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Cited by 19Dental Implant Techniques and OutcomesOral microbiology and periodontitis researchPeriodontal Regeneration and Treatments

Effect of argon plasma pre-treatment of healing abutments on peri-implant microbiome and soft tissue integration: a proof-of-concept randomized study

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Canullo, Luigi, Rakic, Mia, Corvino, Emilio, Burton, Maria, Krumbeck, Janina A., Chittoor Prem, Aishani, Ravidà, Andrea, Ignjatović, Nenad +3 more·2023·BMC Oral Health
DOI 10.1186/s12903-023-02729-1PMC PMC9843976
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Abstract

Purpose: Biofilm-free implant surface is ultimate prerequisite for successful soft and bone tissue integration. Objective of the study was to estimate the effects of argon plasma healing abutment pre-treatment (PT) on peri-implant soft-tissue phenotype (PiSP), inflammation, plaque accumulation and the microbiome (PiM) between non-treated (NPT) and treated (PT) abutments following 3-months healing period. The hypothesis was that cell-conductive and antimicrobial properties of PT would yield optimal conditions for soft tissue integration. Material and Methods: Two months following second-phase surgery, microbiological and clinical parameters were assessed around thirty-six healing abutments with two types of microtopography, smooth surface (MACHINED) and ultrathin threaded microsurface (ROUGH). A two level randomization schema was used to achieve equal distribution and abutments were randomly divided into rough and machined groups, and then divided into PT and NPT groups. PiM was assessed using next-generation DNA sequencing. Results: PiM bacterial composition was highly diverse already two months post-implantation, consisting of key-stone pathogens, early and late colonizers, while the mycobiome was less diverse. PT was associated with lower plaque accumulation and inflammation without significant impact on PiSP, while in NPT clinical parameters were increased and associated with periopathogens. NPT mostly harbored late colonizers, while PT exerted higher abundance of early colonizers suggesting less advanced plaque formation. Interaction analysis in PT demonstrated S. mitis co-occurrence with pro-healthy Rothia dentocariosa and co-exclusion with Parvimonas micra, Porphyromonas endodontalis and Prevotella oris. PiSP parameters were generally similar between the groups, but significant association between PiM and keratinized mucosa width was observed in both groups, with remarkably more expressed diversity in NPT compared to PT. PT resulted in significantly lower BOP and PI around rough and machined abutments, respectively, without specific effect on PiM and PiSP. Conclusions: PT contributed to significantly the less advanced biofilm accumulation and inflammation without specific effects on PiSP.

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  • Short-term adhesion or wound closure results obtained under simplified experimental conditions may not directly predict long-term mucosal retention, peri-implant soft tissue sealing, or clinical healing outcomes.

    “Therefore, short-term adhesion or wound closure results obtained under simplified experimental conditions may not directly predict long-term mucosal retention, peri-implant soft tissue sealing, or clinical healing outcomes.61,62”

    From Polydopamine-Based Biomaterials in Oral Medicine: Applications, Mechanisms, and Translational Challenges (2026) · cites this paper as [62]

    The Discussion (page unavailable) cautions that low-throughput validation can miss complex biological interactions and recommends more comprehensive biological assessment in preclinical and clinical studies. That supports caution about extrapolating from simplified experiments, but the paper does not specifically assess whether short-term adhesion or wound-closure results predict long-term mucosal retention, soft-tissue sealing, or clinical healing. (LLM, conf=0.78)

    Experimental — accuracy not yet measured

  • Cell culture, antibacterial adhesion assays, and mucosal/wound healing models indicate that PDA-based coatings or hydrogels can improve wet adhesion, antioxidative protection, localized drug delivery, inflammation regulation, and wound healing.

    “Cell culture, antibacterial adhesion assays, and mucosal/wound healing models indicate that PDA-based coatings or hydrogels can improve wet adhesion, antioxidative protection, localized drug delivery, inflammation regulation, and wound healing.”

    From Polydopamine-Based Biomaterials in Oral Medicine: Applications, Mechanisms, and Translational Challenges (2026) · cites this paper as [62]

    The Introduction discusses argon plasma pretreatment of titanium healing abutments, and the Results report clinical measures of plaque and inflammation. Searches for PDA, polydopamine coatings, and hydrogels found no passage addressing their claimed effects on wet adhesion, antioxidative protection, drug delivery, or wound healing. (LLM, conf=0.76)

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Authors
Canullo, L., Rakic, M., Corvino, E., Burton, M., Krumbeck, J. A., Chittoor Prem, A., Ravidà, A., Ignjatović, N., Sculean, A., Menini, M., & Pesce, P.
Affiliations
  • University of Bern (CH)
  • University of Florence (IT)
  • Zymo Research Corporation (United States) (US)
  • University of Michigan (US)
  • Serbian Academy of Sciences and Arts (RS)
  • University of Genoa (IT)
Corresponding author
Pesce, Paolo
ORCID
Venue
BMC Oral Health
Publisher
Springer Science and Business Media LLC
Published
2023-01-17
Volume
23
Issue
1
Pages
27-27
ISSN
1472-6831 (ISSN-L)
DOI
10.1186/s12903-023-02729-1
PMC
PMC9843976
OpenAlex
W4316813207
Cited by
19
References
71
Citations by year
2026: 3 · 2025: 8 · 2024: 4 · 2023: 4
FWCI
4.86
Type
journal article
Language
en
Open access
Licence
Locations
  • BMC Oral Health (publishedVersion, cc-by)
  • PubMed Central (publishedVersion, cc-by)
  • PubMed (publishedVersion)
  • Bern Open Repository and Information System (University of Bern) (submittedVersion, cc-by)
  • Digital Archive of SASA (Serbian Academy of Sciences and Arts) (submittedVersion, cc-by)
  • DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion, cc-by-sa)
  • CINECA IRIS Institutial Research Information System (University of Genoa) (submittedVersion)
Topics
  • Health Sciences › Dentistry › Oral Surgery › Dental Implant Techniques and Outcomes
  • Health Sciences › Dentistry › Periodontics › Oral microbiology and periodontitis research
  • Health Sciences › Medicine › Urology › Periodontal Regeneration and Treatments
Keywords
healing abutment, biofilm accumulation, peri-implant inflammation, early colonizers, Rothia dentocariosa, Porphyromonas endodontalis, Prevotella oris, keratinized mucosa width, dental implants
MeSH terms
Argon, Dental Implantation, Endosseous, Dental Plaque, Humans, Inflammation, Titanium, Dental Implants, Dental Prosthesis Design, Plasma Gases, Microbiota

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