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Cited by 232Curcumin's Biomedical ApplicationsPharmacological Effects of Medicinal PlantsOsteoarthritis Treatment and Mechanisms

Efficacy and safety of curcumin and its combination with boswellic acid in osteoarthritis: a comparative, randomized, double-blind, placebo-controlled study

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Haroyan, Armine, Mukuchyan, Vahan, Mkrtchyan, Nana, Minasyan, Naira, Gasparyan, Srbuhi, Sargsyan, Aida, Narimanyan, Mikael, Hovhannisyan, Areg·2018·BMC Complementary and Alternative Medicine
DOI 10.1186/s12906-017-2062-zPMC PMC5761198
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Abstract

BACKGROUND: The aim of this clinical trial was to assess the efficacy and safety of curcuminoid complex extract from turmeric rhizome with turmeric volatile oil (CuraMed®) and its combination with boswellic acid extract from Indian frankincense root (Curamin®) vs placebo for the treatment of 40- to 70-year-old patients with osteoarthritis (OA). METHODS: The effects of CuraMed® 500-mg capsules (333 mg curcuminoids) and Curamin® 500-mg capsules (350 mg curcuminoids and 150 mg boswellic acid) taken orally three times a day for 12 weeks in 201 patients was investigated in a three-arm, parallel-group, randomized, double-blinded, placebo-controlled trial. Primary outcome efficacy measures included OA physical function performance-based tests, the WOMAC recommended index of joint pain, morning stiffness, limitations of physical function, and the patients' global assessment of disease severity. RESULTS: Favorable effects of both preparations compared to placebo were observed after only 3 months of continuous treatment. A significant effect of Curamin® compared to placebo was observed both in physical performance tests and the WOMAC joint pain index, while superior efficacy of CuraMed vs placebo was observed only in physical performance tests. The effect size compared to placebo was comparable for both treatment groups but was superior in the Curamin® group. The treatments were well tolerated. CONCLUSIONS: Twelve-week use of curcumin complex or its combination with boswellic acid reduces pain-related symptoms in patients with OA. Curcumin in combination with boswellic acid is more effective. Combining Curcuma longa and Boswellia serrata extracts in Curamin® increases the efficacy of OA treatment presumably due to synergistic effects of curcumin and boswellic acid. TRIAL REGISTRATION: This trial is registered at the database www.clinicaltrials.gov . https://clinicaltrials.gov/ct2/show/NCT02390349?term=EuroPharma&rank=1 . Study registration number: NCT02390349 .

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  1. [1]Aggarwal BB Gupta SC Sung B Curcumin: an orally bioavailable blocker of TNF and other pro-inflammatory biomarkers Br J Pharmacol 2013 169 1672 1692 10.1111/bph.12131 23425071 PMC3753829 · DOI
  2. [2]Nakagawa Y Mukai S Yamada S Matsuoka M Tarumi E Hashimoto T Tamura C Imaizumi A Nishihira J Nakamura T Short-term effects of highly-bioavailable curcumin for treating knee osteoarthritis: a randomized, double-blind, placebo-controlled prospective study J Orthop Sci 2014 19 933 939 10.1007/s00776-014-0633-0 25308211 PMC4244558 · DOI
  3. [3]Belcaro G Cesarone MR Dugall M Pellegrini L Ledda A Grossi MG Togni S Appendino G Efficacy and safety of Meriva®, a curcumin-phosphatidylcholine complex, during extended administration in osteoarthritis patients Altern Med Rev 2010 15 337 344 21194249
  4. [4]Belcaro G Cesarone MR Dugall M Pellegrini L Ledda A Grossi MG Togni S Appendino G Product-evaluation registry of Meriva®, a curcumin-phosphatidylcholine complex, for the complementary management of osteoarthritis Panminerva Med 2010 52 55 62 20657536
  5. [5]Chandran B Goel A A randomized, pilot study to assess the efficacy and safety of curcumin in patients with active rheumatoid arthritis Phytother Res 2012 26 1719 1725 10.1002/ptr.4639 22407780 · DOI
  6. [6]Asher GN Spelman K Clinical utility of curcumin extract Altern Ther Health Med 2013 19 20 22 23594449
  7. [7]Henrotin Y Gharbi M Dierckxsens Y Priem F Marty M Seidel L Albert A Heuse E Bonnet V Castermans C Decrease of a specific biomarker of collagen degradation in osteoarthritis, Coll2-1, by treatment with highly bioavailable curcumin during an exploratory clinical trial BMC Complement Altern Med 2014 14 159 10.1186/1472-6882-14-159 24886572 PMC4032499 · DOI
  8. [8]Kuptniratsaikul V Thanakhumtorn S Chinswangwatanakul P Wattanamongkonsil L Thamlikitkul V Efficacy and safety of Curcuma Domestica extracts in patients with knee osteoarthritis J Altern Complement Med 2009 15 891 897 10.1089/acm.2008.0186 19678780 · DOI
  9. [9]Kuptniratsaikul V Dajpratham P Taechaarpornkul W Buntragulpoontawee M Lukkanapichonchut P Chootip C Saengsuwan J Tantayakom K Laongpech S Efficacy and safety of curcuma domestica extracts compared with ibuprofen in patients with knee osteoarthritis: a multicenter study Clin Interv Aging 2014 9 451 458 10.2147/CIA.S58535 24672232 PMC3964021 · DOI
  10. [10]Madhu K Chanda K Saji MJ Safety and efficacy of curcuma longa extract in the treatment of painful knee osteoarthritis: a randomized placebo-controlled trial Inflammopharmacology 2013 21 129 136 10.1007/s10787-012-0163-3 23242572 · DOI
  11. [11]Panahi Y Rahimnia AR Sharafi M Alishiri G Saburi A Sahebkar A Curcuminoid treatment for knee osteoarthritis: a randomized double-blind placebo-controlled trial Phytother Res 2014 28 1625 1631 10.1002/ptr.5174 24853120 · DOI · Paper page
  12. [12]Pinsornsak P Niempoog S The efficacy of curcuma Longa L. extract as an adjuvant therapy in primary knee osteoarthritis: a randomized control trial J Med Assoc Thail 2012 95 S51 S58 23964444
  13. [13]Rahimnia AR Panahi Y Alishiri G Sharafi M Sahebkar A Impact of supplementation with curcuminoids on systemic inflammation in patients with knee osteoarthritis: findings from a randomized double-blind placebo-controlled trial Drug Res (Stuttg) 2015 65 521 525 25050518
  14. [14]Chin KY The spice for joint inflammation: anti-inflammatory role of curcumin in treating osteoarthritis Drug Des Devel Ther 2016 10 3029 3042 10.2147/DDDT.S117432 27703331 PMC5036591 · DOI
  15. [15]Grover AK Samson SE Benefits of antioxidant supplements for knee osteoarthritis: rationale and reality Nutr J 2016 15 1 10.1186/s12937-015-0115-z 26728196 PMC4700773 · DOI
  16. [16]Daily JW Yang M Park S Efficacy of turmeric extracts and curcumin for alleviating the symptoms of joint arthritis: a systematic review and meta-analysis of randomized clinical trials J Med Food 2016 19 717 729 10.1089/jmf.2016.3705 27533649 PMC5003001 · DOI
  17. [17]Onakpoya IJ Spencer EA Perera R Heneghan CJ Effectiveness of curcuminoids in the treatment of knee osteoarthritis: a systematic review and meta-analysis of randomized clinical trials Int J Rheum Dis 2017 20 420 433 10.1111/1756-185X.13069 28470851 · DOI
  18. [18]Mirzaei H Shakeri A Rashidi B Jalili A Banikazemi Z Sahebkar A Phytosomal curcumin: a review of pharmacokinetic, experimental and clinical studies Biomed Pharmacother 2017 85 102 112 10.1016/j.biopha.2016.11.098 27930973 · DOI
  19. [19]Prasad S Tyagi AK Aggarwal BB Recent developments in delivery, bioavailability, absorption and metabolism of curcumin: the golden pigment from golden spice Cancer Res Treat 2014 46 2 18 10.4143/crt.2014.46.1.2 24520218 PMC3918523 · DOI
  20. [20]Kurien BT Singh A Matsumoto H Scofield RH Improving the solubility and pharmacological efficacy of curcumin by heat treatment Assay Drug Dev Technol 2007 5 567 576 10.1089/adt.2007.064 17767425 · DOI
  21. [21]Kurien BT Matsumoto H Scofield RH Nutraceutical value of pure curcumin Pharmacogn Mag 2017 13 Suppl 1 S161 S163 10.4103/0973-1296.203988 28479742 PMC5407110 · DOI
  22. [22]Antony B, Merina B, Iyer VS, Judy N, Lennertz K, Joyal S. A pilot cross-over study to evaluate human oral bioavailability of BCM-95 CG (Biocurcumax) a novel bioenhanced preparation of curcumin. Indian J Pharm Sci. 2008:445–9. PMC2792534 20046768
  23. [27]Shoba G Joy D Joseph T Majeed M Rajendran R Srinivas PS Influence of piperine on the pharmacokinetics of curcumin in animals and human volunteers Planta Med 1998 64 353 356 10.1055/s-2006-957450 9619120 · DOI
  24. [28]Hani U Shivakumar HG Solubility enhancement and delivery systems of curcumin a herbal medicine: a review Curr Drug Deliv 2014 11 792 804 10.2174/1567201811666140825130003 25176028 · DOI
  25. [30]Liju VB Jeena K Kuttan R An evaluation of antioxidant, anti-inflammatory, and antinociceptive activities of essential oil from Curcuma Longa L Indian J Pharmacol 2011 43 526 531 10.4103/0253-7613.84961 22021994 PMC3195121 · DOI
  26. [34]Kizhakkedath R Clinical evaluation of a formulation containing Curcuma Longa and Boswellia Serrata extracts in the management of knee osteoarthritis Mol Med Rep 2013 8 1542 1548 10.3892/mmr.2013.1661 24002213 · DOI
  27. [35]Ammon HP Boswellic acids in chronic inflammatory diseases Planta Med 2006 72 1100 1116 10.1055/s-2006-947227 17024588 · DOI
  28. [36]Ammon HP Modulation of the immune system by Boswellia Serrata extracts and boswellic acids Phytomedicine 2010 17 862 867 10.1016/j.phymed.2010.03.003 20696559 · DOI
  29. [37]Abdel-Tawab M Werz O Schubert-Zsilavecz M Boswellia Serrata: an overall assessment of in vitro, preclinical, pharmacokinetic and clinical data Clin Pharmacokinet 2011 50 349 369 10.2165/11586800-000000000-00000 21553931 · DOI
  30. [38]Etzel R Special extract of BOSWELLIA Serrata (H 15) in the treatment of rheumatoid arthritis Phytomedicine 1996 3 91 94 10.1016/S0944-7113(96)80019-5 23194870 · DOI
  31. [39]Gupta PK Samarakoon SM Chandola HM Ravishankar B Clinical evaluation of Boswellia Serrata (Shallaki) resin in the management of Sandhivata (osteoarthritis) Ayu 2011 32 478 482 10.4103/0974-8520.96119 22661840 PMC3361921 · DOI
  32. [40]Cameron M Chrubasik S Oral herbal therapies for treating osteoarthritis Cochrane Database Syst Rev 2014 5 CD002947 PMC4494689 24848732
  33. [41]Kimmatkar N Thawani V Hingorani L Khiyani R Efficacy and tolerability of Boswellia Serrata extract in treatment of osteoarthritis of knee--a randomized double blind placebo controlled trial Phytomedicine 2003 10 3 7 10.1078/094471103321648593 12622457 · DOI
  34. [42]Sengupta K Alluri KV Satish AR Mishra S Golakoti T Sarma KV Dey D Raychaudhuri SP A double blind, randomized, placebo controlled study of the efficacy and safety of 5-Loxin for treatment of osteoarthritis of the knee Arthritis Res Ther 2008 10 R85 10.1186/ar2461 18667054 PMC2575633 · DOI
  35. [43]Sengupta K Krishnaraju AV Vishal AA Mishra A Trimurtulu G Sarma KV Raychaudhuri SK Raychaudhuri SP Comparative efficacy and tolerability of 5-Loxin and Aflapin against osteoarthritis of the knee: a double blind,randomized, placebo controlled clinical study Int J Med Sci 2010 7 366 377 10.7150/ijms.7.366 21060724 PMC2974165 · DOI
  36. [44]Vishal AA Mishra A Raychaudhuri SP A double blind, randomized, placebo controlled clinical study evaluates the early efficacy of aflapin in subjects with osteoarthritis of knee Int J Med Sci 2011 8 615 622 10.7150/ijms.8.615 22022214 PMC3198257 · DOI
  37. [45]Chrubasik JE Roufogalis BD Chrubasik S Evidence of effectiveness of herbal antiinflammatory drugs in the treatment of painful osteoarthritis and chronic low back pain Phytother Res 2007 21 675 683 10.1002/ptr.2142 17444576 · DOI
  38. [46]Ernst E Frankincense: systematic review BMJ 2008 337 a 2813 10.1136/bmj.a2813 PMC2605614 19091760 · DOI
  39. [47]Efferth T Koch E Complex interactions between phytochemicals. The multi-target therapeutic concept of phytotherapy Curr Drug Targets 2011 12 122 132 10.2174/138945011793591626 20735354 · DOI
  40. [48]Panossian A Seo EJ Wikman G Efferth T Synergy assessment of fixed combinations of Herba Andrographidis and radix Eleutherococci extracts by transcriptome-wide microarray profiling Phytomedicine 2015 22 981 992 10.1016/j.phymed.2015.08.004 26407940 · DOI
  41. [49]Comblain F Sanchez C Lesponne I Balligand M Serisier S Henrotin Y Curcuminoids extract, hydrolyzed collagen and green tea extract synergically inhibit inflammatory and catabolic mediator's synthesis by normal bovine and osteoarthritic human chondrocytes in monolayer PLoS One 2015 10 e0121654 10.1371/journal.pone.0121654 25799427 PMC4370821 · DOI
  42. [50]Chopra A Lavin P Patwardhan B Chitre D A 32-week randomized, placebo-controlled clinical evaluation of RA-11, an Ayurvedic drug, on osteoarthritis of the knees J Clin Rheumatol 2004 10 236 245 10.1097/01.rhu.0000138087.47382.6d 17043520 · DOI
  43. [51]Chopra A Saluja M Tillu G Sarmukkaddam S Venugopalan A Narsimulu G Handa R Sumantran V Raut A Bichile L Joshi K Patwardhan B Ayurvedic medicine offers a good alternative to glucosamine and celecoxib in the treatment of symptomatic knee osteoarthritis: a randomized, double-blind, controlled equivalence drug trial Rheumatology (Oxford) 2013 52 1408 1417 10.1093/rheumatology/kes414 23365148 · DOI
  44. [52]Kulkarni RR Patki PS Jog VP Gandage SG Patwardhan B Treatment of osteoarthritis with a herbomineral formulation: a double-blind, placebo-controlled, cross-over study J Ethnopharmacol 1991 33 91 95 10.1016/0378-8741(91)90167-C 1943180 · DOI
  45. [54]Bennell K Dobson F Hinman R Measures of physical performance assessments: self-paced walk test (SPWT), stair climb test (SCT), six-minute walk test (6MWT), chair stand test (CST), timed up & go (TUG), sock test, lift and carry test(LCT), and car task Arthritis Care Res (Hoboken) 2011 63 Suppl 11 S350 S370 10.1002/acr.20538 22588756 · DOI
  46. [55]Dobson F Hinman RS Roos EM Abbott JH Stratford P Davis AM Buchbinder R Snyder-Mackler L Henrotin Y Thumboo J Hansen P Bennell KLOARSI recommended performance-based tests to assess physical function in people diagnosed with hip or knee osteoarthritis Osteoarthr Cartil 2013 21 1042 1052 10.1016/j.joca.2013.05.002 23680877 · DOI
  47. [57]Sahebkar A Are curcuminoids effective C-reactive protein-lowering agents in clinical practice? Evidence from a meta-analysis Phytother Res 2014 28 633 642 10.1002/ptr.5045 23922235 · DOI
  48. [58]Keenan RT Swearingen CJ Yazici Y Erythrocyte sedimentation rate and C-reactive protein levels are poorly correlated with clinical measures of disease activity in rheumatoid arthritis, systemic lupus erythematosus and osteoarthritis patients Clin Exp Rheumatol 2008 26 814 819 19032813
  49. [59]Mobasheri A Henrotin Y Biesalski HK Shakibaei M Scientific evidence and rationale for the development of curcumin and resveratrol as nutraceutricals for joint health Int J Mol Sci 2012 13 4202 4232 10.3390/ijms13044202 22605974 PMC3344210 · DOI
  50. [60]Henrotin Y Lambert C Couchourel D Ripoll C Chiotelli E Nutraceuticals: do they represent a new era in the management of osteoarthritis? - a narrative review from the lessons taken with five products Osteoarthr Cartil 2011 19 1 21 10.1016/j.joca.2010.10.017 21035558 · DOI
  51. [61]Henrotin Y Priem F Mobasheri A Curcumin: a new paradigm and therapeutic opportunity for the treatment of osteoarthritis: curcumin for osteoarthritis management Spring 2013 2 56 10.1186/2193-1801-2-56 PMC3591524 23487030 · DOI
  52. [62]Olsen NJ Nutraceuticals for the treatment of osteoarthritis Minerva Med 2011 102 33 40 21317847
  53. [63]Shakibaei M John T Schulze-Tanzil G Lehman I Mobasheri A Suppression of NF-kappa-B activation by curcumin leads to inhibition of expression of cyclooxygenase-2 and matrix metalloproteinase-9 in human articular chondrocytes: Implication for the treatment of osteoarthritis Biochem Pharmacol. 2007 73 1434 45 10.1016/j.bcp.2007.01.005 17291458 · DOI
  54. [64]Colitti M Gaspardo B Della Pria A Scaini C Stefanon B Transcriptome modification of white blood cells after dietary administration of curcumin and non-steroidal anti-inflammatory drug in osteoarthritic affected dogs Vet Immunol Immunopathol 2012 147 136 146 10.1016/j.vetimm.2012.04.001 22591841 · DOI
  55. [65]Shen CL Smith BJ Lo DF Chyu MC Dunn DM Chen CH Kwun IS Dietary polyphenols and mechanisms of osteoarthritis J Nutr Biochem 2012 23 1367 1377 10.1016/j.jnutbio.2012.04.001 22832078 · DOI
  56. [66]Henrotin Y Clutterbuck AL Allaway D Lodwig EM Harris P Mathy-Hartert M Shakibaei M Mobasheri A Biological actions of curcumin on articular chondrocytes Osteoarthr Cartil 2010 18 141 149 10.1016/j.joca.2009.10.002 19836480 · DOI
  57. [67]Mathy-Hartert M Jacquemond-Collet I Priem F Sanchez C Lambert C Henrotin Y Curcumin inhibits pro-inflammatory mediators and metalloproteinase-3 production by chondrocytes Inflamm Res 2009 58 899 908 10.1007/s00011-009-0063-1 19579007 · DOI
  58. [68]Sengupta K Kolla JN Krishnaraju AV Yalamanchili N Rao CV Golakoti T Raychaudhuri S Raychaudhuri SP Cellular and molecular mechanisms of anti-inflammatory effect of Aflapin: a novel Boswellia Serrata extract Mol Cell Biochem 2011 354 189 197 10.1007/s11010-011-0818-1 21479939 · DOI
  59. [69]Moussaieff A Mechoulam R Boswellia resin: from religious ceremonies to medical uses; a review of in-vitro, in-vivo and clinical trials J Pharm Pharmacol 2009 61 1281 1293 10.1211/jpp.61.10.0003 19814859 · DOI
  60. [70]Takada Y Ichikawa H Badmaev V Aggarwal BB Acetyl-11-Ketob-boswellic acid potentiates apoptosis, inhibits invasion, and abolishes osteoclastogenesis by suppressing NF-kB and NF-kB regulated gene expression J Immunol 2006 176 3127 3140 10.4049/jimmunol.176.5.3127 16493072 · DOI
  61. [71]Blain EJ Ali AY Duance VC Boswellia Frereana (frankincense) suppresses cytokine-induced matrimetalloproteinase expression and production of pro-inflammatory molecules in articular cartilage Phytother Res 2010 24 905 912 19943332
  62. [72]Zhang W Robertson J Jones AC Dieppe PA Doherty M The placebo effect and its determinants in osteoarthritis: meta-analysis of randomized controlled trials Ann Rheum Dis 2008 67 1716 1723 10.1136/ard.2008.092015 18541604 · DOI
  63. [73]Zou K Wong J Abdullah N Chen X Smith T Doherty M Zhang W Examination of overall treatment effect and the proportion attributable to contextual effect in osteoarthritis: meta-analysis of randomized controlled trials Ann Rheum Dis 2016 75 1964 1970 10.1136/annrheumdis-2015-208387 26882927 PMC5099197 · DOI
  64. [74]Sabina EP Indu H Rasool M Efficacy of boswellic acid on lysosomal acid hydrolases, lipid peroxidation and anti-oxidant status in gouty arthritic mice Asian Pac J Trop Biomed 2012 2 128 133 10.1016/S2221-1691(11)60206-2 23569882 PMC3609259 · DOI
  65. [75]Reddy GK Dhar SC Effect of a new non-steroidal anti-inflammatory agent on lysosomal stability in adjuvant induced arthritis Ital J Biochem 1987 36 205 217 3429205

Cited by

Sorted by citations

Authors
Haroyan, A., Mukuchyan, V., Mkrtchyan, N., Minasyan, N., Gasparyan, S., Sargsyan, A., Narimanyan, M., & Hovhannisyan, A.
Affiliations
Erebouni Medical Center (AM)
Corresponding author
Haroyan, Armine
ORCID
Hovhannisyan, Areg
Venue
BMC Complementary and Alternative Medicine
Publisher
Springer Science and Business Media LLC
Published
2018-01-09
Volume
18
Issue
1
Pages
7-7
ISSN
1472-6882 (ISSN-L)
DOI
10.1186/s12906-017-2062-z
PMC
PMC5761198
OpenAlex
W2783826729
Cited by
232
References
1
Citations by year
2026: 8 · 2025: 20 · 2024: 19 · 2023: 26 · 2022: 33 · 2021: 49 · 2020: 43 · 2019: 25 · 2018: 9
FWCI
11.56
Type
journal article
Language
en
Open access
Licence
cc-by
Locations
  • BMC Complementary and Alternative Medicine (publishedVersion, cc-by)
  • PubMed Central (publishedVersion, cc-by)
  • PubMed (publishedVersion)
  • DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion, cc-by-sa)
Funders
EuroPharma USA Inc (2012-01)
Topics
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Medicine › Curcumin's Biomedical Applications
  • Health Sciences › Medicine › Pharmacology › Pharmacological Effects of Medicinal Plants
  • Health Sciences › Medicine › Rheumatology › Osteoarthritis Treatment and Mechanisms
Keywords
osteoarthritis, curcumin, boswellic acids, Boswellia serrata, turmeric, turmeric rhizome extract, herbal combination, joint pain, physical function, WOMAC index, morning stiffness, drug safety
MeSH terms
Aged, Curcumin, Double-Blind Method, Female, Humans, Male, Middle Aged, Osteoarthritis, Triterpenes, Range of Motion, Articular

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