Cited by 127Gout, Hyperuricemia, Uric AcidDiet, Metabolism, and DiseaseInflammatory Biomarkers in Disease Prognosis

Serum Uric Acid and Mortality Form Cardiovascular Disease: EPOCH-JAPAN Study

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Zhang, Wen, Iso, Hiroyasu, Murakami, Yoshitaka, Miura, Katsuyuki, Nagai, Masato, Sugiyama, Daisuke, Ueshima, Hirotsugu, Okamura, Tomonori +1 more·2016·Journal of Atherosclerosis and Thrombosis

Abstract

AIM: To investigate the relationship between serum uric acid levels and cardiovascular disease in Asians. METHODS: We examined the above relationship using the data of Evidence for Cardiovascular Prevention from Observational Cohorts in Japan (EPOCH-JAPAN Study). The data of 36,313 subjects (15,628 men and 20,685 women aged 35-89 years without histories of stroke, coronary heart disease, or cancer at baseline) were used for the analyses. Sex-specific hazard ratios (HRs) of mortality from cardiovascular disease were estimated according to the quintiles of serum uric acid using Cox hazard models stratified by cohorts. RESULTS: During 441,771 person-years of follow-up, we documented 1,288 cardiovascular deaths. A J- or U-shaped relationship between serum uric acid level and cardiovascular disease mortality was observed. Compared with the lowest quintile of serum uric acid levels, the highest quintile was associated with an increased cardiovascular disease mortality in men [HR: 1.28; 95% confidence interval (CI): 1.01-1.63] and women (HR: 1.51; 95% CI: 1.14-1.99). However, there was no significant association with mortality from stroke, coronary heart disease or heart failure in both men and women. CONCLUSION: This large pooled analysis in Japan suggested a J- or U-shaped relationship between serum uric acid levels and cardiovascular mortality. The highest quintile of serum uric acid levels was associated with increased cardiovascular disease mortality in both Japanese men and women.

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  1. Choi HK, Curhan G.Independent impact of gout on cohort studies. Hypertension. 2008; 51: 1483-1491
  2. Freedman DS ,Williamson DF, Croft JB, Ballew C, Byers mortality and risk for coronary heart disease. Circulation. 2007; 116: 894-900
  3. Yu ZF, Bruce-Keller AJ, Goodman Y, Mattson MP. Uric acid protects neurons against excitotoxic and metabolic insults in cell culture, and against focal ischemic brain injury in vivo. J Neurosci Res. 1998; 53: 613-625

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Authors
Zhang, W., Iso, H., Murakami, Y., Miura, K., Nagai, M., Sugiyama, D., Ueshima, H., Okamura, T., & EPOCH-JAPAN GROUP
Affiliations
  • Fukushima Medical University (JP)
  • The University of Osaka (JP)
  • Toho University (JP)
  • Shiga University of Medical Science (JP)
  • Keio University (JP)
Venue
Journal of Atherosclerosis and Thrombosis
Published
2016
Volume
23
Issue
6
Pages
692-703
ISSN
  • 1340-3478 (ISSN-L)
  • 1880-3873
OpenAlex
W2337745131
Cited by
127
References
40
Citations by year
2026: 6 · 2025: 8 · 2024: 10 · 2023: 11 · 2022: 17 · 2021: 23 · 2020: 30 · 2019: 7 · 2018: 3 · 2017: 8 · 2016: 4
FWCI
7.37
Type
journal article
Language
en
Open access
Licence
cc-by-nc-sa
Locations
  • Journal of Atherosclerosis and Thrombosis (publishedVersion, cc-by-nc-sa)
  • Europe PMC (PubMed Central) (publishedVersion, cc-by)
  • PubMed Central (publishedVersion, cc-by)
  • PubMed Central (publishedVersion)
  • PubMed (publishedVersion)
  • Institutional Repositories DataBase (IRDB) (submittedVersion)
Funders
  • National Cerebral and Cardiovascular Center (22-4-5)
  • Keio University
  • Dokkyo Medical University
  • Ministry of Health, Labour and Welfare
  • Jichi Medical University
  • Hokkaido University
  • Fujita Health University
Topics
  • Health Sciences › Medicine › Nephrology › Gout, Hyperuricemia, Uric Acid
  • Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Diet, Metabolism, and Disease
  • Health Sciences › Medicine › Oncology › Inflammatory Biomarkers in Disease Prognosis
Keywords
serum uric acid, cardiovascular mortality, J-shaped association, U-shaped relationship, sex differences, stroke mortality, coronary heart disease mortality, heart failure mortality, Japanese adults
MeSH terms
Adult, Aged, Aged, 80 and over, Cardiovascular Diseases, Female, Humans, Male, Middle Aged, Prognosis, Prospective Studies, Risk Factors, Sex Factors, Uric Acid, Biomarkers, Survival Rate

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