The DOI matches its Crossref record; 43 of the 43 references it cites were found in a registry or an index.
Human germline editing in the era of CRISPR-Cas: risk and uncertainty, inter-generational responsibility, therapeutic legitimacy
Abstract
Background: Clustered Regularly Interspaced Short Palindromic Repeats-associated (CRISPR-Cas) technology may allow for efficient and highly targeted gene editing in single-cell embryos. This possibility brings human germline editing into the focus of ethical and legal debates again. Main body: Against this background, we explore essential ethical and legal questions of interventions into the human germline by means of CRISPR-Cas: How should issues of risk and uncertainty be handled? What responsibilities arise regarding future generations? Under which conditions can germline editing measures be therapeutically legitimized? For this purpose, we refer to a scenario anticipating potential further development in CRISPR-Cas technology implying improved accuracy and exclusion of germline transmission to future generations. We show that, if certain concepts regarding germline editing are clarified, under such conditions a categorical prohibition of one-generation germline editing of single-cell embryos appears not to be ethically or legally justifiable. Conclusion: These findings are important prerequisites for the international debate on the ethical and legal justification of germline interventions in the human embryo as well as for the harmonization of international legal standards.
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“There currently exists a natural mutation rate that is and must be tolerated in reproduction as molecular biology cannot circumvent the occurrence of mutations entirely (Schleidgen et al. 2020).”
From Initial heritable genome editing: mapping a responsible pathway from basic research to the clinic (2023) · cites this paper as Schleidgen et al. 2020
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A Programmable Dual-RNA–Guided DNA Endonuclease in Adaptive Bacterial Immunity
Jinek, M., Chylinski, K., Fonfara, I., Hauer, M., Doudna, J. A., & Charpentier, E. (2012) · Science · doi:10.1126/science.1225829 · Cited by 17,116
Multiplex Genome Engineering Using CRISPR/Cas Systems
Cong, L., Ran, F. A., Cox, D., Lin, S., Barretto, R., Habib, N., Hsu, P. D., Wu, X., Jiang, W., Marraffini, L. A., et al. (2013) · Science · doi:10.1126/science.1231143 · Cited by 15,339
The new frontier of genome engineering with CRISPR-Cas9
Doudna, J. A., & Charpentier, E. (2014) · Science · doi:10.1126/science.1258096 · Cited by 7,062
Parfit, D. (1986) · Stanford University Press eBooks · doi:10.1093/019824908x.001.0001 · Cited by 5,860
CRISPR/Cas9-mediated gene editing in human tripronuclear zygotes
Liang, P., Xu, Y., Zhang, X., Ding, C., Huang, R., Zhang, Z., Lv, J., Xie, X., Chen, Y., Li, Y., et al. (2015) · Protein & Cell · doi:10.1007/s13238-015-0153-5 · Cited by 1,135
Friedmann, T., & Roblin, R. (1972) · Science · doi:10.1126/science.175.4025.949 · Cited by 815
(2005) · Scandinavian Journal of Disability Research · doi:10.1080/15017410500246111 · Cited by 754
WRONGFUL LIFE, PROCREATIVE RESPONSIBILITY, AND THE SIGNIFICANCE OF HARM
Shiffrin, S. V. (1999) · Legal Theory · doi:10.1017/s1352325299052015 · Cited by 574
Structure of Cre recombinase complexed with DNA in a site-specific recombination synapse
Guo, F., Gopaul, D. N., & Van Duyne, G. D. (1997) · Nature · doi:10.1038/37925 · Cited by 573
The Moral Limits of the Criminal Law Volume 1: Harm to Others
Feinberg, J. (1987) · doi:10.1093/0195046641.001.0001 · Cited by 569
Research works printed but not linked: 2
- Berlin-Brandenburg Academy of Sciences and Humanities. 2015. Human genome surgery. Towards a responsible evaluation of a new technology. http://www.gentechnologiebericht.de/bilder/BBAW_Human-Genome-Surgery_PDF-A1b-1.pdf. Accessed 18 Dec 2019.
- EU Charter of Fundamental Rights. Official Journal of the European Union, C 326, 26.10.2012.
Cited by
Initial heritable genome editing: mapping a responsible pathway from basic research to the clinic
Ranisch, R., Trettenbach, K., & Arnason, G. (2023) · Medicine, Health Care and Philosophy · doi:10.1007/s11019-022-10115-x · Cited by 19
Metadata
- Authors
- Schleidgen, S., Dederer, H.-G., Sgodda, S., Cravcisin, S., Lüneburg, L., Cantz, T., & Heinemann, T.
- Venue
- BMC Medical Ethics
- Published
- 2020-09-11
- Volume
- 21
- Issue
- 1
- ISSN
- 1472-6939
- PMC
- PMC7488432
- Cited by
- 43
- References
- 43
- Language
- en
- Licence
- creativecommons.org/licenses/by/4.0 (tdm)
- creativecommons.org/licenses/by/4.0 (vor)
- Funders
- Bundesministerium für Bildung und Forschung (01GP1616A-C)
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