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Cited by 79Yeasts and Rust Fungi StudiesFungal and yeast genetics researchAntifungal resistance and susceptibility

Distribution and impact of yeast thermal tolerance permissive for mammalian infection

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Robert, Vincent, Cardinali, Gianluigi, Casadevall, Arturo·2015·BMC Biology
DOI 10.1186/s12915-015-0127-3PMC PMC4381509
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Abstract

BACKGROUND: From the viewpoint of fungal virulence in mammals, thermal tolerance can be defined as the ability to grow in the 35°C to 40°C range, which is essential for inhabiting these hosts. RESULTS: We used archival information in a fungal collection to analyze the relationship between thermal tolerance and genetic background for over 4,289 yeast strains belonging to 1,054 species. Fungal genetic relationships were inferred from hierarchical trees based on pairwise alignments using the rRNA internal transcribed spacer and large subunit rDNA (LSU) sequences. In addition, we searched for correlations between thermal tolerance and other archival information including antifungal susceptibility, carbon sources, and fermentative capacity. Thermal tolerance for growth at mammalian temperatures was not monophyletic, with thermally tolerant species being interspersed among families that include closely related species that are not thermal tolerant. Thermal tolerance and resistance to antifungal drugs were not correlated, suggesting that these two properties evolved independently. Nevertheless, the ability to grow at higher temperatures did correlate with origin from lower geographic latitudes, capacity for fermentation and assimilation of certain carbon sources. CONCLUSIONS: Thermal tolerance was significantly more common among ascomycetous than basidiomycetous yeasts, suggesting an explanation for the preponderance of ascomycetous yeasts among human pathogenic fungi. Analysis of strain maximum tolerable temperature as a function of collection time suggested that basidiomycetous yeasts are rapidly adapting to global warming. The analysis identified genera with a high prevalence of the thermal-tolerant species that could serve as sources of emerging pathogenic fungi.

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Authors
Robert, V., Cardinali, G., & Casadevall, A.
Affiliations
  • Westerdijk Fungal Biodiversity Institute (NL)
  • University of Perugia (IT)
  • Albert Einstein College of Medicine (US)
Corresponding author
  • Robert, Vincent
  • Cardinali, Gianluigi
  • Casadevall, Arturo
ORCID
Venue
BMC Biology
Publisher
Springer Science and Business Media LLC
Published
2015-02-26
Volume
13
Issue
1
Pages
18-18
ISSN
1741-7007 (ISSN-L)
DOI
10.1186/s12915-015-0127-3
PMC
PMC4381509
OpenAlex
W2075455725
Cited by
79
References
43
Citations by year
2026: 6 · 2025: 16 · 2024: 9 · 2023: 9 · 2022: 8 · 2021: 8 · 2020: 7 · 2019: 8 · 2018: 4 · 2017: 2 · 2016: 2
FWCI
1.16
Type
journal article
Language
en
Open access
Licence
Locations
  • BMC Biology (publishedVersion, cc-by)
  • Europe PMC (PubMed Central) (publishedVersion, cc-by)
  • PubMed Central (publishedVersion, cc-by)
  • PubMed (publishedVersion)
  • KNAW research portal (Royal Academy of Art and Sciences (KNAW)) (publishedVersion, other-oa)
  • Data Archiving and Networked Services (DANS) (submittedVersion, other-oa)
Funders
  • National Institutes of Health (5r01hl059842-23, 5r01ai052733-16, 5R01AI052733, 5R37AI033142, 5R01HL059842, 5r37ai033142-24)
  • National Heart, Lung, and Blood Institute (R01-HL059842, 5R01HL059842)
  • National Institute of Allergy and Infectious Diseases (R37-AI033142, R01-AI052733, 5R37AI033142, 5R01AI052733., R01AI033774)
Topics
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Yeasts and Rust Fungi Studies
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Fungal and yeast genetics research
  • Health Sciences › Medicine › Infectious Diseases › Antifungal resistance and susceptibility
Keywords
fungal virulence, mammalian infection, ascomycetous yeasts, basidiomycetous yeasts, antifungal resistance, fermentative capacity, carbon source assimilation, latitude, climate change adaptation
MeSH terms
Adaptation, Physiological, Animals, Antifungal Agents, Fermentation, Geography, Glucose, Humans, Mammals, Microbial Sensitivity Tests, Mycoses, Phylogeny, Temperature, Yeasts, Genetic Loci

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