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Cited by 3Gestational Diabetes Research and ManagementMaternal and Neonatal HealthcareBirth, Development, and Health

Mediating effect of gestational weight gain on the preventive effect of exercise during pregnancy on macrosomia: a randomized clinical trial

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Yang, Xuanjin, Wang, Guifang, Liu, Nana, Wang, Yaxin, Zhang, Suhan, Lin, Hang, Zhu, Can, Liu, Li +2 more·2024·BMC Pregnancy and Childbirth
DOI 10.1186/s12884-024-06527-7PMC PMC11112785
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Abstract

Objective: We sought to investigate the impact of individualized exercise guidance during pregnancy on the incidence of macrosomia and the mediating effect of gestational weight gain (GWG). Design: A prospective randomized clinical trial. Setting: A Hospital in Xingtai District, Hebei Province. Population: Older than 20 years of age, mid-pregnancy, and singleton pregnant women without contraindications to exercise during pregnancy. Methods: A randomized clinical trial was conducted from December 2021 to September 2022 to compare the effects of standard prenatal care with individualized exercise guidance on the incidence of macrosomia. Main outcome measure: Incidence of macrosomia. Results: In all, 312 singleton women were randomized into an intervention group (N = 162) or a control group (N = 150). Participants who received individualized exercise guidance had a significantly lower incidence of macrosomia (3.73% vs. 13.61%, P = 0.002) and infants large for gestational age (9.94% vs. 19.73%, P = 0.015). However, no differences were observed in the rate of preterm birth (1.86% vs. 3.40%, P = 0.397) or the average gestational age at birth (39.14 ± 1.51 vs. 38.69 ± 1.85, P = 0.258). Mediation analysis revealed that GWG mediated the effect of exercise on reducing the incidence of macrosomia. Conclusion: Individualized exercise guidance may be a preventive tool for macrosomia, and GWG mediates the effect of exercise on reducing the incidence of macrosomia. However, evidence does not show that exercise increases the rate of preterm birth or affects the average gestational age at birth. Trial registration: The trial is registered at www.clinicaltrails.gov [registration number: NCT05760768; registration date: 08/03/2023 (retrospectively registered)].

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  • Individualized exercise guidance reduced macrosomia and large-for-gestational-age births, mediated by gestational weight gain, but did not report long-term offspring metabolic outcomes.

    “For example, individualized exercise guidance reduced macrosomia and large-for-gestational-age births, mediated by gestational weight gain, but did not report long-term offspring metabolic outcomes [182].”

    From Maternal Overnutrition and Fetal Programming: Long-Term Metabolic, Cognitive, and Epigenetic Consequences (2026) · cites this paper as [182]

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Cited by

Sorted by citations

Authors
Yang, X., Wang, G., Liu, N., Wang, Y., Zhang, S., Lin, H., Zhu, C., Liu, L., Sun, Y., & Ma, L.
Affiliations
Chinese Academy of Medical Sciences & Peking Union Medical College (CN)
Corresponding author
  • Sun, Yin
  • Ma, Liangkun
ORCID
Venue
BMC Pregnancy and Childbirth
Publisher
Springer Science and Business Media LLC
Published
2024-05-22
Volume
24
Issue
1
Pages
384-384
ISSN
1471-2393 (ISSN-L)
DOI
10.1186/s12884-024-06527-7
PMC
PMC11112785
OpenAlex
W4398205822
Cited by
3
References
3
Citations by year
2026: 3
FWCI
1.66
Type
journal article
Language
en
Open access
Licence
Locations
  • BMC Pregnancy and Childbirth (publishedVersion, cc-by)
  • PubMed Central (publishedVersion, cc-by)
  • PubMed (publishedVersion)
  • DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion, cc-by-sa)
Funders
  • Chinese Academy of Medical Sciences (2021-I2M-1-023)
  • Peking Union Medical College Hospital
  • Peking Union Medical College
  • National Key Research and Development Program of China (2020-I2M-2-009, 2022YFC2703304)
Topics
  • Health Sciences › Medicine › Obstetrics and Gynecology › Gestational Diabetes Research and Management
  • Health Sciences › Health Professions › General Health Professions › Maternal and Neonatal Healthcare
  • Health Sciences › Medicine › Pediatrics, Perinatology and Child Health › Birth, Development, and Health
Keywords
macrosomia, gestational weight gain, exercise during pregnancy, prenatal care, large for gestational age, preterm birth, mediation analysis, singleton pregnancy
MeSH terms
Gestational Weight Gain, Adult, China, Female, Fetal Macrosomia, Humans, Infant, Newborn, Pregnancy, Prenatal Care, Prospective Studies, Exercise, Incidence

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