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Serum uric acid and risk of cardiovascular mortality: a systematic review and dose-response meta-analysis of cohort studies of over a million participants

Rahimi-Sakak, Fatemeh, Maroofi, Mahsa, Rahmani, Jamal, Bellissimo, Nick, Hekmatdoost, Azita·2019·BMC Cardiovascular Disorders
DOI 10.1186/s12872-019-1215-z
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Abstract

Background: Cardiovascular disease (CVD) is the leading cause of death worldwide. Some studies have suggested anassociation between serum uric acid levels and cardiovascular mortality; however, the results have not been summarized in a meta-analysis. Methods: A comprehensive search of all related studies until April 2018was performed in MEDLINE/PubMed and Scopus databases DerSimonianand Laird random-effects models were used to combine hazard ratios (HRs) with 95% confidence intervals (CIs). Dose-response analysis was also carried out. Results: Thirty-two studies containing forty-four arms with 1,134,073 participants reported association between uric acid and risk of CVD mortality were included in our analysis. Pooled results showed a significant positive association between uric acid levels and risk of CVD mortality (HR 1.45, 95% CI 1.33–1.58, I 2 = 79%). Sub-group analysis showed this relationshipwasstronger in women compared to men. Moreover, there was a significant non-linear association between uric acid levels and the risk of CVD mortality (r = 0.0709, p = 0.001). Conclusion: Our analysis indicates a positive dose-response association between SUA and CVD mortality risk.

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Cited by

Metadata

Authors
Rahimi-Sakak, F., Maroofi, M., Rahmani, J., Bellissimo, N., & Hekmatdoost, A.
Venue
BMC Cardiovascular Disorders
Publisher
Springer Science and Business Media LLC
Published
2019-10-15
Volume
19
Issue
1
ISSN
1471-2261
DOI
10.1186/s12872-019-1215-z
Cited by
130
References
0
Language
en
Licence
Funders
SBMU (1397/69621)

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