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Cited by 23Osteoarthritis Treatment and MechanismsPeriodontal Regeneration and TreatmentsMesenchymal stem cell research

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Autologous adipose tissue injection versus platelet-rich plasma (PRP) injection in the treatment of knee osteoarthritis: a randomized, controlled study – study protocol

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Bąkowski, Paweł, Kaszyński, Jakub, Wałecka, Joanna, Ciemniewska-Gorzela, Kinga, Bąkowska-Żywicka, Kamilla, Piontek, Tomasz·2020·BMC Musculoskeletal Disorders
DOI 10.1186/s12891-020-03345-8PMC PMC7240999
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Abstract

Background: Knee osteoarthritis (OA) is a common, chronic, progressive and degenerative disease which affects patients’ quality of life and may cause disability and social isolation. OA is a huge economic burden for the patient and a large strain for the whole healthcare system. Articular cartilage has a small potential to repair, with progressively more clinicians emphasizing cellular therapy. Subcutaneous fat tissue in human body is a large reservoir of mesenchymal stem cells (MSCs) and is been harvested in minimally invasive, simple procedure. Up to date there is no prospective randomized controlled studies demonstrating effectiveness and role of adipose tissue injections in OA treatment. The purpose of this study is to assess functional and clinical changes among patients with symptomatic knee OA treated with intra-articular injections of autologous adipose tissue or platelet rich plasma (PRP) and to compare efficacy of both therapeutic methods. Methods: This is a prospective, randomized, controlled study. Patients who meet inclusion criteria will be allocated to Fat Tissue group or PRP group randomly. Subjects will receive an intra articular injection with autologous adipose tissue and PRP respectively. Patients will be assessed five times: before treatment and 1, 3, 6 and 12 months after the treatment. The assessment consists of patient reported outcome measures (The Knee injury and Osteoarthritis Outcome Score, International Knee Documentation Committee 2000, the Western Ontario and McMaster Universities Osteoarthritis Index, the Health Questionnaire EQ- 5D- 5 L), three functional tests (The Timed Up and Go Test, The 5 Times Sit to Stand Test, The 10 m Walk Test) and Maximal Isometric Voluntary Contraction. Discussion: This study protocol has several strengths and weaknesses. One of strongest point of this study is the wide, multidimensional functional assessment which will give a large amount of objective data. On the other hand, lack of blinding has to be considered as a risk of both subject and investigator bias. Trial registration: name of registry: ClinicalTrials.gov, trial registration number: NCT04321629, retrospectively registered on date of registration.

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Metadata

Authors
Bąkowski, P., Kaszyński, J., Wałecka, J., Ciemniewska-Gorzela, K., Bąkowska-Żywicka, K., & Piontek, T.
Affiliations
  • Rehasport Clinic (PL)
  • Poznan University of Medical Sciences (PL)
Corresponding author
Bąkowski, Paweł
ORCID
Venue
BMC Musculoskeletal Disorders
Publisher
Springer Science and Business Media LLC
Published
2020-05-20
Volume
21
Issue
1
Pages
314-314
ISSN
1471-2474 (ISSN-L)
DOI
10.1186/s12891-020-03345-8
PMC
PMC7240999
OpenAlex
W3027439523
Cited by
23
References
1
Citations by year
2026: 4 · 2025: 3 · 2024: 1 · 2023: 1 · 2022: 8 · 2021: 5 · 2020: 1
FWCI
2.83
Type
journal article
Language
en
Open access
Licence
Locations
  • BMC Musculoskeletal Disorders (publishedVersion, cc-by)
  • PubMed Central (publishedVersion, cc-by)
  • PubMed (publishedVersion)
  • DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion, cc-by-sa)
Topics
  • Health Sciences › Medicine › Rheumatology › Osteoarthritis Treatment and Mechanisms
  • Health Sciences › Dentistry › Periodontics › Periodontal Regeneration and Treatments
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Cell Biology › Mesenchymal stem cell research
Keywords
knee osteoarthritis, platelet-rich plasma, intra-articular injection, mesenchymal stem cells, articular cartilage repair, functional outcome, patient-reported outcome measures
MeSH terms
Patient Reported Outcome Measures, Adipose Tissue, Humans, Injections, Intra-Articular, Pain Measurement, Prospective Studies, Quality of Life, Randomized Controlled Trials as Topic, Treatment Outcome, Clinical Trials, Phase II as Topic, Osteoarthritis, Knee, Platelet-Rich Plasma

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CoChat. (2026). Citation check: Autologous adipose tissue injection versus platelet-rich plasma (PRP) injection in the treatment of knee osteoarthritis: a randomized, controlled study – study protocol. https://app.cochat.ai/papers/10.1186/s12891-020-03345-8
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Bąkowski, P., Kaszyński, J., Wałecka, J., Ciemniewska-Gorzela, K., Bąkowska-Żywicka, K., & Piontek, T. (2020). Autologous adipose tissue injection versus platelet-rich plasma (PRP) injection in the treatment of knee osteoarthritis: a randomized, controlled study – study protocol. BMC Musculoskeletal Disorders. https://doi.org/10.1186/s12891-020-03345-8

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