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Nicotine delivery, tolerability and reduction of smoking urge in smokers following short-term use of one brand of electronic cigarettes

D’Ruiz, Carl D., Graff, Donald W., Yan, X. Sherwin·2015·BMC Public Health
DOI 10.1186/s12889-015-2349-2PMC PMC4588874
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Crossref · 10.1186/s12889-015-2349-2

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  • The study results and literature-reported PK values for cigarettes and MST indicate that the nicotine delivery and subjective effects of the tested NPs are not likely to be greater than cigarette or MST.

    “indicate that the nicotine delivery and subjective effects of NPs tested are not likely to be greater than cigarette or MST.”

    From Nicotine pharmacokinetics and subjective responses after using nicotine pouches with different nicotine levels compared to combustible cigarettes and moist smokeless tobacco in adult tobacco users (2022) · cites this paper as D’Ruiz et al. 2015

    The Results and discussion sections (pages not provided) report that the tested e-cigarettes generally produced nicotine exposure comparable to or lower than the cigarette and measured comparable smoking-urge reductions during controlled use. The paper compares the products with a cigarette, but the passages do not provide an MST comparison or support the claim about subjective effects relative to MST. (LLM, conf=0.86)

    Experimental — accuracy not yet measured

  • The mean nicotine Cmax measured during use of the 8 mg NP (15.4 ng/mL) was within the range reported in published literature for cigarettes (11.8 to 23 ng/mL) and MST products (10.6 to 21.4 ng/ml).

    “the mean nicotine Cmax measured during use of the 8 mg NP (15.4 ng/mL) was within the range reported in published literature”

    From Nicotine pharmacokinetics and subjective responses after using nicotine pouches with different nicotine levels compared to combustible cigarettes and moist smokeless tobacco in adult tobacco users (2022) · cites this paper as D’Ruiz et al. 2015

    Table 3 in Results and discussion (page unavailable) reports a mean cigarette Cmax of 15.8 ng/mL, which provides a relevant comparison for 15.4 ng/mL. It does not report the claimed published cigarette or MST ranges; Methods > Products tested (page unavailable) lists e-cigarettes and a tobacco cigarette, not an 8 mg NP. (LLM, conf=0.80)

    Experimental — accuracy not yet measured

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Cites

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Research works printed but not linked: 23

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Sorted by citations

Authors
D’Ruiz, C. D., Graff, D. W., & Yan, X. S.
Venue
BMC Public Health
Publisher
Springer Science and Business Media LLC
Published
2015-09-30
Volume
15
Issue
1
ISSN
1471-2458
DOI
10.1186/s12889-015-2349-2
PMC
PMC4588874
Cited by
52
References
1
Language
en
Licence
www.springer.com/tdm (unspecified)

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