.For instance, bioinformaticians found that the gene markers or network markers recommended from an AI disease diagnosis system may not explain themselves, i.e., the identified markers not only cannot apply themselves well in clinical practice, but also those markers that do well in the clinical practice may not be recommended from the AI system [1].
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Studies show the feasibility of reidentifying anonymized data.
“Studies showing the feasibility of reidentifying anonymized data highlight the need for advanced data protection and anonymization methods.”
From Balancing Privacy and Progress: A Review of Privacy Challenges, Systemic Oversight, and Patient Perceptions in AI-Driven Healthcare (2024) · cites this paper as [37]
The involvement of major technology corporations like Google, Microsoft, and Apple in healthcare AI, requiring access to vast amounts of patient health data, amplifies privacy issues.
“The involvement of major technology corporations like Google, Microsoft, and Apple in healthcare AI, requiring access to vast amounts of patient health data, further amplifies these privacy issues.”
From Balancing Privacy and Progress: A Review of Privacy Challenges, Systemic Oversight, and Patient Perceptions in AI-Driven Healthcare (2024) · cites this paper as [37]
The deployment of AI in healthcare is marked by challenges like potential errors, biases, and opaque learning algorithms.
“The deployment of AI in healthcare, marked by challenges like potential errors, biases, and opaque learning algorithms, underscores the importance of tailored regulatory systems.”
From Balancing Privacy and Progress: A Review of Privacy Challenges, Systemic Oversight, and Patient Perceptions in AI-Driven Healthcare (2024) · cites this paper as [37]
Private corporations' control of patient health information in AI applications poses significant privacy risks, with instances of inadequate privacy protection.
“Furthermore, private corporations' control of patient health information in AI applications poses significant privacy risks, with instances of inadequate privacy protection calling for stringent regulation and oversight.”
From Balancing Privacy and Progress: A Review of Privacy Challenges, Systemic Oversight, and Patient Perceptions in AI-Driven Healthcare (2024) · cites this paper as [37]
The evolving nature of AI and algorithms introduces risks to the security of health information, even when anonymized.
“The evolving nature of AI and algorithms introduces risks to the security of health information, even when anonymized.”
From Balancing Privacy and Progress: A Review of Privacy Challenges, Systemic Oversight, and Patient Perceptions in AI-Driven Healthcare (2024) · cites this paper as [37]
As AI continues to promise significant improvements in health outcomes, its commercial implementation faces privacy challenges.
“As AI continues to promise significant improvements in health outcomes, its commercial implementation faces privacy challenges.”
From Balancing Privacy and Progress: A Review of Privacy Challenges, Systemic Oversight, and Patient Perceptions in AI-Driven Healthcare (2024) · cites this paper as [37]
Implementing commercial healthcare AI raises legal and ethical issues, including the necessity of patient consent and data protection.
“Implementing commercial healthcare AI raises several legal and ethical issues, including the necessity of patient consent and data protection.”
From Balancing Privacy and Progress: A Review of Privacy Challenges, Systemic Oversight, and Patient Perceptions in AI-Driven Healthcare (2024) · cites this paper as [37]
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- Authors
- Han, H., & Liu, X.
- Affiliations
- Baylor University (US)
- Xiamen University (CN)
- Corresponding author
- Han, Henry
- Venue
- BMC Bioinformatics
- Published
- 2021-12
- Volume
- 22
- Issue
- S12
- Pages
- 443-443
- ISSN
- 1471-2105 (ISSN-L)
- PMC
- PMC8772040
- OpenAlex
- W4205631037
- Cited by
- 59
- References
- 3
- Citations by year
- 2026: 5 · 2025: 11 · 2024: 17 · 2023: 15 · 2022: 11
- Type
- journal article
- Language
- en
- Open access
- gold
- doi.org
- Licence
- Locations
- BMC Bioinformatics (publishedVersion, cc-by)
- PubMed Central (publishedVersion, cc-by)
- PubMed (publishedVersion)
- DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion, cc-by-sa)
- Funders
- Baylor University
- Topics
- Physical Sciences › Computer Science › Artificial Intelligence › Explainable Artificial Intelligence (XAI)
- Health Sciences › Medicine › Health Informatics › Artificial Intelligence in Healthcare and Education
- Physical Sciences › Computer Science › Artificial Intelligence › Machine Learning in Healthcare
- Keywords
- explainable AI, interpretability, biomedical data science, deep learning interpretability, model robustness, trustworthiness, transparency, AI decision-making, disease diagnosis, bioinformatics
- MeSH terms
- Data Science, Artificial Intelligence, Delivery of Health Care
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