The DOI matches its Crossref record; 33 of the 33 references it cites were found in a registry or an index.
Prognostic value of the creatinine-albumin ratio in acute pancreatitis debridement
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Abstract
Background: Increases in the levels of serum C-reactive protein (CRP) and creatinine (Cr) and decreases in those of albumin (Alb) are commonly observed in acute pancreatitis (AP). We aimed to evaluate the efficacy of the Cr/Alb and CRP/Alb ratios in the prediction of surgical treatment effect in AP patients. Methods: This study retrospectively analyzed clinical data obtained from 140 AP patients who underwent debridement from January 2008 to November 2018 in Shanghai Ruijin Hospital. The Cr/Alb and CRP/Alb ratios at admission and before surgery were assessed in the analysis of clinical statistics, prediction of prognoses, and logistic regression analysis. Results: The admission Cr/Alb had the best predictive value of the four ratios. This value was significantly higher in patients with re-operation and those who died ( P < 0.05) and was correlated with the Acute Physiology and Chronic Health Evaluation (APACHE II) score, admission CRP/Alb, preoperative Cr/Alb, and post-operative complications. The admission Cr/Alb could predict the risk of AP-related re-operation and mortality with sensitivities, specificities and areas under the curve of 86.3%, 61.7% and 0.824, and 73.4%, 81.3% and 0.794, respectively. At a cut-off value of 3.43, admission Cr/Alb values were indicative of a worse clinical state, including impaired laboratory test values, APACHE II scores, rates of post-operative complications and re-operation, and mortality ( P < 0.05). In the logistic regression analysis, admission Cr/Alb values were independently related to the APACHE II score, post-operative renal failure, and mortality. Conclusion: Cr/Alb is a novel but promising, easy-to-measure, reproducible, non-invasive prognostic score for the prediction of the effect of debridement in AP patients.
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Combined biomarkers can effectively improve the sensitivity of prediction compared with a single biological marker.
“However, for complicated diseases, like a lot of physical diseases and psychotic illnesses, one single biological marker often could not display satisfactory predictive value, while combined biomarkers can effectively improve the sensitivity of prediction.7”
From Albumin and Associated Biomarkers in Severe Neuropsychiatric Disorders: Acute-Phase Schizophrenia and Bipolar Disorder (2023) · cites this paper as [7]
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Akut pankreatitte şiddeti belirlemede biyokimyasal belirteçlerin yeri
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Metadata
- Authors
- Zhao, Z., Yu, Y., Xie, R., Yang, K., Xu, D., Li, L., Lin, J., Zheng, L., Zhang, C., Xu, X., Chen, Y., Xu, Z., Chen, E., Luo, M., & Fei, J.
- Affiliations
- Shanghai Jiao Tong University (CN)
- Corresponding author
- Chen, Ying
- Luo, Meng
- Fei, Jian
- ORCID
- Venue
- BMC Surgery
- Published
- 2020-12
- Volume
- 20
- Issue
- 1
- Pages
- 322-322
- ISSN
- 1471-2482 (ISSN-L)
- PMC
- PMC7727165
- OpenAlex
- W3112334141
- Cited by
- 37
- References
- 33
- Citations by year
- 2026: 4 · 2025: 8 · 2024: 5 · 2023: 14 · 2022: 5 · 2021: 1
- FWCI
- 4.57
- Type
- journal article
- Language
- en
- Open access
- gold
- doi.org
- Licence
- Locations
- BMC Surgery (publishedVersion, cc-by)
- Research Square (acceptedVersion, cc-by)
- PubMed Central (publishedVersion, cc-by)
- PubMed (publishedVersion)
- DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion, cc-by-sa)
- Funders
- National Natural Science Foundation of China (81670581)
- Topics
- Health Sciences › Medicine › Surgery › Pancreatitis Pathology and Treatment
- Health Sciences › Medicine › Critical Care and Intensive Care Medicine › Sepsis Diagnosis and Treatment
- Health Sciences › Medicine › Gastroenterology › Gallbladder and Bile Duct Disorders
- Keywords
- acute pancreatitis, C-reactive protein, albumin, prognostic factors, surgical debridement, reoperation, mortality, APACHE II score, postoperative complications, postoperative renal failure
- MeSH terms
- Serum Albumin, Human, Acute Disease, Adult, C-Reactive Protein, China, Creatinine, Debridement, Female, Humans, Male, Middle Aged, Pancreatitis, Predictive Value of Tests, Prognosis, Retrospective Studies, ROC Curve, Biomarkers
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