Parathyroidectomy improves cardiovascular risk factors in normocalcemic and hypercalcemic primary hyperparathyroidism
Open accessAbstract
BACKGROUND: Parathyroidectomy has ameliorated cardiovascular risk factors in patients with hypercalcemic primary hyperparathyroidism (PHPT), but the effect of parathyroidectomy on normocalcemic PHPT is not exactly known. This case-controlled study aimed to investigate the effect of parathyroidectomy on cardiovascular risk factors in patients with normocalcemic and hypercalcemic PHPT. METHODS: Subjects with normocalcemic PHPT (n = 35), age- and sex-matched hypercalcemic PHPT (n = 60) and age- and sex-matched control (n = 60) were included. Cardiometabolic disorders were investigated with traditional cardiometabolic risk factors and the Framingham cardiovascular risk score (CRS) before and 6 months after parathyroidectomy. RESULTS: Diabetes, dyslipidemia, hypertension, obesity, insulin resistance, osteoporosis, having fractures were similarly increased in the hypercalcemic and normocalcemic PHPT groups (p > 0.05) compared with the controls (p < 0.05). Blood pressures, glucose metabolism (glucose, insulin, HOMA-IR) and lipid profiles were similarly increased in the PHPT groups (p > 0.05) compared with the controls (p < 0.05). After parathyroidectomy, blood pressures, serum total cholesterol, and HOMA-IR were decreased in both PHPT groups (p < 0.05). CRS was lower in the controls (5.74 ± 3.24, p < 0.05). After parathyroidectomy, CRS was decreased in the normocalcemic (11.98 ± 10.11 vs. 7.37 ± 4.48) and hypercalcemic (14.62 ± 11.06 vs. 8.05 ± 7.72) PHPT groups. Increased blood pressures were independent predictors of serum iPTH. CONCLUSION: The normocalcemic and hypercalcemic PHPT groups had similarly increased cardiovascular risk factors, even independently of serum calcium. Parathyroidectomy ameliorated the increased cardiovascular risk factors in both normocalcemic and hypercalcemic PHPT.
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Evaluation and Management of Elevated Parathyroid Hormone Levels in Normocalcemic Patients
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Cano-Valderrama, Ó., Cámara, S. O., Sanabria, C., Familiar, C., Díaz, J., Picazo, S., Carlín, P. S., & Torres, A. J. (2021) · Updates in Surgery · doi:10.1007/s13304-021-01108-1 · Cited by 7 · see citing works
Cardiovascular Involvement in Primary Hyperparathyroidism
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Twenty-four hour Holter ECG in normocalcemic and hypercalcemic patients with hyperparathyroidism
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Factors associated with changes in echocardiographic parameters following kidney transplantation
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Surgery for Normocalcemic Hyperparathyroidism
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Normocalcemic primary hyperparathyroidism: an update
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“Несмотря на высокую распространенность, в настоящее время сопутствующая кардиоваскулярная патология, включая АГ, не входит в перечень показаний к хирургическому лечению ПГПТ, поскольку положительное влияние паратиреоидэктомии (ПТЭ) на состояние сердечно-сосудистой системы остается спорным [4, 6, 9, 28].”
Surgery for normocalcemic hyperparathyroidism is safe and effective
Frye, C. C., Song, Z., Balachandra, S., Swaminathan, N., Gillis, A., Fazendin, J. M., Lindeman, B. M., & Chen, H. (2025) · Surgery · doi:10.1016/j.surg.2025.109707 · Cited by 4 · see citing works
Parathyroidectomy and Cardiometabolic Risks in Patients With Primary Hyperparathyroidism
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Osteoporosis and Normocalcemic Primary Hyperparathyroidism (Conservatively or Surgically Managed)
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Normocalcemic primary hyperparathyroidism: an update
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Hypertension in thyroid disease and primary hyperparathyroidism
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Primary Hyperparathyroidism: An Analysis Amid the Co-Occurrence of Type 2 Diabetes Mellitus
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Unusual body weight loss due to primary hyperparathyroidism: A case study with literature review
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Corticosteroid rhythms in hypoparathyroid patients
Astor, M. C., Løvås, K., Methlie, P., Šimůnková, K., Aßmus, J., & Husebye, E. S. (2024) · European Journal of Endocrinology · doi:10.1093/ejendo/lvae102 · Cited by 2 · see citing works
Normocalcemic primary hyperparathyroidism is not associated with cardiometabolic alterations
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Association between inflammatory markers and primary hyperparathyroidism
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Humanidades ¿estudios culturales?
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Letter to editor: Primary hyperparathyroid surgery under local anesthesia: benefits of hypnosis
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Os et hyperparathyroïdie primaire
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Research Progress on the Effect of Primary Hyperparathyroidism on Cardiovascular System
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Primary Hyperparathyroidism: Evaluation and Current Management Guidelines
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Normocalcemic Hyperparathyroidism: Surgical Intervention Versus Continued Observation
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- Authors
- Beysel, S., Caliskan, M., Kizilgul, M., Apaydin, M., Kan, S., Ozbek, M., & Cakal, E.
- Affiliations
- Başkent University (TR)
- Dışkapı Yıldırım Beyazıt Eğitim ve Araştırma Hastanesi (TR)
- Corresponding author
- Beysel, Selvihan
- Venue
- BMC Cardiovascular Disorders
- Published
- 2019-05-08
- Volume
- 19
- Issue
- 1
- Pages
- 106-106
- ISSN
- 1471-2261 (ISSN-L)
- PMC
- PMC6505186
- OpenAlex
- W2947367046
- Cited by
- 95
- References
- 43
- Citations by year
- 2026: 11 · 2025: 9 · 2024: 9 · 2023: 21 · 2022: 8 · 2021: 20 · 2020: 15 · 2019: 1
- FWCI
- 8.50
- Type
- journal article
- Language
- en
- Open access
- gold
- doi.org
- Licence
- Locations
- BMC Cardiovascular Disorders (publishedVersion, cc-by)
- PubMed Central (publishedVersion, cc-by)
- PubMed (publishedVersion)
- DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion, cc-by-sa)
- Topics
- Health Sciences › Medicine › Nephrology › Parathyroid Disorders and Treatments
- Health Sciences › Medicine › Surgery › Thyroid and Parathyroid Surgery
- Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Hormonal Regulation and Hypertension
- Keywords
- parathyroidectomy, primary hyperparathyroidism, normocalcemic hyperparathyroidism, cardiovascular risk factors, Framingham risk score, insulin resistance, HOMA-IR, blood pressure, dyslipidemia, diabetes mellitus, hypertension, obesity, osteoporosis
- MeSH terms
- Adult, Calcium, Cardiovascular Diseases, Female, Humans, Hypercalcemia, Male, Middle Aged, Risk Factors, Biomarkers, Case-Control Studies, Parathyroidectomy, Treatment Outcome, Risk Assessment, Hyperparathyroidism, Primary
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