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Cited by 201Attention Deficit Hyperactivity DisorderAsthma and respiratory diseasesFood Allergy and Anaphylaxis Research

Allergic diseases in children with attention deficit hyperactivity disorder: a systematic review and meta-analysis

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Miyazaki, Celine, Koyama, Momoko, Ota, Erika, Swa, Toshiyuki, Mlunde, Linda B., Amiya, Rachel M., Tachibana, Yoshiyuki, Yamamoto-Hanada, Kiwako +1 more·2017·BMC Psychiatry
DOI 10.1186/s12888-017-1281-7PMC PMC5374627
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Abstract

BACKGROUND: Reports of frequent manifestation of allergic diseases in children with attention deficit hyperactivity disorder (ADHD) have been the subject of mounting clinical interest. However, evidence supporting the association between ADHD and allergies is inconsistent and has yet to be systematically reviewed. The objective of this study was to compile and assess available studies on the association between ADHD and allergic diseases in children. METHODS: A comprehensive search using MEDLINE, EMBASE, the Cochrane library, and CINAHL databases was completed in 23 November 2015. The inclusion criteria for studies were that the research assessed allergic diseases in children, 18 years of age and younger, with a diagnosis of ADHD and that a distinct comparison group was incorporated. Any comparative studies, encompassing both randomized controlled trials and observational studies, were considered for inclusion. Two review authors independently assessed the quality of the selected studies by the use of validated assessment tools, performed data extraction and conducted meta-analysis according to Cochrane Collaboration guidelines. RESULTS: Five eligible studies were included in this systematic review. Of these studies, three were case-control and two were cross sectional studies. A majority of information from the five studies was classified as having low or unclear risk of bias. The meta-analysis showed an association between children with ADHD and asthma compared with the control groups (OR: 1.80, 95% CI: 1.57 - 2.07; five studies, low quality of evidence), but did not indicate an association between food allergy and ADHD (OR: 1.13, 95% CI: 0.88 - 1.47; three studies very low quality of evidence). The odds of experiencing allergic rhinitis, atopic dermatitis, and allergic conjunctivitis were slightly higher in children with ADHD compared with control groups, though a substantial statistical heterogeneity was notable in the overall effect estimates. CONCLUSIONS: The findings from this review and meta-analysis show that children with ADHD are more likely to have asthma, allergic rhinitis, atopic dermatitis, and allergic conjunctivitis than their counterparts. Interventions including strategies for managing allergies in children with ADHD would be beneficial.

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  • Dysfunction of immunoregulation by Treg cells and imbalance in the Th1/Th2 response might be a crucial factor in the development of allergies in children with ADHD, or a factor relating Th2-mediated hypersensitivity to ADHD development.

    “This dysfunction of the immunoregulation by Treg cells and imbalance in the Th1/Th2 response might be a crucial factor in the development of allergies in children with ADHD [110], or a factor relating Th2-mediated hypersensitivity to ADHD development [111, 112].”

    From Molecular Characterisation of the Mechanism of Action of Stimulant Drugs Lisdexamfetamine and Methylphenidate on ADHD Neurobiology: A Review (2022) · cites this paper as [110]

    The Discussion suggests a possible link between immune regulation and asthma in children with ADHD, but discusses Th17 differentiation, not Treg-cell dysfunction or a Th1/Th2 imbalance. It also says the mechanisms remain unclear and that the review does not establish causative pathways, so it does not support calling the proposed mechanism a crucial factor. (LLM, conf=0.78)

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  1. [1]Marshall P Attention deficit disorder and allergy: a neurochemical model of the relation between the illnesses Psychol Bull 1989 106 3 434 446 10.1037/0033-2909.106.3.434 2682719 · DOI
  2. [3]American Psychiatric Association Diagnostic and statistical manual of mental disorders 5th ed 2013 Washington American Psychiatric Association Press
  3. [4]August GJ Realmuto GM MacDonald AW III Nugent SM Crosby R Prevalence of ADHD and comorbid disorders among elementary school children screened for disruptive behavior J Abnorm Child Psychol 1996 24 5 571 595 10.1007/BF01670101 8956085 · DOI
  4. [5]Voeller KK Attention-deficit hyperactivity disorder (ADHD) J Child Neurol 2004 19 10 798 814 10.1177/08830738040190100901 15559895 · DOI
  5. [6]Warshaw EM Paller AS Fowler JF Zirwas MJ Practical management of cutaneous reactions to the methylphenidate transdermal system: recommendations from a dermatology expert panel consensus meeting Clin Ther 2008 30 2 326 337 10.1016/j.clinthera.2008.01.022 18343271 · DOI
  6. [7]Vashi NA Souza A Cohen N Franklin B Cohen DE Allergic contact dermatitis caused by methylphenidate Contact Dermatitis 2011 65 3 183 185 10.1111/j.1600-0536.2011.01949.x 21827513 · DOI
  7. [8]Wigal SB McGough JJ McCracken JT Biederman J Spencer TJ Posner KL Wigal TL Kollins SH Clark TM Mays DA A laboratory school comparison of mixed amphetamine salts extended release (Adderall XR) and atomoxetine (Strattera) in school-aged children with attention deficit/hyperactivity disorder J Atten Disord 2005 9 1 275 289 10.1177/1087054705281121 16371674 · DOI
  8. [9]Chang HY Seo J-H Kim HY Kwon J-W Kim B-J Kim HB Lee S-Y Jang GC Song DJ Kim WK Allergic diseases in preschoolers are associated with psychological and behavioural problems Allergy Asthma Immunol Res 2013 5 5 315 321 10.4168/aair.2013.5.5.315 24003389 PMC3756179 · DOI
  9. [10]Comings DE Gade-Andavolu R Gonzalez N Wu S Muhleman D Blake H Chiu F Wang E Farwell K Darakjy S Multivariate analysis of associations of 42 genes in ADHD, ODD and conduct disorder Clin Genet 2000 58 1 31 40 10.1034/j.1399-0004.2000.580106.x 10945659 · DOI
  10. [11]Lee YH, Song GG. Meta-analysis of case-control and family-based associations between the 5-HTTLPR L/S polymorphism and susceptibility to ADHD. J Atten Disord. 2015 26048879
  11. [12]Merikangas KR Calkins ME Burstein M He J-P Chiavacci R Lateef T Ruparel K Gur RC Lehner T Hakonarson H Comorbidity of physical and mental disorders in the neurodevelopmental genomics cohort study Pediatrics 2015 135 4 e927 e938 10.1542/peds.2014-1444 25755242 PMC4379458 · DOI
  12. [13]Petra AI Panagiotidou S Hatziagelaki E Stewart JM Conti P Theoharides TC Gut-microbiota-brain axis and its effect on neuropsychiatric disorders with suspected immune dysregulation Clin Ther 2015 37 5 984 995 10.1016/j.clinthera.2015.04.002 26046241 PMC4458706 · DOI · Paper page
  13. [14]Miyazaki C Koyama M Ota E Swa T Amiya RM Mlunde LB Tachibana Y Yamamoto-Hanada K Mori R Allergies in children with autism spectrum disorder: a systematic review and meta-analysis Rev J Autism Dev Disord 2015 2 4 374 401 10.1007/s40489-015-0059-4 · DOI
  14. [16]Isgren A Jakobsson J Pålsson E Ekman CJ Johansson AG Sellgren C Blennow K Zetterberg H Landén M Increased cerebrospinal fluid interleukin-8 in bipolar disorder patients associated with lithium and antipsychotic treatment Brain Behav Immun 2015 43 198 204 10.1016/j.bbi.2014.10.001 25451615 · DOI
  15. [17]Gillberg C Gillberg IC Rasmussen P Kadesjö B Söderström H Råstam M Johnson M Rothenberger A Niklasson L Co–existing disorders in ADHD – implications for diagnosis and intervention Eur Child Adolesc Psychiatry 2004 13 Suppl 1 i80 i92 15322959
  16. [18]Subcommittee on Attention-Deficit/Hyperactivity Disorder, Steering Committee on Quality Improvement and Management, Wolraich M, Brown L, Brown RT, DuPaul G, Earls M, Feldman HM, Ganiats TG, Kaplanek B, et al. ADHD: clinical practice guideline for the diagnosis, evaluation, and treatment of attention-deficit/hyperactivity disorder in children and adolescents. Pediatrics 2011; 128(5):1007-1022. PMC4500647 22003063
  17. [19]Schmitt J Apfelbacher C Chen C-M Romanos M Sausenthaler S Koletzko S Bauer C-P Hoffmann U Krämer U Berdel D Infant-onset eczema in relation to mental health problems at age 10 years: results from a prospective birth cohort study (German Infant Nutrition Intervention plus) J Allergy Clin Immunol 2010 125 2 404 410 10.1016/j.jaci.2009.10.055 20159252 · DOI
  18. [20]Schmitt J Buske-Kirschbaum A Roessner V Is atopic disease a risk factor for attention-deficit/hyperactivity disorder? A systematic review Allergy 2010 65 12 1506 1524 10.1111/j.1398-9995.2010.02449.x 20716320 · DOI
  19. [21]Boris M Goldblatt A Pollen exposure as a cause for the deterioration of neurobehavioral function in children with autism and attention deficit hyperactive disorder: nasal pollen challenge J Nutr Environ Med 2004 14 1 47 54 10.1080/13590840410001695176 · DOI
  20. [22]Biederman J Milberger S Faraone SV Guite J Warburton R Associations between childhood asthma and ADHD: issues of psychiatric comorbidity and familiality J Am Acad Child Adolesc Psychiatry 1994 33 6 842 848 10.1097/00004583-199407000-00010 8083141 · DOI
  21. [24]Moher D Liberati A Tetzlaff J Altman DG The PRISMA Group Preferred reporting items for systematic reviews and meta-analyses: the PRISMA statement Ann Internal Med 2009 151 4 264 269 10.7326/0003-4819-151-4-200908180-00135 19622511 · DOI · Paper page
  22. [25]American Psychiatric Association Diagnostic and statistical manual of mental disorders text-revision 4th ed 2000 Washington American Psychiatric Association Press
  23. [26]National Institute for Health and Clinical Excellence Attention deficit hyperactivity disorder: diagnosis and management. Clinical guideline[72] 2016 London NICE 29634174
  24. [29]Review Manager (RevMan) [Computer program]. Version 5.3. Copenhagen: The Nordic Cochrane Centre, The Cochrane Collaboration; 2014.
  25. [33]Chen M-H Su T-P Chen Y-S Hsu J-W Huang K-L Chang W-H Bai Y-M Attention deficit hyperactivity disorder, tic disorder, and allergy: is there a link? A nationwide population-based study J Child Psychol Psychiatry 2013 54 5 545 551 10.1111/jcpp.12018 23140273 · DOI
  26. [34]Hak E de Vries TW Hoekstra PJ Jick SS Association of childhood attention-deficit/hyperactivity disorder with atopic diseases and skin infections? A matched case-control study using the General Practice Research Database Ann Allergy Asthma Immunol 2013 111 2 102 106 10.1016/j.anai.2013.05.023 23886227 · DOI
  27. [35]Suwan P Akaramethathip D Noipayak P Association between allergic sensitization and attention deficit hyperactivity disorder (ADHD) Asian Pac J Allergy Immunol 2011 29 1 57 65 21560489
  28. [36]Kwon HJ Lee MY Ha M Yoo SJ Paik KC Lim J-H Sakong J Lee C-G Kang D-M Hong SJ The associations between ADHD and asthma in Korean children BMC Psychiatry 2014 14 70 10.1186/1471-244X-14-70 24606878 PMC3975298 · DOI
  29. [37]Romanos M Gerlach M Warnke A Schmitt J Association of attention-deficit/hyperactivity disorder and atopic eczema modified by sleep disturbance in a large population-based sample J Epidemiol Community Health 2010 64 3 269 273 10.1136/jech.2009.093534 19692717 · DOI
  30. [38]Mill J Curran S Richards S Taylor E Asherson P Polymorphisms in the dopamine D5 receptor (DRD5) gene and ADHD Am J Med Genet B Neuropsychiatr Genet 2004 125 1 38 42 10.1002/ajmg.b.20127 14755441 · DOI
  31. [39]Ostadali MR Ahangari G Eslami MB Razavi A Zarrindast MR Ahmadkhaniha HR Boulhari J The detection of dopamine gene receptors (DRD1-DRD5) expression on human peripheral blood lymphocytes by real time PCR Iran J of Allergy Asthma Immunol 2004 3 4 169 174 17301410
  32. [40]Wu J Xiao H Sun H Zou L Zhu L-Q Role of dopamine receptors in ADHD: a systematic meta-analysis Mol Neurobiol 2012 45 3 605 620 10.1007/s12035-012-8278-5 22610946 · DOI · Paper page
  33. [41]Nakagome K Imamura M Okada H Kawahata K Inoue T Hashimoto K Harada H Higashi T Takagi R Nakano K Dopamine D1-like receptor antagonist attenuates Th17-mediated immune response and ovalbumin antigen-induced neutrophilic airway inflammation J Immunol 2011 186 10 5975 5982 10.4049/jimmunol.1001274 21471450 · DOI
  34. [42]Bielory L Allergic conjunctivitis and the impact of allergic rhinitis Curr Allergy Asthma Rep 2010 10 2 122 134 10.1007/s11882-010-0087-1 20425504 · DOI
  35. [43]Morar N Willis-Owen SA Moffatt MF Cookson WO The genetics of atopic dermatitis J Allergy Clin Immunol 2006 118 3 559 10.1016/j.jaci.2006.07.042 16815134 · DOI
  36. [44]Palmer CN Irvine AD Terron-Kwiatkowski A Zhao Y Liao H Lee SP Goudie DR Sandilands A Campbell LE Smith FJ Common loss-of-function variants of the epidermal barrier protein filaggrin are a major predisposing factor for atopic dermatitis Nat Genet 2006 38 4 441 446 10.1038/ng1767 16550169 · DOI · Paper page
  37. [45]Johnston LK Chien KB Bryce PJ The Immunology of Food Allergy J Immunol 2014 192 6 2529 2534 10.4049/jimmunol.1303026 24610821 PMC3988470 · DOI
  38. [46]Gratten J Wray NR Keller MC Visscher PM Large-scale genomics unveils the genetic architecture of psychiatric disorders Nat Neurosci 2014 17 6 782 790 10.1038/nn.3708 24866044 PMC4112149 · DOI · Paper page

Cited by

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Authors
Miyazaki, C., Koyama, M., Ota, E., Swa, T., Mlunde, L. B., Amiya, R. M., Tachibana, Y., Yamamoto-Hanada, K., & Mori, R.
Affiliations
  • National Center For Child Health and Development (JP)
  • The University of Tokyo (JP)
  • St. Luke's International University (JP)
Corresponding author
Ota, Erika
ORCID
Venue
BMC Psychiatry
Publisher
Springer Science and Business Media LLC
Published
2017-03-31
Volume
17
Issue
1
Pages
120-120
ISSN
1471-244X (ISSN-L)
DOI
10.1186/s12888-017-1281-7
PMC
PMC5374627
OpenAlex
W2600345547
Cited by
201
References
4
Citations by year
2026: 22 · 2025: 13 · 2024: 25 · 2023: 27 · 2022: 20 · 2021: 30 · 2020: 28 · 2019: 14 · 2018: 17 · 2017: 5
FWCI
2.66
Type
journal article
Language
en
Open access
Licence
cc-by
Locations
  • BMC Psychiatry (publishedVersion, cc-by)
  • PubMed Central (publishedVersion, cc-by)
  • PubMed (publishedVersion)
  • DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion)
Funders
  • National Center for Child Health and Development Grant ((26A-5))
  • The Clinical Research Program for Child Health and Development (AMED (No. 27300101))
Topics
  • Health Sciences › Medicine › Psychiatry and Mental health › Attention Deficit Hyperactivity Disorder
  • Health Sciences › Medicine › Physiology › Asthma and respiratory diseases
  • Health Sciences › Medicine › Immunology and Allergy › Food Allergy and Anaphylaxis Research
Keywords
attention deficit hyperactivity disorder, allergic diseases, asthma, food allergy, allergic rhinitis, atopic dermatitis, allergic conjunctivitis, children, comorbidities
MeSH terms
Asthma, Attention Deficit Disorder with Hyperactivity, Child, Cross-Sectional Studies, Dermatitis, Atopic, Food Hypersensitivity, Humans, Case-Control Studies, Rhinitis, Allergic

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