The DOI matches its Crossref record; 7 of the 7 references it cites were found in a registry or an index.
Effects of physical activity and exercise on the cognitive function of patients with Alzheimer disease: a meta-analysis
Open accessAbstract
BACKGROUND: Alzheimer's disease (AD), as the most common cause of dementia, brings huge economic burden for patients and social health care systems, which motivates researchers to study multiple protective factors, among which physical activity and exercise have been proven to be both effective and economically feasible. METHODS: A systematic literature search was performed for eligible studies published up to November 1st 2018 on three international databases (PubMed, Cochrane Library, and Embase) and two Chinese databases (Wanfang Data, China National Knowledge Infrastructure). All analyses were conducted using Stata 14.0. Due to heterogeneity between studies, a random-effects model was used for this meta-analysis. Meta-analysis was used to explore if physical activity and exercise can exert positive effects on cognition of elderly with AD and subgroup analyses were conducted to find out if there are dose-response effects. RESULTS: A total of 13 randomized controlled trials were included with a sample size of 673 subjects diagnosed with AD. Intervention groups showed a statistically significant improvement in cognition of included subjects measured by the MMSE score (SMD = 1.12 CI:0.66~1.59) compared to the control groups. Subgroup analyses showed different amounts of physical activity and exercise can generate different effects. CONCLUSIONS: As one of few meta-analyses comparing different quantities of physical activity and exercise interventions for AD in details, our study suggests that physical activity and exercise can improve cognition of older adults with AD. While the concomitant effects on cognition functions of high frequency interventions was not greater than that of low frequency interventions, the threshold remains to be settled. However, more RCTs with rigorous study design are needed to support our findings.
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Cites
2016 Alzheimer's disease facts and figures
Alzheimer's Association (2016) · Alzheimer's & Dementia · doi:10.1016/j.jalz.2016.03.001 · Cited by 5,069
Querfurth, H. W., & LaFerla, F. M. (2010) · New England Journal of Medicine · doi:10.1056/nejmra0909142 · Cited by 4,569
Smith, P. J., Blumenthal, J. A., Hoffman, B. M., Cooper, H., Strauman, T. A., Welsh-Bohmer, K., Browndyke, J. N., & Sherwood, A. (2010) · Psychosomatic Medicine · doi:10.1097/psy.0b013e3181d14633 · Cited by 1,714
Hertzog, C., Kramer, A. F., Wilson, R. S., & Lindenberger, U. (2008) · Psychological Science in the Public Interest · doi:10.1111/j.1539-6053.2009.01034.x · Cited by 1,495 · cited 1×
“There are studies suggesting physical activity has the most support as protective against the deleterious effects of age on health and cognition [10, 11].”
BackgroundSurvival in dementia and predictors of mortality: a review
Todd, S., Barr, S., Roberts, M., & Passmore, A. P. (2013) · International Journal of Geriatric Psychiatry · doi:10.1002/gps.3946 · Cited by 417
Physical activity and Alzheimer's disease: from prevention to therapeutic perspectives
Rolland, Y., Abellan van Kan, G., & Vellas, B. (2008) · Journal of the American Medical Directors Association · doi:10.1016/j.jamda.2008.02.007 · Cited by 312
Beyond vascularization: aerobic fitness is associated with N-acetylaspartate and working memory.
Erickson, K. I., Weinstein, A. M., Sutton, B. P., Prakash, R. S., Voss, M. W., Chaddock, L., Szabo, A. N., Mailey, E. L., White, S. M., Wojcicki, T. R., et al. (2012) · Brain and Behavior · doi:10.1002/brb3.30 · Cited by 110
Cited by
Dominguez, L. J., Veronese, N., Vernuccio, L., Catanese, G., Inzerillo, F., Salemi, G., & Barbagallo, M. (2021) · Nutrients · doi:10.3390/nu13114080 · Cited by 433
Exercise benefits on Alzheimer’s disease: State-of-the-science
Valenzuela, P. L., Castillo-García, A., Morales, J. S., de la Villa, P., Hampel, H., Emanuele, E., Lista, S., & Lucia, A. (2020) · Ageing Research Reviews · doi:10.1016/j.arr.2020.101108 · Cited by 337
Recommendations of the 5th Canadian Consensus Conference on the diagnosis and treatment of dementia
Ismail, Z., Black, S. E., Camicioli, R., Chertkow, H., Herrmann, N., Laforce, R., Montero‐Odasso, M., Rockwood, K., Rosa‐Neto, P., Seitz, D., et al. (2020) · Alzheimer's & Dementia · doi:10.1002/alz.12105 · Cited by 245
López-Ortiz, S., Valenzuela, P. L., Seisdedos, M. M., Morales, J. S., Vega, T., Castillo-García, A., Nisticò, R., Mercuri, N. B., Lista, S., Lucia, A., et al. (2021) · Ageing Research Reviews · doi:10.1016/j.arr.2021.101479 · Cited by 152
Can exercise training teach us how to treat Alzheimer's disease?
Huuha, A. M., Norevik, C. S., Moreira, J. B. N., Kobro-Flatmoen, A., Scrimgeour, N., Kivipelto, M., Van Praag, H., Ziaei, M., Sando, S. B., Wisløff, U., et al. (2022) · Ageing Research Reviews · doi:10.1016/j.arr.2022.101559 · Cited by 79
Hill, M. A., & Gammie, S. C. (2022) · Scientific Reports · doi:10.1038/s41598-022-22179-z · Cited by 56
Liu, W., Zhang, J., Wang, Y., Li, J., Chang, J., & Jia, Q. (2022) · Frontiers in Psychiatry · doi:10.3389/fpsyt.2022.927128 · Cited by 50
Self-citationLiew, T. M. (2021) · Age and Ageing · doi:10.1093/ageing/afab044 · Cited by 38
Ceyzériat, K., Badina, A. M., Petrelli, F., Montessuit, S., Nicolaides, A., Millet, P., Savioz, A., Martinou, J.-C., & Tournier, B. B. (2024) · Neurobiology of Disease · doi:10.1016/j.nbd.2024.106623 · Cited by 18
Metadata
- Authors
- Jia, R.-X., Liang, J.-H., Xu, Y., & Wang, Y.-Q.
- Venue
- BMC Geriatrics
- Published
- 2019-07-02
- Volume
- 19
- Issue
- 1
- Pages
- 181-181
- ISSN
- 1471-2318 (ISSN-L)
- OpenAlex
- W2955058279
- Cited by
- 448
- References
- 7
- FWCI
- 9.27
- Type
- journal article
- Language
- en
- Open access
- gold
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